journal
https://read.qxmd.com/read/38745836/hemoglobin-concentration-and-blood-shift-during-dry-static-apnea-in-elite-breath-hold-divers
#61
JOURNAL ARTICLE
Thomas Kjeld, Thomas O Krag, Anders Brenøe, Ann Merete Møller, Henrik Christian Arendrup, Jens Højberg, Dan Fuglø, Søren Hancke, Lars Poulsen Tolbod, Lars Christian Gormsen, John Vissing, Egon Godthaab Hansen
INTRODUCTION: Elite breath-hold divers (BHD) enduring apneas of more than 5 min are characterized by tolerance to arterial blood oxygen levels of 4.3 kPa and low oxygen-consumption in their hearts and skeletal muscles, similar to adult seals. Adult seals possess an adaptive higher hemoglobin-concentration and Bohr effect than pups, and when sedated, adult seals demonstrate a blood shift from the spleen towards the brain, lungs, and heart during apnea. We hypothesized these observations to be similar in human BHD...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38742156/deletion-of-sigmar1-leads-to-increased-arterial-stiffness-and-altered-mitochondrial-respiration-resulting-in-vascular-dysfunction
#62
JOURNAL ARTICLE
Naznin Sultana Remex, Chowdhury S Abdullah, Richa Aishwarya, Gopi K Kolluru, James Traylor, Mohammad Alfrad Nobel Bhuiyan, Christopher G Kevil, A Wayne Orr, Oren Rom, Christopher B Pattillo, Md Shenuarin Bhuiyan
Sigmar1 is a ubiquitously expressed, multifunctional protein known for its cardioprotective roles in cardiovascular diseases. While accumulating evidence indicate a critical role of Sigmar1 in cardiac biology, its physiological function in the vasculature remains unknown. In this study, we characterized the expression of Sigmar1 in the vascular wall and assessed its physiological function in the vascular system using global Sigmar1 knockout (Sigmar1-/- ) mice. We determined the expression of Sigmar1 in the vascular tissue using immunostaining and biochemical experiments in both human and mouse blood vessels...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38742155/the-difference-of-affect-improvement-effect-of-music-intervention-in-aerobic-exercise-at-different-time-periods
#63
JOURNAL ARTICLE
Li Lu, Meng Tao, Jingchuan Gao, Mengru Gao, Houwei Zhu, Xiaolong He
Objectives: A randomized controlled experimental design that combines exercise and music intervention was adopted in this study to verify whether this approach could help improve human affect. The differences in the effect of music listening on affective improvement were compared in four different periods: before, during, and after aerobic power cycling exercise and the whole exercise course. Method: A total of 140 subjects aged 19-30 years (average age: 23.6 years) were recruited and randomly divided into four music intervention groups, namely, the pre-exercise, during-exercise, post-exercise, and the whole-course groups...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38742154/association-between-circadian-syndrome-and-chronic-diarrhea-a-cross-sectional-study-of-nhanes-2005-2010-data
#64
JOURNAL ARTICLE
Liang Ding, Jinnan Duan, Tao Yang, Chaoqiong Jin, Shanmei Lv, Ahuo Ma, Yuehua Qin
BACKGROUND: Circadian rhythms are reported to influence physiological processes in the gastrointestinal system, but associations between circadian syndrome (Circs) and chronic diarrhea (CD) remain unclear. Here, we explored such relationships to provide new insights into CD management. METHODS: We conducted a cross-sectional retrospective analysis using the National Health and Nutrition Examination Survey (NHANES) data between 2005 and 2010. Univariate and multivariable logistic regression analyses were performed on weighted data to explore associations between Circs and CD...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737833/cell-type-specific-effects-of-mineralocorticoid-receptor-gene-expression-suggest-intercellular-communication-regulating-fibrosis-in-skeletal-muscle-disease
#65
JOURNAL ARTICLE
Chetan K Gomatam, Pratham Ingale, Gabriel Rodriguez, Sarah Munger, Rachel Pomeranets, Swathy Krishna, Jeovanna Lowe, Zachary M Howard, Jill A Rafael-Fortney
