journal
https://read.qxmd.com/read/38737582/cardiovascular-consequences-of-sickle-cell-disease
#1
JOURNAL ARTICLE
Salem Bahashwan, Rahaf Mohammad Almuhanna, Maryam Taher Al Hazza, Reem Wajdi Baarma, Abdulrahman Yousif AlNajjar, Faris Sameer Siddiqui, Shouq Ziyad Fatani, Ahmed Barefah, Hatem Alahwal, Abdullah Almohammadi, Osman Radhwi, Alaa S Algazzar, Eman M Mansory
BACKGROUND: Sickle cell disease is an inherited blood disorder which can lead to severe complications, particularly in the cardiovascular and respiratory systems, potentially resulting in arrhythmias, pulmonary hypertension (PH), and cardiomegaly. This study aims to investigate the risk of PH and arrhythmias in adult SCD patients. METHODS: Retrospective analysis of medical records from King Abdulaziz University Hospital (KAUH) for patients with SCD aged 15 and above between 2009 and 2021...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38737581/can-covid-19-increase-platelet-in-adult-immune-thrombocytopenia-during-the-tpo-ra-administration-a-real-world-observational-study
#2
JOURNAL ARTICLE
Xiaoyu Wang, Yingqiao Zhu, Dan Liu, Lijun Zhu, Juan Tong, Changcheng Zheng
INTRODUCTION: COVID-19 infection has brought new challenges to the treatment of adult patients with immune thrombocytopenia (ITP). In adult ITP patients, there have been no relevant reports exploring the incidence, clinical characteristics, and risk factors of platelet elevation after COVID-19 infection. MATERIALS AND METHODS: A total of 66 patients with previously diagnosed ITP from December 2022 to February 2023 in a single-center were collected and analyzed for this real-world clinical retrospective observational study...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38699197/risk-of-intracranial-hemorrhage-in-persons-with-hemophilia-a-in-the-united-states-real-world-retrospective-cohort-study-using-the-athndataset
#3
JOURNAL ARTICLE
Jianzhong Hu, Martin Chandler, Christopher Matthew Manuel, Jorge Caicedo, Michael Denne, Bruce Ewenstein, Ali G Mokdad, Shan Xing, Michael Recht
INTRODUCTION: Intracranial hemorrhage (ICH), a serious complication in persons with hemophilia A (PWHA), causes high rates of mortality and morbidity. Identified ICH risk factors from patient data spanning 1998-2008 require reassessment in light of changes in the current treatment landscape. AIM AND METHODS: PWHA identified in the ATHNdataset were evaluated retrospectively to assess incidence of ICH and determine the association between ICH risk and key characteristics using time-to-event analyses (Cox proportional-hazards models, survival curves, and sensitivity analyses)...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38686358/the-role-of-direct-oral-anticoagulants-in-the-treatment-of-cancer-associated-venous-thromboembolism-review-by-middle-east-and-north-african-experts
#4
REVIEW
Shouki Bazarbashi, Heba Mohamed El Zawahry, Tarek Owaidah, Mohammad A AlBader, Ashraf Warsi, Mahmoud Marashi, Emad Dawoud, Hassan Jaafar, Sherif M Sholkamy, Fady Haddad, Alexander T Cohen
Venous thromboembolism is a leading cause of morbidity and mortality in patients with active cancer who require anticoagulation treatment. Choice of anticoagulant is based on careful balancing of the risks and benefits of available classes of treatment: vitamin K antagonists, low-molecular-weight heparin (LMWH), and direct oral anticoagulants (DOACs). Results from randomized controlled trials have shown the consistent efficacy of DOACs versus LMWH in the treatment of cancer-associated venous thromboembolism (VTE)...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38545444/hematological-abnormalities-and-associated-factors-among-patients-with-hypothyroidism-at-the-university-of-gondar-comprehensive-specialized-hospital
#5
JOURNAL ARTICLE
Dereje Mengesha Berta, Yemataw Gelaw, Elias Shiferaw, Abateneh Melkamu, Gebrehiwot Lema Legese, Tiruneh Adane, Befikad Mandefro
OBJECTIVE: Abnormalities in blood cells are frequently associated with thyroid hormone disorders as a result of their involvement in the proliferation and production of blood cells. This study aimed to determine the magnitude and associated factors of hematological abnormalities in patients with hypothyroidism. METHODS: A cross-sectional study was conducted from January 1 to June 30, 2023, at the University of Gondar Comprehensive Specialized Hospital. The present study included a total of 300 patients with hypothyroidism prospectively using the systematic random sampling technique...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38532889/immuno-hematological-and-biochemical-changes-in-patients-with-tuberculosis-in-dessie-comprehensive-specialized-hospital-dessie-ethiopia
