journal
https://read.qxmd.com/read/38292666/what-are-the-changes-in-the-hotspots-and-frontiers-of-micrornas-in-hepatocellular-carcinoma-over-the-past-decade
#1
JOURNAL ARTICLE
Lu Zhang, Zu-Yuan Chen, Xiao-Xian Wei, Jian-Di Li, Gang Chen
BACKGROUND: Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies. AIM: To make a comprehensive analysis of recent studies concerning miRNAs in HCC. METHODS: All relevant publications were retrieved from the Web of Science Core Collection database...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292665/scinderin-promotes-glioma-cell-migration-and-invasion-via-remodeling-actin-cytoskeleton
#2
JOURNAL ARTICLE
Xin Lin, Zhao Zhao, Shu-Peng Sun, Wei Liu
BACKGROUND: Glioma is one of the most common intracranial tumors, characterized by invasive growth and poor prognosis. Actin cytoskeletal rearrangement is an essential event of tumor cell migration. The actin dynamics-related protein scinderin (SCIN) has been reported to be closely related to tumor cell migration and invasion in several cancers. AIM: To investigate the role and mechanism of SCIN in glioma. METHODS: The expression and clinical significance of SCIN in glioma were analyzed based on public databases...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292664/inflammatory-response-in-gastrointestinal-cancers-overview-of-six-transmembrane-epithelial-antigens-of-the-prostate-in-pathophysiology-and-clinical-implications
#3
REVIEW
Ze-Xuan Fang, Wen-Jia Chen, Zheng Wu, Yan-Yu Hou, Yang-Zheng Lan, Hua-Tao Wu, Jing Liu
Chronic inflammation is known to increase the risk of gastrointestinal cancers (GICs), the common solid tumors worldwide. Precancerous lesions, such as chronic atrophic inflammation and ulcers, are related to inflammatory responses in vivo and likely to occur in hyperplasia and tumorigenesis. Unfortunately, due to the lack of effective therapeutic targets, the prognosis of patients with GICs is still unsatisfactory. Interestingly, it is found that six transmembrane epithelial antigens of the prostate (STEAPs), a group of metal reductases, are significantly associated with the progression of malignancies, playing a crucial role in systemic metabolic homeostasis and inflammatory responses...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292663/prognostic-factors-of-breast-cancer-brain-metastasis
#4
EDITORIAL
Melek Yakar, DurmuĊŸ Etiz
In this editorial we comment on the article by Chen et al published in the recent issue of the World Journal of Clinical Oncology . Brain metastasis is one of the most serious complications of breast cancer and causes high morbidity and mortality. Brain metastases may involve the brain parenchyma and/or leptomeninges. Symptomatic brain metastases develop in 10%-16% of newly recognized cases each year, and this rate increases to 30% in autopsy series. Depending on the size of the metastatic foci, it may be accompanied by extensive vasogenic edema or may occur as small tumor foci...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292662/identification-of-the-key-genes-and-mechanisms-associated-with-transcatheter-arterial-chemoembolisation-refractoriness-in-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Jie-Zhuang Huang, Jian-Di Li, Gang Chen, Rong-Quan He
BACKGROUND: Transcatheter arterial embolisation (TACE) is the primary treatment for intermediate-stage hepatocellular carcinoma (HCC) patients while some HCC cases have shown resistance to TACE. AIM: To investigate the key genes and potential mechanisms correlated with TACE refractoriness in HCC. METHODS: The microarray datasets of TACE-treated HCC tissues, HCC and non-HCC tissues were collected by searching multiple public databases. The respective differentially expressed genes (DEGs) were attained via limma R package...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292661/gene-signatures-to-therapeutics-assessing-the-potential-of-ivermectin-against-t-4-14-multiple-myeloma
#6
JOURNAL ARTICLE
Yang Song, Hao-Jun Zhang, Xia Song, Jie Geng, Hong-Yi Li, Li-Zhong Zhang, Bo Yang, Xue-Chun Lu
BACKGROUND: Multiple myeloma (MM) is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone marrow. The translocation, (t)(4;14), results in high-risk MM with limited treatment alternatives. Thus, there is an urgent need for identification and validation of potential treatments for this MM subtype. Microarray data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic targets...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292660/re-evaluating-the-role-of-pelvic-radiation-in-the-age-of-modern-precision-medicine-and-systemic-therapy
