journal
https://read.qxmd.com/read/38328886/novel-kokumi-peptides-from-yeast-extract-and-their-taste-mechanism-via-an-in-silico-study
#41
JOURNAL ARTICLE
Haofeng Lao, Jincui Chang, Haining Zhuang, Shiqing Song, Min Sun, Lingyun Yao, Huatian Wang, Qian Liu, Jian Xiong, Pei Li, Chuang Yu, Tao Feng
Yeast extract, a widely utilized natural substance in the food industry and biopharmaceutical field, holds significant potential for flavor enhancement. Kokumi peptides within yeast extracts were isolated through ultrafiltration and gel chromatography, followed by identification using liquid chromatography tandem mass spectrometry (LC-MS/MS). Two peptides, IQGFK and EDFFVR, were identified and synthesized using solid-phase methods based on molecular docking outcomes. Sensory evaluations and electronic tongue analyses conducted with chicken broth solutions revealed taste thresholds of 0...
February 8, 2024: Food & Function
https://read.qxmd.com/read/38328833/dietary-supplementation-with-%C3%AE-ionone-alleviates-chronic-uvb-exposure-induced-skin-photoaging-in-mice
#42
JOURNAL ARTICLE
Ruixuan Geng, Seong-Gook Kang, Kunlun Huang, Tao Tong
Photoaging is widely regarded as the most significant contributor to skin aging damage. It is triggered by prolonged exposure to ultraviolet (UV) light and typically manifests as dryness and the formation of wrinkles. Nutritional intervention is a viable strategy for preventing and treating skin photoaging. In previous studies, we demonstrated that α-ionone had ameliorating effects on photoaging in both epidermal keratinocytes and dermal fibroblasts. Here, we investigated the potential anti-photoaging effects of dietary α-ionone using a UVB-irradiated male C57BL/6N mouse model...
February 8, 2024: Food & Function
https://read.qxmd.com/read/38323507/a-systematic-review-of-ginsenoside-biosynthesis-spatiotemporal-distribution-and-response-to-biotic-and-abiotic-factors-in-american-ginseng
#43
REVIEW
Lixia Tian, Ranran Gao, Yuxiang Cai, Junxian Chen, Hongmei Dong, Shanshan Chen, Zaichang Yang, Yu Wang, Linfang Huang, Zhichao Xu
American ginseng ( Panax quinquefolius ) has gained recognition as a medicinal and functional food homologous product with several pharmaceutical, nutritional, and industrial applications. However, the key regulators involved in ginsenoside biosynthesis, the spatiotemporal distribution characteristics of ginsenosides, and factors influencing ginsenosides are largely unknown, which make it challenging to enhance the quality and chemical extraction processes of the cultivated American ginseng. This review presents an overview of the pharmacological effects, biosynthesis and spatiotemporal distribution of ginsenosides, with emphasis on the impacts of biotic and abiotic factors on ginsenosides in American ginseng...
February 7, 2024: Food & Function
https://read.qxmd.com/read/38323487/therapeutic-effects-of-a-walnut-derived-peptide-on-nlrp3-inflammasome-activation-synaptic-plasticity-and-cognitive-dysfunction-in-t2dm-mice
#44
JOURNAL ARTICLE
Yanru Li, Qiao Dang, Yue Shen, Linxin Guo, Chunlei Liu, Dan Wu, Li Fang, Yue Leng, Weihong Min
NLRP3 inflammasome activation plays a key role in the development of diabetes-induced cognitive impairment. However, strategies to inhibit NLRP3 inflammasome activation remain elusive. Herein, we evaluated the impact of a walnut-derived peptide, TWLPLPR (TW-7), on cognitive impairment in high-fat diet/streptozotocin-induced type 2 diabetes mellitus (T2DM) mice and explored its underlying mechanisms in high glucose-induced HT-22 cells. In the Morris water maze test, TW-7 alleviated cognitive deficits in mice; this was confirmed at the level of synaptic structure and dendritic spine density in the mouse hippocampus using transmission electron microscopy and Golgi staining...
February 7, 2024: Food & Function
https://read.qxmd.com/read/38323473/gut-microbiota-modulation-and-effects-of-a-diet-enriched-in-apple-pomace-on-inflammation-in-a-dss-induced-colitis-mouse-model
#45
JOURNAL ARTICLE
Inés Calvete-Torre, Carlos Sabater, Begoña Cantabrana, Abelardo Margolles, Manuel Sánchez, Lorena Ruiz
Certain types of soluble dietary fibre, such as pectin and pectic oligosaccharides from different sources, have demonstrated protective effects against inflammation in DSS-induced colitis mouse models. In this work, we have evaluated the impact of a diet enriched in apple pomace (AP-diet), an agricultural by-product with a significant content of pectin and that previously demonstrated prebiotic properties in human fecal batch fermentation models, on the gut microbiota composition, intestinal damage and inflammation markers in a DSS-induced colitis model...
