journal
https://read.qxmd.com/read/38125786/current-status-and-challenges-in-delivering-comprehensive-care-for-patients-with-hemophilia
#21
REVIEW
Shosaku Nomura
The importance of comprehensive care as a treatment strategy for patients with hemophilia is recognized worldwide. Comprehensive care entails addressing full spectrum of medical and psychological aspects impacting both patients and their families. The primary objective of comprehensive care for individuals with hemophilia is to enable them to lead their daily lives just as anyone else would. To achieve this goal, it is necessary to have a positive and collaborative approach across various healthcare disciplines...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/38116327/hyperviscosity-syndrome-induced-bilateral-visual-and-auditory-impairment-in-therapy-resistant-waldenstr%C3%A3-m-macroglobulinemia-with-myd88-and-cxcr4-mutations
#22
Marie M Plante, ErinMarie O Kimbrough, Amit K Agarwal, Liuyan Jiang, Kirk Bourgeois, Greta C Stamper, Michael W Stewart, Han W Tun
Hyperviscosity syndrome (HVS) is an emergent complication of Waldenström macroglobulinemia (WM) characterized by visual, neurologic, and rarely auditory impairment. We report a 69-year-old female with MYD88 and CXCR4-mutant WM who developed HVS resulting in bilateral blindness and deafness associated with neurologic manifestations including confusion, severe generalized weakness, and imbalance. Ophthalmologic evaluation revealed bilateral central retinal vein occlusion (CRVO), diffuse retinal hemorrhages, macular edema, and serous macular detachments (SMD)...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/38084255/paroxysmal-nocturnal-hemoglobinuria-current-management-unmet-needs-and-recommendations
#23
REVIEW
Monika Oliver, Christopher J Patriquin
Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-rare, acquired clonal abnormality, which renders hematopoietic cells exquisitely sensitive to complement-mediated destruction. Classical features of PNH include intravascular hemolytic anemia, increased thrombotic risk, and manifestations related to end-organ damage (eg fatigue, chest pain, dyspnea, renal failure, and pulmonary hypertension). With supportive care alone, mortality rate of patients with PNH is approximately 35%. The anti-C5 monoclonal antibody, eculizumab, was the first targeted therapy approved for PNH, and led to improved hemoglobin, quality of life, reduced transfusion need, reduced thrombosis, and greater overall survival...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/38053640/patient-blood-management-and-its-role-in-supporting-blood-supply
#24
REVIEW
Richard R Gammon, Rounak Dubey, Gaurav K Gupta, Colleen Hinrichsen, Aikaj Jindal, Divjot Singh Lamba, Sadhana Mangwana, Amita Radhakrishnan Nair, Shaughn Nalezinski, Christopher Bocquet
Blood donors and voluntary blood donations are essential for ensuring the blood supply that can be maintained by good patient blood management (PBM) practices. This review article explores the role of blood donation in PBM and highlights the importance of donor screening and selection processes in different regions worldwide. The donor health questionnaires and the focused physical examination guidelines have changed in the last decade to increase donor and recipient safety. This article also discusses the status of transfusion practices, including the challenges of ensuring a safe blood supply...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/38047247/deferasirox-in-patients-with-chronic-kidney-disease-assessing-the-potential-benefits-and-challenges
#25
REVIEW
Abdulqadir J Nashwan, Mohamed A Yassin
Chronic kidney disease (CKD) is a major global health concern, affecting millions of people worldwide. The progressive decline in kidney function often necessitates renal replacement therapy, such as hemodialysis (HD) or peritoneal dialysis (PD), to maintain a patient's health. Iron overload, which is common in CKD patients on dialysis, can lead to severe complications, including cardiovascular disease and infections where most of the existing iron chelators are deemed unsuitable due to their suboptimal clearance in patients with compromised renal function, it becomes a significant challenge to effectively manage iron overload...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/38023805/prevalence-and-associated-factors-of-anemia-among-hospital-admitted-patients-in-eastern-ethiopia
