journal
https://read.qxmd.com/read/38601468/effect-of-uric-acid-reduction-on-chronic-kidney-disease-systematic-review-and-meta-analysis
#21
Alfredo G Casanova, Ana I Morales, Laura Vicente-Vicente, Francisco J López-Hernández
Accumulating evidence suggests that hyperuricemia is a pathological factor in the development and progression of chronic kidney disease. However, the potential benefit afforded by the control of uric acid (UA) is controversial. Individual studies show discrepant results, and most existing meta-analysis, especially those including the larger number of studies, lack a placebo or control group as they aim to compare efficacy between drugs. On these grounds, we performed a me-ta-analysis restricted to studies including the action of any anti-gout therapies referenced to a control or placebo arm...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601467/does-preterm-birth-increase-the-initiation-of-antidepressant-use-during-the-postpartum-a-population-based-investigation
#22
JOURNAL ARTICLE
Giovanna Esposito, Anna Cantarutti, Angela Lupattelli, Matteo Franchi, Giovanni Corrao, Fabio Parazzini
BACKGROUND: Preterm birth may affect maternal mental health. We explored the relationship between preterm birth and the risk of initiating antidepressant use during the year after birth. METHODS: We conducted a population-based investigation using regional healthcare utilization databases. The exposure considered was preterm birth. The outcome was having at least one prescription for antidepressant medications during the year after birth. We used a log-binomial regression model including terms for maternal age at birth, nationality, educational level, parity, modality of conception, modality of delivery, use of other psychotropic drugs, and diabetes to estimate relative risk (RR) and 95% confidence intervals (CI) for the association between preterm birth and the initiation of antidepressant use...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601466/patient-experience-of-medication-administration-and-development-of-a-patient-experience-and-preference-questionnaire-pepq-for-patients-with-advanced-or-metastatic-cancer
#23
JOURNAL ARTICLE
Anne Skalicky, Bryan Bennett, Judith Raimbourg, Sara Lonardi, Julia Correll, Iwona Lugowska, Matthew Dixon, Nashmel Sargalo, Mona L Martin
Introduction: A better understanding of patient experience of intravenous (IV) or subcutaneous (SC) routes of administration is fundamental to providing optimal administration of medical therapies to oncology patients. The objective of this study was to examine patient experiences of IV and SC treatment with nivolumab and confirm the relevance of item concepts in the Patient Experience and Preference Questionnaire (PEPQ). The PEPQ is a clinical outcomes' assessment instrument developed to obtain patient-centric data and understand the experience with IV and SC treatment administration...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601465/phloretic-acid-requires-the-insulin-igf-1-pathway-and-autophagy-to-enhance-stress-resistance-and-extend-the-lifespan-of-caenorhabditis-elegans
#24
JOURNAL ARTICLE
Bo Li, Li Dong, Wei Meng, Shi-Ying Xiong, Gui-Sheng Wu, Wen-Zhe Ma, Huai-Rong Luo
Objective: In humans, aging is associated with increased susceptibility to most age-related diseases. Phloretic acid (PA), a naturally occurring compound found in Ginkgo biloba and Asparagus, exhibits has potential as an anti-aging agent and possesses antioxidant, anti-inflammatory, and immunomodulatory properties. This study aimed to investigate the effects of PA on longevity and stress resistance in Caenorhabditis elegans ( C.elegans ) and the mechanisms that underlie its effects. Methods: First, we examined the effects of PA on lifespan and healthspan assay, stress resistance and oxidative analysis, lipofuscin levels...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601464/comparison-of-the-therapeutic-effects-of-mesenchymal-stem-cells-derived-from-human-dental-pulp-dp-adipose-tissue-ad-placental-amniotic-membrane-pm-and-umbilical-cord-uc-on-postmenopausal-osteoporosis
#25
JOURNAL ARTICLE
Chuncai Li, Yincong Liu, Mingxing Deng, Jun Li, Shengqi Li, Xiaoyu Li, Yuling Zuo, Chongyang Shen, Yichao Wang
