journal
https://read.qxmd.com/read/38979640/longevity-extension-in-rats-via-improved-redox-homeostasis-with-high-carbohydrate-diet-intervention-from-weaning-to-adulthood-a-comprehensive-multi-omics-study
#21
JOURNAL ARTICLE
Yuanjie Dong, Qiushuang Zhu, Yuqiao Li, Ruohua Wang, Wenyu Xu, Xuanfeng Tang, Xiaoqing Li, Xinyi Lv, Xiangju Kong, Liying Cai, Yucun Niu
Early dietary patterns potentially influence the health status and lifespan throughout adulthood and the entire lifespan. However, dietary behaviors are difficult for everyone to control during adolescence. It is even more important to study the effects of interventions of early dietary patterns on the lifespan under arbitrary feeding conditions. The research involves observing the survival status and lifespan of rats from weaning to adulthood with three different dietary patterns (a high-carbohydrate diet (HC), a high-protein diet (HP), and a high-fat diet (HF)) under ad libitum feeding conditions...
July 9, 2024: Food & Function
https://read.qxmd.com/read/38973338/characterisation-of-pancreatic-lipase-inhibitors-from-brassica-rapa-l-ssp-chinensis
#22
JOURNAL ARTICLE
Joanne Yi Hui Toy, Yu Yan Lim, Habiba Shalash, Dejian Huang
Obesity has become a significant global health concern, affecting millions of people worldwide. One well-studied approach to identifying potential anti-obesity agents is the inhibition of pancreatic lipase (PL), an enzyme responsible for dietary fat digestion. This study investigated the inhibitory effects and mechanisms of galactolipid monogalactosyldiacylglycerol (MGDG), that was extracted from Brassica rapa ssp. chinensis on PL. Five different MGDG compounds were isolated and the results showed that compounds containing shorter fatty acid side chains and a higher degree of unsaturated bonds exhibit a greater inhibition effect on PL...
July 8, 2024: Food & Function
https://read.qxmd.com/read/38973334/individual-and-interaction-effects-of-monounsaturated-fatty-acids-on-their-associations-with-hypertension-in-chinese-residents
#23
JOURNAL ARTICLE
Yuyan Liu, Yuanhong Liang, Xiaoyu Zhao, Shuxian Ma, Guifan Sun, Yongfang Li
Currently, associations between dietary intakes of individual monounsaturated fatty acids (MUFAs) and hypertension were not well disclosed, and the interaction effects of MUFAs on their associations with hypertension were unknown. Obesity was correlated with both MUFAs and hypertension, while if anthropometric obesity indices performed mediating roles in associations between MUFAs and hypertension remained underdetermined. In our study, 8509 Chinese adults investigated from 2004 to 2011 were included. Dietary information collection and physical examinations were performed at baseline and each timepoint of follow-up...
July 8, 2024: Food & Function
https://read.qxmd.com/read/38973330/association-of-vitamin-d-intake-during-pregnancy-with-small-vulnerable-newborns-a-population-based-cohort-study
#24
JOURNAL ARTICLE
Shanshan Wang, Gabriela Maria Villagrán Escobar, Ziyu Chen, Xiu Li, Guoping Xiong, Xuefeng Yang, Jian Shen, Liping Hao
Maternal vitamin D deficiency is common worldwide and has a significant impact on newborns. However, whether vitamin D intake during pregnancy is related to small vulnerable newborns (SVN) has not been confirmed. Thus, we sought to examine the relationship between maternal vitamin D intake, including vitamin D supplementation and dietary intake, and the risk of SVN. A total of 2980 Chinese mother-infant pairs were included in this study. Information on vitamin D supplementation and dietary intake was prospectively collected through face-to-face interviews...
