journal
https://read.qxmd.com/read/38775706/gut-microbiota-bile-acid-axis-mediated-the-beneficial-associations-between-dietary-lignans-and-hyperuricemia-a-prospective-study
#1
JOURNAL ARTICLE
Lai-Bao Zhuo, Yingdi Yang, Congmei Xiao, Fanqin Li, Lishan Lin, Yue Xi, Yuanqing Fu, Ju-Sheng Zheng, Yu-Ming Chen
Background : The escalating prevalence of hyperuricemia is emerging as a significant public health concern. The association between dietary lignans and hyperuricemia is yet to be fully elucidated. Our study aims to evaluate the relationships between dietary lignan intake and hyperuricemia among middle-aged and elderly Chinese individuals, with an additional focus on investigating the underlying mechanisms. Methods : Dietary lignan intake was measured using a validated Food Frequency Questionnaire in 3801 participants at the baseline...
May 22, 2024: Food & Function
https://read.qxmd.com/read/38771619/anti-obesity-effects-of-a-standardized-ethanol-extract-of-eisenia-bicyclis-by-regulating-the-ampk-signaling-pathway-in-3t3-l1-cells-and-hfd-induced-mice
#2
JOURNAL ARTICLE
Young-Seo Yoon, Kyung-Sook Chung, Su-Yeon Lee, So-Won Heo, Ye-Rin Kim, Jong Kil Lee, Hyunjae Kim, Soyoon Park, Yu-Kyong Shin, Kyung-Tae Lee
Obesity requires treatment to mitigate the potential development of further metabolic disorders, including diabetes, hyperlipidemia, tumor growth, and non-alcoholic fatty liver disease. We investigated the anti-obesity effect of a 30% ethanol extract of Eisenia bicyclis (Kjellman) Setchell (EEB) on 3T3-L1 preadipocytes and high-fat diet (HFD)-induced obese C57BL/6 mice. Adipogenesis transcription factors including peroxisome proliferator-activated receptor (PPAR)γ, CCAAT/enhancer-binding protein-alpha (C/EBPα), and sterol regulatory element-binding protein-1 (SREBP-1) were ameliorated through the AMP-activated protein kinase (AMPK) pathway by EEB treatment in differentiated 3T3-L1 cells...
May 21, 2024: Food & Function
https://read.qxmd.com/read/38771590/compressed-fluid-based-technology-for-downstream-isolation-of-bluish-anthocyanin-derived-pigments-obtained-from-blueberry-surplus
#3
JOURNAL ARTICLE
Ana N Nunes, Joana Oliveira, Maria Rosário Bronze, Ana A Matias
A dynamic compressed fluid-based separation process combining carbon dioxide and ethanol was explored to isolate portisins previously hemi-synthesized from blueberry surplus anthocyanins. The influence of process parameters such as pressure (100-500 bar), temperature (40-60 °C), and ethanol content in the compressed fluid mixture (20-50 wt%) on extraction yield, portisins yield, and portisins content in the extract was investigated. The two-step isolation process includes (1) a first step at 100 bar, 60 °C, and 20 wt% ethanol content in the compressed fluid mixture to remove the low polarity compounds; and (2) a second step at 500 bar, 40 °C, and 100 wt% ethanol to recover portisins, resulting in a 1...
May 21, 2024: Food & Function
https://read.qxmd.com/read/38771159/the-effectiveness-of-probiotics-as-an-adjunct-therapy-in-patients-under-mechanical-ventilation-an-umbrella-systematic-review-and-meta-analysis
#4
REVIEW
Paniz Anvarifard, Maryam Anbari, Faezeh Ghalichi, Zohreh Ghoreishi, Meysam Zarezadeh
The literature regarding the role of probiotics in critically ill patients who have undergone mechanical ventilation (MV) is unclear; therefore, this umbrella systematic review and meta-analysis was carried out to clarify the effects of probiotics on the clinical outcomes of mechanically ventilated patients. The Scopus, PubMed/Medline, ISI Web of Science, and Google Scholar online databases were searched up to February 2023. All meta-analyses evaluating the impact of probiotics in patients under MV were considered eligible...