#26
JOURNAL ARTICLE
Mohammed Umer Yusuf, Nuredin Abdurahman, Haftu Asmerom, Tesfaye Atsbaha, Adisu Alemu, Fitsum Weldegebreal
BACKGROUND: Anemia is one of the most common comorbidities frequently seen in admitted patients. However, there is a scarcity of evidence regarding anemia among hospital admitted patients in Ethiopia, particularly in the Harari Region. Therefore, this study aimed to assess the prevalence and associated factors of anemia among hospital admitted patients in Eastern Ethiopia. METHODS: A hospital-based cross-sectional study was conducted from October 25 to December 30, 2022...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37965639/acquired-clotting-factor-deficits-during-treatment-with-asparaginase-in-an-institutional-cohort
#27
Vasiliki Papadopoulou, Giulia Schiavini
We invariably see prolongation of activated partial thromboplastin time in patients treated with asparaginase in our clinical practice, but have noted that, contrary to hypofibrinogenemia and low antithrombin, clotting times' prolongation by asparaginase is largely unreported in the literature and guidelines and is not widely known to clinicians. We report on aPTT prolongations in a small cohort of patients, and on their origin, as investigated by measurements of clotting factors, fibrinogen, and D-dimers before and after asparaginase administration...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37941894/glanzmann-thrombasthenia-associated-with-siderotic-synovitis-and-arthropathy-a-case-report
#28
Mouhammad J Alawad, Mohammad Abu-Tineh, Awni Alshurafa, Alaa Al-Taie, Anil Yousaf, Mohamed A Yassin
Glanzmann thrombasthenia is a bleeding disorder with a low incidence. It typically manifests as superficial bleeding episodes, which tend to be mild. Deep organ involvement is not uncommon but remains rare due to the rarity of the disease itself and the unusual association between platelet disorders and deep organ implications. A 17-year-old boy with Glanzmann thrombasthenia since infancy developed ankle pain after a minor trauma. His initial workup was negative, but he continued to experience ankle pain. A magnetic resonance imaging (MRI) done after four weeks suggested siderotic synovitis...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37915624/the-correlation-between-sp-selectin-and-platelet-count-in-covid-19-patients-in-referral-hospital-west-java-indonesia
#29
JOURNAL ARTICLE
Delita Prihatni, Frany Charisma Budianto, Basti Andriyoko, Suryarini Trisa
INTRODUCTION: sP-selectin is a glycoprotein located in α granules of platelet and endothelial's Weibel Palade body, as expression to platelet activation and endothelial cell stimulation by SARS-CoV-2 binding with ACE2 receptor. Consumptive thrombocytopenia is also related to platelet activation. Elevation of sP-selectin and thrombocytopenia are related to COVID-19 complication and often correlated with severity of COVID-19. PURPOSE: Assess the correlation between sP-selectin and platelet in COVID-19 patients at intensive care and non-intensive care...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37881654/immunohematological-outcome-among-adult-hiv-patients-taking-highly-active-antiretroviral-therapy-for-at-least-six-months-in-yabelo-hospital-borana-ethiopia
#30
JOURNAL ARTICLE
Girma Ashenafi, Melatwork Tibebu, Dagnamyelew Tilahun, Aster Tsegaye
BACKGROUND: Immunohematological abnormalities among human immunodeficiency virus-infected patients are common abnormalities associated with severe depletion of the immune system, covering a stage of acute syndrome to an advanced disease. The greatest impact was observed in the low- and middle-income countries. However, in Ethiopia, little attention has been paid, and only limited published information exists regarding immunohematological abnormalities among individuals receiving highly active antiretroviral treatment...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37849564/correlation-between-hypercoagulable-state-and-severity-level-of-ischemic-stroke-with-covid-19-infection