July 8, 2024: Food & Function
https://read.qxmd.com/read/38967492/circulating-low-molecular-weight-poly-phenol-metabolites-in-the-brain-unveiling-in-vitro-and-in-vivo-blood-brain-barrier-transport
#25
JOURNAL ARTICLE
Rafael Carecho, Daniela Marques, Diogo Carregosa, Domenico Masuero, Mar Garcia-Aloy, Federica Tramer, Sabina Passamonti, Urska Vrhovsek, M Rita Ventura, Maria Alexandra Brito, Cláudia Nunes Dos Santos, Inês Figueira
Circulating metabolites resulting from colonic metabolism of dietary (poly)phenols are highly abundant in the bloodstream, though still marginally explored, particularly concerning their brain accessibility. Our goal is to disclose (poly)phenol metabolites' blood-brain barrier (BBB) transport, in vivo and in vitro , as well as their role at BBB level. For three selected metabolites, benzene-1,2-diol-3-sulfate/benzene-1,3-diol-2-sulfate (pyrogallol-sulfate - Pyr-sulf), benzene-1,3-diol-6-sulfate (phloroglucinol-sulfate - Phlo-sulf), and phenol-3-sulfate (resorcinol-sulfate - Res-sulf), BBB transport was assessed in human brain microvascular endothelial cells (HBMEC)...
July 5, 2024: Food & Function
https://read.qxmd.com/read/38967456/insights-into-chemical-components-health-promoting-effects-and-processing-impact-of-golden-chanterelle-mushroom-cantharellus-cibarius
#26
REVIEW
Xinlei Chen, Baojun Xu
Cantharellus cibarius (CC) is a culinary mushroom with significant commercial potential due to its diverse components and bioactive functions. CC is rich in carbohydrates, proteins, minerals, vitamins, and aroma compounds while being low in fat and calories. Moreover, CC contains an abundance of bioactive substances including phenolic compounds, vitamin precursors, and indole derivatives. Numerous studies have claimed that CC has diverse functions such as antioxidant, antimicrobial, immunoregulation, anti-inflammatory, antitumor, neuroprotective, antidiabetic, and prebiotic effects in in vivo or in vitro settings...
July 5, 2024: Food & Function
https://read.qxmd.com/read/38967438/identification-screening-and-molecular-mechanisms-of-natural-stable-angiotensin-converting-enzyme-ace-inhibitory-peptides-from-foxtail-millet-protein-hydrolysates-a-combined-in-silico-and-in-vitro-study
#27
JOURNAL ARTICLE
Yiqing Zhu, Changyu Chen, Zijian Dai, Han Wang, Yiyun Zhang, Qingyu Zhao, Yong Xue, Qun Shen
The stability of bioactive peptides under various food processing conditions is the basis for their use in industrial manufacturing. This study aimed to identify natural ACE inhibitors with excellent stability and investigate their physicochemical properties and putative molecular mechanisms. Five novel ACE inhibitory peptides (QDPLFPL, FPGVSPF, SPAQLLPF, LVPYRP, and WYWPQ) were isolated and identified using RP-HPLC and Nano LC-MS/MS with foxtail millet protein hydrolysates as the raw material. These peptides are non-toxic and exhibit strong ACE inhibitory activity in vitro (IC50 values between 0...
July 5, 2024: Food & Function
https://read.qxmd.com/read/38967039/synbiotic-therapy-with-clostridium-sporogenes-and-xylan-promotes-gut-derived-indole-3-propionic-acid-and-improves-cognitive-impairments-in-an-alzheimer-s-disease-mouse-model
#28
JOURNAL ARTICLE
Ling Li, Cong Yang, Mengzhen Jia, Yuhao Wang, Yu Zhao, Qingyuan Li, Jun Gong, Ying He, Kun Xu, Xuebo Liu, Xuhui Chen, Jun Hu, Zhigang Liu
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized primarily by cognitive impairment. Recent investigations have highlighted the potential of nutritional interventions that target the gut-brain axis, such as probiotics and prebiotics, in forestalling the onset of AD. In this study, whole-genome sequencing was employed to identify xylan as the optimal carbon source for the tryptophan metabolism regulating probiotic Clostridium sporogenes ( C. sporogenes ). Subsequent in vivo studies demonstrated that administration of a synbiotic formulation comprising C...
