journal
https://read.qxmd.com/read/37780889/antifungal-resistance-profile-of-fungal-isolates-from-fungal-rhinosinusitis-patients-a-study-from-tertiary-care-hospital
#1
JOURNAL ARTICLE
Lavanya Sriramajayam, Ravinder Kaur, Megh Singh Dhakad, Achal Gulati
Objective  Fungal rhinosinusitis is on the rise worldwide and it is endemic especially in North India. The main purpose of this study was to determine the antifungal resistance profile of fungal isolates from the cases of fungal rhinosinusitis. Methods  Antifungal susceptibility testing of isolated fungi to fluconazole, amphotericin B, itraconazole, and voriconazole was determined by standard CLSI broth microdilution method. Results  Sixty-eight fungal isolates of Aspergillus spp . ( n  = 49), Rhizopus spp...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780888/prevalence-and-impact-of-hmox1-polymorphism-rs2071746-a%C3%A2-%C3%A2-t-in-indian-sickle-cell-disease-patients
#2
JOURNAL ARTICLE
Hareram Pandey, Kanwaljeet Singh, Ravi Ranjan, Jasmita Dass, Seema Tyagi, Tulika Seth, Renu Saxena, Manoranjan Mahapatra
Introduction  Fetal hemoglobin (HbF) levels play significant role in lowering down the morbidity and mortality in sickle cell disease (SCD) patients. Coinheritance of heme oxygenase-1 (HMOX1) rs2071746:A > T polymorphism may contribute to variable HbF levels in Indian SCD patients. Objective  This study was aimed to evaluate the role of HMOX1 polymorphism and its impact on HbF level in Indian SCD patients. Materials and Methods  One-hundred twenty confirmed cases of SCD and 50 healthy controls were recruited...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780887/deciphering-the-patterns-of-dual-primary-cases-registered-at-the-hospital-based-cancer-registry-first-experience-from-rural-cancer-center-in-north-india
#3
JOURNAL ARTICLE
Sankalp Sancheti, Alok Kumar Goel, Anshul Singla, Kuldeep Singh Chauhan, Kiran Arora, Debashish Chaudhary, Tapas Dora, Shweta Tahlan, Prithviraj Kadam, Prachi Joshi, Akash Sali, Rahatdeep Singh Brar, Atul Budukh, Ashish Gulia, Jigeeshu Vasishtha Divatia, Rajendra Badwe
Objectives  The objective is to present the patterns of dual primary malignancies diagnosed at the Pathology Laboratory of Cancer Hospital with the support from hospital-based cancer registry (HBCR), Sangrur, Punjab, India for the years 2018 and 2019. Methods  HBCR abstracts data from electronic medical records. Trained cancer registry staff abstracts cases in standard pro forma. Dual primary was coded as per the International Agency for Research on Cancer rule and was rechecked by the pathologist...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780886/in-vitro-susceptibility-of-burkholderia-pseudomallei-isolates-to-cefiderocol-and-ceftazidime-avibactam-from-odisha-india
#4
JOURNAL ARTICLE
Jayanti Jena, Bijayini Behera, Gayatree Nayak, Srujana Mohanty, Ashoka Mahapatra, Prashanth Purushotham, Anjuna Radhakrishnan, Manaswiny Tripathy
Introduction and Objectives  The availability of a limited arsenal of antibacterial agents effective against Burkholderia pseudomallei, the causative agent of melioidosis, together with sporadic reports of emergence of resistance necessitates an evaluation of in vitro activity of new antimicrobials against clinical B. pseudomallei isolates. Cefiderocol (CFDC), a novel siderophore cephalosporin, and ceftazidime-avibactam (CZA), a new β lactam combination agent, have shown promising results for the treatment of difficult-to-treat Gram-negative bacilli infections with limited treatment options...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780885/toluidine-blue-stain-as-a-rapid-onsite-tool-for-preliminary-diagnosis-in-imprint-smears-of-bronchoscopic-biopsy-a-cytohistopathological-correlation
#5
JOURNAL ARTICLE
Abhishek Chowdhury, Riju Bhattacharya, Joyshree Panda, Debashis Chakrabarty
