journal
https://read.qxmd.com/read/38783958/investigation-of-the-molecular-mechanism-of-smilax-glabra-roxb-in-treating-hypertension-based-on-proteomics-and-bioinformatics
#41
JOURNAL ARTICLE
Xin Yang, Haibing Qian, Changfu Yang, Zhiyuan Zhang
BACKGROUND: Smilax glabra Roxb. (named tufuling in Chinese, SGR) has both medicinal and edible value. SGR has obvious pharmacological activity, especially in anti-inflammation and treating immune system diseases. This study investigated differential protein expression and its relationship with immune infiltration in hypertension treated with SGR using proteomics and bioinformatics. METHODS: N-Nitro L-arginine methyl ester (L-NAME) was used to replicate the hypertension model, with SGR administered by gavage for 4 weeks, and the systolic and diastolic blood pressure in each group of rats was measured using the tail-cuff method every 7 days...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783957/experimental-and-computational-study-on-anti-gastric-cancer-activity-and-mechanism-of-evodiamine-derivatives
#42
JOURNAL ARTICLE
Jingli Liu, Yingying Xue, Kaidi Bai, Fei Yan, Xu Long, Hui Guo, Hao Yan, Guozheng Huang, Jing Zhou, Yuping Tang
Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer compounds. The design and discovery of inhibitors targeting TOP1 are of great significance for the development of anticancer drugs. Evodiamine and thieno [2,3-d] pyridine hybrids show potential antitumor activity. Herein, the anti-gastric cancer activities of these hybrids were investigated. Methods: The inhibitory effects of different concentrations of ten evodiamine derivatives on the gastric cancer cell line SGC-7901 were assessed using a methyl thiazolyl tetrazolium assay...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783956/a-chinese-classical-prescription-maimendong-decoction-in-treatment-of-pulmonary-fibrosis-an-overview
#43
REVIEW
Qiurong Lao, Xianbin Wang, Guangqing Zhu, Haochen Yuan, Ting Ma, Ning Wang
Pulmonary fibrosis (PF) is a chronic and progressive disease characterized by fibrosis and interstitial pneumonia. It has similar clinical symptoms to "Fei Bi" and "Fei Wei" as described in the traditional Chinese medicine (TCM) classic Jingui Yaolue written by Zhang Zhongjing in the Han Dynasty. This study explored the potential of Maimendong Decoction (MMDD). MMDD consists of Ophiopogon japonicus (L.f) ( ophiopogonis ), Pinellia ternata (Thunb.) Breit. ( pinellia ), Panax ginseng C. A. Mey. ( ginseng ), Glycyrrhiza uralensis Fisch...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783955/treatment-of-colorectal-cancer-by-traditional-chinese-medicine-prevention-and-treatment-mechanisms
#44
REVIEW
Jiaxin Sun, Ying Wei, Jia Wang, Mingxing Hou, Liya Su
Colorectal cancer (CRC) is a significant global health burden, with high morbidity and mortality rates. It is often diagnosed at middle to advanced stage, affecting approximately 35% of patients at the time of diagnosis. Currently, chemotherapy has been used to improve patient prognosis and increase overall survival. However, chemotherapy can also have cytotoxic effects and lead to adverse reactions, such as inhibiting bone marrow hematopoiesis, causing digestive dysfunction, hand-foot syndrome, and even life-threatening conditions...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783954/safety-and-efficacy-evaluation-of-halicin-as-an-effective-drug-for-inhibiting-intestinal-infections
#45
JOURNAL ARTICLE
Maolu Zhang, Shuqian Lin, Lianquan Han, Jiaming Zhang, Shaoning Liu, Xiuzhen Yang, Ruiming Wang, Xiaohui Yang, Yunpeng Yi
Halicin, the first antibacterial agent discovered by artificial intelligence, exerts broad-spectrum antibacterial effects and has a unique structure. Our study found that halicin had a good inhibitory effect on clinical isolates of drug-resistant strains and Clostridium perfringens ( C. perfringens ). The safety of halicin was evaluated by acute oral toxicity, genotoxicity and subchronic toxicity studies. The results of acute toxicity test indicated that halicin, as a low-toxicity compound, had an LD50 of 2018...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783953/improving-prediction-of-tacrolimus-concentration-using-a-combination-of-population-pharmacokinetic-modeling-and-machine-learning-in-chinese-renal-transplant-recipients