#6
JOURNAL ARTICLE
Angesom Gebreweld, Temesgen Fiseha, Edosa Kebede, Zemenu Tamir, Brhane Gebremariam, Fikadu Miruts, Haftay Haileslasie
BACKGROUND: Tuberculosis (TB) is a serious worldwide health issue, particularly in developing nations like Ethiopia. Patients with tuberculosis experience a range of hematological, immunological, and biochemical alterations. The purpose of this study was to evaluate immunological, hematological, and biochemical alterations of newly diagnosed TB patients at Dessie comprehensive specialized hospital, Dessie, Ethiopia. METHODS: A comparative, cross-sectional study was carried out to evaluate the immuno-hematological and biochemical changes in patients with tuberculosis at Dessie comprehensive specialized hospital from January to July 2018...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38524734/the-montana-interfacility-blood-network-a-novel-lifesaving-hand-off-for-the-optimal-care-of-rural-patients
#7
JOURNAL ARTICLE
Gordon M Riha, Alyssa Johnson, Sadie Arnold, Michael S Englehart, Simon J Thompson
PURPOSE: The state of Montana encompasses and defines rural health care as it is known in the United States (US) today. This vast area is punctuated by pockets of health care availability with varying access to blood products for transfusion. Furthermore, timely transport is frequently challenged by weather that may limit air transportation options, resulting in multiple hours in ground transport to definitive care. PATIENTS AND METHODS: The Montana State Trauma Care Committee (MT-STCC) developed the Montana Interfacility Blood Network (MT-IBN) to ensure blood availability in geographically distanced cases where patients may otherwise not survive...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38510843/prevalence-and-associated-factors-of-anemia-among-newborns-at-jimma-medical-center-south-west-ethiopia
#8
JOURNAL ARTICLE
Gebeyaw Arega Berihun, Girum Tesfaye, Wondimagegn Adissu, Edosa Tadasa, Kidist Adamu, Abinet Tantu Kombe, Lealem Gedefaw
BACKGROUND: Newborn anemia is among the most common hematological problems and it can cause asymptomatic or severe to acute life-threatening events. It leads to impairment in brain maturation and development, tissue hypoxia, and stunted growth and then arrested growth if left untreated. The prevalence of anemia among newborns ranges from 23.4-66% in sub-Saharan Africa. But, there is limited information in Ethiopia regarding the prevalence of newborn anemia and its risk factors. Therefore, this study aimed to determine the prevalence of newborn anemia and its associated factors at Jimma Medical Center (JMC), South-west Ethiopia...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38495774/case-study-rosai-dorfman-disease-and-its-multifaceted-aspects
#9
Daniela Oliveira Werneck Rodrigues, Roberta Wolp Diniz, Leonardo Cunha Dentz, Monica de Albuquerque Costa, Roberto Heleno Lopes, Lucas Fernandes Suassuna, Jane Rocha Duarte Cintra, Christian Domenge
Rosai-Dorfman Disease (RDD) is a rare non-Langerhans histiocytosis, usually self-limited and presenting with massive, painless, bilateral cervical lymphadenopathy, with or without constitutional symptoms. Extranodal disease is frequently present, and may happen in the absence of lymph node involvement, symptomatology and differential diagnosis will depend on the site affected and fatal cases may occur. The authors present two cases of Rosai-Dorfman disease (RDD), diagnosed through immunohistochemistry, with different progressions, one with complete remission and one culminating in death, highlighting the variety of presentations and the diagnostic difficulty...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38481741/a-post-authorization-safety-surveillance-study-to-report-clinical-experience-with-purified-factor-ix-concentrate-in-pediatric-patients-with-hemophilia-b
#10
JOURNAL ARTICLE
Zoran Igrutinović, Hélène Louise Hooimeijer, Karim Kentouche, Jaco Botha, Peter L Turecek, Marta Kokot-Kierepa, Hanna T Gazda
INTRODUCTION: Purified factor IX (FIX) concentrate (IMMUNINE® , Takeda Manufacturing Austria AG, Vienna, Austria) is indicated for the treatment and prophylaxis of bleeding episodes in patients with congenital hemophilia B. Data on the use of purified FIX concentrate in patients ≤6 years old with congenital hemophilia B are limited. AIM: Document real-world clinical experience with purified FIX concentrate in routine practice for pediatric patients with hemophilia B...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38434928/presentation-and-outcome-of-patients-with-multiple-myeloma-mm-single-centre-experience-from-windsor-essex-regional-cancer-centre
