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Journal of Blood Medicine

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https://read.qxmd.com/read/30881167/how-the-discovery-of-rituximab-impacted-the-treatment-of-b-cell-non-hodgkin-s-lymphomas
#1
REVIEW
Raihan Mohammed, Artemis Milne, Kayani Kayani, Utkarsh Ojha
Non-Hodgkin's lymphoma (NHL) is the sixth-most common cancer in the UK, accounting for around 13,700 new cases every year. Until the late 1990s, treatment relied on intensive chemotherapy, such as CHOP (cyclophosphamide-doxorubicin HCl-vincristine [Oncovin]-prednisone). The use of standard CHOP therapy and its variations had resulted in poor five-year survival rates (as low as 26%), particularly in patients with aggressive NHL. Rituximab (Rituxan) was the first chimeric (mouse/human) monoclonal antibody approved for the treatment of NHL...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30804693/erratum-lenograstim-and-filgrastim-in-the-febrile-neutropenia-prophylaxis-of-hospitalized-patients-efficacy-and-cost-of-the-prophylaxis-in-a-retrospective-survey-corrigendum
#2
(no author information available yet)
[This corrects the article on p. 21 in vol. 10, PMID: 30643475.].
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30787644/cost-for-sickle-cell-disease-screening-using-isoelectric-focusing-with-dried-blood-spot-samples-and-estimation-of-price-thresholds-for-a-point-of-care-test-in-uganda
#3
Mercy Mvundura, Charles Kiyaga, Mutsumi Metzler, Carol Kamya, Jeanette M Lim, Catherine Maiteki-Sebuguzi, Patricia S Coffey
Background: Early identification through newborn screening is the first step in active management of sickle cell disease (SCD). Uganda currently screens newborns and infants under 2 years for SCD in high HIV-burden districts using isoelectric focusing with dried blood spot samples. Our analysis sought to estimate the costs per child screened for SCD using this method in Uganda and then to use those data to estimate the price threshold for screening with a point-of-care (POC) test. Methods: We estimated the financial and economic costs per child screened for SCD using data from health facilities and the Central Public Health Laboratory...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30774493/residual-risk-of-hiv-hcv-and-hbv-transmission-by-blood-transfusion-between-2015-and-2017-at-the-regional-blood-transfusion-center-of-ouagadougou-burkina-faso
#4
REVIEW
Arzouma Paul Yooda, Salam Sawadogo, Serge Théophile Soubeiga, Dorcas Obiri-Yeboah, Koumpingnin Nebie, Abdoul Karim Ouattara, Birama Diarra, Abibou Simpore, Yetema Dieudonné Yonli, Abdoul-Guaniyi Sawadogo, Bia Emile Drabo, Seimbou Zalla, Anita Pierrette Siritié, Rodrigue Sosthène Nana, Honorine Dahourou, Jacques Simpore
Introduction: In sub-Saharan Africa, the high endemicity of blood-borne infections is a serious threat to transfusion safety. In order to improve transfusion safety, Burkina Faso has undertaken in recent years a reorganization of its blood-transfusion system through the creation of a National Blood Transfusion Center, which is the only blood operator in the whole country. This study aimed to estimate the residual risk of transmission of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) by blood transfusion at the Regional Blood Transfusion Center (RBTC) of Ouagadougou...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30774492/analysis-of-the-most-common-causes-of-blood-donor-deferral-in-northern-jeddah-a-single-center-study
#5
Afnan K AlNouri, Lamees A Maghrabi, Samah S Hamdi, Shereen M Abd El-Ghany, Khalid A AlNouri
Purpose: We aimed to conduct a retrospective study in order to statistically analyze the commonest causes for blood donor rejection in northern Jeddah, Kingdom of Saudi Arabia according to the American Association of Blood Banks. This will help in developing better strategies to minimize the loss of treasured blood donors. Subjects and methods: A sample of 500 rejected donors was randomly selected from a single blood bank between October 2016 to May 2017. The evaluation of blood donors was according to the personal history questionnaire and a medical examination done before the blood donation proceeded...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30655711/traditional-and-emerging-technologies-for-washing-and-volume-reducing-blood-products
#6
REVIEW
Madeleine Lu, Dalia L Lezzar, Eszter Vörös, Sergey S Shevkoplyas
