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World Journal of Clinical Oncology

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https://read.qxmd.com/read/30627522/stereotactic-body-radiation-therapy-for-non-small-cell-lung-cancer-a-review
#1
REVIEW
Kavitha M Prezzano, Sung Jun Ma, Gregory M Hermann, Charlotte I Rivers, Jorge A Gomez-Suescun, Anurag K Singh
Stereotactic body radiation therapy (SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer (NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC...
January 10, 2019: World Journal of Clinical Oncology
https://read.qxmd.com/read/30627521/long-term-outcomes-of-interventions-for-radiation-induced-xerostomia-a-review
#2
REVIEW
Sung Jun Ma, Charlotte I Rivers, Lucas M Serra, Anurag K Singh
Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen, submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia...
January 10, 2019: World Journal of Clinical Oncology
https://read.qxmd.com/read/30622928/radiation-associated-epithelial-myoepithelial-carcinoma-among-five-secondary-malignancies-a-case-report-and-review-of-literature
#3
Mohamed H Khattab, Alexander D Sherry, Carolyn G Ahlers, Austin N Kirschner
BACKGROUND: Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade, malignant tumor that constitutes less than one percent of all salivary gland tumors. To date, only one other case report has described radiation-associated EMC in the English language medical literature. CASE SUMMARY: In this report, we describe the case of a 56-year-old male patient who presented with a neck mass diagnosed as EMC of the left submandibular gland approximately 30 years after mantle field radiation and chemotherapy for Hodgkin lymphoma...
December 20, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30622927/combination-immunotherapy-with-survivin-and-luteinizing-hormone-releasing-hormone-fusion-protein-in-murine-breast-cancer-model
#4
Himani Garg, Rohit Singh Hada, Jagdish C Gupta, G P Talwar, Shweta Dubey
AIM: To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6leu)-LTB] for immunotherapy of breast cancer. METHODS: Murine 4T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo . Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice...
December 20, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30622926/role-of-senescence-induction-in-cancer-treatment
#5
REVIEW
Shenghui Qin, Bradley A Schulte, Gavin Y Wang
Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening, DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types, suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment...
December 20, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30622925/current-status-of-pi3k-mtor-inhibition-in-hormone-receptor-positive-her2-negative-breast-cancer
#6
EDITORIAL
Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante
Breast cancer (BC) is the most common cancer in women and second only to lung cancer in terms of mortality. Among the three different BC subtypes, the oestrogen receptor positive represents nearly 70% of all cases and it is usually treated with anti-oestrogen drugs. However, the majority of hormone receptor positive metastatic BC patients develop resistance to anti-oestrogen treatments. The need for more down-stream therapies brought to the development of therapeutic strategies inhibiting the phosphatidylinositol 3-kinase-mammalian target of rapamycin (mTOR) pathway...
December 20, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30622924/malignant-peritoneal-effusion-acting-as-a-tumor-environment-in-ovarian-cancer-progression-impact-and-significance
#7
EDITORIAL
Alain Piché
Until recently, ovarian cancer research has mainly focused on the tumor cells themselves ignoring for the most part the surrounding tumor environment which includes malignant peritoneal effusions. However, one of the major conceptual advances in oncology over the last few years has been the appreciation that cancer progression cannot be explained by aberrations in cancer cells themselves and is strongly influenced by the surrounding tumor environment. The mechanisms of ovarian cancer progression differ from that of other solid tumors because ovarian cancer cells primarily disseminate within the peritoneal cavity...
December 20, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30425941/giant-exophytic-renal-angiomyolipoma-masquerading-as-a-retroperitoneal-liposarcoma-a-case-report-and-review-of-literature
#8
Gopal Sharma, Ayush Jain, Prerit Sharma, Sonal Sharma, Vinita Rathi, Pankaj Kumar Garg
A 42-years-old lady, presented with a large retroperitoneal mass which was preoperatively diagnosed as a retroperitoneal liposarcoma following an image guided core biopsy. She underwent a margin-negative resection of the retroperitoneal mass (multi visceral resection - enbloc excision of the retroperitoneal mass with a left nephrectomy and a segmental descending colectomy). The final histopathological examination of the resected specimen confirmed an exophytic renal angiomyolipoma (AML) which was extending into the retroperitoneum...