February 7, 2024: Food & Function
https://read.qxmd.com/read/38321832/association-between-dietary-intake-of-saturated-fatty-acid-subgroups-and-breast-cancer-risk
#46
JOURNAL ARTICLE
Ying Jiang, Lan-Ting Li, Si-Han Hou, Le-Ning Chen, Cai-Xia Zhang
The impact of dietary saturated fatty acids (SFAs) on breast cancer risk may vary depending on their carbon chain lengths, attributable to the discrepancy in their dietary sources and biological activities. The associations between SFA subgroups classified by chain length and breast cancer risk remain controversial. In this case-control study, we aimed to investigate the association between the dietary intake of SFA subgroups, classified by chain lengths, and odds of breast cancer in China. This study included 1661 cases of breast cancer (confirmed as primary and histologically) and 1674 frequency-matched controls...
February 7, 2024: Food & Function
https://read.qxmd.com/read/38319687/antirotaviral-activity-of-dairy-byproducts-enriched-in-fractions-from-hyperimmune-bovine-colostrum-the-effect-of-thermal-and-high-hydrostatic-pressure-treatments
#47
JOURNAL ARTICLE
Dimitra Graikini, Laura García, Inés Abad, María Lavilla, Eduardo Puértolas, María Dolores Pérez, Lourdes Sánchez
Nowadays, rotaviruses remain a major health burden, especially in developing countries, and strategies complementary to vaccination are needed. In this view, dairy fractions have attracted great scientific interest, due to their high content of bioactive compounds. The objective of this study was to evaluate the antiviral activity of whey and buttermilk enriched in proteins from hyperimmune bovine colostrum (HBC) against rotavirus. The enriched fractions were spray-dried and subsequently tested for their neutralizing activity against the bovine rotavirus WC3 strain in vitro , using differentiated Caco-2/TC7 cells...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38319599/effects-of-the-apoe-genotype-on-cognitive-function-in-aging-mice-fed-with-a-high-fat-diet-and-the-protective-potential-of-n-3-polyunsaturated-fatty-acids
#48
JOURNAL ARTICLE
Xin Zhang, Tianzhi Xie, Shuang Zhou, Yingxuan Yuan, Weixuan Chen, Jie Zheng, Xuebo Liu, Tian Yuan, Yanhui Lu, Zhigang Liu
The ApoE4 allele is the strongest genetic determinant for Alzheimer's disease (AD), while obesity is a strong environmental risk for AD. The modulatory effect of the ApoE genotype on aging-related cognitive function in tandem with a high-fat diet (HFD) remains uncertain. This study aimed to elucidate the effects of ApoE3/ApoE4 genotypes in aged mice exposed to a HFD, and the benefits of n-3 polyunsaturated fatty acids (PUFAs) from fish oil. Remarkably, the HFD led to weight gain and lipid accumulation, more pronounced in ApoE3 mice, while ApoE4 mice experienced exacerbated cerebral insulin resistance, neuroinflammation, and oxidative stress...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38318946/exploring-novel-kokumi-peptides-in-agaricus-bisporus-selection-identification-and-tasting-mechanism-investigation-through-sensory-evaluation-and-computer-simulation-analysis
#49
JOURNAL ARTICLE
Tao Feng, Chenwei Ma, Sha Chen, Haining Zhuang, Shiqing Song, Min Sun, Lingyun Yao, Huatian Wang, Qian Liu, Chuang Yu
Agaricus bisporus contains amino acids associated with thickness and full-mouthfeel, making it a potential candidate for salt substitutes and flavor enhancers in various food applications. Kokumi peptides were isolated from the enzymatic digest of Agaricus bisporus using ultrafiltration nanofiltration, gel chromatographic separation, and RP-HPLC, coupled with sensory evaluation. Subsequently, the peptides, EWVPVTK and EYPPLGR, were selected for solid-phase synthesis based on molecular docking. Sensory analysis, including thresholds, time intensity, and dose-configuration relationships, indicated that EWVPVTK and EYPPLGR exhibited odor thresholds of 0...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38318756/the-role-of-free-fatty-acid-receptor-1-in-gastric-contractions-in-suncus-murinus
#50
JOURNAL ARTICLE
Jin Huang, Miu Suzuki, Ami Endo, Ayumi Watanabe, Ichiro Sakata
Motilin is an important hormonal regulator in the migrating motor complex (MMC). Free fatty acid receptor-1 (FFAR1, also known as GPR40) has been reported to stimulate motilin release in human duodenal organoids. However, how FFAR1 regulates gastric motility in vivo is unclear. This study investigated the role of FFAR1 in the regulation of gastric contractions and its possible mechanism of action using Suncus murinus . Firstly, intragastric administration of oleic acid (C18:1, OA), a natural ligand for FFAR1, stimulated phase II-like contractions, followed by phase III-like contractions in the fasted state, and the gastric emptying rate was accelerated...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38318730/-in-vitro-inhibitory-effect-of-five-natural-sweeteners-on-%C3%AE-glucosidase-and-%C3%AE-amylase
