journal
https://read.qxmd.com/read/38617793/improving-the-pharmacokinetics-biodistribution-and-plasma-stability-of-monobodies
#1
JOURNAL ARTICLE
Adrian Valentin Dinh-Fricke, Oliver Hantschel
Cancer is a leading cause of death worldwide. Several targeted anticancer drugs entered clinical practice and improved survival of cancer patients with selected tumor types, but therapy resistance and metastatic disease remains a challenge. A major class of targeted anticancer drugs are therapeutic antibodies, but their use is limited to extracellular targets. Hence, alternative binding scaffolds have been investigated for intracellular use and better tumor tissue penetration. Among those, monobodies are small synthetic protein binders that were engineered to bind with high affinity and selectivity to central intracellular oncoproteins and inhibit their signaling...
April 4, 2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38617792/understanding-the-action-mechanisms-of-metformin-in-the-gastrointestinal-tract
#2
REVIEW
Meihui Cheng, Lili Ren, Xianxian Jia, Jianwei Wang, Bin Cong
Metformin is the initial medication recommended for the treatment of type 2 diabetes mellitus (T2DM). In addition to diabetes treatment, the function of metformin also can be anti-aging, antiviral, and anti-inflammatory. Nevertheless, further exploration is required to fully understand its mode of operation. Historically, the liver has been acknowledged as the main location where metformin reduces glucose levels, however, there is increasing evidence suggesting that the gastrointestinal tract also plays a significant role in its action...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606182/optimizing-fluconazole-embedded-transfersomal-gel-for-enhanced-antifungal-activity-and-compatibility-studies
#3
JOURNAL ARTICLE
Zhiqiang Cheng, Ujjwala Kandekar, Xiaoshi Ma, Vishal Bhabad, Ashlesha Pandit, Liming Liu, Jiping Luo, Neha Munot, Trushal Chorage, Abhinandan Patil, Sandip Patil, Liang Tao
Fungal infections are of major concern all over the globe, and fluconazole is the most prevalently used drug to treat it. The goal of this research work was to formulate a fluconazole-embedded transfersomal gel for the treatment of fungal infections. A compatibility study between fluconazole and soya lecithin was performed by differential scanning calorimetry (DSC). Transfersomes were formulated by a thin-film hydration technique using soya lecithin and Span 80. A central composite design was adopted to prepare different formulations...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606181/osimertinib-in-the-treatment-of-resected-egfr-mutated-non-small-cell-lung-cancer-a-cost-effectiveness-analysis-in-the-united-states
#4
JOURNAL ARTICLE
Gengwei Huo, Ying Song, Wenjie Liu, Xuchen Cao, Peng Chen
Background: In the double-blind phase III ADAURA randomized clinical trial, adjuvant osimertinib showed a substantial overall survival benefit in patients with stage IB to IIIA, EGFR-mutated, completely resected non-small cell lung cancer (NSCLC). We conduct a cost-effectiveness analysis comparing the use of adjuvant osimertinib to placebo in patients with stage IB to IIIA, EGFR-mutated, resected NSCLC. Methods: Based on the results obtained from the ADAURA trial, a Markov model with three-state was employed to simulate patients who were administered either osimertinib or placebo until disease recurrence or completion of the study period (3 years)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606180/gut-microbes-combined-with-metabolomics-reveal-the-protective-effects-of-qijia-rougan-decoction-against-ccl-4-induced-hepatic-fibrosis
#5
JOURNAL ARTICLE
Xue Li, Xinyi Xu, Sian Tao, Yue Su, Li Wen, Dong Wang, Jibin Liu, Quansheng Feng
Background: The occurrence and development of Hepatic fibrosis (HF) are closely related to the gut microbial composition and alterations in host metabolism. Qijia Rougan decoction (QJ) is a traditional Chinese medicine compound utilized clinically for the treatment of HF with remarkable clinical efficacy. However, its effect on the gut microbiota and metabolite alterations is unknown. Therefore, our objective was to examine the impact of QJ on the gut microbiota and metabolism in Carbon tetrachloride (CCl4 )-induced HF...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606179/anti-osteoporotic-effects-of-yi-mai-jian-on-bone-metabolism-of-ovariectomized-rats