Introduction: Duchenne muscular dystrophy (DMD) is a fatal striated muscle degenerative disease. DMD is caused by loss of dystrophin protein, which results in sarcolemmal instability and cycles of myofiber degeneration and regeneration. Pathology is exacerbated by overactivation of infiltrating immune cells and fibroblasts, which leads to chronic inflammation and fibrosis. Mineralocorticoid receptors (MR), a type of nuclear steroid hormone receptors, are potential therapeutic targets for DMD. MR antagonists show clinical efficacy on DMD cardiomyopathy and preclinical efficacy on skeletal muscle in DMD models...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737832/is-muscle-activation-diverse-in-females-with-isolated-patellofemoral-osteoarthritis-contrasted-with-age-matched-healthy-controls-during-stair-descent-task
#66
JOURNAL ARTICLE
Jilan Adel, Reham E Hamoda, Ayah Mahmoud Mohamed, Alaa Eldin Balbaa, Neama H Neamat Allah, Hamada Ahmed Hamada
Background: Patellofemoral osteoarthritis (PF OA) is exceptionally predominant and limiting. However, little is known about the risk factors that contribute to its onset and progression. Purpose: The aim of this study was to decide if women with PF OA descend stairs using different muscular activation strategies compared to similarly aged healthy controls. Methods: Thirty-one women with isolated PF OA and 11 similarly aged healthy women took part in this study. The activation onset and duration of PF OA in vastus medialis oblique (VMO), vastus lateralis (VL), gluteus medius (GM), transversus abdominis (TrA), and multifidus muscles were evaluated during the stair descent task using surface electromyography (EMG)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737831/a-comparative-study-of-8-week-complex-training-and-resistance-training-on-athletic-performance-of-amateur-futsal-players
#67
JOURNAL ARTICLE
Yuan Zhai, Guoyang Qin
Background: Despite the acknowledged importance of resistance training (RT) in enhancing physical performance in futsal players., the comparative effectiveness of RT and complex training (CT) on both physical and technical performance in futsal players remains underexplored. This study aimed to compare the effects of RT vs. CT on physical and technical performance in amateur futsal players. Method: Players from two amateur futsal teams were assigned to RT (one team of 16 players; 18 years) and CT (one team of 16 players; 18 years) to perform an 8-week intervention with two weekly sessions...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737830/low-lung-function-in-bipolar-disorder-and-schizophrenia-a-hidden-risk
#68
JOURNAL ARTICLE
Cristina Ruiz-Rull, María José Jaén-Moreno, Gloria Isabel Del Pozo, Cristina Gómez, Francisco Javier Montiel, Montserrat Alcántara, Laura Carrión, Geli Marie Chauca, Nuria Feu, Ipek Guler, Fernando Rico-Villademoros, Cristina Camacho-Rodríguez, Luis Gutierrez-Rojas, David Mannino, Fernando Sarramea
Introduction: People with serious mental illness (SMI), such as schizophrenia and bipolar disorder, have a higher risk of premature morbidity and mortality. In the general population, impaired lung function is associated with increased morbidity and mortality. We compared lung function between people with and without serious mental illnesses using a cross-sectional study in 9 community mental health units. Methods: Subjects aged 40-70 years with a diagnosis of schizophrenia or bipolar disorder were recruited consecutively...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737829/the-impact-of-exercise-on-the-gut-microbiota-in-middle-aged-amateur-serious-runners-a-comparative-study
#69
JOURNAL ARTICLE
Rui Duan, Yu Liu, Yonglian Zhang, Jinrong Shi, Rong Xue, Ruijie Liu, Yuanxin Miao, Xianfeng Zhou, Yongling Lv, Hexiao Shen, Xiongwei Xie, Xu Ai
INTRODUCTION: Exercise, health, and the gut microbiota (GM) are strongly correlated. Research indicates that professional athletes, especially ultra-marathon runners, have unique GM characteristics. However, more research has focused on elite athletes, with little attention given to amateur sports enthusiasts, especially those in the middle-aged population. Therefore, this study focuses on the impact of long-term running on the composition and potential functions of the GM in middle-aged individuals...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737828/exploring-the-interplay-of-trunk-and-shoulder-rotation-strength-a-cross-sport-analysis
