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American Journal of Cancer Research

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https://read.qxmd.com/read/30755822/significance-of-integrin-linked-kinase-ilk-in-tumorigenesis-and-its-potential-implication-as-a-biomarker-and-therapeutic-target-for-human-cancer
#1
REVIEW
Can-Can Zheng, Hui-Fang Hu, Pan Hong, Qi-Hua Zhang, Wen Wen Xu, Qing-Yu He, Bin Li
Integrin-linked kinase (ILK), which is an ankyrin repeat-containing serine/threonine protein kinase, interacts with integrin β1 and the β3 cytoplasmic domain and phosphorylates integrin β1. ILK has multiple functions in cells, such as cell-extracellular matrix interactions, cell cycle, apoptosis, cell proliferation and cell motility, which are associated with the interacting partners of ILK and downstream signaling pathways. Upregulation of ILK is frequently observed in cancer tissues compared to corresponding normal tissues...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755821/an-essential-role-of-prmt1-mediated-egfr-methylation-in-egfr-activation-by-ribonuclease-5
#2
Wei-Jan Wang, Jung-Mao Hsu, Ying-Nai Wang, Heng-Huan Lee, Hirohito Yamaguchi, Hsin-Wei Liao, Mien-Chie Hung
Methylation at Arg198 and Arg200 residues of the EGFR extracellular domain by PRMT1 have been demonstrated to enhance EGFR activation by the canonical ligands, EGF and TGFα. On the other hand, RNase 5 was identified as a new ligand of EGFR recently. However, the interplay between EGFR methylation and RNase 5 in EGFR activation is still unclear. Here, we showed that RNase 5 activated EGFR and enhanced cell proliferation in colorectal cancer cells. PRMT1 positively regulated EGFR signaling activation by RNase 5...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755820/neural-correlates-of-chemotherapy-induced-emotion-regulation-impairment-in-breast-cancer-patients
#3
Chen Gan, Yue Lv, Jingjing Zhao, Herta H Chao, Chiang-Shan R Li, Congjun Zhang, Fengqiong Yu, Huaidong Cheng
To investigate the chemotherapy-induced emotion regulation impairment and its neural correlates in breast cancer (BC) patients by event-related potentials (ERP), seventeen BC patients were investigated on emotion regulation paradigms while undergoing the recording of an event-related potential (ERP) both before and after chemotherapy. The performance of behavioral and ERP was compared for the data collected before and after chemotherapy (BCB and BCA, respectively). The correlation of the difference between the peak and the latency of each component before and after chemotherapy were compared with the difference in behavior (RT and AR)...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755819/serum-ca125-and-ascites-leptin-level-ratio-predicts-baseline-clinical-resistance-to-first-line-platinum-based-treatment-and-poor-prognosis-in-patients-with-high-grade-serous-ovarian-cancer
#4
Isabelle Matte, Perrine Garde-Granger, Paul Bessette, Alain Piché
About 20% of patients with high grade serous epithelial ovarian carcinoma (HGSOC) are intrinsically resistant to standard first-line platinum-based combination therapy. There is no marker yet available to identify these patients. In that context, all patients with HGSOC initially receive the same standard first-line platinum-based therapy, and those with intrinsically resistant diseases can only be identified retrospectively after they experienced early relapse to therapy. The aim of this study was to evaluate serum or ascites CA125 and ascites leptin in patients with intrinsic resistance and to compare them with those of sensitive patients...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755818/synergistic-effects-of-shp2-and-pi3k-pathway-inhibitors-in-gab2-overexpressing-ovarian-cancer
#5
Bowen Sun, Nathaniel R Jensen, Dongjun Chung, Meixiang Yang, Amanda C LaRue, Hiu Wing Cheung, Qi Wang
The scaffold/adaptor growth factor receptor bound 2 (GRB2)-associated binding protein 2 (GAB2) is frequently amplified and/or overexpressed in primary high-grade serous ovarian cancers (HGSOCs). Here we investigate a novel treatment strategy by targeting SHP2 and PI3K signaling in HGSOCs with GAB2 amplification/overexpression (GAB2High ). The expression of GAB2 was analyzed in primary HGSOCs and ovarian cancer cell lines. In vitro and in vivo assays were performed to demonstrate the effect of SHP2 and PI3K-mediated GAB2High HGSOC progression...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755817/dysregulated-enpp1-increases-the-malignancy-of-human-lung-cancer-by-inducing-epithelial-mesenchymal-transition-phenotypes-and-stem-cell-features