July 5, 2024: Food & Function
https://read.qxmd.com/read/38962816/gut-derived-wild-blueberry-phenolic-acid-metabolites-modulate-extrinsic-cutaneous-damage
#29
JOURNAL ARTICLE
John Ivarsson, Abby Bennett, Francesca Ferrara, Renee Strauch, Andrea Vallase, Massimo Iorizzo, Alessandra Pecorelli, Mary Ann Lila, Giuseppe Valacchi
As the first line of defense, the skin is equipped with various physiological mechanisms positioned to prevent incoming oxidative damage from numerous environmental insults. With persistent exposure to the environment, understanding ways to augment the skin defenses is paramount in protecting from premature aging. In this study, we investigated the ability of five dietary phenolic metabolites, typically found in the bloodstream after wild blueberry consumption, to successfully defend the skin from UV light exposure in a novel ex vivo co-culture model of human skin explants and primary endothelial cells...
July 4, 2024: Food & Function
https://read.qxmd.com/read/38961720/hop-humulus-lupulus-l-extract-reverts-glycaemic-imbalance-and-cognitive-impairment-in-an-animal-model-of-obesity
#30
JOURNAL ARTICLE
Mariana da Rocha Alves, Roberto de Paula Nascimento, Ana Paula da Fonseca Machado, Philipe Dos Santos, Eduardo Aledo, Milena Morandi Vuolo, Carolina Oliveira Cavalheiro, Vinícius Oliveira Giaculi, Patrícia Berilli, Nathália Medina Dos Santos, Mario Roberto Marostica Junior
The rates of overweight and obesity around the world have increased in past years. The body's adipose tissue stimulates the antioxidant and oxidation imbalance capacity at the cellular level. This scenario favors an inflammatory low-grade systemic condition starting with insulin resistance, which in turn may involve diabetes mellitus type 2 and cognitive decline afterward. Neurological diseases have been correlated to senile age diseases over time. This scenario calls for a change in the incidence of obesity in the younger generation...
July 4, 2024: Food & Function
https://read.qxmd.com/read/38958644/association-between-dietary-quality-and-accelerated-aging-a-cross-sectional-study-of-two-cohorts
#31
JOURNAL ARTICLE
Yue Chen, Xin Zheng, Yiming Wang, Chenan Liu, Jinyu Shi, Tong Liu, Shiqi Lin, Hailun Xie, Heyang Zhang, Xiaoyue Liu, Zhaoting Bu, Li Deng, Shouling Wu, Hanping Shi
Background : Diet quality significantly influences aging processes and age-related health outcomes. This study aims to explore the association between dietary quality and accelerated aging in two large cohorts. Methods : This study collected data from the Kailuan and National Health and Nutrition Examination Survey (NHANES) cohorts; participants' dietary quality was evaluated using the American Heart Association (AHA) dietary score and Healthy Eating Index-2015 (HEI-2015), respectively. Accelerated aging in participants was determined by calculating the difference between phenotypic age and chronological age...
July 3, 2024: Food & Function
https://read.qxmd.com/read/38953736/beneficial-effects-of-a-new-probiotic-formulation-on-adipocytokines-appetite-regulating-hormones-and-metabolic-parameters-in-obese-women
#32
JOURNAL ARTICLE
Nina Okuka, Neda Milinkovic, Ksenija Velickovic, Snezana Polovina, Mirjana Sumarac-Dumanovic, Rajna Minic, Davor Korčok, Brizita Djordjevic, Nevena Dj Ivanovic
Obesity is often accompanied by low-grade chronic inflammation and metabolic syndrome. It has been established that microbiota influences many physiological processes, including the development of obesity, and dysbiosis has been observed in obese individuals. In this study, we aimed to evaluate the impact of a new probiotic formulation, containing two probiotic strains and the bioactive compound octacosanol, on body weight, metabolic parameters, and concentrations of certain adipocytokines and appetite-regulating hormones in obese women...