Introduction  Lung cancer is currently the most common cause of cancer-related mortality, with 11.4% of cancers and 18% of cancer-related deaths worldwide whereas Indian figures are 6.9 and 9.3%, respectively. Hence, the need for early diagnosis. Bronchial biopsy has the highest sensitivity among all the samples that can be obtained by bronchoscopic techniques in case of endobronchial lesions. Imprint cytology has emerged as an important cytological method. Toluidine blue has been studied for its use as rapid onsite stain for cytological evaluation on various samples of cytology in different anatomic sites...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780884/effect-of-abca1-r219k-polymorphism-in-serum-lipid-parameters-in-patients-under-statin-therapy-visiting-tertiary-cardiac-center-of-nepal
#6
JOURNAL ARTICLE
Sapana Ghimire, Binod Kumar Yadav, Sweta Shrestha, Jivan Shakya, Chandra Mani Poudel, Eans Tara Tuladhar, Vijay Kumar Sharma, Mithilesh Raut, Aseem Bhattarai, Krishna Das Manandhar, Vivek Pant, Deependra Shrestha
Introduction  ATP-binding cassette transporter A1 (ABCA1) encoded by ABCA1 gene is one of the important protein involved in lipid metabolism. The effect of statin therapy on dyslipidemia varies among individuals and it may be due to different genetic polymorphism. The R219K polymorphism of ABCA1 gene is found to have a significant role in the response of statin. Objective  This study was designed to evaluate the effect of R219K polymorphism in lipid-lowering action of statin in patients with dyslipidemia...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780883/effect-of-statins-on-the-inflammatory-markers-in-patients-with-coronary-artery-disease
#7
JOURNAL ARTICLE
Sujatha Mahadevarao Premnath, Sunil Kumar Nanda, Lopamudra Ray, Mark Chirstopher Arokiaraj
Introduction  Atherosclerosis mediated by inflammatory markers is the corner stone in the pathology of coronary artery disease (CAD). Hyperlipidemia, one of the risk factors is treated with statins. Statins also have a pleotropic role in reducing inflammation. Effect of statins on two inflammatory markers pentraxin 3(PTX 3) and high sensitivity C-reactive protein (hs-CRP) is explored in this study. Objective  This article estimates the levels of serum PTX 3 and hs-CRP in CAD patients with and without statin therapy and correlates the levels with low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) in CAD patients without statin therapy...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780882/martin-s-formula-as-the-most-suitable-method-for-estimation-of-low-density-lipoprotein-cholesterol-in-indian-population
#8
JOURNAL ARTICLE
Fatima Farheen, Sudha Ambiger, Kamarudin Jaalam, Shivalingappa Javali
Background  Because of cost effectiveness, most of the laboratories in India estimate low-density lipoprotein cholesterol (LDL-C) levels with the Friedewald's formula. There were many shortcomings of the Friedewald's formula. Recently, Martin and colleagues have derived a new formula for calculating LDL-C. The present study was undertaken to calculate LDL-C using various formulae (Friedewald's formula, Anandaraja's formula, and Martin's formula) and to compare directly measured LDL-C (D-LDL-C) with calculated LDL-C at various ranges of triglyceride (TG) concentration...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780881/understanding-the-constraints-and-optimization-of-serum-immunofixation-electrophoresis-and-serum-free-light-chains-for-detecting-monoclonal-proteins-a-single-center-experience
#9
JOURNAL ARTICLE
Malvika Shastri, Pankaj Malhotra, Harvinder Kaur, Ritu Aggarwal
Introduction  Serum immunofixation electrophoresis (SIFE) and serum free light chain (SFLC) assay are imperative investigations in diagnosis and follow-up of multiple myeloma (MM). SFLC assays are reported to have higher sensitivity than SIFE. However, discrepancies have been reported between them. The current study was aimed at assessing concordance and discordance between SIFE and SFLC results in MM. Methods  A total of 450 observations of both SIFE and SFLC were obtained from treatment-naive and follow-up MM patients...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780880/profile-of-cutaneous-bacterial-flora-in-pemphigus-patients
#10
JOURNAL ARTICLE
Srujana Mohanty, Swarnatrisha Saha, Shehnaz Firdaus, Chandra Sekhar Sirka
