journal
https://read.qxmd.com/read/38600953/successful-treatment-of-an-aml-patient-infected-with-hypervirulent-st463-pseudomonas-aeruginosa-harboring-rare-carbapenem-resistant-genes-blaafm-1-and-blakpc-2-following-allogeneic-hematopoietic-stem-cell-transplantation
#1
Yingying Shen, Junmin Cao, Tonglin Hu, Xiawan Yang, Yuechao Zhao, Yiping Shen, Baodong Ye, Yunsong Yu, Dijiong Wu
BACKGROUND: Carbapenem-resistant P. aeruginosa (CRPA) is a common hospital-acquired bacterium. It exhibits high resistance to many antibiotics, including ceftazidime/avibactam and cefteolozane/tazobactam . The presence of carbapenem-resistant genes and co-existence Klebsiella pneumoniae carbapenemase (KPC) and metallo-β-lactamases (MBLs) further inactivated all β-lactams. Understanding the resistance genes of CRPA can help in uncovering the resistance mechanism and guiding anti-infective treatment...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38596535/hiv-negative-case-of-talaromyces-marneffei-pulmonary-infection-with-liver-cirrhosis-in-china-a-case-report-and-literature-review
#2
Yu Liu, Hongying Guo, Wei Yuan, Ying Zou, Zhiping Qian, Xue Mei, Liujuan Ji, Jiefei Wang, Yuyi Zhang
BACKGROUND: Talaromyces marneffei (TM) is the third most prevalent opportunistic infection in HIV-positive patients after tuberculosis and cryptococcosis. However, such infection of non-HIV individuals has rarely been reported. CASE PRESENTATION: We describe a very rare case of a 52-year-old male who presented with a single space-occupying lesion on the right lung and was eventually diagnosed with pulmonary TM infection. The patient was HIV-negative and had liver cirrhosis with portal vein thrombosis...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38596534/emr-combined-with-crb-65-superior-to-curb-65-in-predicting-mortality-in-patients-with-community-acquired-pneumonia-response-to-letter
#3
COMMENT
Yi Sun, Hong Wang, Minghao Gu, Xingyu Zhang, Xiudi Han, Xuedong Liu
No abstract text is available yet for this article.
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38596533/clinical-distribution-and-drug-susceptibility-characterization-of-invasive-candida-isolates-in-a-tertiary-hospital-of-xinjiang-province
#4
JOURNAL ARTICLE
Songdi Zhang, Lijuan Zhang, Aikedai Yusufu, Hadiliya Hasimu, Xiaodong Wang, Paride Abliz
OBJECTIVE: This study aims to investigate the clinical distribution characteristics and drug susceptibility profiles of invasive Candida isolates in a tertiary hospital in Urumqi. METHODS: The examination was conducted on samples obtained from patients who were clinically diagnosed with invasive candidiasis in this hospital. A total of 109 strains of Candida strains were identified through the use of internal transcribed spacer (ITS) sequencing and fungal cultivation methods...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38590553/diagnosis-of-a-familial-psittacosis-outbreak-with-clinical-analysis-and-metagenomic-next-generation-sequencing-under-covid-19-a-case-series
#5
Jiaru Wang, Peiyao Jia, Dong Zhang, Ying Zhao, Xin Sui, Zhengyu Jin, Wei Song
PURPOSE: To explore the clinical characteristics, diagnosis, and treatment of family outbreak of psittacosis and to improve the success rate of treatment. PATIENTS AND METHODS: The clinical characteristics, diagnosis, treatment, and outcome of family outbreak of psittacosis, which consists three patients, diagnosed by clinical analysis and metagenomic next-generation sequencing (mNGS) in our hospital were analyzed retrospectively. RESULTS: We report on three instances of clustered atypical pneumonia, which were caused by Chlamydia psittaci during the COVID-19 pandemic...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38585416/epidemiological-and-clinical-characteristics-of-neonatal-ureaplasma-urealyticum-infection
#6
JOURNAL ARTICLE
Jun'e Ma, Zhenhui Wang, Chuanjin Luo, Jin'ou Xi, Xiaojing Wang, Yan Hu, Chengliang Zhu, Zhengjiang Jin