May 21, 2024: Food & Function
https://read.qxmd.com/read/38770619/the-ameliorative-mechanism-of-lactiplantibacillus-plantarum-njau-01-against-d-galactose-induced-oxidative-stress-a-hepatic-proteomics-and-gut-microbiota-analysis
#5
JOURNAL ARTICLE
Du-Xin Jin, Chao-Yang Jia, Bo Yang, Yue-Hao Wu, Lei Chen, Rui Liu, Man-Gang Wu, Hai Yu, Qing-Feng Ge
Probiotic intervention is an effective strategy to alleviate oxidative stress-related diseases. Our previous studies found that Lactiplantibacillus plantarum NJAU-01 (NJAU-01) exhibited antioxidant effects in a D-galactose (D-gal)-induced aging mouse model. However, the underlying mechanism remains to be unveiled. This study was aimed to investigate the ameliorative effect and mechanism of NJAU-01 against oxidative stress induced by D-gal. The results showed that NJAU-01 could reverse the tendency of a slow body weight gain induced by D-gal...
May 21, 2024: Food & Function
https://read.qxmd.com/read/38768319/interactive-association-of-the-dietary-oxidative-balance-score-and-cardiovascular-disease-with-mortality-in-older-adults-evidence-from-nhanes
#6
JOURNAL ARTICLE
HuanRui Zhang, Wen Tian, GuoXian Qi, BaoSen Zhou, YuJiao Sun
Objectives : We conducted an assessment to explore potential associations of the dietary oxidative balance score (DOBS), cardiovascular disease (CVD), with all-cause mortality among older adults, while also exploring the potential moderating effect of DOBS on the relationship between CVD and mortality. Methods : This study included 9059 older adults (≥60 years) from NHANES 2003-2014. Determination of DOBS involves scoring the combination of 16 nutrients, comprising 2 pro-oxidants and 14 anti-oxidants...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38768294/protection-effect-of-lutein-loaded-pickering-emulsion-prepared-via-ultrasound-assisted-maillard-reaction-conjugates-on-dry-age-related-macular-degeneration
#7
JOURNAL ARTICLE
Kangjing Liu, Yu Li, Xu Zhong, Yitong Hou, Siyuan Fei, Entao Chen, Mingqian Tan
Age-related macular degeneration (AMD) is a prominent cause of vision loss among the elderly, and the treatment options for dry AMD (dAMD) are severely limited. Lutein has a favorable effect on the treatment of dAMD. Algae oil, rich in docosahexaenoic acid (DHA), is considered an effective intervention for eye diseases. In this study, casein-mannose conjugates were prepared to form algal oil-in-water Pickering emulsions by ultrasound-assisted Maillard reaction. As the ultrasound time increased from 0 to 25 min, the droplet size decreased to 648...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38767618/biological-fate-functional-properties-and-design-strategies-for-oral-delivery-systems-for-cinnamaldehyde
#8
REVIEW
Xiaolan Weng, Chi-Tang Ho, Muwen Lu
Cinnamaldehyde (CA) is the main bioactive component extracted from the internal bark of cinnamon trees with many health benefits. In this paper, the bioavailability and biological activities of cinnamaldehyde, and the underlying molecular mechanism are reviewed and discussed, including antioxidant, cardioprotective, anti-inflammatory, anti-obesity, anticancer, and antibacterial properties. Common delivery systems that could improve the stability and bioavailability of CA are also summarized and evaluated, such as micelles, microcapsules, liposomes, nanoparticles, and nanoemulsions...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38767501/maternal-fructose-intake-aggravates-the-harmful-effects-of-a-western-diet-in-rat-male-descendants-impacting-their-cholesterol-metabolism
#9
JOURNAL ARTICLE
E Fauste, M I Panadero, M Pérez-Armas, C Donis, P López-Laiz, J Sevillano, M G Sánchez-Alonso, M P Ramos-Álvarez, P Otero, C Bocos