#6
Min Hu, Wenzheng Guo, Yueling Liao, Dongliang Xu, Beibei Sun, Hongyong Song, Tong Wang, Yanbin Kuang, Bo Jing, Kaimi Li, Jing Ling, Feng Yao, Jiong Deng
Induction of cancer stem cell (CSC) characters and epithelial mesenchymal transition (EMT) features are crucial in tumor initiation, progression and metastasis. However, underlying mechanisms remain incompletely understood. Here, we showed that ENPP1 plays an important role in inducing and maintaining EMT phenotypes and CSC features in lung cancer. ENPP1 is upregulated in lung cancer cells. ENPP1-knockdown in lung cancer HCC827 cells and A549 cells resulted in suppressed colonogenic formation, anchorage-independent growth in vitro, and tumorigenicity in vivo...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755816/vascular-endothelial-response-to-idh1-mutant-fibrosarcoma-secretome-and-metabolite-implications-on-cancer-microenvironment
#7
Maiya J Mao, Donna E Leonardi
Isocitrate dehydrogenases (IDHs) are enzymes involved in the production of α-ketoglutarate (αkg) in normal cellular metabolism. Cells with IDH mutations reduce αkg to 2-hydroxyglutarate (2HG), an oncometabolite, and 2HG directly transforms normal cells to malignant cells through histone demethylation and epigenetic dysregulation. However, whether IDH mutations affect cancer stromal cells is elusive, and little is known whether 2HG may impact the tumor microenvironment. We hypothesized that the IDH mutant cancer secretome and metabolites would stimulate primitive vascular-endothelial genesis...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755815/long-noncoding-rna-gas5-inhibits-metastasis-by-targeting-mir-182-angptl1-in-hepatocellular-carcinoma
#8
Fei Chen, Yuhong Li, Meijun Li, Liang Wang
Intrahepatic and extrahepatic metastases are responsible for the majority of hepatocellular carcinoma (HCC)-related mortalities. Long noncoding RNAs (lncRNAs) exert important functions in modulating various tumor behaviors. However, the functions and mechanisms of lncRNAs in HCC metastasis remain largely unknown. In this study, downregulation of lncRNA growth arrest-specific 5 (GAS5) was observed in HCC tissues and cells, and predicted poor prognosis of patients with HCC. Through performing gain- and loss-of-function experiments, we found that GAS5 could obviously inhibit migration and invasion of HCC cells in vitro, and suppress tumor metastasis in vivo...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755814/functional-impairment-of-the-hipk2-small-ubiquitin-like-modifier-sumo-interacting-motif-in-acute-myeloid-leukemia
#9
Ki Sa Sung, Sun-Jick Kim, Sang Woo Cho, Ye-Jin Park, Kun Tae, Cheol Yong Choi
Covalent conjugations of the SUMO-1 moiety on a target protein play important roles in the regulation of cellular protein function. SUMO-conjugation of PML is a regulatory step for PML nuclear body (PML-NB) formation, and HIPK2 is SUMO-conjugated and recruited into the PML-NBs. Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, little is known about the underlying mechanisms by which HIPK2 mutations are associated with the pathogenesis of leukemia...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755813/a-p53-stabilizing-agent-cp-31398-induces-p21-expression-with-increased-g2-m-phase-through-the-yy1-transcription-factor-in-esophageal-carcinoma-defective-of-the-p53-pathway
#10
Boya Zhong, Masato Shingyoji, Michiko Hanazono, Thảo Thi Thanh Nguyễn, Takao Morinaga, Yuji Tada, Kenzo Hiroshima, Hideaki Shimada, Masatoshi Tagawa
Restoration of p53 functions is one of the therapeutic strategies for esophageal carcinoma which is often defective of the p53 pathway. We examined effects of CP-31398 which potentially increased expression of wild-type p53 or converted mutated p53 to the wild-type. We used 9 kinds of human squamous esophageal carcinoma cells with different p53 genotypes and examined expression of p53 and the related molecules in CP-31398-treated cells. Cisplatin, a DNA damaging agent, induced cleavages of PARP and caspase-3 without increase of p53 levels, indicating that the p53 down-stream pathway was disrupted in these cells...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755812/a-novel-cd7-chimeric-antigen-receptor-modified-nk-92mi-cell-line-targeting-t-cell-acute-lymphoblastic-leukemia
