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International Journal of Nephrology and Renovascular Disease

https://read.qxmd.com/read/38685967/hospital-acquired-acute-kidney-injury-in-non-critical-medical-patients-in-a-developing-country-tertiary-hospital-incidence-and-predictors
#1
JOURNAL ARTICLE
Nahom Dessalegn Mekonnen, Tigist Workneh Leulseged, Buure Ayderuss Hassen, Kidus Haile Yemaneberhan, Helen Surafeal Berhe, Nebiat Adane Mera, Anteneh Abera Beyene, Lidiya Zenebe Getachew, Birukti Gebreyohannes Habtezgi, Feven Negasi Abriha
BACKGROUND: Acute kidney injury (AKI) is a frequent complication in critical patients, leading to a worse prognosis. Although its consequences are worse among critical patients, AKI is also associated with less favorable outcomes in non-critical patients. Therefore, understanding the magnitude of the problem in these patients is crucial, yet there is a scarcity of evidence in non-critical settings, especially in resource limited countries. Hence, the study aimed at determining the incidence and predictors of hospital acquired acute kidney injury (HAAKI) in non-critical medical patients who were admitted at a large tertiary hospital in Ethiopia...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38566818/factors-associated-with-the-development-of-chronic-kidney-disease-in-patients-with-arterial-hypertension
#2
JOURNAL ARTICLE
Evelyn Del Socorro Goicochea-Rios, Ana María Chian-García, Irma Luz Yupari-Azabache, Néstor Iván Gómez Goicochea
INTRODUCTION: Chronic kidney disease affects a large part of the population with hypertension, diabetes mellitus as well as those over 50 years of age. Research reported that male sex and other comorbidities such as obesity and anemia are more frequent in Chronic kidney disease, as well as uncontrolled diabetes mellitus or hypertension. OBJECTIVE: To determine the risk factors associated with the development of chronic kidney disease in adults with arterial hypertension...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38562530/acute-kidney-injury-prediction-model-using-cystatin-c-beta-2-microglobulin-and-neutrophil-gelatinase-associated-lipocalin-biomarker-in-sepsis-patients
#3
JOURNAL ARTICLE
Hani Susianti, Aswoco Andyk Asmoro, Sujarwoto, Wiwi Jaya, Heri Sutanto, Amanda Yuanita Kusdijanto, Kevin Putro Kuwoyo, Kristian Hananto, Matthew Brian Khrisna
INTRODUCTION: AKI is a frequent complication in sepsis patients and is estimated to occur in almost half of patients with severe sepsis. However, there is currently no effective therapy for AKI in sepsis. Therefore, the therapeutic approach is focused on prevention. Based on this, there is an opportunity to examine a panel of biomarker models for predicting AKI. MATERIAL AND METHODS: This prospective cohort study analysed the differences in Cystatin C, Beta-2 Microglobulin, and NGAL levels in sepsis patients with AKI and sepsis patients without AKI...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38525412/advances-in-human-centered-care-to-address-contemporary-unmet-needs-in-chronic-dialysis
#4
REVIEW
Sumedh Jayanti, Gopala K Rangan
Advances in the treatment of kidney failure with chronic dialysis have stagnated over the past three decades, with over 50% of patients still managed by conventional in-hospital haemodialysis. In parallel, the demands of chronic dialysis medical care have changed and evolved due to a growing population that has higher frailty and multimorbidity. Thus, the gap between the needs of kidney failure patients and the healthcare capability to provide effective overall management has widened. To address this problem, healthcare policy has increasingly aligned towards a human-centred approach...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38495741/post-transplant-glomerulonephritis-challenges-and-solutions
#5
REVIEW
Marcos Vinicius de Sousa
Glomeruli can be damaged in several conditions after kidney transplantation, with a potential impact on the graft function and survival. Primary glomerulonephritis, a group of glomerular immunological damage that results in variable histological patterns and clinical phenotypes, can occur in kidney transplant recipients as a recurrent or de novo condition. Specific immunologic conditions associated with kidney transplantation, such as acute rejection episodes, can act as an additional trigger after transplantation, impacting the incidence of these glomerulopathies...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38405026/25-oh-vitamin-d-and-intact-parathyroid-hormone-in-congolese-hemodialysis-patients-evaluation-of-kdigo-targets