#46
JOURNAL ARTICLE
Yu-Ping Wang, Xiao-Ling Lu, Kun Shao, Hao-Qiang Shi, Pei-Jun Zhou, Bing Chen
AIMS: The population pharmacokinetic (PPK) model-based machine learning (ML) approach offers a novel perspective on individual concentration prediction. This study aimed to establish a PPK-based ML model for predicting tacrolimus (TAC) concentrations in Chinese renal transplant recipients. METHODS: Conventional TAC monitoring data from 127 Chinese renal transplant patients were divided into training (80%) and testing (20%) datasets. A PPK model was developed using the training group data...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783952/inhibition-of-the-naja-naja-venom-toxicity-by-polymeric-nanoparticles-loaded-with-leucas-aspera-methanolic-extract
#47
JOURNAL ARTICLE
Priyanka Singh, Gurunathan Jayaraman
BACKGROUND: Snakebite is a neglected tropical disease that affects millions of people worldwide. Developing effective treatments can make a significant contribution to global health efforts and public health initiatives. To reduce mortality due to snakebite, there is an immediate need to explore novel and effective treatment methodologies. In that context, nanoparticle-based drug delivery is gaining a lot of attention. Hydrophilic nanoparticles are suitable for the delivery of therapeutic peptides, proteins, and antigens...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783951/assessing-the-safety-of-bedaquiline-insight-from-adverse-event-reporting-system-analysis
#48
JOURNAL ARTICLE
Jiaqiang Wu, Hong Pan, Li Shen, Mingyi Zhao
BACKGROUND: The development and marketing of Bedaquiline (BDQ) represent significant advancements in treating tuberculosis, particularly multidrug-resistant forms. However, comprehensive research into BDQ's real-world safety remains limited. PURPOSE: We obtained BDQ related adverse event (AE) information from the US Food and Drug Administration's Adverse Event Reporting System (FAERS) to assess its safety and inform drug usage. METHODS: The AE data for BDQ from 2012 Q4 to 2023 Q3 was collected and standardized...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783950/exploring-the-therapeutic-opportunities-of-potassium-channels-for-the-treatment-of-rheumatoid-arthritis
#49
REVIEW
Nikhil Eknath More, Rahul Mandlik, Sandip Zine, Vaibhavkumar S Gawali, Angel Pavalu Godad
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the synovial joint, which leads to inflammation, loss of function, joint destruction, and disability. The disease biology of RA involves complex interactions between genetic and environmental factors and is strongly associated with various immune cells, and each of the cell types contributes differently to disease pathogenesis. Several immunomodulatory molecules, such as cytokines, are secreted from the immune cells and intervene in the pathogenesis of RA...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783949/therapeutic-potential-of-berries-in-age-related-neurological-disorders
#50
REVIEW
Narges Norouzkhani, Shaghayegh Afshari, Sayedeh-Fatemeh Sadatmadani, Mohammad Mahdi Mollaqasem, Shakila Mosadeghi, Hani Ghadri, Safa Fazlizade, Keyvan Alizadeh, Pouyan Akbari Javar, Hamidreza Amiri, Elaheh Foroughi, Arina Ansari, Kourosh Mousazadeh, Bozorgmehr Abdullahzadeh Davany, Ata Akhtari Kohnehshahri, Alaleh Alizadeh, Parisa Alsadat Dadkhah, Mohadeseh Poudineh
Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer's, Parkinson's, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783948/post-marketing-safety-concerns-with-lumateperone-a-pharmacovigilance-analysis-based-on-the-fda-adverse-event-reporting-system-faers-database
#51
JOURNAL ARTICLE
Dan Zhao, Wangxin Zhang, Yan Liu, Zhaojun Yan
