journal
https://read.qxmd.com/read/38563230/structure-characteristics-protective-effect-and-mechanisms-of-ethanol-fractional-polysaccharides-from-dendrobium-officinale-on-acute-ethanol-induced-gastritis
#61
JOURNAL ARTICLE
Hua Zhu, Lei Xu, Peng Chen, Zhenhao Li, Wujin Yu, Peilong Sun, Jianyong Wu, Ming Cai
Gastritis is a common disease characterized by gastric ulcers and severe bleeding. Excessive daily alcohol consumption can cause acute gastritis, impacting individuals' quality of life. This study aims to explore the protective effects of different ethanol-fractional polysaccharides of Dendrobium officinale (EPDO) on acute alcohol-induced gastric injury in vivo . Results showed that EPDO-80, identified as a β-glucan, exhibited significant anti-inflammatory properties in pathology. It could reduce the area of gastric mucosal injury and cell infiltration...
April 2, 2024: Food & Function
https://read.qxmd.com/read/38563197/pickering-emulsion-emulsified-using-novel-cellulose-nanofibers-significantly-lowers-the-lipid-release-rate-and-cellular-absorption
#62
JOURNAL ARTICLE
Yin-Liang Kuo, Yu-Jou Chou, Jing-Yu Hu, Yuwen Ting
A Pickering emulsion is an emulsion system stabilized by solid particles and represents a promising candidate for emulsifying lipids. Cellulose nanofibers (CNFs) have excellent ability to control the lipid release rate. This study aims to find the optimal formulation for a nanocellulose-stabilized Pickering emulsion that is the most effective in reducing the lipid release rate. The Pickering emulsion was prepared by homogenizing pretreated nanocellulose with medium-chain triglycerides using high-speed and ultrasonic homogenizers...
April 2, 2024: Food & Function
https://read.qxmd.com/read/38563085/%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-leads-to-phospholipase-d2-pld2-activation-and-alters-circadian-rhythms-in-myotubes
#63
JOURNAL ARTICLE
Meytal Cohen-Or, Nava Chapnik, Oren Froy
β-Hydroxy-β-methylbutyrate (HMB) is a breakdown product of leucine, which promotes muscle growth. Although some studies indicate that HMB activates AKT and mTOR, others show activation of the downstream effectors, P70S6K and S6, independent of mTOR. Our aim was to study the metabolic effect of HMB around the circadian clock in order to determine more accurately the signaling pathway involved. C2C12 myotubes were treated with HMB and clock, metabolic and myogenic markers were measured around the clock...
April 2, 2024: Food & Function
https://read.qxmd.com/read/38546528/oral-administration-of-egg-ovalbumin-allergen-induces-dysregulation-of-tryptophan-metabolism-in-sensitized-balb-c-mice
#64
JOURNAL ARTICLE
Zhongliang Wang, Jie Zhang, Jin Yuan, Fangfang Min, Jinyan Gao, Wenfeng Liu, Meijia Huang, Yong Wu, Hongbing Chen
Food allergy (FA), triggered by specific dietary allergens, has emerged as a substantial global concern for food safety and public health. While studies have elucidated changes in immune cells and cytokines associated with allergen exposure, a comprehensive analysis of the host's metabolic features and the interaction between metabolites and the gut microbiota has not been conducted. In this study, egg allergen ovalbumin (OVA) was administered by the oral route to sensitized BALB/c mice to faithfully replicate key aspects of human FA, including severe allergic diarrhea, mast cell infiltration, and elevated levels of serum IgE, mMCPT-1, and Th2 cell hallmark cytokines (such as IL-4, IL-5, and IL-13)...
March 28, 2024: Food & Function
https://read.qxmd.com/read/38546454/increased-nitrate-intake-from-beetroot-juice-over-4-weeks-affects-nitrate-metabolism-but-not-vascular-function-or-blood-pressure-in-older-adults-with-hypertension
#65
JOURNAL ARTICLE
Rebeka Fejes, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Karl-Heinz Wagner, Hans-Peter Stüger, Jonathan M Peake, Richard J Woodman, Kevin D Croft, Catherine P Bondonno, Jonathan M Hodgson, Michael Wolzt, Oliver Neubauer
The decline in vascular function and increase in blood pressure with aging contribute to an increased cardiovascular disease risk. In this randomized placebo-controlled crossover study, we evaluated whether previously reported cardiovascular benefits of plant-derived inorganic nitrate via nitric oxide (NO) translate into improved vascular function and blood pressure-lowering in 15 men and women (age range: 56-71 years) with treated hypertension. We investigated the effects of a single ∼400 mg-dose at 3 hours post-ingestion (3H POST) and the daily consumption of 2 × ∼400 mg of nitrate through nitrate-rich compared with nitrate-depleted (placebo) beetroot juice over 4 weeks (4WK POST)...
