journal
https://read.qxmd.com/read/38860166/-sophora-flavescens-astragalus-mongholicus-herb-pair-in-the-progression-of-hepatitis-cirrhosis-and-hepatocellular-carcinoma-a-possible-mechanisms-and-relevant-therapeutic-substances
#61
JOURNAL ARTICLE
Xiao Yang, Chen Liang, Li Shao, Wenxuan Cui, Ruobing Ning, Fan Ke, Yue Wang, Peng Gao, Yidi Yin, Qing Li
BACKGROUND: Both Sophora flavescens (SF) and Astragalus mongholicus (AM) are known for their anti-inflammatory, antifibrotic, and anticancer activities. However, the efficacy, multi-target mechanisms, and therapeutic substances of SF-AM herb pair on the progression of hepatitis-cirrhosis-hepatocellular carcinoma hepatocellular carcinoma (HCC) remain unclear. PURPOSE: To investigate the efficacy, mechanisms, and potential therapeutic substances of SF-AM herb pair in the progression of hepatitis-cirrhosis-HCC...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38860165/efficacy-and-safety-of-anti-angiogenic-drug-monotherapy-and-combination-therapy-for-ovarian-cancer-a-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#62
JOURNAL ARTICLE
Yao Xie, Fei Zhou
BACKGROUND: As the development of novel anti-angiogenic drugs and the continuous evolution of guideline recommendations, the efficacy and safety of anti-angiogenic agents in ovarian cancer (OC) remains unclear. Consequently, a meta-analysis was carried out to assess the efficacy and safety of anti-angiogenic drug monotherapy and combination therapy for OC. METHODS: An exhaustive literature review was performed across multiple databases, including PubMed, Embase, Web of Science, and Cochrane, encompassing all relevant randomized controlled trials (RCTs) up until 6 April 2024...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38860164/gossypetin-targets-the-liver-brain-axis-to-alleviate-pre-existing-liver-fibrosis-and-hippocampal-neuroinflammation-in-mice
#63
JOURNAL ARTICLE
Cenlu Xu, Haoran Tai, Yanan Chu, Ye Liu, Jiacheng He, Yiran Wang, Bingyin Su, Shurong Li
Liver fibrosis occurs in response to chronic damage and inflammation to the liver. Leaving untreated, it can lead to decreased liver function and can eventually progress to cirrhosis, a more advanced and irreversible state of liver damage. Clinical investigations showed that chronic liver disease associated with neurological symptoms including anxiety, depression, and cognitive decline. However, few therapeutic options are available for treating liver and related brain pathologies simultaneously. In this study, we aim to find therapeutic candidates that target the liver-brain axis...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855757/editorial-women-in-obstetric-and-pediatric-pharmacology-2023
#64
EDITORIAL
Ariela Hoxha, Nicoletta Mainini, Silvia Visentin
No abstract text is available yet for this article.
