journal
https://read.qxmd.com/read/38699142/plasticity-of-bone-marrow-derived-cell-differentiation-depending-on-microenvironments-in-the-skin
#41
JOURNAL ARTICLE
Junko Okano, Takahiko Nakagawa, Hideto Kojima
Bone marrow-derived cells (BMDCs) are heterogeneous populations in which not only pluripotent stem cells, namely, hematopoietic stem cells (HSCs), mesenchymal stem cells (MSC) but also endothelial progenitor cells (EPC) are involved. BMDCs contribute to the maintenance of homeostasis and recovery from disrupted homeostasis as the immune, endocrine, and nervous systems. The skin is the largest organ in which various tissues, such as the epidermis, dermis, skin appendages (i.e., hair follicles), fats, muscles, and vessels, are tightly and systematically packed...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38699141/cftr-dysfunction-leads-to-defective-bacterial-eradication-on-cystic-fibrosis-airways
#42
REVIEW
Min Wu, Jeng-Haur Chen
Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung disease that involves multiple disorders of epithelial function likely results from loss of CFTR function as an anion channel conducting chloride and bicarbonate ions and its function as a cellular regulator modulating the activity of membrane and cytosol proteins. In the absence of CFTR activity, abundant mucus accumulation, bacterial infection and inflammation characterize CF airways, in which inflammation-associated tissue remodeling and damage gradually destroys the lung...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38694209/ladder-based-resistance-training-with-the-progression-of-training-load-altered-the-tibial-nerve-ultrastructure-and-muscle-fiber-area-without-altering-the-morphology-of-the-postsynaptic-compartment
#43
JOURNAL ARTICLE
Walter Krause Neto, Wellington Silva, Tony Oliveira, Alan Vilas Boas, Adriano Ciena, Érico Chagas Caperuto, Eliane Florencio Gama
Scientific evidence regarding the effect of different ladder-based resistance training (LRT) protocols on the morphology of the neuromuscular system is scarce. Therefore, the present study aimed to compare the morphological response induced by different LRT protocols in the ultrastructure of the tibial nerve and morphology of the motor endplate and muscle fibers of the soleus and plantaris muscles of young adult Wistar rats. Rats were divided into groups: sedentary control (control, n = 9), a predetermined number of climbs and progressive submaximal intensity (fixed, n = 9), high-intensity and high-volume pyramidal system with a predetermined number of climbs (Pyramid, n = 9) and lrt with a high-intensity pyramidal system to exhaustion (failure, n = 9)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38694208/liver-x-receptor-agonist-upregulates-lpcat3-in-human-aortic-endothelial-cells
#44
JOURNAL ARTICLE
Delphine Bousquet, Elie Nader, Philippe Connes, Nicolas Guillot
OBJECTIVE: Endothelial cells (ECs) play an important role in tissue homeostasis. Recently, EC lipid metabolism has emerged as a regulator of EC function. The liver X receptors (LXRs) are involved in the transcriptional regulation of genes involved in lipid metabolism and have been identified as a potential target in cardiovascular disease. We aimed to decipher the role of LXRs in the regulation of lipid metabolism in human aortic endothelial cells. APPROACH AND RESULTS: Lipid composition analysis of endothelial cells treated with the LXR agonist T0901317 revealed that LXR activation increased the proportion of polyunsaturated fatty acids (PUFAs) and decreased the proportion of saturated fatty acids...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38694207/effectiveness-of-a-sensorimotor-exercise-program-on-proprioception-balance-muscle-strength-functional-mobility-and-risk-of-falls-in-older-people
#45
JOURNAL ARTICLE
Ivelize Freire, Adérito Seixas
INTRODUCTION: Sensory systems provide the necessary information for a motor response to be provided. In this sense, the objective of this study is to evaluate the effectiveness of a sensorimotor exercise program on proprioceptive acuity, balance, muscle strength, functional mobility and risk of falls in institutionalized elderly. METHODOLOGY: 56 participants (84.6 ± 8.4 years) were randomly distributed between the control (CG, n = 28) and intervention groups (IG, n = 28)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38694206/the-nonvesicular-sterol-transporter-aster-c-plays-a-minor-role-in-whole-body-cholesterol-balance
#46
JOURNAL ARTICLE