#6
JOURNAL ARTICLE
Bin Shi, Che-Chun Lin, Chia-Jung Lee, De-Shan Ning, Chao-Chi Lin, Hong-Wei Zhao, Chang-Syun Yang, Shun-Xin Deng, Yung-Jia Chiu, Ching-Chiung Wang
Yi Mai Jian herbal formula (YMJ) is formulated with Eucommiae Folium, Astragali Radix, Ligustri Lucidi Fructus, and Elaeagnus Fructus to improve bone function in traditional Chinese medicine. The anti-osteoporotic effects of YMJ in bone metabolism were evaluated in ovariectomized (OVX) rats. The skeletal structure of the femur and vertebrae was analyzed after treating OVX rats with YMJ for 114 days. The results showed that YMJ significantly increased the bone mineral density (BMD) and trabecular number (Tb...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606178/dose-reduction-of-biologics-in-patients-with-plaque-psoriasis-a-review
#7
REVIEW
C A M van Riel, C A J Michielsens, M E van Muijen, L S van der Schoot, J M P A van den Reek, E M G J de Jong
Dose reduction (DR) of first-generation biologics for plaque psoriasis (TNF-alpha inhibitors (i) and interleukin (IL)-12/23i) has been described in a previous scoping review. The literature on the DR of the newest generation of biologics (IL-17/23i) was scarce. The current review provides a literature update on the previous scoping review on the DR of all biologics, including the newest generation, with a focus on the uptake and implementation of DR in practice. The current literature search on DR revealed 14 new articles in addition to those in the previous review...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606177/characterization-and-anti-aging-activities-of-polysaccharide-from-rana-dybowskii-guenther
#8
JOURNAL ARTICLE
Yiping Li, Xuyan Zhao, Jing Wang, Qi Yu, Jing Ren, Ziye Jiang, Lili Jiao
Introduction: Rana dybowskii Guenther (RDG), as a traditional Chinese medicine, has been shown to have antioxidant effects. However, studies on the anti-aging effect of RDG are still limited. Methods: In this study, we prepared polysaccharides from the skin of RDG (RDGP) by hot water extraction, alcohol precipitation, ion-exchange chromatography and gel chromatography. The proteins were removed using the Sevage method in combination with an enzymatic method. The structural features were analyzed using high-performance gel permeation chromatography, β-elimination reaction and Fourier transform infrared spectra...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606176/inhibitory-effect-of-aloperine-on-transient-outward-potassium-currents-in-rat-cardiac-myocytes
#9
JOURNAL ARTICLE
Xiao-Na Dong, Meng-Ting Li
OBJECTIVE: Aloperine (ALO) is an effective quinolizidine alkaloid. Previous research has demonstrated its antiarrhythmic effect by inhibiting voltage-gated sodium currents in rat ventricular myocytes. This study explored its effect on transient outward potassium currents (Ito ) in rat atrial myocytes to identify potential targets in the context of ion channel currents. METHODS: The Ito characteristics in rat atrial myocytes were recorded using a whole-cell patch-clamp technique...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606175/evidence-mapping-of-traditional-chinese-medicine-in-diabetic-peripheral-neuropathy-treatment
#10
Yujie Fu, Yiming Wang, Zhenghong Li, Ke Huang, Yating Gao, Shanqiong Xu, Qingna Li, Xingfang Liu, Guangde Zhang
Objective: Diabetic peripheral neuropathy (DPN) stands as a crucial complication of diabetes, significantly affecting patients' quality of life. This study aims to elucidate the evidence distribution from clinical randomized controlled trials (RCTs) on DPN treatment with traditional Chinese medicine (TCM) through evidence mapping. Methods: A comprehensive search was conducted from January 2017 to October 2022 in databases such as Wanfang (China Online Journals), CNKI (China National Knowledge Infrastructure), VIP (China Science and Technology Journal Database), SinoMed (Chinese Biomedical Literature Database), PubMed, Web of Science, and Cochrane Library...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606174/effectiveness-of-pharmacist-led-medication-reconciliation-on-medication-errors-at-hospital-discharge-and-healthcare-utilization-in-the-next-30-days-a-pragmatic-clinical-trial
#11
