Li-Man Wang, Yan Chen, Li-Li Xu, Meng-Fei Dai, Yi-Jun Ke, Bao-Yan Wang, Lin Zhou, Ji-Fan Zhang, Zhang-Qi Wu, Yu-Jie Zhou, Zhi-Chun Gu, Hang Xu
Background: Percutaneous left atrial appendage occlusion (LAAO) has emerged as a stroke prevention strategy in patients with nonvalvular atrial fibrillation (NVAF), and these patients were required to receive antithrombotic therapy post-procedure. However, the optimal antithrombotic strategy after LAAO remains controversial. This study explored the safety and efficacy of different antithrombotic strategies after LAAO through a network comparison method. Methods: We systematically searched the MEDLINE, Embase, and Cochrane Library databases for studies that reported the interested efficacy and safety outcomes (stroke, device-related thrombus (DRT), and major bleeding) of different antithrombotic strategies [DAPT (dual antiplatelet therapy), DOACs (direct oral anticoagulants), and VKA (vitamin k antagonist)] in patients who had experienced LAAO...
2023: Frontiers in Pharmacology