#51
JOURNAL ARTICLE
Jiequn Jiang, Heliang Fan, Jie Zhou, Jingkai Qin, Zhongyi Qin, Mei Chen, Yuanyuan Shen, Xiaoling Liu
A promising and efficacious approach to manage diabetes is inhibiting α-glucosidase and α-amylase activity. Therefore, the inhibitory activities of five natural sweeteners (mogrosides (Mog), stevioside (Ste), glycyrrhizinic acid (GA), crude trilobatin (CT), and crude rubusoside (CR)) against α-glucosidase and α-amylase and their interactions were evaluated in vitro using enzyme kinetics, fluorescence spectroscopy, Fourier infrared spectroscopy, and molecular docking. The inhibitor sequence was CT > GA > Ste, as GA competitively inhibited α-glycosidase activity while CT and Ste exhibited mixed inhibitory effects...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38317482/benefits-of-monascus-anka-solid-state-fermentation-for-quinoa-polyphenol-bioaccessibility-and-the-anti-obesity-effect-linked-with-gut-microbiota
#52
JOURNAL ARTICLE
Kai Huang, Guoqiang Chu, Pei Yang, Yongyong Liu, Yu Zhang, Xiao Guan, Sen Li, Hongdong Song, Ying Zhang
In our previous study, a polyphenol-utilization targeted quinoa product was developed via solid-state fermentation with Monascus anka . In this study, we investigated the polyphenol-related novel functions of the fermented product further. Compared with unfermented quinoa, M. anka fermented quinoa alleviated the trapping effect of the macromolecules, especially in the colonic fermentation stage, resulting in enhanced polyphenol bioaccessibility. Lachnoclostridium , Megasphaera , Megamonas , Dialister , and Phascolarctobacterium might contribute to polyphenol liberation and metabolism in fermented quinoa...
February 6, 2024: Food & Function
https://read.qxmd.com/read/38315542/ginsenoside-a-promising-natural-active-ingredient-with-steroidal-hormone-activity
#53
REVIEW
Jun Li, Jiarui Zhao, Xinhe Wang, Zhi Lin, He Lin, Zhe Lin
Ginsenosides are a class of natural products with hormone-like activity of triterpenoid saponins and have a variety of pharmacological activities such as anti-aging, immune regulation and cognitive improvement. With the great research interest in alternative medicine and natural products, they are gradually becoming research hotspots. Ginsenosides have a four-ring rigid steroid backbone similar to steroid hormones, and a series of experimental studies have shown that they can exhibit hormone-like activity by binding to nuclear receptors or affecting hormone levels, thereby affecting a wide range of inflammatory conditions, cancers, and menopause-related diseases...
February 5, 2024: Food & Function
https://read.qxmd.com/read/38315103/formation-of-egcg-oxidation-self-assembled-nanoparticles-and-their-antioxidant-activity-in-vitro-and-hepatic-redox-regulation-activity-in-vivo
#54
JOURNAL ARTICLE
Ximing Wu, Yijun Wang, Dongxu Wang, Ziqi Wang, Mingchuan Yang, Lumin Yang, Fuming Wang, Wei Wang, Xiangchun Zhang
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in tea and exerts several health-promoting effects. It easily autoxidizes into complex polymers and becomes deactivated due to the presence of multiple phenolic hydroxyl structures. Nonetheless, the morphology and biological activity of complex EGCG polymers are yet to be clarified. The present study demonstrated that EGCG autoxidation self-assembled nanoparticles (ENPs) exhibit antioxidant activity in vitro and hepatic REDOX homeostasis regulation activity in vivo ...
February 5, 2024: Food & Function
https://read.qxmd.com/read/38314832/gut-brain-communication-mediates-the-impact-of-dietary-lipids-on-cognitive-capacity
#55
REVIEW
Chenhan Fan, Jingxuan Xu, Haoxiang Tong, Yucheng Fang, Yiming Chen, Yangzhuo Lin, Rui Chen, Fuhao Chen, Guoqing Wu
Cognitive impairment, as a prevalent symptom of nervous system disorders, poses one of the most challenging aspects in the management of brain diseases. Lipids present in the cell membranes of all neurons within the brain and dietary lipids can regulate the cognition and memory function. In recent years, the advancements in gut microbiome research have enabled the exploration of dietary lipids targeting the gut-brain axis as a strategy for regulating cognition. This present review provides an in-depth overview of how lipids modulate cognition via the gut-brain axis depending on metabolic, immune, neural and endocrine pathways...