PURPOSE: To understand the epidemiology and clinical features of Ureaplasma urealyticum (UU) infection in hospitalized neonates due to vertical transmission from mother to child. METHODS: Respiratory secretions were collected from neonates hospitalized in the neonatology department of the Maternal and Child Health Hospital of Hubei Province from July 2020 to June 2022, and PCR was used to detect UU-DNA in respiratory secretions. The neonates were divided into UU-positive and UU-negative groups, the epidemiological and clinical characteristics of two groups, were statistically analyzed...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38585415/factors-associated-with-mortality-among-severe-omicron-patients-for-covid-19
#7
JOURNAL ARTICLE
Shuting Wu, Guichan Liao, Jingchun Mao, Haiming Yan, Juanjuan Chen, Jie Peng
PURPOSE: The purpose of the study was to explore the potential risk factors of mortality in patients with severe pneumonia during the omicron pandemic in South China in 2022. METHODS: Clinical data was collected from patients hospitalized with omicron COVID-19. Then, patients were categorized into the non-survival and survival groups. A comprehensive analysis was conducted to analyze the factors associated with negative outcome in individuals suffering from severe omicron COVID-19...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38576824/whole-genome-sequence-analysis-of-two-oxacillin-resistant-and-meca-positive-strains-of-staphylococcus-haemolyticus-isolated-from-ear-swab-samples-of-patients-with-otitis-media
#8
JOURNAL ARTICLE
Zhao Liu, Ling Wang, Jiabing Sun, Qinghuan Zhang, Yue Peng, Susu Tang, Limei Zhang, Xiaobin Li, Zhijian Yu, Tao Zhang
OBJECTIVE: Staphylococcus haemolyticus can cause a series of infections including otitis media (OM), and the oxacillin-resistant S. haemolyticus has become a serious health concern. This study aimed to investigate the genomic characteristics of two strains of oxacillin-resistant and mecA -positive S. haemolyticus isolated from the samples of ear swabs from patients with OM and explore their acquired antibiotic resistance genes (ARGs) and the mobile genetic elements (MGEs). METHODS: Two oxacillin-resistant S...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38576823/extracorporeal-membrane-oxygenation-in-septic-cardiomyopathy-caused-by-aspergillus-infection-the-first-case-report
#9
Nengwen Wu, Xiaoqing Shen, Jianwei Li, Miaolian Chen, Guishen Wu, Haiming Niu, Hongkai Liang, Ting Yang
Septic cardiomyopathy (SCM) is often associated with bacterial infections but also occurs with infections with viruses such as influenza and spirochetes, including syphilis. However, there has been no systematic investigation into whether Aspergillus infections can cause septic cardiomyopathy. We report on such a case for the first time in a patient without immunodeficiency. Therefore, clinicians should be concerned with septic cardiomyopathy caused by some atypical or rare pathogens when admitting such patients...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38572421/reduced-viral-shedding-time-in-high-risk-covid-19-patients-infected-by-omicron-and-treated-with-paxlovid-a-real-world-study-from-china
#10
JOURNAL ARTICLE
Wei Yang, Yahui Peng, Changsong Wang, Hongliu Cai, Lina Zhang, Jun Xu, Yongjie Wang, Maonan Wang, Mingyan Zhao, Kaijiang Yu
INTRODUCTION: The purpose of this study was to compare the viral shedding time in patients infected with the Omicron variant during Paxlovid therapy and conventional therapy and to analyze the effects of Paxlovid on patients infected with COVID-19. METHODS: In this study, the demographic and clinical characteristics and laboratory data of 3159 patients infected with the SARS-CoV-2 Omicron variant treated at Jilin Province People's Hospital were collected and analyzed...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38566771/ceftazidime-avibactam-combination-therapy-versus-monotherapy-for-the-treatment-carbapenem-resistant-gram-negative-bacterial-infections-a-retrospective-observational-study
#11
JOURNAL ARTICLE
Keyang Li, Debao Li, Hongliang Dong, Dongmei Ren, Dandan Gong, Shubo Wang, Yang Li, Yuanyuan Wu, Jikang Yang, Wenjuan Yan, Yi Li
