journal
https://read.qxmd.com/read/38045035/ceragenins-exhibit-bactericidal-properties-that-are-independent-of-the-ionic-strength-in-the-environment-mimicking-cystic-fibrosis-sputum
#1
JOURNAL ARTICLE
Karol Skłodowski, Łukasz Suprewicz, Sylwia Joanna Chmielewska-Deptuła, Szczepan Kaliniak, Sławomir Okła, Magdalena Zakrzewska, Łukasz Minarowski, Robert Mróz, Tamara Daniluk, Paul B Savage, Krzysztof Fiedoruk, Robert Bucki
The purpose of the work was to investigate the impact of sodium chloride (NaCl) on the antimicrobial efficacy of ceragenins (CSAs) and antimicrobial peptides (AMPs) against bacterial and fungal pathogens associated with cystic fibrosis ( CF ) lung infections. CF -associated bacterial ( Pseudomonas aeruginosa , Ochrobactrum spp., and Staphylococcus aureus ), and fungal pathogens ( Candida albicans , and Candida tropicalis ) were used as target organisms for ceragenins (CSA-13 and CSA-131) and AMPs (LL-37 and omiganan)...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045034/shift-in-dominant-genotypes-of-japanese-encephalitis-virus-and-its-impact-on-current-vaccination-strategies
#2
REVIEW
Qiqi Xia, Yang Yang, Yan Zhang, Lujia Zhou, Xiaochun Ma, Changguang Xiao, Junjie Zhang, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Jianchao Wei, Zhiyong Ma
Japanese encephalitis (JE) is a zoonotic ailment from the Japanese encephalitis virus (JEV). JEV belongs to the flavivirus genus and is categorized into a solitary serotype consisting of five genetically diverse genotypes (I, II, III, IV, and V). The JEV genotype III (GIII) was the prevailing strain responsible for multiple outbreaks in countries endemic to JEV until 1990. In recent years, significant improvements have occurred in the epidemiology of JE, encompassing the geographical expansion of the epidemic zone and the displacement of prevailing genotypes...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045033/structural-characterization-of-a-novel-cyclic-2-3-diphosphoglycerate-synthetase-involved-in-extremolyte-production-in-the-archaeon-methanothermus-fervidus
#3
JOURNAL ARTICLE
Simone A De Rose, Michail N Isupov, Harley L Worthy, Christina Stracke, Nicholas J Harmer, Bettina Siebers, Jennifer A Littlechild
The enzyme cyclic di-phosphoglycerate synthetase that is involved in the production of the osmolyte cyclic 2,3-diphosphoglycerate has been studied both biochemically and structurally. Cyclic 2,3-diphosphoglycerate is found exclusively in the hyperthermophilic archaeal methanogens, such as Methanothermus fervidus , Methanopyrus kandleri , and Methanothermobacter thermoautotrophicus . Its presence increases the thermostability of archaeal proteins and protects the DNA against oxidative damage caused by hydroxyl radicals...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045032/effects-of-replacing-hybrid-giant-napier-with-sugarcane-bagasse-and-fermented-sugarcane-bagasse-on-growth-performance-nutrient-digestibility-rumen-fermentation-characteristics-and-rumen-microorganisms-of-simmental-crossbred-cattle
#4
JOURNAL ARTICLE
Yadong Jin, Yanru Huang, Haocen Luo, Langzhou Wang, Binlong Chen, Yi Zhang, Kaimei Deng, Ningbo Zhao, Anqiang Lai
This study investigated the effects of replacing hybrid giant napiers with sugarcane bagasse and fermented sugarcane bagasse on the growth performance, apparent nutrient digestibility, rumen fermentation characteristics, and rumen microorganisms of Simmental crossbred cattle. Twenty-one Simmental crossbred cattle with similar initial body weight (363.42 ± 8.67 kg) were randomly divided into three groups: Group CON (20% hybrid giant napier +45% distillers grains +35% concentrate mixture), Group SB (20% sugarcane bagasse +45% distillers grains +35% concentrate mixture), and Group FSB (20% fermented sugarcane bagasse +45% distillers grains +35% concentrate mixture)...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045031/cytological-studies-reveal-high-variation-in-ascospore-number-and-shape-and-conidia-produced-directly-from-ascospores-in-morchella-galilaea
#5
JOURNAL ARTICLE
Xi-Hui Du, Si-Yue Wang, Martin Ryberg, Yong-Jie Guo, Jing-Yi Wei, Donald H Pfister, Hanna Johannesson