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855756/the-use-and-potential-abuse-of-psychoactive-plants-in-southern-africa-an-overview-of-evidence-and-future-potential
#65
REVIEW
Norman Zimunda Nyazema, Jonathan Tinotenda Chanyandura, Bronwyn Egan
BACKGROUND: Most Bantu ethnic groups in southern Africa utilize indigenous herbal medicines, some of which have psychoactive properties. Traditional medical practitioners (TMPs) commonly use them not only for divinatory purposes but to treat and manage mental and other illnesses. Unfortunately, the research on their results, risks, and benefits do not align. Little is known about their potential abuse among TMPs and community members in southern Africa. Herbal medicines are complex because whole plants are sometimes used, unlike in other treatments which use only one active ingredient...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855755/the-influence-of-drug-induced-metabolic-enzyme-activity-inhibition-and-cyp3a4-gene-polymorphism-on-aumolertinib-metabolism
#66
JOURNAL ARTICLE
Feng Ye, Jinhuan Ni, Xinyue Li, Jing Wang, Jianchao Luo, Shiyu Wang, Xiaoyu Xu, Yunshan Zhong, Jianchang Qian, Zhongxiang Xiao
The purpose of this study is to clarify the drug interaction profile of aumolertinib, and the influence of CYP3A4 genetic polymorphism on aumolertinib metabolic characteristics. Through microsomal enzyme reactions, we screened 153 drugs and identified 15 that significantly inhibited the metabolism of aumolertinib. Among them, telmisartan and carvedilol exhibited potent inhibitory activities in rat liver microsomes (RLM) and human liver microsomes (HLM). In vivo , the pharmacokinetic parameters of aumolertinib, including AUC and Cmax , were significantly altered when co-administered with carvedilol, with a notable decrease in the clearance rate CLz/F ...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855754/application-and-challenge-of-pancreatic-organoids-in-therapeutic-research
#67
REVIEW
Jin Chen, Jin Lu, Shu-Na Wang, Chao-Yu Miao
The in-vivo non-human primate animal and in-vitro cell disease models play a crucial part in the study of the mechanisms underlying the occurrence and development of pancreatic diseases, but with increasingly prominent limitations with in-depth research. Organoids derived from human pluripotent and adult stem cells resemble human in-vivo organs in their cellular composition, spatial tissue structure and physiological function, making them as an advantageous research tool. Up until now, numerous human organoids, including pancreas, have been effectively developed, demonstrating significant potential for research in organ development, disease modeling, drug screening, and regenerative medicine...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855753/dorsomorphin-attenuates-abcg2-mediated-multidrug-resistance-in-colorectal-cancer
#68
JOURNAL ARTICLE
Xiao-Peng Li, Liang-Qi Cao, Ze-Zhong Yu, Ke He, Peng-Bo Ding, Ji-Sheng Li, Yi-Yao Shan, Yu-Bin Su, Zhong-Min Yuan, Zhi Shi
Colorectal cancer is a common malignant tumor with high mortality, for which chemotherapy resistance is one of the main reasons. The high expression of ABCG2 in the cancer cells and expulsion of anticancer drugs directly cause multidrug resistance (MDR). Therefore, the development of new ABCG2 inhibitors that block the active causes of MDR may provide a strategy for the treatment of colorectal cancer. In this study, we find that dorsomorphin (also known as compound C or BML-275) potently inhibits the transporter activity of ABCG2, thereby preserving the chemotherapeutic agents mitoxantrone and doxorubicin to antagonize MDR in ABCG2-overexpressing colorectal cancer cells...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855752/phytotherapeutic-options-for-the-treatment-of-epilepsy-pharmacology-targets-and-mechanism-of-action
#69
REVIEW
Abdul Waris, Ata Ullah, Muhammad Asim, Rafi Ullah, Md Rafe Rajdoula, Stephen Temitayo Bello, Fahad A Alhumaydhi