#7
EDITORIAL
Tao-Wei Ke, Yu-Min Liao, Sheng-Chi Chang, Che-Hung Lin, William Tzu-Liang Chen, Ji-An Liang, Chun-Ru Chien
The efficacy of pelvic radiation in the management of locally advanced stage rectal cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC ( J Clin Oncol 2019; 37: 3223-3233), NCT04165772 ( N Engl J Med 2022; 386: 2363-2376), and PROSPECT ( N Engl J Med 2023; 389: 322-334). In this review, we comprehensively assess these pivotal trials and offer additional insights into the evolving role of pelvic radiation in contemporary oncology...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292659/prognostic-and-immunological-roles-of-heat-shock-protein-a4-in-lung-adenocarcinoma
#8
JOURNAL ARTICLE
Xuan Wu, Shen-Ying Yang, Yi-Hua Zhang, Jin-Zhou Fang, Shuai Wang, Zhi-Wei Xu, Xiao-Ju Zhang
BACKGROUND: Heat shock protein A4 (HSPA4) belongs to molecular chaperone protein family which plays important roles within variable cellular activities, including cancer initiation and progression. However, the prognostic and immunological significance of HSPA4 in lung adenocarcinoma (LUAD) has not been revealed yet. AIM: To explore the prognostic and immunological roles of HSPA4 to identify a novel prognostic biomarker and therapeutic target for LUAD. METHODS: We assessed the prognostic and immunological significance of HSPA4 in LUAD using data from The Cancer Genome Atlas database...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292658/predicting-colorectal-cancer-prognosis-based-on-long-noncoding-rnas-of-disulfidptosis-genes
#9
JOURNAL ARTICLE
Kui-Ling Wang, Kai-Di Chen, Wen-Wen Tang, Ze-Peng Chen, Yu-Ji Wang, Guo-Ping Shi, Yu-Gen Chen
BACKGROUND: A recently hypothesized cause of cell death called disulfidptosis has been linked to the expansion, emigration, and vascular rebuilding of cancer cells. Cancer can be treated by targeting the pathways that trigger cell death. AIM: To discover the long non-coding RNA of the disulfidaptosis-related lncRNAs (DRLs), prognosis clinical survival, and treat patients with colorectal cancer with medications. METHODS: Initially, we queried the Cancer Genome Atlas database to collect transcriptome, clinical, and genetic mutation data for colorectal cancer (CRC)...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292657/uveal-melanoma-recent-advances-in-immunotherapy
#10
REVIEW
Francesco Saverio Sorrentino, Francesco De Rosa, Patrick Di Terlizzi, Giacomo Toneatto, Andrea Gabai, Lucia Finocchio, Carlo Salati, Leopoldo Spadea, Marco Zeppieri
Uveal melanoma (UM) is the most common primary intraocular cancer in adults. The incidence in Europe and the United States is 6-7 per million population per year. Although most primary UMs can be successfully treated and locally controlled by irradiation therapy or local tumor resection, up to 50% of UM patients develop metastases that usually involve the liver and are fatal within 1 year. To date, chemotherapy and targeted treatments only obtain minimal responses in patients with metastatic UM, which is still characterized by poor prognosis...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292656/fatty-acid-binding-protein-5-is-a-novel-therapeutic-target-for-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Yan Li, William Lee, Zhen-Gang Zhao, Yi Liu, Hao Cui, Hao-Yu Wang
BACKGROUND: Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide. Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival, growth, and evolution. Emerging evidence suggests the importance of fatty acid binding proteins (FABPs) in contribution to cancer progression and metastasis; however, how these FABPs are dysregulated in cancer cells, especially in HCC, and the roles of FABPs in cancer progression have not been well defined...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38292655/radiotherapy-for-hyoid-bone-metastasis-from-lung-adenocarcinoma-a-case-report
#12
Jonathan Hsu, Kambridge Hribar, Joseph Poen
BACKGROUND: Metastasis to the hyoid bone is an exceptionally rare occurrence, with documented cases limited to breast, liver, colon, skin, lung, and prostate cancers. This report highlights an unusual case involving the metastasis of lung adenocarcinoma to the hyoid bone, accompanied by a distinctive headache. Previous documentation involved surgical resection of the hyoid mass. We present a case displaying the benefits of palliative radiotherapy. CASE SUMMARY: A 72-year-old non-smoking, non-alcoholic woman, initially under investigation for a year-long elevation in absolute lymphocyte count, presented with a month-long history of intermittent throat pain...