Spores are important as dispersal and survival propagules in fungi. In this study we investigated the variation in number, shape, size and germination mode of ascospores in Morchella galilaea , the only species of the genus Morchella known to fruit in the autumn. Based on the observation of five samples, we first discovered significant variation in the shape and size of ascospores in Morchella . One to sixteen ascospores were found in the asci. Ascospore size correlated negatively with ascospore number, but positively with ascus size, and ascus size was positively correlated with ascospore number...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045030/gut-microbiota-and-common-gastrointestinal-diseases-a-bidirectional-two-sample-mendelian-randomized-study
#6
JOURNAL ARTICLE
Binxu Qiu, Zixiong Shen, Dongliang Yang, Xinxin Qin, Wenyong Ren, Quan Wang
BACKGROUND: Several recent studies have shown an association between gut microbiota and gastrointestinal diseases. However, the causal relationship between gut microbiota and gastrointestinal disorders is unclear. METHODS: We assessed causal relationships between gut microbiota and eight common gastrointestinal diseases using Mendelian randomization (MR) analyses. IVW results were considered primary results. Cochrane's Q and MR-Egger tests were used to test for heterogeneity and pleiotropy...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045029/metabolic-flux-reprogramming-in-mycobacterium-tuberculosis-infected-human-macrophages
#7
JOURNAL ARTICLE
Khushboo Borah Slater, Luana Moraes, Ye Xu, Daniel Kim
Metabolic fluxes are at the heart of metabolism and growth in any living system. During tuberculosis (TB) infection, the pathogenic Mycobacterium tuberculosis (Mtb) adapts its nutritional behaviour and metabolic fluxes to survive in human macrophages and cause infection. The infected host cells also undergo metabolic changes. However, our knowledge of the infected host metabolism and identification of the reprogrammed metabolic flux nodes remains limited. In this study, we applied systems-based 13 C-metabolic flux analysis (MFA) to measure intracellular carbon metabolic fluxes in Mtb-infected human THP-1 macrophages...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045028/profiling-toxin-genes-and-antibiotic-resistance-in-bacillus-cereus-isolated-from-pre-launch-spacecraft
#8
JOURNAL ARTICLE
Barakatullah Mohammadi, Natalia Gorkina, Marco Esteban Pérez-Reyes, Stephanie A Smith
Characterization of the microbiomes of pre-launch spacecraft in spacecraft assembly facilities is an important step in keeping crews healthy during journeys that can last several hundred days in small artificial environments in space. Bacillus cereus , a foodborne pathogenic bacterium, has the potential to be a significant source of food contamination in such environments. This bacterium is a spore-forming bacteria that resists different antimicrobial treatments in cleanrooms where spacecraft are assembled...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045027/a-long-awaited-taxogenomic-investigation-of-the-family-halomonadaceae
#9
JOURNAL ARTICLE
Rafael R de la Haba, David R Arahal, Cristina Sánchez-Porro, Maria Chuvochina, Stijn Wittouck, Philip Hugenholtz, Antonio Ventosa
The family Halomonadaceae is the largest family composed of halophilic bacteria, with more than 160 species with validly published names as of July 2023. Several classifications to circumscribe this family are available in major resources, such as those provided by the List of Prokaryotic names with Standing in Nomenclature (LPSN), NCBI Taxonomy, Genome Taxonomy Database (GTDB), and Bergey's Manual of Systematics of Archaea and Bacteria (BMSAB), with some degree of disagreement between them. Moreover, regardless of the classification adopted, the genus Halomonas is not phylogenetically consistent, likely because it has been used as a catch-all for newly described species within the family Halomonadaceae that could not be clearly accommodated in other Halomonadaceae genera...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045026/a-mechanism-based-pathway-toward-administering-highly-active-n-phage-cocktails