#70
JOURNAL ARTICLE
Mikulas Hank, Petr Miratsky, Kevin R Ford, Christian Clarup, Osman Imal, Ferdia Fallon Verbruggen, Frantisek Zahalka, Tomas Maly
Introduction: Trunk and shoulder strength are consistently shown to be involved in performance limitations, as well as contributing to stability, power output, and reducing the risk of injury. Although their biomechanical interaction is a critical aspect for athletes, there is limited research on the relationship between trunk and shoulder strength in sports where upper body mechanics are critical for optimal performance. Purpose: This study examined the differences and relationships between trunk rotational strength and shoulder rotational strength among athletes participating in mixed martial arts (MMA), tennis, swimming, and baseball...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38737827/time-dependent-effects-of-tumor-necrosis-factor-%C3%AE-on-ca-2-dependent-secretion-in-murine-small-intestinal-organoids
#71
JOURNAL ARTICLE
Svenja Mareike Pauer, Brigitta Buß, Martin Diener, Jasmin Ballout
BACKGROUND: Intestinal organoids are stem cell-derived, 3D "mini-guts" with similar functions as the native intestinal epithelium such as electrolyte transport or establishment of an epithelial barrier. During intestinal inflammation, epithelial functions are dysregulated by proinflammatory cytokines like tumor necrosis factor α (TNFα) and other messengers from the immune system resulting in a loss of electrolytes and water due to an impaired epithelial barrier and higher net secretion...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725573/voluntary-wheel-running-reduces-tumor-growth-and-increases-capillarity-in-the-heart-during-doxorubicin-chemotherapy-in-a-murine-model-of-breast-cancer
#72
JOURNAL ARTICLE
Tytti-Maria Uurasmaa, Chloé Ricardo, Anu Autio, Ilkka H A Heinonen, Helene Rundqvist, Katja Anttila
Introduction: The possible beneficial effects of physical activity during doxorubicin treatment of breast cancer need further investigation as many of the existing studies have been done on non-tumor-bearing models. Therefore, in this study, we aim to assess whether short-term voluntary wheel-running exercise during doxorubicin treatment of breast cancer-bearing mice could induce beneficial cardiac effects and enhance chemotherapy efficacy. Methods: Murine breast cancer I3TC cells were inoculated subcutaneously to the flank of female FVB mice ( n = 16) that were divided into exercised and non-exercised groups...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725572/effects-of-aerobic-and-resistance-exercise-for-9-months-on-serum-free-light-chains-in-type-2-diabetes
#73
JOURNAL ARTICLE
Youyoung Kim, John P Campbell, Neil M Johannsen, Timothy S Church, Eunhan Cho, Jennifer Heaney, Guillaume Spielmann
Background and aims: Serum polyclonal free light chains (FLCs) levels are associated with overall survival in the general population, reflecting their utility as a biomarker of underlying immune activation and inflammation. Regular exercise is known to ameliorate low-grade inflammation in chronic diseases such as type 2 diabetes; however, the effects of different exercise training modalities on FLCs in adults with type 2 diabetes is unknown. This study investigated the effects of 9-month of aerobic, resistance or combined supervised exercise on serum FLCs in 164 patients with type 2 diabetes (age 58 ± 8 years; 63% female)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725571/transient-deoxyhemoglobin-formation-as-a-contrast-for-perfusion-mri-studies-in-patients-with-brain-tumors-a-feasibility-study
#74
JOURNAL ARTICLE
Vittorio Stumpo, Ece Su Sayin, Jacopo Bellomo, Olivia Sobczyk, Christiaan Hendrik Bas van Niftrik, Martina Sebök, Michael Weller, Luca Regli, Zsolt Kulcsár, Athina Pangalu, Andrea Bink, James Duffin, David D Mikulis, Joseph A Fisher, Jorn Fierstra
