Wenya Xue, Manon F Pritchard, Saira Khan, Lydia C Powell, Joana Stokniene, Jingxiang Wu, Nicholas Claydon, Paul Reddell, David W Thomas, Katja E Hill
BACKGROUND: Peri-implantitis has become an inexorable clinical challenge in implantology. Topical immunomodulatory epoxy-tiglianes (EBCs), derived from the Queensland blushwood tree, which induce remodeling and resolve dermal infection via induction of the inflammasome and biofilm disruption, may offer a novel therapeutic approach. DESIGN: In vitro antimicrobial activity of EBC structures (EBC-46, EBC-1013 and EBC-147) against Streptococcus mutans , Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in minimum inhibitory concentration, growth curve and permeabilization assays were determined...
2023: Journal of Oral Microbiology