#10
JOURNAL ARTICLE
Nicholas M Smith, Thomas D Nguyen, Wai Hoe Chin, Jacob T Sanborn, Harriet de Souza, Brian M Ho, Tiffany Luong, Dwayne R Roach
Bacteriophage (phage) therapy is being explored as a possible response to the antimicrobial resistance public health emergency. Administering a mixture of different phage types as a cocktail is one proposed strategy for therapeutic applications, but the optimal method for formulating phage cocktails remains a major challenge. Each phage strain has complex pharmacokinetic/pharmacodynamic (PK/PD) properties which depend on the nano-scale size, target-mediated, self-dosing nature of each phage strain, and rapid selection of resistant subpopulations...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38045025/antimicrobial-resistance-genes-and-associated-mobile-genetic-elements-in-lactobacillales-from-various-sources
#11
JOURNAL ARTICLE
Eszter Kaszab, Levente Laczkó, Gábor Kardos, Krisztián Bányai
Lactobacillales are commonly used in food products and as probiotics in animal and human medicine. Despite being generally recognized as safe, lactic acid bacteria may harbor a variety of antimicrobial resistance genes (ARGs), which may be transferable to human or veterinary pathogens, thus, may pose veterinary and public health concerns. This study investigates the resistome of Lactobacillales. A total of 4,286 whole-genome sequences were retrieved from NCBI RefSeq database. We screened ARGs in whole genome sequences and assessed if they are transmissible by plasmid transfer or by linkage to integrative mobile genetic elements...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033599/influence-of-different-sample-preparation-techniques-on-imaging-viruses-and-virus-like-particles-by-scanning-electron-and-scanning-transmission-electron-microscopes
#12
JOURNAL ARTICLE
Monika Kąkol, Ezher Tagliasacchi, Andrzej Borkowski, Mirosław Słowakiewicz
Scanning electron microscopy (SEM) and scanning transmission electron microscopy (STEM) were applied in many laboratories to visualize and image viruses and virus-like particles (VLPs). Two bacteriophages, P1 and Φ6, were chosen as model microorganisms known for their distinct structure, and viruses obtained from biofilms associated with modern travertines (Terme di Saturnia, Italy; Karahayıt "Kızılsu" and Pamukkale, Turkey) were also investigated. Three protocols, (1) full , (2) simplified , and (3) all at once were developed and tested for sample preparation and imaging...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033598/causal-associations-between-gut-microbiota-and-primary-biliary-cholangitis-a-bidirectional-two-sample-mendelian-randomization-study
#13
JOURNAL ARTICLE
Jiahao Zhang, Gefeng Wu, Yuhong Tang, Huanxiang Liu, Xinyu Ge, Rui Peng, Jun Cao, Daoyuan Tu, Bingbing Su, Shengjie Jin, Guoqing Jiang, Chi Zhang, Dousheng Bai
BACKGROUND: Previous studies have suggested an association between gut microbiota and primary biliary cholangitis (PBC). Nonetheless, the causal relationship between gut microbiota and PBC risk remains unclear. METHODS: A bidirectional two-sample Mendelian Randomization (MR) study was employed using summary statistical data for gut microbiota and PBC from the MiBioGen consortium and Genome-Wide Association Studies (GWAS) database to investigate causal relationships between 211 gut microbiota and PBC risk...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033597/corrigendum-assessment-of-the-accuracy-of-11-different-diagnostic-tests-for-the-detection-of-schistosomiasis-mansoni-in-individuals-from-a-brazilian-area-of-low-endemicity-using-latent-class-analysis
#14
Silvia Gonçalves Mesquita, Roberta Lima Caldeira, Tereza Cristina Favre, Cristiano Lara Massara, Lílian Christina Nóbrega Holsbach Beck, Taynãna César Simões, Gardênia Braz Figueiredo de Carvalho, Flória Gabriela Dos Santos Neves, Gabriela de Oliveira, Larisse de Souza Barbosa Lacerda, Matheus Alves de Almeida, Omar Dos Santos Carvalho, Marina Moraes Mourão, Edward Oliveira, Rosiane A Silva-Pereira, Cristina Toscano Fonseca
[This corrects the article DOI: 10.3389/fmicb.2022.1048457.].