Background: Transient hypoxia-induced deoxyhemoglobin (dOHb) has recently been shown to represent a comparable contrast to gadolinium-based contrast agents for generating resting perfusion measures in healthy subjects. Here, we investigate the feasibility of translating this non-invasive approach to patients with brain tumors. Methods: A computer-controlled gas blender was used to induce transient precise isocapnic lung hypoxia and thereby transient arterial dOHb during echo-planar-imaging acquisition in a cohort of patients with different types of brain tumors (n = 9)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725570/in-the-fed-state-autophagy-plays-a-crucial-role-in-assisting-the-insect-vector-rhodnius-prolixus-mobilize-tag-reserves-under-forced-flight-activity
#75
JOURNAL ARTICLE
Samara Santos-Araujo, Fabio Gomes, Luiz Fernando Carvalho-Kelly, José Roberto Meyer-Fernandes, Katia C Gondim, Isabela Ramos
Autophagy is a cellular degradation pathway mediated by highly conserved autophagy-related genes (Atgs). In our previous work, we showed that inhibiting autophagy under starvation conditions leads to significant physiological changes in the insect vector of Chagas disease Rhodnius prolixus ; these changes include triacylglycerol (TAG) retention in the fat body, reduced survival and impaired locomotion and flight capabilities. Herein, because it is known that autophagy can be modulated in response to various stimuli, we further investigated the role of autophagy in the fed state, following blood feeding...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725569/cold-resistance-of-mammalian-hibernators-%C3%A2-a-matter-of-ferroptosis
#76
REVIEW
Masamitsu Sone, Yoshifumi Yamaguchi
Most mammals adapt thermal physiology around 37°C and large deviations from their range, as observed in severe hypothermia and hyperthermia, resulting in organ dysfunction and individual death. A prominent exception is mammalian hibernation. Mammalian hibernators resist the long-term duration of severe low body temperature that is lethal to non-hibernators, including humans and mice. This cold resistance is supported, at least in part, by intrinsic cellular properties, since primary or immortalized cells from several hibernator species can survive longer than those from non-hibernators when cultured at cold temperatures...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725568/targeting-hypoxia-signaling-pathways-in-angiogenesis
#77
REVIEW
Sara Monaci, Federica Coppola, Irene Filippi, Alessandro Falsini, Fabio Carraro, Antonella Naldini
Oxygen (O2 ) supply is constantly maintained by the vascular network for a proper tissue oxygenation. Hypoxia is the result of an increased O2 demand and/or decreased supply and is common in both physiological conditions and human diseases. Angiogenesis is one of the adaptive responses to hypoxia and is mainly regulated by the hypoxia-inducible factors, HIFs. These heterodimeric transcription factors are composed of one of three O2 -dependent α subunits (HIF-1, HIF-2, and HIF-3) and a constitutively expressed O2 -insensitive subunit (HIF-1β)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725567/determination-of-speed-and-assessment-of-conditioning-in-horses-submitted-to-a-lactate-minimum-test-alternative-approaches
#78
JOURNAL ARTICLE
Gabriel Vieira Ramos, Angélica Cristina Titotto, Guilherme Barbosa da Costa, Guilherme de Camargo Ferraz, José Corrêa de Lacerda-Neto
The maximal lactate steady state (MLSS) is a well-known gold standard method for determining the aerobic capacity of athletic horses. Owing to its high cost and complex execution, there is a search for standardized exercise tests that can predict this value in a single session. One of the methods described for this purpose is the lactate minimum test (LMT), which could be more accurate despite being adequate to predict MLSS. This study aimed to examine the impact of training on the speed corresponding to lactate minimum speed (LMS) and to apply new mathematical methods to evaluate the fitness level of horses based on the curve obtained by the LMT...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725566/editorial-climate-change-and-developmental-physiology
#79
EDITORIAL
Sukanta Mondal, Rafael Martinez-Garcia
No abstract text is available yet for this article.
2024: Frontiers in Physiology
https://read.qxmd.com/read/38725565/editorial-rising-stars-in-chronobiology-2022
#80
EDITORIAL
Joanna C Chiu
No abstract text is available yet for this article.
2024: Frontiers in Physiology
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