January 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38179407/current-perspectives-on-the-management-of-lateral-pelvic-lymph-nodes-in-rectal-cancer
#13
REVIEW
Jonathan Yu Jin Chua, James Chi Yong Ngu, Nan Zun Teo
Significant controversies exist with regards to the optimal management of lateral pelvic lymph nodes metastases (mLLN) in patients with low rectal cancer. The differing views held by Japanese and Western clinicians on the management of mLLN have been well documented. However, the adequacy of pelvic lymph node dissection (PLND) or neoadjuvant chemoradiation (NACRT) alone in addition to total mesorectal excision (TME) have recently come into question, due to the relatively high incidence of lateral local recurrences following PLND and TME, or NACRT and TME alone...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38179406/update-on-current-diagnosis-and-management-of-anaplastic-thyroid-carcinoma
#14
REVIEW
Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis
Well-differentiated thyroid carcinoma has a favorable prognosis with a 5-year survival rate of over 95%. However, the undifferentiated or anaplastic type accounting for < 0.2%, usually in elderly individuals, exhibits a dismal prognosis with rapid growth and disappointing outcomes. It is the most aggressive form of thyroid carcinoma, with a median survival of 5 mo and poor quality of life (airway obstruction, dysphagia, hoarseness, persistent pain). Early diagnosis and staging are crucial. Diagnostic tools include biopsy (fine needle aspiration, core needle, open surgery), high-resolution ultrasound, computed tomography, magnetic resonance imaging, [(18)F]fluoro-D-glucose positron emission tomo-graphy/computed tomography, liquid biopsy and microRNAs...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38179405/adenosine-triphosphate-induced-cell-death-mechanisms-and-implications-in-cancer-biology-and-therapy
#15
REVIEW
Hao-Ling Zhang, Doblin Sandai, Zhong-Wen Zhang, Zhi-Jing Song, Dinesh Babu, Yasser Tabana, Sabbar Saad Dahham, Mowaffaq Adam Ahmed Adam, Yong Wang, Wei Wang, Hao-Long Zhang, Rui Zhao, Khaled Barakat, Mohammad Syamsul Reza Harun, Siti Nurfatimah Mohd Shapudin, Bronwyn Lok
Adenosine triphosphate ( ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer biology. This review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of cancer. This is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis, deciphering the intricate mechanisms governing AICD, elucidating its intricate involvement in cancer signaling pathways, and scrutinizing validated key genes...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38179404/anti-tumor-effect-of-coix-seed-based-on-the-theory-of-medicinal-and-food-homology
#16
REVIEW
Fan-Di Meng, Ling Yuan, Dou-Dou Lu, Ya-Ting Yang, Duo-Jie Xu, Meng-Ying Che, Yi Nan
Coix seed is a dry and mature seed of Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf in the Gramineae family. Coix seed has a sweet, light taste, and a cool nature. Coix seed enters the spleen, stomach, and lung meridians. It has the effects of promoting diuresis and dampness, strengthening the spleen to prevent diarrhea, removing arthralgia, expelling pus, and detoxifying and dispersing nodules. It is used for the treatment of edema, athlete's foot, poor urination, spleen deficiency and diarrhea, dampness and obstruction, lung carbuncle, intestinal carbuncle, verruca, and cancer...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38179403/rapid-transformation-of-branched-pancreatic-duct-derived-intraductal-tubulopapillary-neoplasm-into-an-invasive-carcinoma-a-case-report