November 10, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30425940/comparison-of-the-eighth-version-of-the-american-joint-committee-on-cancer-manual-to-the-seventh-version-for-colorectal-cancer-a-retrospective-review-of-our-data
#9
Guo-Jun Tong, Gui-Yang Zhang, Jian Liu, Zhao-Zheng Zheng, Yan Chen, Ping-Ping Niu, Xu-Ting Xu
AIM: To analyze the survival trends in colorectal cancer (CRC) based on the different classifications recommended by the seventh and eighth editions of the American Joint Committee on Cancer staging system (AJCC-7th and AJCC-8th ). METHODS: The database from our institution was queried to identify patients with pathologically confirmed stage 0-IV CRC diagnosed between 2006 and 2012. Data from 2080 cases were collected and 1090 cases were evaluated through standardized inclusion and exclusion criteria...
November 10, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30425939/interconversion-of-two-commonly-used-performance-tools-an-analysis-of-5844-paired-assessments-in-1501-lung-cancer-patients
#10
Kuruswamy Thurai Prasad, Harpreet Kaur, Valliappan Muthu, Ashutosh Nath Aggarwal, Digambar Behera, Navneet Singh
AIM: To establish the Karnofsky performance status (KPS) categories which would facilitate the interconversion of the KPS scale to the Eastern Cooperative Oncology Group (ECOG) performance status (PS) scale. METHODS: This was a retrospective analysis of all patients attending the lung cancer clinic at a tertiary care center over a 5-year period (September 2009 to August 2014). All patients were assessed with both KPS and ECOG PS scales at each visit. Correlation between KPS and ECOG PS was assessed using Spearman's correlation coefficient...
November 10, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30425938/mismatch-repair-protein-expression-and-intratumoral-budding-in-rectal-cancer-are-associated-with-an-increased-pathological-complete-response-to-preoperative-chemoradiotherapy-a-case-control-study
#11
Leonardo S Lino-Silva, Armando Gamboa-Domínguez, Diego Zúñiga-Tamayo, Rosa A Salcedo-Hernández, Lucely Cetina, David Cantú-de-León
AIM: To determine whether the association of rectal adenocarcinoma with a defective-mismatch repair system (dMMR) was associated with a pathological complete response (pCR) to preoperative chemoradiotherapy. METHODS: A case-control study was designed with the aim of determining if patients with rectal adenocarcinoma with dMMR had an associated high pCR rate in response to neoadjuvant chemoradiotherapy (nCRT). RESULTS: Seventy-two cases with pCR were compared against 144 controls without pCR...
November 10, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30425937/lymphocyte-subsets-predictive-value-and-possible-involvement-of-human-papilloma-virus-infection-on-breast-cancer-molecular-subtypes
#12
Andreína Fernandes, Adriana Pesci-Feltri, Isabel García-Fleury, Marco López, Vincent Guida, Marisol De Macedo, María Correnti
AIM: To detect human papilloma virus (HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS: A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIPA HPV Genotyping Extra test (Innogenetics, Ghent, Belgium)...
November 10, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30425936/risk-of-colorectal-cancer-in-patients-with-diverticular-disease
#13
EDITORIAL
Jeremy Meyer, Nicolas Christian Buchs, Frédéric Ris
Colorectal cancer constitutes an important burden on the healthcare system. Screening at-risk populations to reduce colorectal cancer-related morbidity and mortality has become part of good clinical practice. However, recommendations regarding subgroups of patients with diverticular disease are subject to controversy. Herein, we review the most recent literature regarding the prevalence of colorectal cancer in patients with diverticular disease, diverticulitis and uncomplicated diverticulitis. The recent literature does not identify diverticular disease as a long-term risk factor for colorectal cancer...
October 24, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30254966/folfiri3-aflibercept-in-previously-treated-patients-with-metastatic-colorectal-cancer
#14
Candice Carola, François Ghiringhelli, Stefano Kim, Thierry André, Juliette Barlet, Leïla Bengrine-Lefevre, Hélène Marijon, Marie-Line Garcia-Larnicol, Christophe Borg, Linda Dainese, Nils Steuer, Hubert Richa, Magdalena Benetkiewicz, Annette K Larsen, Aimery de Gramont, Benoist Chibaudel
AIM: To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer. METHODS: This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3 (day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m2 , irinotecan 90 mg/m2 , 5-fluorouracil infusion 2400 mg/m2 per 46 h; day 3: irinotecan 90 mg/m2 ) in patients with previously treated metastatic colorectal cancer...