Scope : fructose consumption from added sugars correlates with the epidemic rise in MetS and CVD. Maternal fructose intake has been described to program metabolic diseases in progeny. However, consumption of fructose-containing beverages is allowed during gestation. Cholesterol is also a well-known risk factor for CVD. Therefore, it is essential to study Western diets which combine fructose and cholesterol and how maternal fructose can influence the response of progeny to these diets. Methods and results : a high-cholesterol (2%) diet combined with liquid fructose (10%), as a model of an unhealthy Western diet, was administered to descendants from control and fructose-fed mothers...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38767386/pyrroloquinoline-quinone-production-defines-the-ability-of-devosia-species-to-degrade-deoxynivalenol
#10
JOURNAL ARTICLE
Chongwen Guo, Jikai Wen, Yu Sun, Guoqiang Liang, Zijiao Wang, Lulu Pan, Jiarun Huang, Yuanxin Liao, Zeyuan Wang, Qingmei Chen, Peiqiang Mu, Yiqun Deng
Deoxynivalenol (DON) is a prevalent mycotoxin that primarily contaminates cereal crops and animal feed, posing a significant risk to human and animal health. In recent years, an increasing number of Devosia strains have been identified as DON degradation bacteria, and significant efforts have been made to explore their potential applications in the food and animal feed industries. However, the characteristics and mechanisms of DON degradation in Devosia strains are still unclear. In this study, we identified a novel DON degrading bacterium, Devosia sp...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38767145/chronic-consumption-of-a-bergamot-based-beverage-does-not-affect-glucose-lipid-and-inflammatory-biomarkers-of-cardiometabolic-risk-in-healthy-subjects-a-randomised-controlled-intervention-study
#11
JOURNAL ARTICLE
Giulia Maggiolo, Raffaella Aldigeri, Cecilia Savini, Martina Mengani, Marta Maggi, Giulia Frigeri, Valentina Spigoni, Gloria Cinquegrani, Federica Fantuzzi, Leonardo Di Donna, Nicole Tosi, Federica Bergamo, Letizia Bresciani, Alice Rosi, Pedro Mena, Francesca Scazzina, Daniele Del Rio, Riccardo C Bonadonna, Alessandra Dei Cas
Background : Pure bergamot juice exerts lipid lowering effects in dyslipidemic subjects. It is unknown whether bergamot-based beverages exert similar effects in healthy subjects. Aim : To assess the effects, if any, of a bergamot-based beverage (BBB, bergamot juice ≤25%) on lipid, metabolic and inflammatory biomarkers. Methods : Forty-five healthy subjects were randomised 1 : 1 to BBB intake (400 mL day-1 ) (55.5%) or control (44.5%) for 12 weeks. Anthropometric (waist circumference, body mass index (BMI)) and clinical (blood pressure) parameters, blood samples (glucose, glycated haemoglobin, insulinemia, lipid profile, liver and renal function, inflammatory biomarkers) and 24-h urine for the analysis of (poly)phenol metabolites were collected at the baseline and at 12 weeks...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38764333/-bifidobacterium-longum-s3-alleviates-loperamide-induced-constipation-by-modulating-intestinal-acetic-acid-and-stearic-acid-levels-in-mice
#12
JOURNAL ARTICLE
Tong Zhang, Huimin Lu, Ting Cheng, Linlin Wang, Gang Wang, Hao Zhang, Wei Chen
Constipation is a major gastrointestinal (GI) symptom worldwide, with diverse causes of formation, and requires effective and safe therapeutic measures. In the present study, we used loperamide hydrochloride to establish a constipation model and assessed the effect of Bifidobacterium on constipation and its possible mechanism of relief. The results showed that B. longum S3 exerted a constipation-relieving effect primarily by improving the gut microbiota, enriching genera including Lactobacillus , Alistipes , and Ruminococcaceae UCG-007 , and decreasing the bacteria Lachnospiraceae NK4B4 group...