Background: Osteoporosis is a systemic bone disease characterized by bone loss and microstructural degeneration. Recent preclinical and clinical trials have further demonstrated that the transplantation of mesenchymal stem cells (MSCs) derived from human adipose tissue (AD), dental pulp (DP), placental amniotic membrane (AM), and umbilical cord (UC) tissues can serve as an effective form of cell therapy for osteoporosis. However, MSC-mediated osteoimmunology and the ability of these cells to regulate osteoclast-osteoblast differentiation varies markedly among different types of MSCs...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601463/advancements-in-research-on-the-immune-inflammatory-mechanisms-mediated-by-nlrp3-inflammasome-in-ischemic-stroke-and-the-regulatory-role-of-natural-plant-products
#26
REVIEW
Kailin Yang, Liuting Zeng, Qi He, Shanshan Wang, Hao Xu, Jinwen Ge
Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization of blood vessels to facilitate timely reperfusion is the primary clinical approach; however, reperfusion itself may trigger cerebral ischemia-reperfusion injury. Emerging evidence strongly implicates the NLRP3 inflammasome as a potential therapeutic target, playing a key role in cerebral ischemia and reperfusion injury. The aberrant expression and function of NLRP3 inflammasome-mediated inflammation in cerebral ischemia have garnered considerable attention as a recent research focus...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601462/detection-of-iodixanol-induced-allergic-reaction-signals-in-chinese-inpatients-a-multi-center-retrospective-database-study-using-prescription-sequence-symmetry-analysis
#27
JOURNAL ARTICLE
Dandan Zhang, Xinchen Yang, Zhangwei Yang, Wei Sun, Shunjie Chen, Lingxiao Xu
OBJECTIVE: This study aimed to explore the signal detection method for allergic reactions induced by inpatient iodixanol injection. METHODS: A database of 3,719,217 hospitalized patients from 20 large Chinese general hospitals was processed and analyzed using the prescription sequence symmetry analysis (PSSA) method. RESULTS: 126,680 inpatients who used iodixanol and were concurrently treated with anti-allergic drugs were analyzed. In the medical records of these patients, only 32 had documented iodixanol allergies...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601461/functional-roles-of-circular-rnas-in-lung-injury
#28
REVIEW
Fei-Fei Gao, Dian-Qing Chen, Yue-Tong Jiang, Cui-Fei Han, Bi-Yun Lin, Zhan Yang, Juan-Hua Quan, Ying-Huan Xiong, Xin-Tian Chen
Lung injury leads to respiratory dysfunction, low quality of life, and even life-threatening conditions. Circular RNAs (circRNAs) are endogenous RNAs produced by selective RNA splicing. Studies have reported their involvement in the progression of lung injury. Understanding the roles of circRNAs in lung injury may aid in elucidating the underlying mechanisms and provide new therapeutic targets. Thus, in this review, we aimed to summarize and discuss the characteristics and biological functions of circRNAs, and their roles in lung injury from existing research, to provide a theoretical basis for the use of circRNAs as a diagnostic and therapeutic target for lung injury...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601460/effect-of-long-term-inorganic-nitrate-administration-on-myocardial-ischemia-reperfusion-injury-in-ovariectomized-rats
#29
JOURNAL ARTICLE
Sajad Jeddi, Nasibeh Yousefzadeh, Maryam Zarkesh, Khosrow Kashfi, Asghar Ghasemi
Introduction: Menopause is associated with reduced nitric oxide (NO) bioavailability and lower tolerance against myocardial ischemia-reperfusion (IR) injury. This study investigated whether long-term nitrate administration provides resistance against myocardial IR injury in ovariectomized (OVX) rats. Method: After ovariectomy, female rats were assigned to the OVX and the OVX + nitrate groups ( n = 14/group); the latter group consumed nitrate (100 mg/L) for 9 months. At month 9, each group was divided into two subgroups ( n = 7/subgroup), of which one subgroup was exposed to myocardial IR (IR+ hearts) and the other was not exposed (IR- hearts)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595925/optimum-programmed-intermittent-epidural-bolus-interval-time-of-ropivacaine-0-0625-with-dexmedetomidine-0-4%C3%A2-%C3%AE-g-ml-at-a-fixed-volume-of-10%C3%A2-ml-a-randomized-controlled-trial
#30
JOURNAL ARTICLE
Zhong Mei, Qingtao Wang, Shaobo Song, Wenying Lu, Jing Yu