#31
JOURNAL ARTICLE
Lisda Amalia
BACKGROUND: Hypercoagulable state in acute ischemic stroke patients with COVID-19, was found to occur in most cases, may affect the severity and clinical outcome of acute ischemic stroke with COVID-19. Ischemic stroke patients with COVID-19 infection have worsen prognosis in mortality regarding hypercoagulable state condition. OBJECTIVE: The study aims to determine the relationship between the hypercoagulable state and the severity of acute ischemic stroke patients with COVID-19...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37753388/flow-cytometric-enumeration-of-peripheral-blood-cd34-cells-predicts-bone-marrow-pathology-in-patients-with-less-than-1-blasts-by-manual-count
#32
JOURNAL ARTICLE
Tomislav M Jelic, Oscar C Estalilla, Jeffrey A Vos, Gary Harvey, Caitlin J Stricker, Ayodele O Adelanwa, Ahmed A Khalid, Milton J Plata
BACKGROUND AND AIMS: Significance of absolute number of CD34+ cells in the peripheral blood of patients with less than 1% myeloblasts by manual differential count is unknown and our aim is to study its relevance in clinical practice. METHODS: We studied 138 peripheral bloods flow cytometric analyses in patients with less than 1% myeloblasts by manual differential, when CD34+ events were present in the gate that encompassed lymphocytes, monocytes, stem cells, and blasts...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37700738/acute-basophilic-leukemia-arising-from-chronic-myeloid-leukemia-with-8-i-17q-q10-and-der-22-t-9-22-after-imatinib-therapy
#33
Peng Shan, Hang Dong, Shilan Li
Acute basophilic leukemia (ABL) arising from chronic myeloid leukemia (CML) with abundant mast cells (MCs), coexisting with a complex karyotype is rare. Here, we report an 81-year-old man admitted to our hospital with a history of ABL. He was diagnosed with CML in the chronic phase in January 2018, and Imatinib was used at a daily dose of 400mg. Then, transformation to ABL with abundant MCs in the bone marrow and complex karyotypes including 48,XY, trisomy 8 (+8), isochromosome 17(q10) [i(17)(q10)], and derivative chromosome 22 t(9;22) [der(22)t(9;22)] were discovered simultaneously in January 2022...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37692069/autoimmune-hemolytic-anemia-caused-by-cold-agglutinin-antibodies-in-systemic-lupus-erythematosus-a-rare-association-case-report
#34
Luis Miguel Osorio-Toro, Jhon Herney Quintana-Ospina, Luis Álvaro Melo-Burbano, Paola Andrea Ruiz-Jiménez, Jorge Enrique Daza-Arana, Giovanna Patricia Rivas-Tafurt, Jorge Hernán Izquierdo-Loaiza
Autoimmune hemolytic anemias (AIHAs) are rare and heterogeneous disorders characterized by the destruction of red blood cells by warm or cold antibodies. Hemolytic anemia associated with warm antibodies is the most common, whereas cold antibodies are rare and infrequent in cases published in the scientific literature. Herein, we present the case of a young patient with systemic lupus erythematosus (SLE) and autoimmune hemolytic anemia caused by cold antibodies. Initially, infectious etiology and hematological malignancy were considered, which were ruled out...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37674760/factors-influencing-blood-donation-practice-among-health-care-providers-of-public-hospitals-in-bahir-dar-city-north-west-ethiopia-a-case-control-study
#35
JOURNAL ARTICLE
Belto Tebabal, Tadele Fentabil Anagaw, Ayinengida Adamu, Desta Debalkie Atnafu
BACKGROUND: Blood donation is a technique in which blood is collected from a healthy individual for transfusion to someone else. WHO estimates that it is necessary to donate blood to 2% to 3% of the country's population to meet blood needs. However, blood donation remains challenging in developing countries. OBJECTIVE: This study aimed to identify factors influencing blood donation practices among healthcare providers in public hospitals in Bahir Dar City. METHODS: This institution-based unmatched case-control study was conducted in Bahir Dar City Public Hospitals from May 01 to May 25, 2022...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37674759/antithrombin-deficiency-and-thrombosis-a-wide-clinical-scenario-reported-in-a-single-institution