March 28, 2024: Food & Function
https://read.qxmd.com/read/38545932/peanut-supplementation-affects-compositions-and-functions-of-gut-microbiome-in-ugandan-children
#66
JOURNAL ARTICLE
Jia-Sheng Wang, Kathy Xue, Zilin Li, John Ssempebwa, Gakenia Wamuyu-Maina, Geofrey Musinguzi, Jamie Rhoads, Dave Hoisington, Lili Tang
Childhood malnutrition remains a serious global health concern, particularly in low-income nations like Uganda. This study investigated the impact of peanut supplementation on the compositions and functions of gut microbiome with nutritional improvement. School children aged 6-9 years from four rural communities were recruited, with half receiving roasted peanut snacks while the other half served as controls. Fecal samples were collected at the baseline (day 0), day 60, and day 90. Microbial DNA was extracted, and 16S rRNA sequencing was performed, followed by the measurement of SCFA concentration in fecal samples using UHPLC...
March 28, 2024: Food & Function
https://read.qxmd.com/read/38536669/extraction-purification-structural-modification-activities-and-application-of-polysaccharides-from-different-parts-of-mulberry
#67
REVIEW
Huilin Wang, Gangliang Huang
The mulberry plant is a member of the Moraceae family and belongs to the Morus genus. Its entire body is a treasure, with mulberries, mulberry leaves, and mulberry branches all suitable for medicinal use. The main active ingredient in mulberries is mulberry polysaccharide. Studies have shown that polysaccharides from different parts of mulberry exhibit antioxidant, antidiabetic, antibacterial, anti-inflammatory, and blood pressure-lowering properties. There are more studies on the biological activities, extraction methods, and structural characterization of polysaccharides from different parts of mulberry...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38535983/nutritional-profiling-fiber-content-and-in-vitro-bioactivities-of-wheat-based-biscuits-formulated-with-novel-ingredients
#68
JOURNAL ARTICLE
Marta Mesias, Francisco J Morales, Cristina Caleja, Tânia C S P Pires, Ricardo C Calhelha, Lillian Barros, Eliana Pereira
This study evaluated the nutritional profile and fiber content of innovative formulations of wheat-based biscuits enriched with chia seeds, carob flour and coconut sugar. The in vitro antioxidant, cytotoxic, anti-inflammatory and antimicrobial activities were also investigated to understand the potential health advantages of the incorporation of these new ingredients. The novel biscuits demonstrated significant improvements in protein and mineral content, with increases of 50% and 100% in chia biscuits, and up to 20% and 40% in carob biscuits, respectively...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38535893/effects-of-quercetin-on-the-dna-methylation-pattern-in-tumor-therapy-an-updated-review
#69
REVIEW
Qin Wang, Chen Ma, Nan Wang, Huixian Mao
Quercetin is a unique bioactive flavonoid, and is an excellent antioxidant and has anti-tumor effects by regulating different tumor-related processes like proliferation, apoptosis, invasion, and spread. The latest investigations reveal that quercetin may have the capability to influence DNA methylation modification, one of the primary factors in the development of tumors. Despite the fact that quercetin has significant therapeutic properties, its use as an anti-tumor medicine is constrained by its poor solubility, short half-life, and ineffective tumor targeting...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38533894/long-term-intake-of-thermo-induced-oxidized-oil-results-in-anxiety-like-and-depression-like-behaviors-involvement-of-microglia-and-astrocytes
#70
JOURNAL ARTICLE
Meishan Lu, Jiachen Shi, Xue Li, Yanjun Liu, Yuanfa Liu
Frequent consumption of fried foods has been strongly associated with a higher risk of anxiety and depression, particularly among young individuals. The existing evidence has indicated that acrylamide produced from starchy foods at high temperatures can induce anxious behavior. However, there is limited research on the nerve damage caused by thermo-induced oxidized oil (TIOO). In this study, we conducted behavioral tests on mice and found that prolonged consumption of TIOO led to significant anxiety behavior and a tendency toward depression...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38533683/molecular-networking-guided-investigation-of-the-secondary-metabolome-of-four-morus-species-and-their-in-vivo-neuroprotective-potential-for-the-mitigation-of-alzheimer-s-disease