May 20, 2024: Food & Function
https://read.qxmd.com/read/38757812/the-use-of-an-in-vitro-fecal-fermentation-model-to-uncover-the-beneficial-role-of-omega-3-and-punicic-acid-in-gut-microbiota-alterations-induced-by-a-western-diet
#13
JOURNAL ARTICLE
Ana Sofia Salsinha, André Cima, Helena Araújo-Rodrigues, Sofia Viana, Flávio Reis, Ezequiel R Coscueta, Luis Miguel Rodríguez-Alcalá, João B Relvas, Manuela Pintado
The influence of gut microbiota in the onset and development of several metabolic diseases has gained attention over the last few years. Diet plays an essential role in gut microbiota modulation. Western diet (WD), characterized by high-sugar and high-fat consumption, alters gut microbiome composition, diversity index, microbial relative levels, and functional pathways. Despite the promising health effects demonstrated by polyunsaturated fatty acids, their impact on gut microbiota is still overlooked. The effect of Fish oil (omega-3 source) and Pomegranate oil (punicic acid source), and a mixture of both oils in gut microbiota modulation were determined by subjecting the oil samples to in vitro fecal fermentations...
May 17, 2024: Food & Function
https://read.qxmd.com/read/38757391/mechanisms-of-epigallocatechin-gallate-egcg-in-ameliorating-hyperuricemia-insights-into-gut-microbiota-and-intestinal-function-in-a-mouse-model
#14
JOURNAL ARTICLE
Haonan Yu, Zhenyou Lou, Tingbo Wu, Xiaochun Wan, Haitao Huang, Yuanyuan Wu, Bo Li, Youying Tu, Puming He, Junsheng Liu
Epigallocatechin gallate (EGCG), a prominent bioactive compound found in tea, offers numerous health benefits. Previous studies have highlighted its potential in mitigating hyperuricemia. In this study, hyperuricemic mice induced by potassium oxonate (PO) were treated with EGCG or the anti-hyperuricemia medication allopurinol (AP) to investigate the mechanisms underlying their anti-hyperuricemic effects. The results demonstrated that both EGCG and AP significantly reduced serum uric acid (UA) levels. Further analysis revealed that EGCG promoted the expression of UA secretion transporter genes ( Oat1 and Oct1 ) while inhibiting the expression of UA reabsorption transporter genes ( Urat1 and Glut9 ) in the kidney...
May 17, 2024: Food & Function
https://read.qxmd.com/read/38757389/a-novel-neuroprotective-peptide-yvyaety-identified-and-screened-from-flammulina-velutipes-protein-hydrolysates-attenuates-scopolamine-induced-cognitive-impairment-in-mice
#15
JOURNAL ARTICLE
Yutong Dong, Qiuhui Hu, Liyan Zhao, Gaoxing Ma, Ning Ma, Junmiao Zhang, Yang Ji, Li Liu
Flammulina velutipes protein hydrolysates are known for their abundant amino acids and excellent developmental values. This study aimed to identify and screen neuroprotective peptides from F. velutipes protein hydrolysates in vitro and validate the protective effects of YVYAETY on memory impairment in scopolamine-induced mice. The F. velutipes protein was hydrolyzed by simulated gastrointestinal digestion, followed by purification through ultrafiltration and gel chromatography. The fraction exhibiting the strongest neuroprotective activity was analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
May 17, 2024: Food & Function
https://read.qxmd.com/read/38753306/6-gingerol-ameliorates-ulcerative-colitis-by-inhibiting-ferroptosis-based-on-the-integrative-analysis-of-plasma-metabolomics-and-network-pharmacology
#16
JOURNAL ARTICLE
Wenwen Li, Yun Zhang, Quyi Wang, Yu Wang, Yuwen Fan, Erxin Shang, Shu Jiang, Jinao Duan
6-Gingerol (6-G), an active ingredient of ginger with anti-inflammation and anti-oxidation properties, can treat ulcerative colitis (UC). However, its underlying mechanism is still unclear. In this study, the pharmacodynamic evaluation of 6-G for treating UC was performed, and the mechanism of 6-G in ameliorating UC was excavated by plasma metabolomics and network pharmacology analysis, which was further validated by experimental and molecular docking. The results showed that 6-G could notably reduce diarrhea, weight loss, colonic pathological damage, and inflammation in UC mice...