#11
Fengtao You, Yinyan Wang, Licui Jiang, Xuejun Zhu, Dan Chen, Lei Yuan, Gangli An, Huimin Meng, Lin Yang
Chimeric antigen receptor (CAR) immunotherapy has recently shown promise in clinical trials for B-cell malignancies; however, designing CARs for T-cell based diseases remain a challenge since most target antigens are shared between normal and malignant cells, leading to CAR-T cell fratricide. CD7 is highly expressed in T-cell acute lymphoblastic leukemia (T-ALL), but it is not expressed in one small group of normal T lymphocytes. Here, we constructed monovalent CD7-CAR-NK-92MI and bivalent dCD7-CAR-NK-92MI cells using the CD7 nanobody VHH6 sequences from our laboratory...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755811/antibody-and-fragment-based-pet-imaging-of-ctla-4-t-cells-in-humanized-mouse-models
#12
Emily B Ehlerding, Hye Jin Lee, Dawei Jiang, Carolina A Ferreira, Christopher D Zahm, Peng Huang, Jonathan W Engle, Douglas G McNeel, Weibo Cai
Imaging of immunotherapy targets using positron emission tomography (PET) can allow for noninvasive monitoring of their dynamic expression and may allow for patient stratification in the future. Therefore, two tracers targeting CTLA-4, one a full antibody and the other a F(ab')2 fragment, were radiolabeled with 64 Cu and validated in humanized mouse models. Ipilimumab was digested to develop ipilimumab-F(ab')2 , and both the intact antibody and the fragment were conjugated with NOTA to chelate 64 Cu for PET...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755810/microrna-758-inhibits-the-malignant-phenotype-of-osteosarcoma-cells-by-directly-targeting-hmga1-and-deactivating-the-wnt-%C3%AE-catenin-pathway
#13
Jia Ren, Mengjie Yang, Fengyang Xu, Juwu Chen
microRNAs (miRNAs) are frequently aberrantly expressed in osteosarcoma (OS) and are implicated in its development. Dysregulation of miR-758 has been reported in various human malignancies. However, whether miR-758 is involved in the oncogenesis and progression of OS remains unclear. In this study, reverse transcription-quantitative polymerase chain reaction was performed to detect miR-758 expression in OS tissues and cell lines. A series of functional experiments were employed to explore the regulatory effects of miR-758 on the malignant behaviors of OS cells both in vitro and in vivo...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755809/overexpressed-acp5-has-prognostic-value-in-colorectal-cancer-and-promotes-cell-proliferation-and-tumorigenesis-via-fak-pi3k-akt-signaling-pathway
#14
Zheng-Qian Bian, Yang Luo, Feng Guo, Yi-Zhou Huang, Ming Zhong, Hui Cao
The tartrate-resistant acid phosphatase (TRAP/ACP5) correlated with tumor progression in many malignancies. However, the role of ACP5 in colorectal cancer (CRC) has not been thoroughly elucidated. In this study, we sought to identify the role for ACP5 in CRC progression. Immunohistochemistry revealed that high ACP5 expression is positively associated with tumor size, tumor classification, lymph node metastasis, distant metastasis and advanced stage cancer in 285 CRC patients. Moreover, high ACP5 expression was significantly associated with poor overall survival and disease-free survival...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30755808/perineural-invasion-of-cancer-a-complex-crosstalk-between-cells-and-molecules-in-the-perineural-niche
#15
REVIEW
Shu-Hai Chen, Bing-Yuan Zhang, Bin Zhou, Cheng-Zhan Zhu, Le-Qi Sun, Yu-Jie Feng
Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor metastasis and invasion and portends the poor prognosis of patients. The pathological description and clinical significance of PNI are clearly understood, but exploration of the underlying molecular mechanism is ongoing. It was previously thought that the low-resistance channel in the anatomic region led to the occurrence of PNI. However, with rapid development of precision medicine and molecular biology, we have gradually realized that the occurrence of PNI is not the result of a single factor...