#71
JOURNAL ARTICLE
Nesrine M Hegazi, Tarik A Mohamed, Abeer Salama, Ahmed R Hamed, Hamada H Saad, Ibrahim A Saleh, Eman H Reda, Ahmed A A Elsayed, Mahmoud A A Ibrahim, Paul W Paré, Thomas Efferth, Mohamed-Elamir F Hegazy
Alzheimer's Disease (AD) is a fatal age-related neurodegenerative condition with a multifactorial etiology contributing to 70% of dementia globally. The search for a multi-target agent to hit different targets involved in the pathogenesis of AD is crucial. In the present study, the neuroprotective effects of four Morus extracts were assessed in LPS-induced AD in mice. Among the studied species, M. macroura exhibited a profound effect on alleviating the loss of cognitive function, improved the learning ability, restored the acetylcholine esterase (AChE) levels to normal, and significantly reduced the tumor necrosis factor alpha (TNF-α) brain content in LPS-treated mice...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38533674/induction-of-autism-related-behavior-in-male-mice-by-early-life-vitamin-d-deficiency-association-with-disruption-of-the-gut-microbial-composition-and-homeostasis
#72
JOURNAL ARTICLE
Jingjing Cui, Shumin Wang, Zidan Zhai, Xiaoyue Song, Ting Qiu, Leilei Yu, Qixiao Zhai, Heng Zhang
Vitamin D deficiency (VDD) during early life emerges as a potential risk factor for autism spectrum disorder (ASD). Individuals with autism commonly exhibit lower vitamin D (VD) levels compared to the general population, and VD deficiency is prevalent during pregnancy and lactation. Moreover, gastrointestinal comorbidity, prevalent in ASD patients, correlates closely with disruptions in the gut microbiota and altered intestinal permeability. Therefore, it is fascinating and significant to explore the effects of maternal VD deficiency during pregnancy and lactation on the maturation of the gut microbiota of the offspring and its relevance to autism spectrum disorders...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38530276/new-neuroprotective-derivatives-of-cinnamic-acid-by-biotransformation
#73
JOURNAL ARTICLE
Hadeer Elkharsawy, Ramadan A Eldomany, Amira Mira, Amal F Soliman, Mohamed Amir, Saleh El-Sharkawy
Microbial transformation is extensively utilized to generate new metabolites in bulk amounts with more specificity and improved activity. As cinnamic acid was reported to exhibit several important pharmacological properties, microbial transformation was used to obtain its new derivatives with enhanced biological activities. By manipulating the 2-stage fermentation protocol of biotransformation, five metabolites were produced from cinnamic acid. Two of them were new derivatives; N -propyl cinnamamide 2̲ and 2-methyl heptyl benzoate 3̲ produced by Alternaria alternata ...
March 26, 2024: Food & Function
https://read.qxmd.com/read/38529619/se-methylselenocysteine-ameliorates-mitochondrial-function-by-targeting-both-mitophagy-and-autophagy-in-the-mouse-model-of-alzheimer-s-disease
#74
JOURNAL ARTICLE
Yongli Xie, Xiaoshan Ke, Zhencong Ye, Xuexia Li, Zetao Chen, Jiantao Liu, Ziyi Wu, Qiong Liu, Xiubo Du
Background : Alzheimer's disease (AD) exerts tremendous pressure on families and society due to its unknown etiology and lack of effective treatment options. Our previous study had shown that Se-methylselenocysteine (SMC) improved the cognition and synaptic plasticity of triple-transgenic AD (3 × Tg-AD) mice and alleviated the related pathological indicators. We are dedicated to investigating the therapeutic effects and molecular mechanisms of SMC on mitochondrial function in 3 × Tg-AD mice. Methods : Transmission electron microscopy (TEM), western blotting (WB), mitochondrial membrane potential (Δ Ψ m ), mitochondrial swelling test, and mitochondrial oxygen consumption test were used to evaluate the mitochondrial morphology and function...