Millions of blood components including red blood cells, platelets, and granulocytes are transfused each year in the United States. The transfusion of these blood products may be associated with adverse clinical outcomes in some patients due to residual proteins and other contaminants that accumulate in blood units during processing and storage. Blood products are, therefore, often washed in normal saline or other media to remove the contaminants and improve the quality of blood cells before transfusion. While there are numerous methods for washing and volume reducing blood components, a vast majority utilize centrifugation-based processing, such as manual centrifugation, open and closed cell processing systems, and cell salvage/autotransfusion devices...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30643476/association-between-serum-zinc-and-copper-levels-and-antioxidant-defense-in-subjects-infected-with-human-t-lymphotropic-virus-type-1
#7
Samaneh Abolbashari, Susan Darroudi, Maryam Tayefi, Zahra Khashyarmaneh, Parvin Zamani, Hamideh Moalemzadeh Haghighi, Amir Hooshang Mohammadpour, Shima Tavalaei, Mahsa Ahmadnezhad, Habibollah Esmaily, Gordon A Ferns, Zahra Meshkat, Majid Ghayour-Mobarhan
Introduction: Copper (Cu) and zinc (Zn) are important trace elements that are also structural ions of superoxide dismutase (SOD), which reduce oxidative stress. Zinc deficiency and excess copper have been reported to be associated with inflammation. The human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus, which is believed to cause systemic inflammation. The aim of this study is to measure levels of Zn, Cu, SOD, and prooxidant-antioxidant balance (PAB) in HTLV-1-positive patients and investigate the association between serum Zn and Cu concentrations and levels of oxidative stress in them...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30643475/lenograstim-and-filgrastim-in-the-febrile-neutropenia-prophylaxis-of-hospitalized-patients-efficacy-and-cost-of-the-prophylaxis-in-a-retrospective-survey
#8
Rolando Innocenti, Luigi Rigacci, Umberto Restelli, Barbara Scappini, Giacomo Gianfaldoni, Rosa Fanci, Francesco Mannelli, Francesca Scolari, Davide Croce, Erminio Bonizzoni, Tania Perrone, Alberto Bosi
Purpose: We conducted a retrospective study to evaluate the efficacy and related costs of using two different molecules of granulocyte-colony stimulating factor (G-CSF) (lenograstim - LENO or filgrastim - FIL) as primary prophylaxis of chemotherapy-induced neutropenia in a hematological inpatient setting. Methods: The primary endpoints of the analysis were the efficacy of the two G-CSFs in terms of the level of white blood cells, hemoglobin and platelets at the end of the treatment and the per capita direct medical costs related to G-CSF prophylaxis...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30643474/associations-between-iron-deficiency-anemia-and-clinical-features-among-pregnant-women-a-prospective-cohort-study-retraction
#9
(no author information available yet)
[This retracts the article on p. 163 in vol. 9, PMID: 30323700.].
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30588141/hiv-infection-compounds-the-lymphopenia-associated-with-cerebral-malaria-in-malawian-children
#10
Wilson L Mandala, Esther N Gondwe, Tonney S Nyirenda, Mark Drayson, Malcolm E Molyneux, Calman A MacLennan
Aim: Cerebral malaria (CM), unlike severe malarial anemia (SMA), has previously been characterized by pan-lymphopenia that normalizes in convalescence, while HIV infection is associated with depletion of CD4+ T cells. In this study, we investigate whether HIV infection in Malawian children exacerbates the pan-lymphopenia associated with CM. Methods: We investigated the absolute and percentage lymphocyte-subset counts and their activation and memory status in Malawian children presenting with either CM who were HIV-uninfected (n=29), HIV-infected (n=9), or SMA who were HIV-uninfected (n=30) and HIV-infected (n=5) in comparison with HIV-uninfected children without malaria (n=42) and HIV-infected children without malaria (n=4)...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30588140/assessment-of-soluble-cytotoxic-t-lymphocyte-associated-antigen-4-transforming-growth-factor-%C3%AE-1-and-platelet-derived-microparticles-during-dasatinib-therapy-for-patients-with-chronic-myelogenous-leukemia
#11
Shosaku Nomura, Tomoki Ito, Atsushi Satake, Kazuyoshi Ishii
Background: The outcome for chronic myelogenous leukemia (CML) patients presented in the chronic phase has changed dramatically since the introduction of tyrosine kinase inhibitor (TKI) therapy. Notably, an increased incidence of large granular lymphocytes (LGLs), which is related to immunological conditions, appears to be predictive of a favorable outcome for dasatinib therapy. We therefore examined the immunological characteristics of CML patients during dasatinib therapy by determining the plasma concentrations of five different biomarkers...