February 5, 2024: Food & Function
https://read.qxmd.com/read/38312068/reduction-of-neutral-lipid-reservoirs-bioconversion-and-untargeted-metabolomics-reveal-distinct-roles-for-vitamin-k-isoforms-on-lipid-metabolism
#56
JOURNAL ARTICLE
Natália Gonçalves Silva, Marco Preto, Vitor Vasconcelos, Ralph Urbatzka
Vitamin K isoforms are known as co-factors for the synthesis of blood-clotting proteins, but several other bioactivities were reported. In this work, we isolated a vitamin K1-analogue (OH-PhQ) from the cyanobacterium Tychonema sp. LEGE 07196 with lipid reducing activity. OH-PhQ reduced neutral lipid reservoirs with an EC50 value of 31 μM after 48 h exposure in zebrafish larvae, while other vitamin K isoforms had EC50 values of 21.1 μM (K2) and 1.2 μM (K3). No lipid reducing activity was observed for K1 up to 50 μM...
February 5, 2024: Food & Function
https://read.qxmd.com/read/38311970/piperlongumine-a-piper-longum-derived-amide-alkaloid-protects-mice-from-ovariectomy-induced-osteoporosis-by-inhibiting-osteoclastogenesis-via-suppression-of-p38-and-jnk-signaling
#57
JOURNAL ARTICLE
Na Luo, Lei Zhang, Chunmei Xiu, Xi Luo, Siyuan Hu, Kaizhong Ji, Qingbai Liu, Jianquan Chen
Postmenopausal osteoporosis (PMOP) is a metabolic bone disease that results from overproduction and hyperactivation of osteoclasts caused by insufficient estrogen in women after menopause. Current therapeutic strategies are mainly focused on treating PMOP patients who have already developed severe bone loss or even osteoporotic fractures. Obviously, a better strategy is to prevent PMOP from occurring in the first place. However, such reagents are largely lacking. Piperlongumine (PLM), an amide alkaloid extracted from long pepper Piper longum , exhibits the anti-osteoclastogenic effect in normal bone marrow macrophages (BMMs) and the protective effect against osteolysis induced by titanium particles in mice...
February 5, 2024: Food & Function
https://read.qxmd.com/read/38305768/a-capsicum-annuum-l-seed-extract-exerts-anti-neuroexcitotoxicity-in-ht22-hippocampal-neurons
#58
JOURNAL ARTICLE
Ji-Yun Kang, Ji-Yeon Gu, Dong-Cheol Baek, Chang-Gue Son, Jin-Seok Lee
The hippocampal memory deficit stands out as a primary symptom in neurodegenerative diseases, including Alzheimer's disease. While numerous therapeutic candidates have been proposed, they primarily serve to delay disease progression. Given the irreversible brain atrophy or injury associated with these conditions, current research efforts are concentrated on preventive medicine strategies. Herein, we investigated whether the extracts of Capsicum annuum L. seeds (CSE) and Capsicum annuum L. pulp (CPE) have preventive properties against glutamate-induced neuroexcitotoxicity (one of the main causes of Alzheimer's disease) in HT22 hippocampal neuronal cells...
February 2, 2024: Food & Function
https://read.qxmd.com/read/38305590/mitigation-of-high-fat-diet-induced-hepatic-steatosis-by-thyme-thymus-quinquecostatus-celak-polyphenol-rich-extract-tpe-insights-into-gut-microbiota-modulation-and-bile-acid-metabolism
#59
JOURNAL ARTICLE
Xialu Sheng, Ping Zhan, Peng Wang, Wanying He, Honglei Tian
Our previous study demonstrated that thyme polyphenol-rich extract (TPE) mitigated hepatic injury induced by a high-fat diet (HFD) through the regulation of lipid metabolism, promotion of short-chain fatty acid production, enhancement of intestinal barrier function, and attenuation of inflammation. In this study, we aimed to further elucidate additional mechanisms underlying TPE-mediated preventive effects on hepatic steatosis, with a specific focus on its impact on the gut microbiota and bile acid (BA) metabolism in HFD-fed mice...
February 2, 2024: Food & Function
https://read.qxmd.com/read/38305587/correction-lactobacillus-fermentum-f40-4-ameliorates-hyperuricemia-by-modulating-the-gut-microbiota-and-alleviating-inflammation-in-mice
#60
Jiayuan Cao, Ting Wang, Yisuo Liu, Wei Zhou, Haining Hao, Qiqi Liu, Boxing Yin, Huaxi Yi
Correction for ' Lactobacillus fermentum F40-4 ameliorates hyperuricemia by modulating the gut microbiota and alleviating inflammation in mice' by Jiayuan Cao et al. , Food Funct. , 2023, 14 , 3259-3268, https://doi.org/10.1039/D2FO03701G.
February 2, 2024: Food & Function
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