#36
Ana Marco-Rico, Pascual Marco-Vera
Congenital antithrombin (AT) deficiency represents the form of thrombophilia with the highest thrombotic risk. It is characterized by a heterogeneous clinical presentation, depending mostly on the family history of thrombosis and type of genetic mutation. Inherited AT deficiency promotes idiopathic thrombosis at an early age (even in the pediatric population) and at atypical sites. Therefore, a positive family background necessitates ruling out this high-risk thrombophilia at a young age. Studying first-degree relatives, even if they are asymptomatic, is essential to establish thromboprophylaxis and a proper therapeutic approach in case of thrombosis...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37641693/effect-of-moringa-oleifera-leaf-powder-on-hematological-profile-of-male-wistar-rats
#37
JOURNAL ARTICLE
Titing Nurhayati, Muhammad Irfan Fathoni, Siti Nur Fatimah, Vita Murniati Tarawan, Hanna Goenawan, Resti Gradia Dwiwina
BACKGROUND: Indonesia is a country with high biodiversity of more than 20,000 plant species, and 35% of them are identified as having health benefits. Moringa oleifera is one plant that almost all of its parts have been used as nutritional supplements and traditional medicines. Moringa leaves contain nutrients, antioxidants, and bioactive substances that have anti-inflammatory, wound healing, and anti-anemia properties. PURPOSE: This study aimed to investigate the hematological effect of Moringa leaf powder in male Wistar rats under normal conditions...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37638257/hematological-abnormalities-among-malaria-infected-adult-patients-in-association-with-abo-blood-groups-at-jinella-health-center-harar-eastern-ethiopia
#38
JOURNAL ARTICLE
Haftu Asmerom, Kabtamu Gemechu, Beza Sileshi, Mesay Arkew
BACKGROUND: Hematological abnormalities are a common complication of malaria infection. However, there is a paucity of evidence regarding it among malaria-infected adult patients in association with the ABO blood group in Ethiopia, particularly in the Harari Region. Therefore, this study aimed to assess the hematological abnormalities among malaria-infected adult patients in association with ABO blood groups at Jinella Health Center, Harar, Eastern Ethiopia. METHODS: An institutional-based cross-sectional study was conducted from July 10, 2022, to January 10, 2023...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37605778/multiply-relapsed-secondary-cns-non-germinal-center-diffuse-large-b-cell-lymphoma-successfully-treated-with-cns-centric-therapy
#39
Lyndsey L Fournier, ErinMarie O Kimbrough, Muhamad Alhaj Moustafa, Ke Li, Madiha Iqbal, Vivek Gupta, Han W Tun
Secondary central nervous system involvement by systemic diffuse large B-cell lymphoma (DLBCL) carries a very poor prognosis. We present a female patient who had two episodes of intracerebral central nervous system (CNS)-only relapse of systemic non-germinal center diffuse large B-cell lymphoma (NGC-DLBCL). Her treatment at initial diagnosis consisted of induction with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and intrathecal (IT) - methotrexate (MTX) followed by consolidation with autologous stem cell transplant (ASCT) after high-dose carmustine, etoposide, cytarabine, and melphalan (BEAM) chemotherapy...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/37588276/prevalence-of-gene-rearrangement-by-multiplex-pcr-in-de-novo-acute-myeloid-leukemia-in-adult-iraqi-patients
#40
JOURNAL ARTICLE
Ali AlJabban, Jaffar Alalsaidissa
INTRODUCTION: Gene rearrangements of acute myeloid leukemia (AML) play a significant role in categorizing patients and provide valuable information about prognosis and treatment choices. However, in Iraq, the prevalence and prognostic significance of gene rearrangements in AML have not been previously examined. METHODS: This study utilized a multiplex reverse transcription real-time PCR (RT-qPCR) system to identify gene rearrangements in a group of 115 adult patients from Iraq who had been diagnosed with De Novo AML...
2023: Journal of Blood Medicine
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