July 2, 2024: Food & Function
https://read.qxmd.com/read/38953279/-allium-tuberosum-derived-nanovesicles-with-anti-inflammatory-properties-prevent-dss-induced-colitis-and-modify-the-gut-microbiome
#33
JOURNAL ARTICLE
Minkyoung Kang, Minji Kang, Juyeon Lee, Jiseon Yoo, Sujeong Lee, Sangnam Oh
Edible plant-derived nanovesicles (ePDNs) have shown potential as a non-pharmacological option for inflammatory bowel disease (IBD) by maintaining gut health and showing anti-inflammatory effects. However, the effects of Allium tuberosum -derived nanovesicles (ADNs) on colitis have not been studied to date. Here, we extracted exosome-like nanovesicles from Allium tuberosum and investigated whether they have an anti-inflammatory effect in RAW 264.7 cells and colitis mice. The results showed that ADNs reduced the elevated levels of inflammatory factors such as IL-1β, IL-6, TNF-α, and NF-κB pathway-related proteins as a consequence of lipopolysaccharide (LPS) stimulation in RAW 264...
July 2, 2024: Food & Function
https://read.qxmd.com/read/38946529/greater-adherence-to-the-mediterranean-dietary-approaches-to-stop-hypertension-intervention-for-neurodegenerative-delay-mind-diet-is-associated-with-lower-risk-of-inflammatory-bowel-disease-a-prospective-cohort-study
#34
JOURNAL ARTICLE
Shuyu Ye, Yuhao Sun, Xuejie Chen, Tian Fu, Xixian Ruan, Lintao Dan, Jie Chen, Zhongyan Du, Xiaoyan Wang
Background : The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet is emerging as a promising candidate for preventive measures against inflammatory bowel disease (IBD), though there is currently no direct evidence from population-based studies. This study aims to bridge the gap in understanding of the association of the MIND diet with IBD risk. Methods : We utilized data from 187 490 participants in the UK Biobank who provided dietary information and were free of IBD at baseline...
July 1, 2024: Food & Function
https://read.qxmd.com/read/38940701/cuo-nanoparticles-elicit-intestinal-immunotoxicity-in-zebrafish-based-on-intestinal-microbiota-dysbiosis
#35
JOURNAL ARTICLE
Bufan Xu, Luyao Zhang, Di Wu, Zihe Qi, Juanjuan Cao, Wenrui Li, Lihua Fan, Yiheng Shi, Yongning Wu, Guoliang Li
Copper II oxide nanoparticles (CuO NPs), a kind of widely used nanomaterial, have been detected in food and the environment, which has aroused widespread public concern. Recently, increasing data have suggested that intestinal microecology is closely related to immune homeostasis. However, the intestinal immunotoxicity induced by CuO NPs through intestinal microbiota is still unknown. Therefore, in this study, zebrafish were exposed to CuO NPs to explore intestinal immunotoxicity by evaluating physiological indicators, intestinal tissue injury, antioxidant enzyme activities, gene expression of immune factors, and changes in intestinal microbiota and its metabolites (short-chain fatty acids (SCFAs) and lipopolysaccharides (LPS))...
June 28, 2024: Food & Function
https://read.qxmd.com/read/38938120/-bifidobacterium-animalis-subsp-lactis-lpl-rh-improves-postoperative-gastrointestinal-symptoms-and-nutrition-indexes-by-regulating-the-gut-microbiota-in-patients-with-valvular-heart-disease-a-randomized-controlled-trial
#36
JOURNAL ARTICLE
Wanqi Lan, Heng Yang, Zhiwang Zhong, Chao Luo, Qin Huang, Wu Liu, Juesheng Yang, Haiyan Xiang, Yanhua Tang, Tingtao Chen
Gastrointestinal symptoms constitute a frequent complication in postoperative patients with valvular heart disease (VHD), impacting their postoperative recovery. Probiotics contribute to regulating human gut microbiota balance and alleviating postoperative gastrointestinal symptoms. Our objective involved assessing the potential of Bifidobacterium animalis subsp. lactis LPL-RH to alleviate postoperative gastrointestinal symptoms and expedite patient recovery. Adult patients diagnosed with VHD scheduled for valve surgery were enrolled...
