Janne Pott, Azin Kheirkhah, Jesper R Gadin, Marcus E Kleber, Graciela E Delgado, Holger Kirsten, Lukas Forer, Stefanie M Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand Van't Hooft, Florian Kronenberg, Markus Scholz
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in women throughout their life. Statin treatment affects PCSK9 levels also showing evidence of sex-differential effects. It remains unclear whether these differences can be explained by genetics. METHODS: We performed genome-wide association meta-analyses (GWAS) of PCSK9 levels stratified for sex and statin treatment in six independent studies of Europeans (8936 women/11,080 men respectively 14,825 statin-free/5191 statin-treated individuals)...
March 26, 2024: Biology of Sex Differences