OBJECTIVE: Lumateperone, a novel antipsychotic drug that was granted by the Food and Drug Administration (FDA) approval in December 2019, remains insufficiently explored for its adverse event profile. This study used the FDA Adverse Event Reporting System (FAERS) database to explore its potential safety issues. METHODS: This study conducted a retrospective analysis of FAERS data from the fourth quarter of 2019 to the third quarter of 2023, extracting reports related to lumateperone...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783947/vitamin-d-level-in-covid-19-patients-has-positive-correlations-with-autophagy-and-negative-correlations-with-disease-severity
#52
JOURNAL ARTICLE
Hongna Dong, Yuqiu Hao, Peng Gao
BACKGROUND AND OBJECTIVES: There is still incomplete understanding of the pathogenesis of COVID-19. Calcitriol, the main form of vitamin D in serum, regulates immune responses and increases resistance to pathogens, but the mechanism by which it protects against COVID-19 is uncertain. Autophagy has antiviral effects and helps to maintain homeostasis, but its specific role in COVID-19 is also uncertain. Both vitamin D and autophagy have important functions in the lung microenvironment. This study examined the relationship of serum vitamin D and autophagy-related proteins in patients with COVID-19 and evaluated their potential use as biomarkers...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783946/clinical-endoscopic-pathological-characteristics-and-management-of-cap-polyposis-experience-from-a-tertiary-hospital-in-china
#53
JOURNAL ARTICLE
Yi Lu, Lingyu Huang, Xiaoying Lou, Chunyu Chen, Jiachen Sun
BACKGROUND AND AIMS: Cap polyposis (CP) is a rare kind of benign disease, and the majority of previously published relevant articles involve a small number of patients. Hence, we summarized our experience to contribute additional data, hoping to raise awareness of this disease. METHODS: From 1 January 2017 to 1 November 2021, consecutive patients diagnosed with CP were retrospectively reviewed. Their medical histories, and laboratory, imaging, endoscopic, and pathology results were analyzed...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783945/comprehensive-evaluation-of-dragon-s-blood-in-combination-with-borneol-in-ameliorating-ischemic-reperfusion-brain-injury-using-rna-sequencing-metabolomics-and-16s-rrna-sequencing
#54
JOURNAL ARTICLE
Jiahui Ren, Xue Zhang, Lingjuan Zhou, Wanyu Cao, Lixia Zhang, Xi Chen, Guang Li
Ischemia/reperfusion (IR) can induce deleterious responses such as apoptosis, inflammation, and oxidative stress; however, there are currently no efficient therapeutics to treat IR brain injury. Dragon's blood (DB) plays a significant role in treating ischemic stroke in China. Borneol (B) is an upper ushering drug that guides drugs to the target organs, including the brain. Therefore, we hypothesized that the combination of DB and B (DB + B) would provide cooperative therapeutic benefits for IR brain injury...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783944/application-of-immune-checkpoint-inhibitors-for-resectable-gastric-gastroesophageal-cancer
#55
REVIEW
Feizhi Lin, Yongming Chen, Bowen Huang, Shenghang Ruan, Jun Lin, Zewei Chen, Chunyu Huang, Baiwei Zhao
Gastric/gastroesophageal junction (G/GEJ) cancer represents a significant global health challenge. Radical surgery remains the cornerstone of treatment for resectable G/GEJ cancer. Supported by robust evidence from multiple clinical studies, therapeutic approaches, including adjuvant chemotherapy or chemoradiation, and perioperative chemotherapy, are generally recommended to reduce the risk of recurrence and enhance long-term survival outcomes post-surgery. In recent years, immune checkpoint inhibitors (ICIs) have altered the landscape of systemic treatment for advanced or metastatic G/GEJ cancer, becoming the standard first-line therapy for specific patients...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783943/the-therapeutic-effect-of-traditional-chinese-medicine-on-breast-cancer-through-modulation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#56
REVIEW
Hongkun Li, Jiawei Li, Yifan Zhang, Chengcheng Zhao, Jun Ge, Yujiao Sun, Hui Fu, Yingpeng Li