#11
JOURNAL ARTICLE
Dalia Kashash, Eric McArthur, Caroline Hamm, Rasna Gupta, Sindu Kanjeekal, Mohammad Jarrar, Lisa A Porter, John W Hudson, Adam Renaud, Indryas Woldie
INTRODUCTION: Outcomes for patients with multiple myeloma has significantly improved through the years. This is mainly related to the use of novel agents. METHODS: This is a retrospective study that reviewed presentation and outcome of 139 patients with multiple myeloma at the Windsor Essex Regional Cancer Centre from Jan. 1, 2015 to Dec. 31, 2019. Median age was 71 years and most patients had higher risk disease (65.5% either R ISS stage II or III). 30% had high risk FISH for myeloma including del...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38434927/magnitude-associated-factors-and-morphological-types-of-anemia-among-hospitalized-6-59-months-age-children-at-jimma-medical-center-southwest-ethiopia-a-hospital-based-cross-sectional-study
#12
JOURNAL ARTICLE
Regassa Alemu Kebede, Tilahun Yemane, Gebeyaw Arega Berihun, Tolera Ambisa Lamesa, Dereje Abebe Regasa
BACKGROUND: Anemia is among the major public health problems that cause significant morbidity and mortality among children around the world. Anemia in children of age 6 months to 5 years is a major health problem in most developing world countries with estimated prevalence of about 43%. OBJECTIVE: To determine the magnitude, associated factors and morphological types of anemia among hospitalized 6-59 months age children from June 15 to October 15, 2022 at Jimma Medical Center, southwest Ethiopia...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38405084/survival-and-treatment-outcomes-of-childhood-acute-lymphoblastic-leukemia-in-a-low-middle-income-country-a-single-center-experience-in-west-java-indonesia
#13
JOURNAL ARTICLE
Monika Hasna Ramadhan, Nur Melani Sari, Stanza Uga Peryoga, Susi Susanah
PURPOSE: This study aimed to determine the survival rates and treatment outcomes of patients with childhood Acute Lymphoblastic Leukemia (ALL) in a single-center study at Indonesia. PATIENTS AND METHODS: Factors contributing to the relapse and survival of ALL in Bandung, Indonesia, were evaluated. Data were collected from the medical record and the Indonesian Pediatric Cancer Registry (IPCAR). Subsequently, univariate and multivariate analyses were evaluated using Cox proportional hazard regression and Kaplan Meier was used for survival analysis...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38375065/hif2-%C3%AE-expression-in-cml-patients-receiving-hydroxyurea-prior-to-imatinib-that-achieved-major-molecular-response-mmr-versus-in-those-not-achieving-mmr
#14
JOURNAL ARTICLE
Ikhwan Rinaldi, Radinal Mauludi, Sri Widia Jusman, Robert Sinto, Kuntjoro Harimurti
INTRODUCTION: Currently, Imatinib (IM) which is a Tyrosine Kinase Inhibitor (TKI), is the main treatment for patients with chronic myeloid leukemia (CML). Major molecular response (MMR) is used as therapeutic response. Resistance to IM may be caused by hypoxia which is regulated by hypoxia inducible factor (HIF) 2-α. The role of HIF2-α is currently not researched extensively. This study aimed to analyse the differences in HIF-2α expression between chronic phase CML patients that achieved MMR and those that did not achieve MMR...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38375064/establishment-of-reference-intervals-of-blood-parameters-among-the-healthy-afghan-population
#15
JOURNAL ARTICLE
Najia Sherzay, Ziauddin Azimi, Siti Hamimah Sheikh Abdul Kadir, Noor Shafina Mohd Nor
PURPOSE: This study was designed and conducted to validate the reference values of hematological parameters for healthy adult male and female residents of Kabul city, Afghanistan. METHODOLOGY: In this cross-sectional study, the samples were collected according to a non-random sampling method. Blood samples were collected from students and employees of Kabul University. The study included 166 males and 125 females, aged 18-45 years. The selection and exclusion of participants were carried out according to a questionnaire and the assessment of serum ferritin and vitamin B12 levels...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38352049/assessing-nutritional-anemia-among-university-students-in-jazan-saudi-arabia-a-public-health-perspective
#16
JOURNAL ARTICLE