PURPOSE: Since the introduction of ceftazidime-avibactam (CZA) in the Chinese market, accumulating clinical evidence has substantiated its efficacy in the treatment of infections caused by carbapenem-resistant gram-negative bacteria (CR-GNB). Nevertheless, an ongoing debate persists concerning the choice between monotherapy and combination therapy when devising clinical anti-infection protocols. PATIENTS AND METHODS: This retrospective, single-center observational study enrolled patients with CR-GNB infections who received CZA treatment between December 2019 and August 2023...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38562405/risk-factors-for-occupational-blood-exposure-compliance-with-policies-of-infection-prevention-and-control-and-costs-associated-with-post-exposure-management-among-nursing-staff
#12
JOURNAL ARTICLE
Yan Liu, Yang Li, Song Yuan, Wei Ma, Si Chen, Li-Yi Wang
OBJECTIVE: To examine the risk factors linked with occupational blood exposure (OBE) among nursing staff (NS), we pinpoint deficiencies in the compliance with policies of infection prevention and control, and assess the expenditures associated with infection prevention and control. METHODS: Healthcare workers that completed an "Occupational Blood Exposure Report Form" were divided into NS (observation) group and non-NS (control) group. Univariate and multivariable analyses were conducted to compare both groups in various aspects...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38562404/the-potentiation-activity-of-azithromycin-in-combination-with-colistin-or-levofloxacin-against-pseudomonas-aeruginosa-biofilm-infection
#13
JOURNAL ARTICLE
Yuhang Wang, Chunsun Li, Huan Zhang, Yulong Chi, Yun Cai
OBJECTIVE: Pseudomonas aeruginosa (PA) often displays drug resistance and biofilm-mediated adaptability. Here, we aimed to evaluate the antibiofilm efficacy of azithromycin-based combination regimens. METHODS: Minimum inhibitory concentrations (MICs), minimal biofilm eradication concentrations (MBECs), and MBEC-combination of azithromycin, colistin, amikacin, and levofloxacin to bioluminescent strain PAO1 and carbapenem-resistant PAO1 (CRPAO1) were assessed. An animal biofilm infection model was established and detected using a live animal bio-photonic imaging system...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38560708/genomic-characterization-of-a-carbapenem-resistant-raoultella-planticola-strain-co-harboring-bla-imp-4-and-bla-shv-12-genes
#14
JOURNAL ARTICLE
Yubin Zhu, Yilu Zhuang, Yawen Yu, Jinyue Wang, Yongtai Liu, Zhi Ruan, Wei Xiao, Yingying Kong
Raoultella planticola is an emerging bacterial pathogen responsible for causing infections in both humans and animals. Unfortunately, sporadic reports of carbapenem-resistant R. planticola (CRRP) have been documented worldwide. Here we first reported the complete genome sequence of a CRRP isolate RP_3045 co-carrying bla IMP-4 and bla SHV-12 , recovered from a patient in China, and its genetic relatedness to 82 R. planticola strains deposited in the NCBI GenBank database, sourced from humans, animals, and the environment...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38560707/immune-dysfunction-associated-elevated-rdw-apache-ii-and-sofa-scores-were-a-possible-cause-of-28-day-mortality-in-sepsis-patients
#15
JOURNAL ARTICLE
Jing Wang, Lisha He, Zhiyan Jin, Guoguang Lu, Sufei Yu, Lingling Hu, Meidan Fang, Xiaxia Jin
OBJECTIVE: To explore the early predictors and their predicting value of 28-day mortality in sepsis patients and to investigate the possible causes of death. METHODS: 127 sepsis patients were included, including 79 cases in the survival group and 48 cases in the death group. The results of all patients on admission were recorded. After screening the risk factors of 28-day mortality, the receiver operating characteristic curve (ROC) was used to determine their predictive value for the 28-day mortality rate on admission, and the Kaplan-Meier curve was drawn to compare the 28-day mortality rate between groups...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38560706/plasma-thrombomodulin-as-a-candidate-biomarker-for-the-diagnosis-and-prognosis-of-hbv-related-acute-on-chronic-liver-failure