2019: American Journal of Cancer Research
https://read.qxmd.com/read/30662814/erratum-phosphodiesterase-5-inhibition-suppresses-colonic-inflammation-induced-tumorigenesis-via-blocking-the-recruitment-of-mdsc
#16
Shiyong Lin, Jing Wang, Lihui Wang, Jing Wen, Yandong Guo, Weiguang Qiao, Jieqiong Zhou, Guoliang Xu, Fachao Zhi
[This corrects the article on p. 41 in vol. 7, PMID: 28123846.].
2018: American Journal of Cancer Research
https://read.qxmd.com/read/30662813/incense-burning-smoke-sensitizes-lung-cancer-cells-to-egfr-tki-by-inducing-areg-expression
#17
Chih-Yen Tu, Bo-Wei Wang, Fang-Ju Cheng, Chia-Hung Chen, Te-Chun Hsia, Ya-Ling Wei, Chih-Yi Chen, I-Shan Hsieh, Yi-Lun Yeh, Li-Yun Wang, Chuan-Mu Chen, Wei-Chao Chang, Wei-Chien Huang
Incense burning is common in Asian countries due to the religious beliefs. Environmental exposure to incense burning smoke is a potential risk factor for tumor development and progression of non-small cell lung cancer (NSCLC). Eastern Asia ethnic origin is strongly associated the clinical benefits of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in NSCLC patients. However, the impact of the oriental custom of incense burning on the cancer progression and the EGFR TKI-sensitivity of NSCLC remains unclear...
2018: American Journal of Cancer Research
https://read.qxmd.com/read/30662812/mir-338-3p-targets-rab23-and-suppresses-tumorigenicity-of-prostate-cancer-cells
#18
Yuxiong Wang, Haiyan Qin
MicroRNA-338-3p (miR-338-3p) has been implicated in several cancers; however, its role in human prostate cancer remains unknown. In this study, we observed downregulation of miR-338-3p in prostate cancer tissues and cell lines. Forced expression of miR-338-3p suppressed prostate cancer cell proliferation, migration, and invasion in vitro and tumor growth in vivo , while apoptosis was induced. Further experiments revealed that RAB23 is a target of miR-338-3p because miR-338-3p bound directly to the 3'-untranslated region (3'-UTR) of RAB23 mRNA, thereby reducing both the mRNA and protein levels of RAB23...
2018: American Journal of Cancer Research
https://read.qxmd.com/read/30662811/cellular-5-hydroxylmethylcytosine-content-determines-tumorigenic-potential-and-prognosis-of-pancreatic-ductal-adenocarcinoma
#19
Yi-Lng Chen, Chun-Mei Hu, Jeh-Ting Hsu, Chin-Chun Chang, Ting-Yu Huang, Pei-Hsun Chiang, Wei-Yi Chen, Yu-Ting Chang, Ming-Chu Chang, Yu-Wen Tien, Eva Yhp Lee, Yung-Ming Jeng, Wen-Hwa Lee
We stratified pancreatic ductal adenocarcinoma (PDAC) based on the tumorigenic properties of cancer cells, and aimed to identify clinically useful immunohistochemical (IHC) markers with mechanistic insights. The tumorigenic properties of PDACs were determined using patient-derived xenograft in NOD/SCID/IL2Rγnull mice. The success of tumor engraftment was significantly correlated to poor survival, and its predictive values were superior to clinicopathological parameters. To search IHC-based biomarkers as surrogate for high tumorigenicity with prognostic values, 11 candidates of potentially clinical useful prognostic markers were selected...
2018: American Journal of Cancer Research
https://read.qxmd.com/read/30662810/local-and-systemic-curcumin-c3-complex-inhibits-4nqo-induced-oral-tumorigenesis-via-modulating-fgf-2-fgfr-2-activation
#20
Alok R Khandelwal, Tara Moore-Medlin, Oleksandr Ekshyyan, Xin Gu, Fleurette Abreo, Cherie-Ann O Nathan
Head and Neck Squamous cell carcinoma (HNSCC) can be characterized by synchronous tumors in the upper aerodigestive tract. Second primary tumors as a result of field cancerization are a significant problem amongst patients with risk factors for HNSCC, indicating a need for chemo preventive agents. We investigated the efficacy of local and systemic Curcumin C3 complex (C3); a purified mixture of Curcumin, bisdemethoxy Curcumin and demethoxy Curcumin as a chemo preventative agent in 4-nitroquinoline-1-oxide (4NQO)-induced tumorigenesis in mice...
2018: American Journal of Cancer Research
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