March 26, 2024: Food & Function
https://read.qxmd.com/read/38526853/reprogramming-of-arachidonic-acid-metabolism-using-%C3%AE-terpineol-to-alleviate-asthma-insights-from-metabolomics
#75
JOURNAL ARTICLE
Ying Rong, Fanglin Liu, Hui Zhou, Tong Yu, Zhaolong Qin, Qianwen Cao, Luyao Liu, Xiaoge Ma, Lingbo Qu, Peirong Xu, Xinglin Liao, Qiman Jiang, Nan Zhang, Xia Xu
Asthma is a chronic inflammatory disorder in airways with typical pathologic features of airway inflammation and mucus hypersecretion. α-Terpineol is a monocyclic terpene found in many natural plants and foods. It has been reported to possess a wide range of pharmacological activities including anti-inflammatory and expectorant effects. However, the role of α-terpineol in asthma and its potential protective mechanism have not been well elucidated. This study is designed to investigate the pharmacological effect and mechanism of α-terpineol on asthmatic mice using the metabolomics platform...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38526568/changes-in-the-structural-physicochemical-and-functional-properties-and-in-vitro-fecal-fermentation-characteristics-of-barley-dietary-fiber-fermented-by-lactiplantibacillus-plantarum-dy-1
#76
JOURNAL ARTICLE
Xiang Xiao, Xiaodong Li, Juan Bai, Songtao Fan, Maria Daglia, Jiaying Li, Yiwei Ding, Yanshun Zhang, Yansheng Zhao
Fermentation is an effective method for improving the nutritional quality and functional characteristics of grains. This study investigated changes in the structural, physicochemical, and functional properties of fermented barley dietary fiber (FBDF) exerted by Lactiplantibacillus plantarum dy-1 ( Lp. plantarum dy-1) as well as its in vitro fecal fermentation characteristics. Lp. plantarum dy-1 fermentation remarkably changed the structure of FBDF, including the microstructure and monosaccharide components, correlating with improved water or oil retaining and cholesterol adsorption capacities...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38526548/stored-white-tea-ameliorates-dss-induced-ulcerative-colitis-in-mice-by-modulating-the-composition-of-the-gut-microbiota-and-intestinal-metabolites
#77
JOURNAL ARTICLE
Zhiyuan Lin, Weidong Dai, Shanshan Hu, Dan Chen, Han Yan, Liang Zeng, Zhi Lin
Changes in the chemical composition of white tea during storage have been studied extensively; however, whether such chemical changes impact the efficacy of white tea in ameliorating colitis remains unclear. In this study, we compared the effects of new (2021 WP) and 10-year-old (2011 WP) white tea on 3% dextrose sodium sulfate (DSS)-induced ulcerative colitis in mice by gavaging mice with the extracts at 200 mg kg-1 day-1 . Chemical composition analysis showed that the levels of 50 compounds, such as flavanols, dimeric catechins, and amino acids, were significantly lower in the 2011 WP extract than in the 2021 WP extract, whereas the contents of 21 compounds, such as N -ethyl-2-pyrrolidinone-substituted flavan-3-ols, theobromine, and (-)-epigallocatechin-3-(3''- O -methyl) gallate, were significantly higher...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38526064/dual-intervention-on-the-gut-and-skin-microbiota-attenuates-facial-cutaneous-aging
#78
JOURNAL ARTICLE
Liujing Zhang, Shun Yu, Yin Guan, Dan Wang, Ju Yang, Jingling Li, Wei Zhao, Feng Zhang
The gut and skin microbiota are microbial barriers, resisting harmful foreign microorganisms and maintaining internal homeostasis. Dysbiosis of the gut and skin microbiota is involved in aging progression. However, interventions targeting facial skin wellness taking into account the gut-skin axis are scarce. In this study, the impact of an eight-week intervention with oral (O), topical (T), and both oral and topical (OT) xylo-oligosaccharides (XOS) by regulating gut and skin microbiota on facial cutaneous aging was investigated in a double-blind placebo-controlled trial in females...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38517682/potential-neuroprotective-benefits-of-plant-based-fermented-foods-in-alzheimer-s-disease-an-update-on-preclinical-evidence
#79
REVIEW
Jie-Hua Chen, Xuan Yin, Hui He, Louise Weiwei Lu, Mingfu Wang, Bin Liu, Ka-Wing Cheng
Alzheimer's disease (AD) currently lacks effective treatments, making its prevention a critical focus. While accumulating evidence supports that plant-based fermented foods may contribute to AD prevention, the neuroprotective effect of plant-based fermented foods on AD has not been comprehensively reviewed. In this study, we conducted a systematic review of preclinical studies on the efficacy of plant-based fermented foods in AD. The literature search was based on databases including PubMed, Embase, Web of Science, and Scopus...
March 22, 2024: Food & Function
https://read.qxmd.com/read/38517352/natural-flavonoid-hesperetin-blocks-amyloid-%C3%AE-protein-fibrillogenesis-depolymerizes-preformed-fibrils-and-alleviates-cytotoxicity-caused-by-amyloids
#80
JOURNAL ARTICLE
Qinchen Dong, Zhan Cui, Xinming Wu, Li Li, Fuping Lu, Fufeng Liu
The aggregation of β-amyloid (Aβ) peptides to form amyloid plaques is one of the primary hallmarks for Alzheimer's disease (AD). Dietary flavonoid supplements containing hesperetin have an ability to decline the risk of developing AD, but the molecular mechanism is still unclear. In this work, hesperetin, a flavanone abundant in citrus fruits, has been proven to prevent the formation of Aβ aggregates and depolymerized preformed fibrils in a concentration-dependent fashion. Hesperetin inhibited the conformational conversion from the natural structure to a β-sheet-rich conformation...
March 22, 2024: Food & Function
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