BACKGROUND: The aim of our study was to administer adequate local anesthetic in programmed intermittent epidural bolus (PIEB) to avoid breakthrough pain and decrease the use of manual and PCEA boluses. We, therefore, conducted this study to determine the effective PIEB interval time between boluses of ropivacaine 0.0625% with dexmedetomidine 0.4 μg/ml at a fixed volume of 10 mL in 90% of subjects (EI90 ), without the use of patient-controlled epidural analgesia (PCEA)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595924/design-and-synthesis-of-novel-dihydropyridine-and-benzylideneimine-based-tyrosinase-inhibitors
#31
JOURNAL ARTICLE
Ifraz Ahmad, Warda Parveen, Shah Noor, Zahoor Udin, Amjad Ali, Ijaz Ali, Riaz Ullah, Hamid Ali
Tyrosinase (TYR) inhibitors are very significant as they inhibit enzyme tyrosinase activity, and its inhibition is vital for skin care, anticancer medication, and antibrowning of fruits and vegetables. This work presents a novel and economical route for the preparation of new synthetic tyrosinase inhibitors using amlodipine (4) . The novel conjugates 6 (a-o) were designed, synthesized, and characterized by spectroscopic analyses, including Fourier transform infrared and low- and high-resolution mass spectroscopy...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595923/cost-effectiveness-of-immune-checkpoint-inhibitors-in-treating-metastatic-urothelial-cancer
#32
JOURNAL ARTICLE
Li-Yu Yang, Jian-Ri Li, Chuan-Shu Chen, Chen-Li Cheng, Sheng-Chun Hung, Kun-Yuan Chiu, Cheng-Kuang Yang, Chiann-Yi Hsu, Shian-Shiang Wang
Objectives: Immune checkpoint inhibitor (ICI) is an important treatment option for metastatic urothelial carcinoma (mUC) patients. A lot of clinical evidence proved the survival benefits of ICI, but cost-effectiveness of the treatment remains unclear. This study evaluates the cost-effectiveness of the ICIs treatment in different sequences among mUC patients. Methods: We retrospectively analyzed mUC patients who had been treated at our hospital between January 2016 and December 2020. These patients received chemotherapy with or without ICI treatment (Pembrolizumab, Atezolizumab, Nivolumab, Durvalumab, or Avelumab)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595922/editorial-the-pharmacotherapy-of-depression-searching-for-new-mechanisms-and-drug-interactions-basic-and-clinical-research-volume-ii
#33
EDITORIAL
Katarzyna Stachowicz, Magdalena Sowa-Kućma, Anna Tabecka-Łonczyńska
No abstract text is available yet for this article.
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595921/inhibition-of-acox1-enhances-the-therapeutic-efficacy-of-obeticholic-acid-in-treating-non-alcoholic-fatty-liver-disease-and-mitigates-its-lipotoxicity
#34
JOURNAL ARTICLE
Yuping Yang, Weinan Yuan, Kun He, Chuangzhen Lin, Shenshen Du, Yanqi Kou, Biao Nie
BACKGROUND AND AIMS: High-dose Obeticholic acid exhibits promise for non-alcoholic fatty liver disease (NAFLD) treatment but can induce lipotoxicity. Our study sought to understand this mechanism and propose a solution. APPROACH AND RESULTS: In a non-alcoholic fatty liver disease (NAFLD) model induced by a high-fat diet in FXR-/- mice, we pinpointed that FXR regulated the expression of ACOX1 through RNA-Seq analysis. In the livers of FXR-/- mice, both ACOX1 mRNA and protein expression notably decreased...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595920/estimating-preferences-and-willingness-to-pay-for-pharmacogenetic-testing-in-populations-who-are-medically-underserved-a-discrete-choice-experiment
#35
JOURNAL ARTICLE
Brian E Gawronski, Ramzi G Salloum, Julio D Duarte
Background: The implementation of pharmacogenetic (PGx) testing may contribute to health disparities if access to testing is inequitable, as medically underserved patients are prescribed higher rates of drugs with PGx guidelines and often experience the benefits of emerging health technologies last. Limited research has evaluated potential implementation of PGx testing in populations who are medically underserved and none have evaluated their preferences regarding PGx test characteristics and cost. Our study endeavored to assess the willingness to pay for PGx testing and key PGx test preferences in a nationwide cohort of medically underserved respondents...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595919/quercetin-reshapes-gut-microbiota-homeostasis-and-modulates-brain-metabolic-profile-to-regulate-depression-like-behaviors-induced-by-cums-in-rats
#36
JOURNAL ARTICLE
Bozhi Li, Yuqi Yan, Tiange Zhang, Hanfang Xu, Xiaofeng Wu, Gaolei Yao, Xingze Li, Can Yan, Li-Li Wu