May 16, 2024: Food & Function
https://read.qxmd.com/read/38753200/emerging-berries-from-the-brazilian-amazon-and-atlantic-forest-biomes-new-sources-of-bioactive-compounds-with-potential-health-benefits
#17
REVIEW
Nathan Hargreaves Noguera, Dyana Carla Lima Hargreaves Noguera, Ana Paula da Fonseca Machado, Livia Mateus Reguengo, Roberto de Paula do Nascimento
Brazil has a broad geographic biodiversity spread across its six different biomes. However, it has been suffering from the abusive exploitation of its resources, which poses a threat to the local fauna and flora. The Amazon and Atlantic Forest, for example, are birthplaces to rare and edible native species, such as bacaba ( Oenocarpus bacaba , Arecaceae) and camu-camu ( Myrciaria dubia , Myrtaceae), and cereja-do-Rio Grande ( Eugenia involucrata , Myrtaceae) and grumixama ( Eugenia brasiliensis , Myrtaceae), respectively...
May 16, 2024: Food & Function
https://read.qxmd.com/read/38752441/a-novel-glycosyltransferase-from-bacillus-subtilis-achieves-zearalenone-detoxification-by-diglycosylation-modification
#18
JOURNAL ARTICLE
Yuqun Zhou, Jiguo Yang, Yuanshan Yu, Yuqian Tang
Zearalenone (ZEN), a nonsteroidal estrogenic mycotoxin produced by Fusarium spp., contaminates cereals and threatens human and animal health by inducing hepatotoxicity, immunotoxicity, and genotoxicity. In this study, a new Bacillus subtilis strain, YQ-1, with a strong ability to detoxify ZEN, was isolated from soil samples and characterized. YQ-1 was confirmed to degrade more than 46.26% of 20 μg mL-1 ZEN in Luria-Bertani broth and 98.36% in fermentation broth within 16 h at 37 °C; one of the two resulting products was ZEN-diglucoside...
May 16, 2024: Food & Function
https://read.qxmd.com/read/38752330/anti-hyperuricemia-bioactive-peptides-a-review-on-obtaining-activity-and-mechanism-of-action
#19
REVIEW
Ying Chen, Hongyan Li, Yunfei Cai, Ke Wang, Yousheng Wang
Hyperuricemia, a disorder of uric acid metabolism, serves as a significant risk factor for conditions such as hypertension, diabetes mellitus, renal failure, and various metabolic syndromes. The main contributors to hyperuricemia include overproduction of uric acid in the liver or impaired excretion in the kidneys. Despite traditional clinical drugs being employed for its treatment, significant health concerns persist. Recently, there has been growing interest in utilizing protein peptides sourced from diverse food origins to mitigate hyperuricemia...
May 16, 2024: Food & Function
https://read.qxmd.com/read/38752307/inhibitory-activities-and-mechanisms-of-free-and-bound-phenolics-on-%C3%AE-glucosidase-in-fresh-fruits-of-phyllanthus-emblica-linn-using-spectroscopy-and-molecular-docking
#20
JOURNAL ARTICLE
Mingxia Xing, Fan Xie, Jingyi Zeng, Zengjin Zhu, Guangqiang Wang, Yongjun Xia, Hui Zhang, Zibo Song, Lianzhong Ai
Phyllanthus emblica Linn. (PE) fresh fruits contain high concentrations of polyphenolics, of which free and bound phenolics are rich in biological activities. In this study, the inhibitory activity and mechanism of PEFP and PEBP on α-glucosidase (α-GLU) were investigated using spectroscopic techniques, kinetic analysis, and molecular docking. The results showed that 13 PEFP and 12 PEBP were identified by UPLC-MS/MS analysis, and Bis-HHDP-hexose and castalagin (vesgalagin) were found for the first time in PE fresh fruits...
May 16, 2024: Food & Function
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