Objectives  Pemphigus, a group of autoimmune bullous diseases, can be fatal, resulting from overwhelming opportunistic infection of lesions secondary to cutaneous bacterial infections. This study aimed to look into the cutaneous bacterial infection profile of pemphigus patients as timely identification and appropriate treatment can play a major role in reducing mortality. Materials and Methods  Pus samples/swabs received from patients with pemphigus over a 2-year period from July 2018 to June 2020 were subjected to standard microbiological culture techniques and susceptibility testing...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780879/evaluation-of-accuracy-of-intraoperative-frozen-section-and-imprint-cytology-in-gynecological-neoplasms-a-descriptive-cross-sectional-study-of-50-cases-in-tertiary-care-center
#11
JOURNAL ARTICLE
Ayushi Kediya, Nadia Shirazi, Ruchira Nautiyal
Aims and Objectives  Gynecological neoplasms are among the most common cancers in female population of India and worldwide. Various new advances have been made to diagnose gynecological pathologies which include imprint cytology and frozen sections in addition to the histopathological techniques. The aim of the study was to assess the diagnostic accuracy of intraoperative diagnostic procedure with gold standard histopathology. Method  The study included 50 patients who had suspected gynecological neoplasm in a time period of 12 months...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780878/-edwardsiella-tarda-causing-fishbone-injury-cellulitis-leading-to-sepsis-in-a-case-of-hematological-malignancy-a-rare-report-and-review-of-literature
#12
Sushree Sarathi, Anupam Brahma, Prabodha Kumar Das, Ashoka Mahapatra, Bijayini Behera
Edwardsiella tarda ( E. tarda ), a gram-negative bacillus, a member of order Enterobacterales , is typically a fish pathogen frequently isolated from fresh and brackish water environments. It is very rarely implicated in human infections such as gastroenteritis (most common), cellulitis, gas gangrene, hepatobiliary infections, peritonitis, empyema, and meningitis. Bacteremia/sepsis caused by E. tarda can be fatal in humans, although very rare (<5%). To date, very few cases of E. tarda sepsis have been reported worldwide including India...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780877/primary-anterior-thoracic-wall-abscess-with-osteomyelitis-by-salmonella-paratyphi-a-case-report
#13
Neetha S Murthy, Rashmi P Mahale, Krishna Karthik Mvs
Salmonella enterica serovar Typhi and Paratyphi have been imputed in the causation of enteric fever. Cardiovascular and extraintestinal Salmonella infections have been documented among immunocompromised individuals. Rarely these pathogens are ascribed in the causation of extraintestinal infections among immunocompetent hosts due to hematogenous seeding. We report a case of anterior chest wall abscess with osteomyelitis in an immunocompetent adult by Salmonella paratyphi A without any prior predisposing conditions or gastrointestinal symptoms...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780876/spectrum-and-trends-of-intestinal-parasitic-infections-at-a-tertiary-care-hospital-during-pandemic-times-a-laboratory-based-retrospective-study
#14
JOURNAL ARTICLE
Suneeta Meena, Jitendra Kumar Meena, Dinesh Kumar, Purva Mathur
Introduction  Intestinal parasitic infections continue to loom in developing countries with low sanitation and socioeconomic conditions. Pandemic times are especially important to study the prevalence of these pathogens since the focus of all healthcare services was coronavirus disease 2019 (COVID-19). This study aimed to evaluate the prevalence and time-trend of intestinal parasitic infections in the capital region of India during the pandemic times. Methods  In this cross-sectional study, a retrospective review based on data from the past 2 years in the post-COVID-19 pandemic was used...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780875/performance-evaluation-of-an-improved-hbsag-assay-hbsag-next-for-the-detection-of-hbsag-levels
#15
JOURNAL ARTICLE
Ekta Gupta, Arjun Bhugra, Jasmine Samal, Arvind Khodare, Keshaw Singh, Aayushi Rastogi, Manoj Kumar Sharma