JOURNAL ARTICLE
Maja Jošt, Mojca Kerec Kos, Mitja Kos, Lea Knez
Transitions of care often lead to medication errors and unnecessary healthcare utilization. Medication reconciliation has been repeatedly shown to reduce this risk. However, the great majority of evidence is limited to the provision of medication reconciliation within clinical trials and countries with well-established clinical pharmacy. Thus, this pragmatic, prospective, controlled trial evaluated the effectiveness of routine pharmacist-led medication reconciliation compared to standard care on medication errors and unplanned healthcare utilization in adult general medical patients hospitalized in a teaching hospital in Slovenia...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606173/early-life-phenobarbital-exposure-dysregulates-the-hippocampal-transcriptome
#12
JOURNAL ARTICLE
Seán Quinlan, Tahiyana Khan, David McFall, Carolina Campos-Rodriguez, Patrick A Forcelli
Introduction: Phenobarbital (PB) and levetiracetam (LEV) are the first-line therapies for neonates with diagnosed seizures, however, a growing body of evidence shows that these drugs given during critical developmental windows trigger lasting molecular changes in the brain. While the targets and mechanism of action of these drugs are well understood-what is not known is how these drugs alter the transcriptomic landscape, and therefore molecular profile/gene expression during these critical windows of neurodevelopment...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606172/unveiling-the-impact-of-cdk8-on-tumor-progression-mechanisms-and-therapeutic-strategies
#13
REVIEW
Xiaomin Yin, Zhilong He, Kun Chen, Kai Ouyang, Changxuan Yang, Jianjun Li, Hailin Tang, Manbo Cai
CDK8 is an important member of the cyclin-dependent kinase family associated with transcription and acts as a key "molecular switch" in the Mediator complex. CDK8 regulates gene expression by phosphorylating transcription factors and can control the transcription process through Mediator complex. Previous studies confirmed that CDK8 is an important oncogenic factor, making it a potential tumor biomarker and a promising target for tumor therapy. However, CDK8 has also been confirmed to be a tumor suppressor, indicating that it not only promotes the development of tumors but may also be involved in tumor suppression...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606171/phytochemical-analysis-and-anticancer-effect-of-camellia-oleifera-bud-ethanol-extract-in-non-small-cell-lung-cancer-a549-cells
#14
JOURNAL ARTICLE
Jingming Niu, Xiaoyan Jia, Nian Yang, Yuanquan Ran, Xia Wu, Furong Ding, Dongxin Tang, Minyi Tian
Camellia oleifera is a medicine food homology plant widely cultivated in the Yangtze River Basin and southern China due to its camellia oil. Camellia oleifera bud and fruit exist simultaneously, and its bud is largely discarded as waste. However, C. oleifera bud has been used in traditional Chinese medicine to treat a variety of ailments. Thus, the purpose of this study was to identify the chemical components of C. oleifera bud ethanol extract (EE) and first evaluate its anticancer effects in non-small cell lung cancer A549 cells...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38606170/a-comprehensive-review-of-the-botany-phytochemistry-pharmacology-and-toxicology-of-murrayae-folium-et-cacumen
#15
REVIEW
Yue Qi, Lin Wang, Na Wang, Siyi Wang, Xu Zhu, Tie Zhao, Qinghua Jiang
Ethnopharmacological relevance: Murrayae Folium et Cacumen (MFC) is a plant considered to be a traditional Chinese medicine with culinary value as well. The dry leaves and twigs of Murraya paniculata and M. exotica are used to treat stomach aches, rheumatism, toothaches, swelling, and insect and snake bites. They are also used to prepare spicy chicken dishes. Aim of the review: This review comprehensively summarizes the available information on the botanical characterization, phytochemistry, pharmacological activities, pharmacodynamics, pharmacokinetics, and toxicity of MFC...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601473/antifungal-effects-of-echinocandins-diminish-when-exposed-to-intestinal-lumen-contents-a-finding-with-potentially-significant-clinical-implications
#16
JOURNAL ARTICLE
Sepideh Mehravar, Gabriela S Leite, Mark Pimentel, Ali Rezaie