2019: Journal of Blood Medicine
https://read.qxmd.com/read/30588142/al-hijamah-wet-cupping-therapy-of-prophetic-medicine-significantly-and-safely-reduces-iron-overload-and-oxidative-stress-in-thalassemic-children-a-novel-pilot-study
#12
Mohamed El-Shanshory, Nahed M Hablas, Yasmin Shebl, Ahmed R Fakhreldin, Mohamed Attia, Hamdi H Almaramhy, Hussam Baghdadi, Mongi Ayat, Amal Albeihany, Amr El-Dardear, Hoda Ali Ibrahim, Hany Salah Mahmoud, Manal Mohamed Helmy Nabo, Salah Mohamed El Sayed
Background: Thalassemia is a major health problem due to iron overload, iron deposition and oxidative stress-induced tissue damage. Here, we introduce Al-hijamah (a minor surgical excretory procedure) as a novel percutaneous iron excretion therapy. Al-hijamah is a wet cupping therapy of prophetic medicine, and prophet Muhammad, peace be upon him, strongly recommended Al-hijamah, saying: "The best of your treatment is Al-hijamah". Aim of the study: Our study aimed at investigating the safety, iron chelation, pharmacological potentiation and oxidant clearance effects exerted by Al-hijamah to thalassemic children...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30568523/continuous-infusion-of-recombinant-activated-factor-vii-a-review-of-data-in-congenital-hemophilia-with-inhibitors-and-congenital-factor-vii-deficiency
#13
REVIEW
Madhvi Rajpurkar, David L Cooper
Introduction: Continuous infusion (CI) of clotting factors as a replacement therapy for perioperative hemostatic protection has been performed for many years, including with factors VIII and IX and recombinant activated factor VII (rFVIIa). This approach provides steady factor levels without requiring frequent administration of bolus doses. Aim: To review safety, efficacy, and dosing data regarding CI of rFVIIa for hemostatic management of patients with congenital hemophilia with inhibitors (CHwI) or congenital factor VII deficiency (C7D)...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30538594/to-test-or-not-occurrence-of-sickle-cell-trait-and-assessment-of-the-awareness-toward-its-screening-among-patients-attending-magale-health-center-iv-namisindwa-district-eastern-uganda
#14
Keneth Mandu, Sharifu K Tusuubira, Bashir Mwambi, Fred Webbo, Christine Atuhairwe, Ivan Mugisha Taremwa
Purpose: To evaluate the occurrence of sickle cell trait (SCT), assess patient awareness and evaluate the performance of a sickle cell hemoglobin-S (dithionate-qualitative solubility) point-of-care test among patients seeking care at Magale Health Center IV, Namisindwa District, Eastern Uganda. Materials and methods: We conducted a cross sectional study, in which we consecutively enrolled participants aged ≥18 years at Magale Health Center IV. Four milliliters of EDTA blood were collected by venipuncture and screened for SCT using solubility testing, and confirmed with hemoglobin (Hb) electrophoresis at Central Public Health Laboratory (CPHL), Kampala, Uganda...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30510462/phenotypical-variability-in-congenital-fvii-deficiency-follows-the-isth-ssc-severity-classification-guidelines-a-review-with-illustrative-examples-from-the-clinic
#15
REVIEW
Shilpa Jain, Jennifer Donkin, Mary-Jane Frey, Skye Peltier, Sriya Gunawardena, David L Cooper
Background: One of the most common rare inherited bleeding disorders, congenital factor VII (FVII) deficiency typically has a milder bleeding phenotype than other rare bleeding disorders. Categorizing severity in terms of factor activity associated with hemophilia (severe <1%, moderate 1%-5%, mild 6%-40%) has led to the observation that bleeding phenotype does not follow closely with FVII activity. Over the past decade, large-scale global registries have investigated bleeding phenotype more thoroughly...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30464671/hematological-parameters-in-ghanaian-sickle-cell-disease-patients