#6
JOURNAL ARTICLE
Samuel Mbadu Lelo, François-Pantaléon Musungayi Kajingulu, Jean-Robert Makulo, Yannick Mayamba Nlandu, Justine Busanga Bukabau, Pierre Koso Mbulupasu, Augustin Luzayadio Longo, Jeanine Nina Losa Luse, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Nazaire Mangani Nseka
BACKGROUND: Data on 25 [OH] vitamin D and intact parathyroid hormone [iPTH] in hemodialysis patients are very limited in sub-Saharan African countries. The present study aimed to assess the magnitude of hypovitaminosis D, and to evaluate the achievement of iPTH KDIGO 2017 targets among chronic hemodialysis patients followed in Kinshasa. METHODS: We conducted a multicenter cross-sectional study in 6 hospitals in Kinshasa. All patients followed on hemodialysis for more than 3 months were included...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38375187/burden-of-tuberculosis-in-end-stage-renal-disease-patients-undergoing-maintenance-hemodialysis-a-multicenter-study-and-experience-from-ethiopian-dialysis-setting
#7
JOURNAL ARTICLE
Eyob Beyene, Zekewos Demissie, Wubshet Tolossa Jote, Seyfemichael Getachew, Addisu Melkie Ejigu, Wondwossen Amogne Degu
BACKGROUND: Patients with end stage renal disease (ESRD) are at a higher risk of developing tuberculosis (TB) due to the immunosuppressed state along with concomitant comorbidities and socioeconomic and demographic factors. Data on the prevalence of tuberculosis in ESRD are scarce despite the high burden of the disease in developing nations. METHODS: A multicenter, cross-sectional study was conducted at eight dialysis centers in Addis Ababa on the prevalence of TB among CKD patients on maintenance hemodialysis from August 2022 to October 2022 G...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38370010/characteristics-of-vascular-access-cannulation-complications-in-end-stage-kidney-disease-patients-in-west-java-from-2018-to-2022-a-retrospective-observational-study
#8
JOURNAL ARTICLE
Teguh Marfen Djajakusumah, Putie Hapsari, Prapanca Nugraha, Arrayyan Muhammad, Kiki Lukman
BACKGROUND: End-stage kidney disease (ESKD) is associated with a tremendous financial burden. Data in Indonesia shows an increasing number of patients with ESKD taking hemodialysis as a routine procedure every year. Establishment and maintenance of vascular access are important in the management of ESKD. Vascular complications that often arise due to hemodialysis are common and one of the main reasons for hospitalization. Cannulation complications ranged from minor hematomas to acute bleeding from pseudoaneurysms that required emergency surgical procedures...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38317662/the-associations-between-abdominal-obesity-and-coronary-artery-calcification-in-chronic-kidney-disease-population
#9
JOURNAL ARTICLE
Peng-Tzu Liu, Jong-Dar Chen
BACKGROUND: Cardiovascular disease (CVD) is the primary cause of mortality in chronic kidney disease (CKD) patients, with metabolic disorders exacerbating this risk. Compared with body mass index, waist circumference (WC) has been proposed as a more effective indicator of abnormal visceral fat. However, the associations among CKD, abnormal WC, and CVD remain understudied. MATERIAL AND METHODS: A cross-sectional study in Taiwan (July 2006 to May 2016) involved 10,342 participants undergoing self-paid health checkups at a single medical center...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38264625/association-of-mitochondrial-pyruvate-carrier-with-the-clinical-and-histological-features-in-lupus-nephritis
#10
JOURNAL ARTICLE
Huanhuan Zhu, Chen Chen, Luhan Geng, Qing Li, Chengning Zhang, Lin Wu, Bo Zhang, Suyan Duan, Changying Xing, Yanggang Yuan
BACKGROUND: Mounting evidence suggests that mitochondrial dysfunction contributes to lupus nephritis (LN) pathogenesis. Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) mediating pyruvate transport from the cytoplasm to the mitochondrial matrix, determines the cell survival and cellular energy supply. Here, we aimed to investigate the association of mitochondrial pyruvate carrier expression with the clinical and histological features in LN. METHODS: Patients with biopsy-proven proliferative LN (class III and class IV, n=18) and membranous LN (class V, n=18) were included...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38223907/effect-of-executive-function-on-health-related-quality-of-life-in-children-with-chronic-kidney-disease