Objectives  Detection of hepatitis B surface antigen (HBsAg) plays an important role in the screening and diagnosis of hepatitis B virus (HBV) infections. There is a need of highly sensitive assays with an improved lower limit of detection (LoD). Here, we evaluate the performance characteristics of the HBsAg NEXT (HBsAg new) assay in the detection of HBsAg in clinical samples. Materials and Methods  This was a cross-sectional study conducted at a tertiary care liver center in North India. The study included 439 clinical samples...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780874/a-case-series-of-fetal-neonatal-ovarian-cyst-from-a-tertiary-care-hospital
#16
JOURNAL ARTICLE
Priyadarshini Kumaraswamy Rajeswaran, Shanthakumari Sivanandam, Pavai Arunachalam
The occurrence of ovarian cyst in the neonate is rare and antenatally diagnosed by ultrasonography. This study aims to increase awareness about its occurrence and histological features. We performed a retrospective review on 10 cases of neonatal ovarian cyst (NOC) during 4 years (2016-2020) in a tertiary care center in South India. The neonates were diagnosed with abdominal cysts by the antenatal ultrasonogram in the third trimester. They were operated from day 5 to 35 days of age. There was no side predilection, and most of them were unilateral (9 out of 10 cases)...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780873/stillbirth-investigations-an-iconographic-and-concise-diagnostic-workup-in-perinatal-pathology
#17
REVIEW
Consolato M Sergi, Deborah Spencer, Taher Al-Jishi
Introduction  Stillbirth is a dramatic event for the parents, health care team, and anyone close to the expectant parents. Multidisciplinary team (MDT) meetings are essential to improve communication in health care. We review the most frequent findings discussed at MDT meetings. Methods  A PubMed search was conducted through December 2021 since the inception (1965) using clinical queries with the key terms "stillbirth" AND "investigation" AND "pathology" AND "human." The search strategy included reviews, meta-analyses, randomized controlled trials, clinical trials, and observational studies...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780872/arm-length-does-it-influence-late-response-in-a-nerve-conduction-study
#18
JOURNAL ARTICLE
Sathya G R, Jayanthi Arulneyam, Venkatachalam J, M Manikandan
Introduction  F wave response, a late response obtained from a motor nerve, can be influenced by various external factors like gender, temperature, height, weight, and limb length, and hence it causes variation in the measured parameters. Since very few studies have studied the impact of arm length on the F wave, this study was conducted to analyze the relation between the arm length on various parameters of F wave and hence to consider the importance of it during conduct of a nerve conduction study...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780871/subphenotypes-of-sars-cov-2-associated-ards-overlap-each-other-a-retrospective-analysis
#19
JOURNAL ARTICLE
Parvathy R Nair, Kavitha Girish, Gouri Mini, Tazeen Khan, Damarla Haritha, Koninica Sanyal, Sulagna Bhattacharjee, Dalim K Baidya, Bikash R Ray, Rahul K Anand, Sudip K Datta, Manish Soneja, Rajeshwari Subramaniam, Souvik Maitra
Background  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus-associated pneumonia and acute respiratory distress syndrome (ARDS) were often associated with hyperinflammation and elevation of several serum inflammatory markers but usually less than what is observed in non-coronavirus disease (COVID) ARDS. Elevated inflammatory markers such as C-reactive protein, interleukin (IL)-6, etc., are associated with severe infection. This study identified subphenotypes of COVID-19 ARDS patients by latent profile analysis in a cohort of Indian patients...
December 2023: Journal of Laboratory Physicians
https://read.qxmd.com/read/37780870/synchronous-malignancies-pathological-analysis-of-three-patients-each-with-dual-malignancies
#20
Md Ali Osama, Priti Chatterjee, Rakesh Kumar, Gunjan Saini, Romesh Lal, Ratna Biswas
Multiple primary malignancies are defined as two or more malignancies arising independently to each other in the same or different anatomical sites, while excluding the possibility of metastasis from the primary malignancy. Here, we present three cases, each with dual malignancies involving different anatomical locations.
December 2023: Journal of Laboratory Physicians
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