Réka Bod, Kinga Tóth, Nour Essam, Estilla Zsófia Tóth, Loránd Erõss, László Entz, Attila G Bagó, Dániel Fabó, István Ulbert, Lucia Wittner
Epilepsy is a prevalent neurological condition, with underlying neuronal mechanisms involving hyperexcitability and hypersynchrony. Imbalance between excitatory and inhibitory circuits, as well as histological reorganization are relatively well-documented in animal models or even in the human hippocampus, but less is known about human neocortical epileptic activity. Our knowledge about changes in the excitatory signaling is especially scarce, compared to that about the inhibitory cell population. This study investigated the firing properties of single neurons in the human neocortex in vitro , during pharmacological blockade of glutamate receptors, and additionally evaluated anatomical changes in the excitatory circuit in tissue samples from epileptic and non-epileptic patients...
2023: Frontiers in Synaptic Neuroscience