#11
JOURNAL ARTICLE
Elrika Anastasia Wijaya, Purboyo Solek, Dedi Rachmadi, Sri Endah Rahayuningsih, Rodman Tarigan, Dany Hilmanto
INTRODUCTION: As the highest function in the brain that regulates our daily activity, executive dysfunction might affect someone's health-related quality of life (HRQoL), especially in those with chronic diseases, including chronic kidney disease (CKD). Neurocognitive functions, including intelligence quotient (IQ) and executive function can be affected through various mechanisms in CKD. However, there was still no specific study regarding how IQ and executive function might affect HRQoL in children with CKD...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38196830/impact-of-sodium-glucose-cotransporter-2-inhibitors-in-the-management-of-chronic-kidney-disease-a-middle-east-and-africa-perspective
#12
JOURNAL ARTICLE
Ahmed Fathi Elkeraie, Saeed Al-Ghamdi, Ali K Abu-Alfa, Torki Alotaibi, Ali Jasim AlSaedi, Abdulkareem AlSuwaida, Mustafa Arici, Tevfik Ecder, Mohammad Ghnaimat, Mohamed Hany Hafez, Mohamed H Hassan, Tarik Sqalli
Chronic kidney disease (CKD) is a major public health concern in the Middle East and Africa (MEA) region and a leading cause of death in patients with type 2 diabetes mellitus (T2DM) and hypertension. Early initiation of sodium-glucose cotransporter - 2 inhibitors (SGLT-2i) and proper sequencing with renin-angiotensin-aldosterone system inhibitors (RAASi) in these patients may result in better clinical outcomes due to their cardioprotective properties and complementary mechanisms of action. In this review, we present guideline-based consensus recommendations by experts from the MEA region, as practical algorithms for screening, early detection, nephrology referral, and treatment pathways for CKD management in patients with hypertension and diabetes mellitus...
2024: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38149041/practical-considerations-for-the-use-of-sparsentan-in-the-treatment-of-patients-with-igan-in-clinical-practice
#13
REVIEW
Kirk N Campbell, Siân Griffin, Howard Trachtman, Rob Geletka, Muh Geot Wong
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. It is characterized by the mesangial deposition of IgA-containing immune complexes, triggering damage to the glomerular filtration barrier that is amplified by the tandem action of endothelin-1 and angiotensin II at their receptors. Proteinuria and progressive glomerular damage cause loss of kidney function in up to 50% of patients within 10-20 years. The risk of progression is strongly associated with persistent proteinuria (>0...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38146433/association-between-elevated-blood-eosinophils-and-chronic-kidney-disease-progression-analyses-of-a-large-united-states-electronic-health-records-database
#14
JOURNAL ARTICLE
Danuta Kielar, Andrew M Jones, Xia Wang, Heide Stirnadel-Farrant, Rohit K Katial, Abhinav Bansal, Manu Garg, Chandrakant Sharma, Shubhankar Thakar, Qin Ye
BACKGROUND: Blood eosinophils can increase in response to infection, inflammation, and hypersensitivity reactions, yet their involvement in the progression of chronic kidney disease (CKD) is poorly understood. This study explores the relationship between blood eosinophils and CKD progression among patients in a real-world setting. METHODS: This retrospective study analyzed data obtained from the Optum® de-identified electronic health records dataset in the United States...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38107557/the-implementation-of-a-modified-fluid-assessment-tool-to-improve-the-clinical-assessment-detection-and-management-of-blood-pressure-control-and-fluid-alterations-among-hemodialysis-patients
#15
JOURNAL ARTICLE
Hussam Al Nusair, Wael Hamdan, Joy Garma, Ahmed Eid, Rafi Alnjadat, Nezam Al-Nsair, Mariezl Fonbuena, Christin Davao