Epilepsy is one of the most common, severe, chronic, potentially life-shortening neurological disorders, characterized by a persisting predisposition to generate seizures. It affects more than 60 million individuals globally, which is one of the major burdens in seizure-related mortality, comorbidities, disabilities, and cost. Different treatment options have been used for the management of epilepsy. More than 30 drugs have been approved by the US FDA against epilepsy. However, one-quarter of epileptic individuals still show resistance to the current medications...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855751/effect-of-a-high-dose-atorvastatin-as-added-on-therapy-on-symptoms-and-serum-ampk-nlrp3-inflammasome-and-il-6-stat3-axes-in-patients-with-major-depressive-disorder-randomized-controlled-clinical-study
#70
JOURNAL ARTICLE
Khlood Mohammad Aldossary, Lashin Saad Ali, Mahmoud S Abdallah, Mostafa M Bahaa, Thanaa A Elmasry, Eman I Elberri, Fedaa A Kotkata, Ramy M El Sabaa, Yasmine M Elmorsi, Mostafa M Kamel, Walaa A Negm, Aya Ibrahim Elberri, Amir O Hamouda, Hayam Ali AlRasheed, Muhammed M Salahuddin, Mohamed Yasser, Manal A Hamouda
BACKGROUND: Neuroinflammation pathways have been associated with the development of major depressive disorders (MDD). The anti-inflammatory characteristics of statins have been demonstrated to have significance in the pathophysiology of depression. AIM: To investigate the mechanistic pathways of high dose atorvastatin in MDD. PATIENTS AND METHODS: This trial included 60 patients with MDD who met the eligibility requirements. Two groups of patients (n = 30) were recruited by selecting patients from the Psychiatry Department...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855750/inducing-ferroptosis-by-traditional-medicines-a-novel-approach-to-reverse-chemoresistance-in-lung-cancer
#71
REVIEW
Yumin Wang, Jing Hu, Joshua S Fleishman, Yulin Li, Zhao Ren, Jinhua Wang, Yukuan Feng, Jichao Chen, Hongquan Wang
Lung cancer is the leading cause of global cancer-related deaths. Platinum-based chemotherapy is the first-line treatment for the most common type of lung cancer, i.e., non-small-cell lung cancer (NSCLC), but its therapeutic efficiency is limited by chemotherapeutic resistance. Therefore, it is vital to develop effective therapeutic modalities that bypass the common molecular mechanisms associated with chemotherapeutic resistance. Ferroptosis is a form of non-apoptotic regulated cell death characterized by iron-dependent lipid peroxidation (LPO)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855749/natural-compound-alternol-exerts-a-broad-anti-cancer-spectrum-and-a-superior-therapeutic-safety-index-in-vivo
#72
JOURNAL ARTICLE
Chenchen He, Linlin Ma, Jeff Hirst, Fei Li, Hao Wu, Wang Liu, Jiang Zhao, Feng Xu, Andrew K Godwin, Xiangwei Wang, Benyi Li
INTRODUCTION: Alternol is a natural compound isolated from the fermentation of a mutated fungus. We have demonstrated its potent anti-cancer effect via the accumulation of radical oxygen species (ROS) in prostate cancer cells in vitro and in vivo . In this study, we tested its anti-cancer spectrum in multiple platforms. METHODS: We first tested its anti-cancer spectrum using the National Cancer Institute-60 (NCI-60) screening, a protein quantitation-based assay...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855748/global-research-status-and-trends-of-enteric-glia-a-bibliometric-analysis
#73
JOURNAL ARTICLE
Huai-Yu Li, Wei-Xin Yan, Jia Li, Jing Ye, Zhi-Guo Wu, Zheng-Kun Hou, Bin Chen
BACKGROUND: Enteric glia are essential components of the enteric nervous system. Previously believed to have a passive structural function, mounting evidence now suggests that these cells are indispensable for maintaining gastrointestinal homeostasis and exert pivotal influences on both wellbeing and pathological conditions. This study aimed to investigate the global status, research hotspots, and future directions of enteric glia. METHODS: The literature on enteric glia research was acquired from the Web of Science Core Collection...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855747/insights-into-the-voltage-gated-sodium-channel-na-v-1-8-and-its-role-in-visceral-pain-perception
#74
REVIEW
J Westley Heinle, Shannon Dalessio, Piotr Janicki, Ann Ouyang, Kent E Vrana, Victor Ruiz-Velasco, Matthew D Coates
Pain is a major issue in healthcare throughout the world. It remains one of the major clinical issues of our time because it is a common sequela of numerous conditions, has a tremendous impact on individual quality of life, and is one of the top drivers of cost in medicine, due to its influence on healthcare expenditures and lost productivity in those affected by it. Patients and healthcare providers remain desperate to find new, safer and more effective analgesics. Growing evidence indicates that the voltage-gated sodium channel Nav 1...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855746/can-chinese-herbal-medicine-offer-feasible-solutions-for-newly-diagnosed-esophageal-cancer-patients-with-malnutrition-a-multi-institutional-real-world-study
