Crystal Gianvecchio, Natalie Ann Lozano, Claire Henderson, Pooneh Kalhori, Austin Bullivant, Alondra Valencia, Lauren Su, Gladys Bello, Michele Wong, Emoni Cook, Lakhia Fuller, Jerome B Neal, Pamela J Yeh
Objectives: Understanding how phenotypic traits vary has been a longstanding goal of evolutionary biologists. When examining antibiotic-resistance in bacteria, it is generally understood that the minimum inhibitory concentration (MIC) has minimal variation specific to each bacterial strain-antibiotic combination. However, there is a less studied resistance trait, the mutant prevention concentration (MPC), which measures the MIC of the most resistant sub-population. Whether and how MPC varies has been poorly understood...
2019: Frontiers in Microbiology