BACKGROUND: Fluid overload is a common complication of the care of End-stage Renal Disease patients that may lead to prolonged hospitalization and mortality. This warrants an effective and systemic approach to early recognition and management to improve patient outcomes. AIM: This study aims to evaluate the effect of a modified fluid assessment tool to improve accurate clinical assessments, detection, and management of blood pressure control and fluid alteration among hemodialysis patients...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38075192/clinical-application-value-of-contrast-enhanced-ultrasound-in-the-diagnosis-of-renal-space-occupying-lesions
#16
JOURNAL ARTICLE
Qiping Liu, Huiling Gong, Qiqi Chen, Chunyan Yuan, Bin Hu
OBJECTIVE: To study the clinical application value of contrast-enhanced ultrasound (CEUS) in diagnosing renal space-occupying lesions. METHODS: Sixty-seven patients with renal space-occupying lesions detected by routine ultrasound examination received the contrast-enhanced ultrasound examination. When observing the perfusion mode of the mass, we analyzed the perfusion characteristics of contrast-enhanced ultrasound and compared them with the surgical pathological results...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/38075191/the-molecular-mechanism-of-renal-tubulointerstitial-inflammation-promoting-diabetic-nephropathy
#17
REVIEW
Rui Xue, Haiting Xiao, Vinod Kumar, Xiqian Lan, Ashwani Malhotra, Pravin C Singhal, Jianning Chen
Diabetic nephropathy (DN) is a common complication affecting many diabetic patients, leading to end-stage renal disease. However, its pathogenesis still needs to be fully understood to enhance the effectiveness of treatment methods. Traditional theories are predominantly centered on glomerular injuries and need more explicit explanations of recent clinical observations suggesting that renal tubules equally contribute to renal function and that tubular lesions are early features of DN, even occurring before glomerular lesions...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/37868106/benefits-of-preserving-residual-urine-output-in-patients-undergoing-maintenance-haemodialysis
#18
JOURNAL ARTICLE
Mikołaj Dopierała, Krzysztof Schwermer, Krzysztof Hoppe, Małgorzata Kupczyk, Krzysztof Pawlaczyk
INTRODUCTION: Chronic kidney disease is a widespread medical problem that leads to higher morbidity, mortality, and a decrease in the overall well-being of the general population. This is especially expressed in patients with end-stage renal disease (ESRD) undergoing maintenance haemodialysis. Several variables could be used to evaluate those patients' well-being and mortality risk. One of them is the presence of residual urine output. MATERIALS AND METHODS: The study was conducted on 485 patients treated with maintenance haemodialysis...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/37849744/current-knowledge-of-beta-blockers-in-chronic-hemodialysis-patients
#19
REVIEW
Intissar Haddiya, Siria Valoti
Beta-blockers include a large spectrum of drugs with various specific characteristics, and a well-known cardioprotective efficacy. They are recommended in heart failure, hypertension and arrhythmia. Their use in chronic hemodialysis patients is still controversial, mainly because of the lack of specific randomized clinical trials. Large observational studies and two important clinical trials have reported almost unanimously their efficacy in chronic hemodialysis patients, which seems to be related to their levels of dialyzability and cardioselectivity...
2023: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/37720493/peritoneal-dialysis-patient-training-program-to-enhance-independence-and-prevent-complications-a-scoping-review
#20
REVIEW
Toni Rahmat Jaelani, Kusman Ibrahim, Jonny Jonny, Sri Hartati Pratiwi, Hartiah Haroen, Nursiswati Nursiswati, Bunga Pinandhita Ramadhani
BACKGROUND: Peritoneal dialysis (PD) training is essential to ensure patient independence and prevent life-threatening complications, such as peritonitis. The International Society for Peritoneal Dialysis (ISPD) recommends that every PD unit worldwide implement local PD training programs with the goal of improving self-care capabilities. This scoping review aims to give an overview of recent literature and recommendations on PD training programs aiming to improve the quality of care and outcomes for PD patients...
2023: International Journal of Nephrology and Renovascular Disease
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