#75
JOURNAL ARTICLE
Yi-Chin Lu, Liang-Wei Tseng, Chiao-En Wu, Ching-Wei Yang, Tsung-Hsien Yang, Hsing-Yu Chen
BACKGROUND: Esophageal cancer (EC) is a major cause of cancer-related mortality in Taiwan and globally. Patients with EC are highly prone to malnutrition, which adversely affects their prognosis. While Chinese herbal medicine (CHM) is commonly used alongside conventional anti-cancer treatments, its long-term impact on EC patients with malnutrition remains unclear. METHODS: This study utilized a multi-center cohort from the Chang Gung Research Database, focusing on the long-term outcomes of CHM in EC patients with malnutrition between 1 January 2001, and 31 December 2018...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855745/-bacillus-coagulans-and-clostridium-butyricum-synergistically-alleviate-depression-in-a-chronic-unpredictable-mild-stress-mouse-model-through-altering-gut-microbiota-and-prefrontal-cortex-gene-expression
#76
JOURNAL ARTICLE
Jingyi Xu, Lei Zhou, Zhaowei Chen, Yuezhu Wang, Fang Xu, Qun Kuang, Yixuan Zhang, Huajun Zheng
Introduction: The prevalence of major depressive disorder (MDD) has gradually increased and has attracted widespread attention. The aim of this study was to investigate the effect of a probiotic compound consisting of Bacillus coagulans and Clostridium butyricum , on a mouse depression model. Methods: Mice were subjected to chronic unpredictable mild stress (CUMS) and then treated with the probiotics at different concentrations. And mice received behavior test such as forced swimming test and tail suspension test...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855744/functionalized-nanoparticles-to-deliver-nucleic-acids-to-the-brain-for-the-treatment-of-alzheimer-s-disease
#77
REVIEW
Chinenye Edith Muolokwu, Bivek Chaulagain, Avinash Gothwal, Arun Kumar Mahanta, Benjamin Tagoe, Babita Lamsal, Jagdish Singh
Brain-targeted gene delivery across the blood-brain barrier (BBB) is a significant challenge in the 21st century for the healthcare sector, particularly in developing an effective treatment strategy against Alzheimer's disease (AD). The Internal architecture of the brain capillary endothelium restricts bio-actives entry into the brain. Additionally, therapy with nucleic acids faces challenges like vulnerability to degradation by nucleases and potential immune responses. Functionalized nanocarrier-based gene delivery approaches have resulted in safe and effective platforms...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855743/erratum-preemptive-use-of-anti-inflammatories-and-analgesics-in-oral-surgery-a-review-of-systematic-reviews
#78
(no author information available yet)
[This corrects the article DOI: 10.3389/fphar.2023.1303382.].
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855742/overlooking-the-obvious-the-importance-of-communicating-safety-and-risks-of-opioids-the-israeli-context
#79
JOURNAL ARTICLE
Maram Khazen, Shelly Kamin-Friedman
No abstract text is available yet for this article.
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38855741/amino-acid-metabolomics-and-machine-learning-for-assessment-of-post-hepatectomy-liver-regeneration
#80
JOURNAL ARTICLE
Yuqing Yan, Qianping Chen, Xiaoming Dai, Zhiqiang Xiang, Zhangtao Long, Yachen Wu, Hui Jiang, Jianjun Zou, Mu Wang, Zhu Zhu
OBJECTIVE: Amino acid (AA) metabolism plays a vital role in liver regeneration. However, its measuring utility for post-hepatectomy liver regeneration under different conditions remains unclear. We aimed to combine machine learning (ML) models with AA metabolomics to assess liver regeneration in health and non-alcoholic steatohepatitis (NASH). METHODS: The liver index (liver weight/body weight) was calculated following 70% hepatectomy in healthy and NASH mice. The serum levels of 39 amino acids were measured using ultra-high performance liquid chromatography-tandem mass spectrometry analysis...
2024: Frontiers in Pharmacology
journal
journal
43343
4
5
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.