Rakhee Banerjee, Rachel C Hohe, Shijie Cao, Bryan M Jung, Anthony J Horak, Iyappan Ramachandiran, William J Massey, Venkateshwari Varadharajan, Natalie I Zajczenko, Amy C Burrows, Sumita Dutta, Maryam Goudarzi, Kala Mahen, Abigail Carter, Robert N Helsley, Scott M Gordon, Richard E Morton, Christopher Strauch, Belinda Willard, Camelia Baleanu Gogonea, Valentin Gogonea, Matteo Pedrelli, Paolo Parini, J Mark Brown
INTRODUCTION: The Aster-C protein (encoded by the Gramd1c gene) is an endoplasmic reticulum (ER) resident protein that has been reported to transport cholesterol from the plasma membrane to the ER. Although there is a clear role for the closely-related Aster-B protein in cholesterol transport and downstream esterification in the adrenal gland, the specific role for Aster-C in cholesterol homeostasis is not well understood. Here, we have examined whole body cholesterol balance in mice globally lacking Aster-C under low or high dietary cholesterol conditions...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38694205/optimal-fibre-length-and-maximum-isometric-force-are-the-most-influential-parameters-when-modelling-muscular-adaptations-to-unloading-using-hill-type-muscle-models
#47
JOURNAL ARTICLE
James Cowburn, Gil Serrancolí, Steffi Colyer, Dario Cazzola
Introduction: Spaceflight is associated with severe muscular adaptations with substantial inter-individual variability. A Hill-type muscle model is a common method to replicate muscle physiology in musculoskeletal simulations, but little is known about how the underlying parameters should be adjusted to model adaptations to unloading. The aim of this study was to determine how Hill-type muscle model parameters should be adjusted to model disuse muscular adaptations. Methods: Isokinetic dynamometer data were taken from a bed rest campaign and used to perform tracking simulations at two knee extension angular velocities (30°·s-1 and 180°·s-1 )...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38690080/pleiotropic-physiological-functions-of-piezo1-in-human-body-and-its-effect-on-malignant-behavior-of-tumors
#48
REVIEW
Yihan Zhang, Wen Zou, Wenlei Dou, Hongliang Luo, Xi Ouyang
Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein. Piezo1 has various effects and plays an important and irreplaceable role in the maintenance of human life activities and homeostasis of the internal environment. In addition, recent studies have shown that Piezo1 plays a vital role in tumorigenesis, progression, malignancy and clinical prognosis. Piezo1 is involved in regulating the malignant behaviors of a variety of tumors, including cellular metabolic reprogramming, unlimited proliferation, inhibition of apoptosis, maintenance of stemness, angiogenesis, invasion and metastasis...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38681143/hydrogen-rich-water-supplementation-promotes-muscle-recovery-after-two-strenuous-training-sessions-performed-on-the-same-day-in-elite-fin-swimmers-randomized-double-blind-placebo-controlled-crossover-trial
#49
JOURNAL ARTICLE
Barbora Sládečková, Michal Botek, Jakub Krejčí, Michal Valenta, Andrew McKune, Filip Neuls, Iva Klimešová
Purpose: Molecular hydrogen has been shown to possess antioxidant, anti-inflammatory, ergogenic, and recovery-enhancing effects. This study aimed to assess the effect of molecular hydrogen administration on muscle performance, damage, and perception of soreness up to 24 h of recovery after two strenuous training sessions performed on the same day in elite fin swimmers. Methods: Eight females (mean ± SD; age 21.5 ± 5.0 years, maximal oxygen consumption 45.0 ± 2.5 mL.kg-1 .min-1 ) and four males (age 18...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38681142/parental-recovered-acute-kidney-injury-causes-prenatal-renal-dysfunction-and-fetal-growth-restriction-with-sexually-dimorphic-implications-for-adult-offspring
#50
JOURNAL ARTICLE
Jessica F Hebert, Yoshio Funahashi, Jacqueline M Emathinger, Megan N Nickerson, Tahnee Groat, Nicole K Andeen, Susan B Gurley, Michael P Hutchens
Introduction: Acute kidney injury (AKI) is rapidly increasing in global incidence and a healthcare burden. Prior maternal AKI diagnosis correlates with later pregnancy complications. As pregnancy influences developmental programming, we hypothesized that recovered parental AKI results in poor pregnancy outcomes, impaired fetal growth, and adult offspring disease. Methods: Using a well-characterized model of rhabdomyolysis-induced acute kidney injury (RIAKI), a form of AKI commonly observed in young people, we confirmed functional renal recovery by assessing glomerular filtration rate (GFR) 2 weeks following RIAKI...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38681141/spontaneously-hypertensive-rats-exhibit-increased-liver-flavin-monooxygenase-expression-and-elevated-plasma-tmao-levels-compared-to-normotensive-and-ang-ii-dependent-hypertensive-rats