September 14, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30254965/tunable-structure-priors-for-bayesian-rule-learning-for-knowledge-integrated-biomarker-discovery
#15
Jeya Balaji Balasubramanian, Vanathi Gopalakrishnan
AIM: To develop a framework to incorporate background domain knowledge into classification rule learning for knowledge discovery in biomedicine. METHODS: Bayesian rule learning (BRL) is a rule-based classifier that uses a greedy best-first search over a space of Bayesian belief-networks (BN) to find the optimal BN to explain the input dataset, and then infers classification rules from this BN. BRL uses a Bayesian score to evaluate the quality of BNs. In this paper, we extended the Bayesian score to include informative structure priors, which encodes our prior domain knowledge about the dataset...
September 14, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30254964/resistance-to-flt3-inhibitors-in-acute-myeloid-leukemia-molecular-mechanisms-and-resensitizing-strategies
#16
REVIEW
Jianbiao Zhou, Wee-Joo Chng
FMS-like tyrosine kinase 3 (FLT3) is classified as a type III receptor tyrosine kinase, which exerts a key role in regulation of normal hematopoiesis. FLT3 mutation is the most common genetic mutation in acute myeloid leukemia (AML) and represents an attractive therapeutic target. Targeted therapy with FLT3 inhibitors in AML shows modest promising results in current ongoing clinical trials suggesting the complexity of FLT3 targeting in therapeutics. Importantly, resistance to FLT3 inhibitors may explain the lack of overwhelming response and could obstruct the successful treatment for AML...
September 14, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30254963/role-of-polymorphisms-in-genes-that-encode-cytokines-and-helicobacter-pylori-virulence-factors-in-gastric-carcinogenesis
#17
REVIEW
Breno Bittencourt de Brito, Filipe Antônio França da Silva, Fabrício Freire de Melo
The Helicobacter pylori ( H. pylori ) infection is a determinant factor in gastric cancer (GC) development. However, the infection outcomes are variable and depend on both host and bacterial characteristics. Some host cytokines such as interleukin (IL)-1β, IL-1Ra, IL-8, IL-10 and tumor necrosis factor-α play important roles in the host immune system response to the pathogen, in the development of gastric mucosal lesions and in cell malignant transformation. Therefore, these host factors are crucial in neoplastic processes...
September 14, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30254962/oxytocin-and-cancer-an-emerging-link
#18
REVIEW
Ben Lerman, Trisheena Harricharran, Olorunseun O Ogunwobi
The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker...
September 14, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30254961/cancer-prevention-in-patients-with-human-immunodeficiency-virus-infection
#19
EDITORIAL
Evripidis Valanikas, Konstantinos Dinas, Konstantinos Tziomalos
Cancer is a leading cause of death in patients with human immunodeficiency virus (HIV) infection. With the advent of antiretroviral treatment, the risk of AIDS-defining cancers declined but the ageing of this population resulted in the emergence of other common cancers, particularly lung and hepatocellular cancer. Accordingly, screening programs similar to the general population should be implemented in patients with HIV infection. Vaccination against common oncogenic viruses is also essential. However, rates of cancer screening and vaccination against HPV and HBV are considerably low in this population, highlighting a pressing need to educate patients and healthcare professionals about the importance of cancer preventive measures in these vulnerable patients...
September 14, 2018: World Journal of Clinical Oncology
https://read.qxmd.com/read/30148069/polyubiquitination-inhibition-of-estrogen-receptor-alpha-and-its-implications-in-breast-cancer
#20
REVIEW
Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín
Estrogen receptor alpha (ERα) is detected in more than 70% of the cases of breast cancer. Nuclear activity of ERα, a transcriptional regulator, is linked to the development of mammary tumors, whereas the extranuclear activity of ERα is related to endocrine therapy resistance. ERα polyubiquitination is induced by the estradiol hormone, and also by selective estrogen receptor degraders, resulting in ERα degradation via the ubiquitin proteasome system. Moreover, polyubiquitination is related to the ERα transcription cycle, and some E3-ubiquitin ligases also function as coactivators for ERα...
August 13, 2018: World Journal of Clinical Oncology
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