#16
Charles Antwi-Boasiako, Ivy Ekem, Mubarak Abdul-Rahman, Frederika Sey, Alfred Doku, Bartholomew Dzudzor, Gifty B Dankwah, Kate Hagar Otu, John Ahenkorah, Robert Aryee
Background: Effective treatment and management of sickle cell disease (SCD) has been a challenge in Africa over the years. Hematological parameters are very useful profiles in the effective management of the disease. However, there is scarcity of studies on the hematological parameters of SCD in Ghana. This study aimed at determining hematological parameters among SCD patients with vaso-occlusion, those in the steady state as well as healthy controls at a teaching hospital in Ghana. Methodology: This was a cross-sectional study involving a total of 628 subjects, including 148 HbAA controls, 208 HbSS patients in steady state, 82 HbSC patients in steady state, 156 HbSS patients in vaso-occlusive crises (VOC), and 34 HbSC patients in VOC...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30464670/prevalence-morphological-characterization-and-associated-factors-of-anemia-among-children-below-5-years-of-age-attending-st-mary-s-hospital-lacor-gulu-district-northern-uganda
#17
Apollo Ocan, Caesar Oyet, Fred Webbo, Bashir Mwambi, Ivan Mugisha Taremwa
Aim/objective: The aim of this study was to determine the prevalence, severity, morphological characterization, and the associated factors of anemia among children under the age of 5 years at St. Mary's Hospital Lacor, Gulu District, Northern Uganda. Materials and methods: A structured questionnaire was administered to each participant's parent/caregiver to collect data on sociodemographic factors, feeding pattern, and history of chronic illness. Hemoglobin (Hb) estimation was performed using a HemoCue 201+ analyzer...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30464669/erratum-ethical-and-legal-considerations-regarding-the-ownership-and-commercial-use-of-human-biological-materials-and-their-derivatives-corrigendum
#18
(no author information available yet)
[This corrects the article on p. 87 in vol. 3, PMID: 22977316.].
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30464668/evaluation-of-bleeding-disorders-in-patients-with-noonan-syndrome-a-systematic-review
#19
Diane J Nugent, Alicia A Romano, Shreya Sabharwal, David L Cooper
Background: Noonan syndrome (NS) is an autosomal dominant genetic condition that has a number of clinical features, including bleeding diathesis and a number of hematological abnormalities including clotting factor deficiencies, von Willebrand disease and abnormal platelet count/function. Methods: We evaluated the frequency/types of bleeding disorders, and associated hematological laboratory findings, in patients with NS, using published data from 1965 to 2014. Results: Of 45 studies identified, 31 included data for 428 patients with NS...
2018: Journal of Blood Medicine
https://read.qxmd.com/read/30349415/evans-syndrome-clinical-perspectives-biological-insights-and-treatment-modalities
#20
REVIEW
José Carlos Jaime-Pérez, Patrizia Elva Aguilar-Calderón, Lorena Salazar-Cavazos, David Gómez-Almaguer
Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive direct anti-human globulin test. It is classified as primary and secondary, with the frequency in patients with autoimmune hemolytic anemia being 37%-73%. It predominates in children, mainly due to primary immunodeficiencies or autoimmune lymphoproliferative syndrome. ES during pregnancy is associated with high fetal morbidity, including severe hemolysis and intracranial bleeding with neurological sequelae and death...
2018: Journal of Blood Medicine
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