#16
JOURNAL ARTICLE
Xingping Zhou, Jinjin Luo, Xi Liang, Peng Li, Keke Ren, Dongyan Shi, Jiaojiao Xin, Jing Jiang, Jiaxian Chen, Lulu He, Hui Yang, Shiwen Ma, Bingqi Li, Jun Li
BACKGROUND AND AIM: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with high short-term mortality. Effective biomarkers are required for its early diagnosis and prognosis. This study aimed to determine the diagnostic and prognostic value of thrombomodulin (TM) in patients with HBV-ACLF. METHODS: The expression of TM during disease progression was evaluated through transcriptomics analysis. The plasma TM concentrations of 393 subjects with HBV-ACLF (n=213), acute-on-chronic hepatic dysfunction (ACHD, n=50), liver cirrhosis (LC, n=50) or chronic hepatitis B (CHB, n=50), and normal controls (NC, n=30) from a prospective multicenter cohort, were measured to verify the diagnostic and prognostic significance of plasma TM for HBV-ACLF patients by enzyme-linked immunosorbent assay (ELISA)...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38560705/inhibiting-peptidoglycan-hydrolase-alleviates-mrsa-pneumonia-through-autolysin-mediated-mdp-nod2-pathway
#17
JOURNAL ARTICLE
Yang Yang, Zongze Yao, Jiazhen Zhang, Wei Shao, Bo Li, Huihui Wu, Wenjian Tang, Jing Zhang
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a cause of staph infection that is difficult to treat because of resistance to some antibiotics. A recent study indicated that diarylurea ZJ-2 is a novel antibacterial agent against multi-drug resistant Enterococcus faecium . In this work, we refined the bactericidal mechanism of ZJ-2 as a peptidoglycan (PG) hydrolase by affecting AtlA-mediated PG homeostasis. METHODS: A wild-type strain (WT) and a mutant strain (Δ atlA ) were used to investigate the effects of ZJ-2 on the cell wall, PG, and autolysin regulatory system by antimicrobial susceptibility testing, hemolytic toxin assay, microanalysis, autolysis assay, qRT-PCR, ELISA and mouse model of pneumonia...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38560704/contezolid-containing-regimen-successfully-treated-multiple-drug-resistance-mycobacterium-abscessus-complex-infection-of-skin-a-case-report-and-literature-review
#18
Xusheng Gao, Caihong Ding, Dan Xie, Qing Wang, Peipei Jiang, Yuyu Wang, Yu Xiong
BACKGROUND: In recent decades, there has been a substantial surge in the incidence of non-tuberculous Mycobacteria (NTM) infections. However, the diagnosis and management of NTM globally present significant challenges, particularly in cases involving Mycobacterium abscessus complex (MABC) infection where effective therapeutic options are limited. CASE PRESENTATION: We reported a 38-year-old female patient who was infected with MABC of skin due to "beauty needle" at a beauty salon, with mass on both cheeks, accompanied by redness, and pain, and some of them was ulcered and effused...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38560703/emr-combined-with-crb-65-superior-to-curb-65-in-predicting-mortality-in-patients-with-community-acquired-pneumonia-letter
#19
JOURNAL ARTICLE
Achmad Jaelani Rusdi, Lilik Afifah
No abstract text is available yet for this article.
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38544964/a-risk-model-for-28-day-in-hospital-mortality-in-173-covid-19-patients-admission-to-icu-a-retrospective-study
#20
JOURNAL ARTICLE
Yiting Hua, Yutong Zhou, Ziyue Qin, Yuan Mu, Ting Wang, Haoyu Ruan
BACKGROUND: The surge in the number of patients diagnosed with COVID-19 since China's open-door policy has placed a huge burden on the public healthcare system, especially the intensive care system. This study's objective was to discover possible clinical outcome predictors in COVID-19 patients treated in intensive care units (ICUs) and to provide useful information for future preventative efforts and therapies. METHODS: This retrospective study included 173 COVID-19 critically ill patients and reviewed the 28-day survival outcome in the First Affiliated Hospital of Nanjing Medical University...
2024: Infection and Drug Resistance
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