Yuzhou Wan, Shaopeng Wang, Kexu Chen, Lin Liu, Xiaoqian Wang, Bo Zhang, Lin Hu, Shunmei Liu, Tingting Zhao, Huimin Qi
Nephrotic syndrome (NS) is characterized by proteinuria, hyperlipidemia, and hypoalbuminemia. Ulva pertusa , a green seaweed, is a nutritional supplement. In this study, the high-sulfated derivative of Ulva pertusa polysaccharide (HU) was prepared by combining U pertusa polysaccharide with chlorosulfonic acid. The NS rat model was established by tail vein single injection of Adriamycin (6.0 mg kg-1 ). Normal rats were used as the control group. NS rat models were treated with HU or U (173 mg kg-1 day-1 ). After treatment for 6 weeks, we assessed urine protein, renal function, and blood lipids, and observed morphology and histologic injury of the kidney and glomerular microstructure...
September 18, 2023: Food & Function