Waleed Hakami, Gasim Dobie, Khadija A Alneami, Misk Shaabi, Khaled Essawi, Muhammad Saboor, Aymen M Madkhali, Mohammed H Nahari, Hassan H Almasoudi, Mohammad S Akhter, Fasial H Hakami, Fatimah A Zarbatan, Ali Hakamy, Rama M Chandika, Ali A Fageehi, Abdullah A Mobarki, Hassan A Hamali
BACKGROUND: Nutritional anemia is a significant public health concern worldwide, particularly affecting young adults and children in Saudi Arabia, where inadequate nutrition is considered a primary contributing factor. This study aims to (i) examine the levels of serum iron, folate, and vitamin B12 in young adult students, with a focus on identifying any deficiencies and their association with anemia; (ii) explore the prevalence of mixed-deficiency anemia resulting from deficiencies in serum iron, folate, and vitamin B12 (iii) explore how sociodemographic characteristics and dietary habits influence serum iron, folate, and vitamin B12 levels...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38344181/prognostic-significance-of-dual-specificity-phosphatase-23-expression-in-acute-myeloid-leukemia
#17
JOURNAL ARTICLE
Xi Liu, Haihui Zhuang, Fenglin Li, Ying Lu, Renzhi Pei
BACKGROUND: Recently, an increasing number of studies have suggested dual-specificity phosphatase 23 (DUSP23) is a critical factor in the development of diffuse connective tissue disease and may be a valuable biomarker for primary human cancers. However, there is a lack of comprehensive studies on the prognostic significance of DUSP23 expression in acute myeloid leukemia (AML). METHODS: RNA sequencing data from The Cancer Genome Atlas (TCGA) (AML = 173), Genotype-Tissue Expression (GTEx) (healthy controls = 70) and GEO (AML = 461, healthy controls = 76) databases were used to compare DUSP23 expression between AML patients and healthy controls...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38283856/assessment-of-erythrocyte-osmotic-fragility-and-its-determinants-and-comparison-of-hematological-indices-among-type-2-diabetes-mellitus-patients-on-follow-up-at-jimma-medical-center-southwest-ethiopia
#18
JOURNAL ARTICLE
Zenebe Tujara, Wondu Reta, Eyasu Tadesse, Ifa Dereje, Mekonnen Tesfa
BACKGROUND: Diabetes Mellitus (DM) is one of the most prevalent non-communicable diseases worldwide. Approximately 9.3% of the general population was estimated to have DM globally in 2019. Erythrocyte osmotic fragility (EOF) in hyperglycemic patients is expected to increase and determine the rate of erythrocyte hemolysis. PURPOSE: This study aimed to assess erythrocyte osmotic fragility (EOF) and its determinants and to compare hematological indices among T2DM patients on follow-up at the Jimma Medical Center (JMC), Jimma, Southwest Ethiopia...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38283855/hematological-parameters-of-gasoline-station-workers-at-hosanna-town-southwest-ethiopia-a-comparative-cross-sectional-study
#19
JOURNAL ARTICLE
Tamirat Ersino Kebamo, Tilahun Yemane, Mesay Arkew, Getachew Alemu Walano, Abinet Tantu, Ageze Abose, Kassahun Haile, Solomon Gebre Bawore, Girum Tesfaye Kiya
BACKGROUND: Human exposure to benzene is associated with many adverse health effects. It is mainly related to impairment of the hematopoietic system and bone marrow suppression, causing abnormalities in hematological parameters. However, the reports obtained from different studies are contradictory, and there are little data regarding the hematological parameters of gas station workers in the study area. Therefore, this study aimed to evaluate the hematological parameters of gas station workers in Hosanna town, southwest Ethiopia, from May 01 to June 15, 2020...
2024: Journal of Blood Medicine
https://read.qxmd.com/read/38283854/severe-cytokine-release-syndrome-and-hemophagocytic-lymphohistiocytosis-hlh-like-syndrome-following-administration-of-combined-brentuximab-vedotin-and-nivolumab-for-recurrent-classical-hodgkin-lymphoma-a-case-report
#20
Osama Mosalem, Tanmayi Pai, Mohammed Alqawasma, Marwan Shaikh, K David Li, Muhamad Alhaj Moustafa
Brentuximab vedotin (BV) and nivolumab are increasingly utilized as a novel regimen in patients with relapsed/refractory classical Hodgkin lymphoma (cHL). A 26-year-old male presented to the hospital with refractory diabetic ketoacidosis and multiple electrolyte abnormalities, 9 days after the first dose of brentuximab vedotin and nivolumab for recurrent classical Hodgkin lymphoma. During his hospitalization, he developed multi-organ failure. His workup showed elevated cytokine levels concerning severe cytokine release syndrome (CRS) and hemophagocytic lymphohistiocytosis (HLH)-like syndrome...
2024: Journal of Blood Medicine
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