#17
Kenta Yamamoto, Yutaka Takada, Takuya Kobayashi, Ryo Ito, Yuka Ikeda, Shogo Ota, Kanna Adachi, Yukari Shimada, Motohito Hayashi, Toshinao Itani, Satsuki Asai, Kojiro Nakamura
BACKGROUND: Intraductal tubulopapillary neoplasm (ITPN) is a rare disease accounting for approximately 3% of all intraductal pancreatic tumors, with intraductal papillary mucinous neoplasm (IPMN) being one of the most common differential diagnoses. Both ITPN and IPMN display slow growth. A branched pancreatic duct type is commonly observed in IPMN, whereas ITPN derived from the branched pancreatic duct has been reported in a limited number of cases; hence, its pathogenesis remains unclear...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38179402/clinical-outcomes-of-newly-diagnosed-primary-central-nervous-system-lymphoma-treated-with-zanubrutinib-based-combination-therapy
#18
JOURNAL ARTICLE
Ning Wang, Fei-Li Chen, Lu Pan, Yan Teng, Xiao-Juan Wei, Han-Guo Guo, Xin-Miao Jiang, Ling Huang, Si-Chu Liu, Zhan-Li Liang, Wen-Yu Li
BACKGROUND: High-dose methotrexate (HD-MTX) combined with other chemotherapeutic agents is an effective treatment for patients with newly diagnosed primary central nervous system lymphoma (PCNSL); however, some patients have adverse reactions. AIM: To retrospectively evaluate disease outcomes and mutational profiles in newly diagnosed PCNSL patients treated with a zanubrutinib/HD-MTX combination regimen. METHODS: Nineteen newly diagnosed PCNSL patients were treated with zanubrutinib/HD-MTX until disease progression, intolerable toxicities, or physician/patient-directed withdrawal...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38059189/analysis-of-clinicopathological-features-and-prognostic-factors-of-breast-cancer-brain-metastasis
#19
JOURNAL ARTICLE
Yu-Rui Chen, Zu-Xin Xu, Li-Xin Jiang, Zhi-Wei Dong, Peng-Fei Yu, Zhi Zhang, Guo-Li Gu
BACKGROUND: Breast cancer (BC) has become the most common malignancy in women. The incidence and detection rates of BC brain metastasis (BCBM) have increased with the progress of imaging, multidisciplinary treatment techniques and the extension of survival time of BC patients. BM seriously affects the quality of life and sur-vival prognosis of BC patients. Therefore, clinical research on the clinicopathological features and prognostic factors of BCBM is valuable. By analyzing the clinicopathological parameters of BCBM patients, and assessing the risk factors and prognostic indicators, we can perform hierarchical diagnosis and treatment on the high-risk population of BCBM, and achieve clinical benefits of early diagnosis and treatment...
November 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38059188/bibliometric-analysis-of-the-global-research-status-and-trends-of-mechanotransduction-in-cancer
#20
JOURNAL ARTICLE
Yi-Zhan Zhang, Meng-Zhu Li, Guang-Xin Wang, Da-Wei Wang
BACKGROUND: The development of cancer is thought to involve the dynamic crosstalk between the tumor cells and the microenvironment they inhabit. Such crosstalk is thought to involve mechanotransduction, a process whereby the cells sense mechanical cues such as stiffness, and translate these into biochemical signals, which have an impact on the subsequent cellular activities. Bibliometric analysis is a statistical method that involves investigating different aspects (including authors' names and affiliations, article keywords, journals and citations) of large volumes of literature...
November 24, 2023: World Journal of Clinical Oncology
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