Long Zhang, Shaobo Mo, Xiurui Zhu, C James Chou, Bo Jin, Zhi Han, James Schilling, Weili Liao, Sheeno Thyparambil, Ruben Y Luo, John C Whitin, Lu Tian, Seema Nagpal, Scott R Ceresnak, Harvey J Cohen, Doff B McElhinney, Karl G Sylvester, Yangming Gong, Chen Fu, Xuefeng B Ling, Junjie Peng
Background: Markers of aging hold promise in the context of colorectal cancer (CRC) care. Utilizing high-resolution metabolomic profiling, we can unveil distinctive age-related patterns that have the potential to predict early CRC development. Our study aims to unearth a panel of aging markers and delve into the metabolomic alterations associated with aging and CRC. Methods: We assembled a serum cohort comprising 5,649 individuals, consisting of 3,002 healthy volunteers, 715 patients diagnosed with colorectal advanced precancerous lesions (APL), and 1,932 CRC patients, to perform a comprehensive metabolomic analysis...
2024: Theranostics