#51
JOURNAL ARTICLE
Marta Gawryś-Kopczyńska, Mateusz Szudzik, Emilia Samborowska, Marek Konop, Dawid Chabowski, Maksymilian Onyszkiewicz, Marcin Ufnal
Background: Flavin monooxygenases (FMOs) are enzymes responsible for the oxidation of a broad spectrum of exogenous and endogenous amines. There is increasing evidence that trimethylamine (TMA), a compound produced by gut bacteria and also recognized as an industrial pollutant, contributes to cardiovascular diseases. FMOs convert TMA into trimethylamine oxide (TMAO), which is an emerging marker of cardiovascular risk. This study hypothesized that blood pressure phenotypes in rats might be associated with variations in the expression of FMOs...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38681140/an-epilepsy-detection-method-based-on-multi-dimensional-feature-extraction-and-dual-branch-hypergraph-convolutional-network
#52
JOURNAL ARTICLE
Jiacen Liu, Yong Yang, Feng Li, Jing Luo
Epilepsy is a disease caused by abnormal neural discharge, which severely harms the health of patients. Its pathogenesis is complex and variable with various forms of seizures, leading to significant differences in epilepsy manifestations among different patients. The changes of brain network are strongly correlated with related pathologies. Therefore, it is crucial to effectively and deeply explore the intrinsic features of epilepsy signals to reveal the rules of epilepsy occurrence and achieve accurate detection...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38681139/mg53-trim72-multi-organ-repair-protein-and-beyond
#53
REVIEW
Yong-Fei Wang, Zi-Yi An, Jian-Wen Li, Zi-Kai Dong, Wei-Lin Jin
MG53, a member of the tripartite motif protein family, possesses multiple functionalities due to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase properties. Initially recognized for its crucial role in membrane repair, the therapeutic potential of MG53 has been extensively explored in various diseases including muscle injury, myocardial damage, acute lung injury, and acute kidney injury. However, further research has revealed that the E3 ubiquitin ligase characteristics of MG53 also contribute to the pathogenesis of certain conditions such as diabetic cardiomyopathy, insulin resistance, and metabolic syndrome...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38665599/magnesium-in-hypertension-mechanisms-and-clinical-implications
#54
REVIEW
Zain AlShanableh, Evan C Ray
Hypertension is associated with increased risk of cardiovascular disease and death. Evidence suggests that Mg2+ depletion contributes to hypertension. It is estimated that 25% or more of the United States population experiences chronic, latent Mg2+ depletion. This review explores mechanisms by which Mg2+ influences blood pressure, modifying risk of hypertension and complicating its treatment. Mechanisms addressed include effects upon i) sympathetic tone, via the modulation of N-methyl-D-aspartate (NMDA) receptor and N-type Ca2+ channel activity, influencing catecholamine release from sympathetic nerve endings; ii) vascular tone, via alteration of L-type Ca2+ and endothelial nitric oxide synthase (eNOS) activity and prostacyclin release; iii) renal K+ handling, influencing systemic K+ balance and potentially indirectly influencing blood pressure; iv) aldosterone secretion from the adrenal cortex; and v) modulation of pro-hypertensive inflammatory processes in dendritic cells and macrophages, including activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome and stimulation of isolevuglandin (IsoLG) production...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38665598/effects-of-anodic-transcranial-direct-current-stimulation-combined-with-physical-training-on-the-performance-of-elite-swimmers
#55
JOURNAL ARTICLE
Xipeng Yang, Jinlong Wu, Yucheng Tang, Zhanbing Ren
OBJECTIVE: Anodal transcranial direct current stimulation (a-tDCS) has been used to improve athletic performance in various populations; however, its role in improving performance in elite athletes is unclear. This study aimed to investigate the effects of a-tDCS on athletic performance in elite athletes. METHODS: We used a single-blind, randomized controlled experimental design and recruited 24 national-level freestyle swimmers from China. All athletes were randomly divided into two groups; the experimental group underwent a-tDCS (current 2 mA for 20 min) combined with physical training, and the control group underwent a-tDCS sham stimulation combined with physical training...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38665597/bt-cnn-a-balanced-binary-tree-architecture-for-classification-of-brain-tumour-using-mri-imaging