June 28, 2024: Food & Function
https://read.qxmd.com/read/38938065/sinensetin-a-polymethoxyflavone-from-citrus-fruits-ameliorates-lps-induced-acute-lung-injury-by-suppressing-txnip-nlrp3-caspase-1-gsdmd-signaling-mediated-inflammatory-responses-and-pyroptosis
#37
JOURNAL ARTICLE
Zaibin Xu, Huiyu Hu, Kongyan Wang, Ziyi Zhou, Xinqian He, Xinan Huang, Yingjie Hu, Jiawen Huang, Zhuohui Luo
Sinensetin (SIN), a polymethoxylated flavonoid, exists widely in citrus fruits with abundant biological activities, such as antioxidant and anti-inflammatory properties, delaying the progression of lung fibers and ameliorating inflammatory lung injury. Herein, an in vivo model of LPS-induced acute lung injury (ALI) in mice and an in vitro model of LPS + IFN-γ-induced M1 polarization in RAW264.7 cells were established to assess the effects and molecular mechanisms of SIN in ameliorating ALI. In the present study, the results showed that SIN significantly reduced BALF IL1β, IL6, and TNF-α levels and neutrophil infiltration, inhibited lung tissue COX2 and iNOS expression, reduced serum and lung tissue inflammatory factor levels, and attenuated lung tissue inflammatory infiltration and ROS levels in animal experiments...
June 28, 2024: Food & Function
https://read.qxmd.com/read/38934780/edible-bird-s-nest-regulates-glucose-and-lipid-metabolic-disorders-via-the-gut-liver-axis-in-obese-mice
#38
JOURNAL ARTICLE
Wei Zhang, Meizhen Zhu, Xuncai Liu, Maoyao Que, Kelsang Dekyi, Linxi Zheng, Yichen Zhang, Youping Lv, Qunyan Fan, Xinyue Wang, Hongwei Li
Edible bird's nest (EBN) is a traditional food known for its nourishing and functional properties and is found to be involved in anti-oxidation, anti-aging, and anti-influenza mechanisms, immune regulation, and improving cardiovascular diseases, among others. However, the potential of EBN to improve glycolipid metabolism disorders in high-fat-diet induced obesity and the underlying mechanisms remain unexplored. We examined the effects of EBN on glycolipid metabolism in obese mice fed a high-fat diet. Male C57BL/6J mice were fed a high-fat diet for 8 weeks to establish an obesity model...
June 27, 2024: Food & Function
https://read.qxmd.com/read/38934729/lower-plasma-linoleic-acids-as-a-risk-factor-for-gout-an-integrated-analysis-of-population-based-cohort-and-genetic-data
#39
JOURNAL ARTICLE
Hao-Wei Tao, Zhong-Yue Liu, Wei Jiang, Meng-Yuan Miao, Jie-Qiong Lyu, Miao Zhao, Jie Zhu, Jin-Si Chen, Hong-Zhen Du, Zeng-Ning Li, Zhengbao Zhu, Jing Yang, Li-Qiang Qin, Wei Chen, Guo-Chong Chen
Background : Gout is a nutrition-related, highly prevalent inflammatory arthritis with undesirable effects on the quality of life. The relationships between circulating fatty acids (FAs) and gout remain poorly understood. Method : We included 268 174 participants with plasma FAs measured using nuclear magnetic resonance at the baseline (2006-2010) from the UK Biobank, of which 15 194 participants had repeated measures of FAs between 2012 and 2013. Cox proportional hazards models were used to assess the association of the baseline and longitudinal changes in relative levels of plasma FAs ( % total FAs) with incident gout...
June 27, 2024: Food & Function
https://read.qxmd.com/read/38932628/resistant-starch-and-tannic-acid-synergistically-ameliorated-dextran-sulfate-sodium-induced-ulcerative-colitis-particularly-in-the-distal-colon
#40
JOURNAL ARTICLE
Zijun Liu, Shunjing Luo, Chengmei Liu, Xiuting Hu
We previously confirmed that tannic acid could delay the metabolism of resistant starch in vitro , which suggested that tannic acid might deliver resistant starch to the distal colon in vivo . Accordingly, co-supplementation of resistant starch and tannic acid might be beneficial for keeping the distal colon healthy. Thus, this study compared the effects of resistant starch, tannic acid and their mixtures on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. It was found that the mixtures had a more profound effect on ameliorating DSS-induced ulcerative colitis than resistant starch or tannic acid...
June 27, 2024: Food & Function
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