Quercetin, an abundant flavonoid compound in plants, is considered a novel antidepressant; however, its mechanisms of action are poorly understood. This study aimed to investigate the therapeutic effects of quercetin on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors in rats and explore the underlying mechanisms by combining untargeted metabolomics and 16S rRNA sequencing analysis of brain tissue metabolites and gut microbiota. Gut microbiota analysis revealed that at the phylum level, quercetin reduced Firmicutes and the Firmicutes/Bacteroidetes (F/B) ratio and enhanced Cyanobacteria ...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595918/dosing-optimization-of-rituximab-for-primary-membranous-nephropathy-by-population-pharmacokinetic-and-pharmacodynamic-study
#37
JOURNAL ARTICLE
Hao Liang, Zhenling Deng, Shu Niu, Weijie Kong, Yang Liu, Song Wang, Haiyan Li, Yue Wang, Danxia Zheng, Dongyang Liu
Primary membranous nephropathy (PMN) is the most common cause for adult nephrotic syndrome. Rituximab has demonstrated promising clinical efficacy by random controlled trials and the off-label use is widely adopted in PMN. However, the standard dosage is borrowed from B cell lymphoma treatment with far more antigens and is oversaturated for PMN treatment, accompanied with additional safety risk and unnecessary medical cost. More than 15% serious adverse events were observed under standard dosage and low dose therapies were explored recently...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595917/the-effect-of-oral-butyrate-on-colonic-short-chain-fatty-acid-transporters-and-receptors-depends-on-microbial-status
#38
JOURNAL ARTICLE
Karla Vagnerová, Tomáš Hudcovic, Martin Vodička, Peter Ergang, Petra Klusoňová, Petra Petr Hermanová, Dagmar Šrůtková, Jiří Pácha
Butyrate, a metabolite produced by gut bacteria, has demonstrated beneficial effects in the colon and has been used to treat inflammatory bowel diseases. However, the mechanism by which butyrate operates remains incompletely understood. Given that oral butyrate can exert either a direct impact on the gut mucosa or an indirect influence through its interaction with the gut microbiome, this study aimed to investigate three key aspects: (1) whether oral intake of butyrate modulates the expression of genes encoding short-chain fatty acid (SCFA) transporters ( Slc16a1 , Slc16a3 , Slc16a4 , Slc5a8 , Abcg2 ) and receptors ( Hcar2 , Ffar2 , Ffar3 , Olfr78 , Olfr558 ) in the colon, (2) the potential involvement of gut microbiota in this modulation, and (3) the impact of oral butyrate on the expression of colonic SCFA transporters and receptors during colonic inflammation...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595916/pharmacological-enhancement-of-cholinergic-neurotransmission-alleviates-neuroinflammation-and-improves-functional-outcomes-in-a-triple-transgenic-mouse-model-of-alzheimer-s-disease
#39
JOURNAL ARTICLE
Antonio Munafò, Anna Flavia Cantone, Giulia Di Benedetto, Sebastiano Alfio Torrisi, Chiara Burgaletto, Carlo Maria Bellanca, Gabriella Gaudio, Giuseppe Broggi, Rosario Caltabiano, Gian Marco Leggio, Renato Bernardini, Giuseppina Cantarella
Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly population worldwide. Due to the multifactorial nature of the disease, involving impairment of cholinergic neurotransmission and immune system, previous attempts to find effective treatments have faced challenges. Methods: In such scenario, we attempted to investigate the effects of alpha-glyceryl-phosphoryl-choline (α-GPC), a cholinomimetic molecule, on neuroinflammation and memory outcome in the triple transgenic mouse model of AD (3xTg-AD)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38595915/unveiling-the-anticancer-effects-of-sglt-2i-mechanisms-and-therapeutic-potential
#40
REVIEW
Min Sun, Jilei Sun, Wei Sun, Xiaonan Li, Zhe Wang, Liwei Sun, Yuehui Wang
Cancer and diabetes are significant diseases that pose a threat to human health. Their interconnection is complex, particularly when they coexist, often necessitating multiple therapeutic approaches to attain remission. Sodium-glucose cotransporter protein two inhibitors (SGLT-2i) emerged as a treatment for hyperglycemia, but subsequently exhibited noteworthy extra-glycemic properties, such as being registered for the treatment of heart failure and chronic kidney disease, especially with co-existing albuminuria, prompting its assessment as a potential treatment for various non-metabolic diseases...
2024: Frontiers in Pharmacology
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