#56
JOURNAL ARTICLE
Sohamkumar Chauhan, Ramalingaswamy Cheruku, Damodar Reddy Edla, Lavanya Kampa, Soumya Ranjan Nayak, Jayant Giri, Saurav Mallik, Srinivas Aluvala, Vijayasree Boddu, Hong Qin
Deep learning is a very important technique in clinical diagnosis and therapy in the present world. Convolutional Neural Network (CNN) is a recent development in deep learning that is used in computer vision. Our medical investigation focuses on the identification of brain tumour. To improve the brain tumour classification performance a Balanced binary Tree CNN (BT-CNN) which is framed in a binary tree-like structure is proposed. It has a two distinct modules-the convolution and the depthwise separable convolution group...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38665596/ensemble-machine-learning-prediction-of-hyperuricemia-based-on-a-prospective-health-checkup-population
#57
JOURNAL ARTICLE
Yongsheng Zhang, Li Zhang, Haoyue Lv, Guang Zhang
Objectives: An accurate prediction model for hyperuricemia (HUA) in adults remain unavailable. This study aimed to develop a stacking ensemble prediction model for HUA to identify high-risk groups and explore risk factors. Methods: A prospective health checkup cohort of 40899 subjects was examined and randomly divided into the training and validation sets with the ratio of 7:3. LASSO regression was employed to screen out important features and then the ROSE sampling was used to handle the imbalanced classes...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38660539/physiology-of-deep-closed-circuit-rebreather-mixed-gas-diving-vascular-gas-emboli-and-biological-changes-during-a-week-long-liveaboard-safari
#58
JOURNAL ARTICLE
Costantino Balestra, Clément Lévêque, Simona Mrakic-Sposta, Alessandra Vezzoli, Pierre Wauthy, Peter Germonpré, Frauke Tillmans, François Guerrero, Pierre Lafère
Introduction: Diving decompression theory hypothesizes inflammatory processes as a source of micronuclei which could increase related risks. Therefore, we tested 10 healthy, male divers. They performed 6-8 dives with a maximum of two dives per day at depths ranging from 21 to 122 msw with CCR mixed gas diving. Methods: Post-dive VGE were counted by echocardiography. Saliva and urine samples were taken before and after each dive to evaluate inflammation: ROS production, lipid peroxidation (8-iso-PGF2), DNA damage (8-OH-dG), cytokines (TNF-α, IL-6, and neopterin)...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38660538/the-two-c-elegans-class-vi-myosins-spe-15-hum-3-and-hum-8-share-similar-motor-properties-but-have-distinct-developmental-and-tissue-expression-patterns
#59
JOURNAL ARTICLE
Ranya Behbehani, Chloe Johnson, Alexander J Holmes, Matthew J Gratian, Daniel P Mulvihill, Folma Buss
Myosins of class VI move toward the minus-end of actin filaments and play vital roles in cellular processes such as endocytosis, autophagy, protein secretion, and the regulation of actin filament dynamics. In contrast to the majority of metazoan organisms examined to date which contain a single MYO6 gene, C. elegans , possesses two MYO6 homologues, SPE-15/HUM-3 and HUM-8. Through a combination of in vitro biochemical/biophysical analysis and cellular assays, we confirmed that both SPE-15/HUM-3 and HUM-8 exhibit reverse directionality, velocities, and ATPase activity similar to human MYO6...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38660537/titin-roles-in-cardiac-function-and-diseases
#60
REVIEW
Dawson Stroik, Zachery R Gregorich, Farhan Raza, Ying Ge, Wei Guo
The giant protein titin is an essential component of muscle sarcomeres. A single titin molecule spans half a sarcomere and mediates diverse functions along its length by virtue of its unique domains. The A-band of titin functions as a molecular blueprint that defines the length of the thick filaments, the I-band constitutes a molecular spring that determines cell-based passive stiffness, and various domains, including the Z-disk, I-band, and M-line, serve as scaffolds for stretch-sensing signaling pathways that mediate mechanotransduction...
2024: Frontiers in Physiology
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