Breast cancer, the most prevalent malignant tumor among women globally, is significantly influenced by the Wnt/β-catenin signaling pathway, which plays a crucial role in its initiation and progression. While conventional chemotherapy, the standard clinical treatment, suffers from significant drawbacks like severe side effects, high toxicity, and limited prognostic efficacy, Traditional Chinese Medicine (TCM) provides a promising alternative. TCM employs a multi-targeted therapeutic approach, which results in fewer side effects and offers a high potential for effective treatment...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783942/protective-effect-of-cinnamon-extract-against-cobalt-induced-multiple-organ-damage-in-rats
#57
JOURNAL ARTICLE
Bahar Isik, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Bulent Yavuzer, Durdu Altuner, Taha Abdulkadir Coban, Halis Suleyman
BACKGROUND: The role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus of previous studies. Cinnamon and its main components have been reported to have protective effects in various tissues with antioxidant and anti-inflammatory effects. AIMS: In this study, the protective effect of cinnamon extract (CE) against possible Co-induced heart, kidney, and liver damage in rats was investigated biochemically. METHODS: Eighteen albino Wistar -type male rats were categorized into three groups ( n = 6 per group): control (CG), CoCL2 -administered (CoCL2 ), and CE + CoCL2 -administered (CE + Co) groups...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783941/variables-affecting-new-drug-prices-in-south-korea-s-pricing-system
#58
JOURNAL ARTICLE
Dong Yun Lee, Seong Ha Cho, Da Hye Lee, Su Jeong Kang, Jong Hyuk Lee
Objective: The price of pharmaceuticals is important from the economic and industrial perspectives but as well as patients' access to treatment. This study aimed to analyze the variables affecting the prices of new drugs in South Korea's pricing system. Methods: Data on 192 new drugs listed in South Korea from 2012 to 2022 were collected from the official website of the Health Insurance Review and Assessment Service. The independent variables included drugs for severe diseases, alternatives, number of patients, number of advanced 7 countries listed, budget impact, and listing period...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783940/application-and-potential-value-of-curcumin-in-prostate-cancer-a-meta-analysis-based-on-animal-models
#59
Shiheng Wang, Fengxia Zhang, Jing Chen
INTRODUCTION: Curcumin is gaining recognition as an agent for cancer chemoprevention and is presently administered to humans. However, the limited number of clinical trials conducted for the treatment of prostate cancer is noteworthy. Animal models serve as valuable tools for enhancing our understanding of disease mechanisms and etiology in humans. The objective of this study was to examine the anti-prostate cancer effects of curcumin in vivo for comprehending its current research status and potential clinical applicability...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38783939/new-insights-into-the-potential-cardioprotective-effects-of-telmisartan-and-nanoformulated-extract-of-spirulina-platensis-via-regulation-of-oxidative-stress-apoptosis-and-autophagy-in-an-experimental-model
#60
JOURNAL ARTICLE
May Almukainzi, Thanaa A El-Masry, Hanaa A Ibrahim, Hebatallah M Saad, Enas I El Zahaby, Asmaa Saleh, Maysa M F El-Nagar
BACKGROUND: Cardiotoxicity is one of the limiting side effects of the commonly used anticancer agent cyclophosphamide (Cyclo). MATERIALS AND METHODS: The possible protective effects of telmisartan and nanoformulated Spirulina platensis (Sp) methanolic extract against Cyclo-induced cardiotoxicity were examined in this study. Experimental groups of rats were randomly divided into nine groups as control vehicle, control polymer, telmisartan (TEL, 10 mg/kg), free Sp extract (300 mg/kg), nano Sp extract (100 mg/kg), Cyclo (200 mg/kg), TEL + Cyclo, free Sp + Cyclo, and nano Sp + Cyclo...
2024: Frontiers in Pharmacology
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