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033596/rhizosphere-microbial-ecological-characteristics-of-strawberry-root-rot
#15
JOURNAL ARTICLE
Meilin Zhang, Zirong Kong, Huijing Fu, Xiaolong Shu, Quanhong Xue, Hangxian Lai, Qiao Guo
INTRODUCTION: Strawberry ( Fragaria × ananassa Duch.) holds a preeminent position among small fruits globally due to its delectable fruits and significant economic value. However, strawberry cultivation is hampered by various plant diseases, hindering the sustainable development of the strawberry industry. The occurrence of plant diseases is closely linked to imbalance in rhizosphere microbial community structure. METHODS: In the present study, a systematic analysis of the differences and correlations among non-culturable microorganisms, cultivable microbial communities, and soil nutrients in rhizosphere soil, root surface soil, and non-rhizosphere soil of healthy and diseased strawberry plants affected by root rot was conducted...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033595/combined-contribution-of-biochar-and-introduced-am-fungi-on-lead-stability-and-microbial-community-in-polluted-agricultural-soil
#16
JOURNAL ARTICLE
Xuedong Chen, Lin Tang, Kongyang Wu, Yifan Mo, Qian Tang, Gaojie Li, Ying Zhu
INTRODUCTION: Lead (Pb) pollution in agricultural soil has been accelerated by industrial development and human activities, and poses a major threat to agricultural ecosystems. Both biochar and arbuscular mycorrhiza (AM) fungi are considered to play an important role in remediation of Pb contaminated soil. METHODS: The combined remediation effects of introduced AM fungi and biochar on soil properties, Pb availability, microbial community and functional profiles were systematically investigated in unsterilized Pb-polluted agricultural soil...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033594/metagenomic-analysis-of-ecological-niche-overlap-and-community-collapse-in-microbiome-dynamics
#17
JOURNAL ARTICLE
Hiroaki Fujita, Masayuki Ushio, Kenta Suzuki, Masato S Abe, Masato Yamamichi, Yusuke Okazaki, Alberto Canarini, Ibuki Hayashi, Keitaro Fukushima, Shinji Fukuda, E Toby Kiers, Hirokazu Toju
Species utilizing the same resources often fail to coexist for extended periods of time. Such competitive exclusion mechanisms potentially underly microbiome dynamics, causing breakdowns of communities composed of species with similar genetic backgrounds of resource utilization. Although genes responsible for competitive exclusion among a small number of species have been investigated in pioneering studies, it remains a major challenge to integrate genomics and ecology for understanding stable coexistence in species-rich communities...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033593/itraq-based-quantitative-proteomic-analysis-of-the-antibacterial-mechanism-of-silver-nanoparticles-against-multidrug-resistant-streptococcus-suis
#18
JOURNAL ARTICLE
Baoling Liu, Dingyu Liu, Tianbao Chen, Xiaohu Wang, Hua Xiang, Gang Wang, Rujian Cai
BACKGROUND: The increase in antibiotic resistance of bacteria has become a major concern in clinical treatment. Silver nanoparticles (AgNPs) have significant antibacterial effects against Streptococcus suis . Therefore, this study aimed to investigate the antibacterial activity and mechanism of action of AgNPs against multidrug-resistant S. suis . METHODS: The effect of AgNPs on the morphology of multidrug-resistant S. suis was observed using scanning electron microscopy (SEM)...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033592/-streptomyces-as-a-promising-biological-control-agents-for-plant-pathogens
#19
REVIEW
Shaista Khan, Seweta Srivastava, Arun Karnwal, Tabarak Malik
Plant diseases caused by pathogenic microorganisms in agriculture present a considerable obstacle, resulting in approximately 30-40% crop damage. The use of conventional techniques to manage these microorganisms, i.e., applying chemical pesticides and antimicrobials, has been discovered to have adverse effects on human health and the environment. Furthermore, these methods have contributed to the emergence of resistance among phytopathogens. Consequently, it has become imperative to investigate natural alternatives to address this issue...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38033591/an-antibiotic-produced-by-pseudomonas-fluorescens-cfbp2392-with-antifungal-activity-against-rhizoctonia-solani
#20
JOURNAL ARTICLE
Nadia Riera, Danilo Davyt, Rosario Durán, Gregorio Iraola, Philippe Lemanceau, Natalia Bajsa
Pseudomonas fluorescens CFBP2392 has been recognized as a potential biocontrol agent due to its ability to suppress damping-off and root rot disease. This isolate has antibacterial activity in vitro as many other strains from the Pseudomonas fluorescens complex. In this work, the antibacterial and antifungal activity of the strain were explored. Dual culture assays evidenced the antifungal activity of the strain against different phytopathogens: Alternaria sp., Pythium ultimun , Fusarium oxysporum , and Rhizoctonia solani ...
2023: Frontiers in Microbiology
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