Echinocandins, a prominent class of antifungals, are known for their broad-spectrum activity and favorable safety profiles. However, their bioavailability and efficacy via oral route are suboptimal. In this study, caspofungin and micafungin, the two most commonly used echinocandins, were evaluated in various in vitro environments simulating intestinal lumen. The results revealed that while both antifungals are effective in standard medium, their efficacy significantly diminishes in the presence of human small bowel aspirates and bovine bile...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601472/aristolochic-acid-induces-acute-kidney-injury-through-ferroptosis
#17
JOURNAL ARTICLE
Xuan Huang, Ruihua Liu, Cuixia Zhan, Haishan Wu, Jinjin Fan, Zhijian Li, Xiao Yang
Aristolochic acid (AA)-induced acute kidney injury (AKI) presents with progressive decline in renal function and rapid progression to end-stage renal disease. Among the multiple mechanisms identified in AKI, ferroptosis has been shown to be involved in various forms of AKI. But few studies have elucidated the role of ferroptosis in AA-induced AKI. In this study, we investigated the role of ferroptosis in AA-induced acute renal tubular injury in vivo and in vitro . Mice with acute aristolochic acid nephropathy showed increased malondialdehyde levels, aggravated lipid peroxidation, decreased superoxide dismutase activity, and glutathione depletion...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601471/case-report-paralytic-ileus-resulted-from-nirmatrelvir-ritonavir-tacrolimus-drug-drug-interaction-in-a-systemic-lupus-erythematosus-patient-with-covid-19
#18
Wei Zhang, Xingguo Zhang, Jinming Han, Wen Zhang, Jiarui Xu, Xin Zhang, Hongjun Bian, Chong Meng, Deya Shang, Yi Zhou, Dawei Wang, Baobao Feng
Patients with systemic autoimmune rheumatic diseases are at a high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and effective antiviral treatments including nirmatrelvir/ritonavir can improve their outcomes. However, there might be potential drug-drug interactions when these patients take nirmatrelvir/ritonavir together with immunosuppressants with a narrow therapeutic window, such as tacrolimus and cyclosporine. We present a case of paralytic ileus resulting from tacrolimus toxicity mediated by the use of nirmatrelvir/ritonavir in a patient with systemic lupus erythematosus (SLE)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601470/influence-of-the-combination-of-sglt2-inhibitors-and-glp-1-receptor-agonists-on-egfr-decline-in-type-2-diabetes-post-hoc-analysis-of-recap-study
#19
JOURNAL ARTICLE
Yoshimi Muta, Kazuo Kobayashi, Masao Toyoda, Atsuhito Tone, Daisuke Suzuki, Daisuke Tsuriya, Hideo Machimura, Hidetoshi Shimura, Hiroshi Takeda, Hisashi Yokomizo, Kei Takeshita, Keiichi Chin, Keizo Kanasaki, Kouichi Tamura, Masaaki Miyauchi, Masuo Saburi, Miwa Morita, Miwako Yomota, Moritsugu Kimura, Nobuo Hatori, Shinichi Nakajima, Shun Ito, Shunichiro Tsukamoto, Takashi Murata, Takaya Matsushita, Takayuki Furuki, Takuya Hashimoto, Tomoya Umezono, Yuichi Takashi, Daiji Kawanami
Accumulating evidence has demonstrated that both SGLT2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1Ra) have protective effects in patients with diabetic kidney disease. Combination therapy with SGLT2i and GLP1Ra is commonly used in patients with type 2 diabetes (T2D). We previously reported that in combination therapy of SGLT2i and GLP1Ra, the effect on the renal composite outcome did not differ according to the preceding drug. However, it remains unclear how the initiation of combination therapy is associated with the renal function depending on the preceding drug...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38601469/clinical-and-pharmacological-factors-influencing-serum-clozapine-and-norclozapine-levels
#20
JOURNAL ARTICLE
Anna Mach, Anna Wnorowska, Marcin Siwek, Marcin Wojnar, Maria Radziwoń-Zaleska
BACKGROUND: Clozapine (CLO) is a very effective antipsychotic, whose use is associated with dose-dependent risk of complications. Due to high interindividual variability in CLO metabolism, there is a need to identify factors affecting the blood concentrations of CLO and its active metabolite, norclozapine (NCLO). METHODS: A total of 446 blood samples (collected from 233 women and 213 men, aged from 18 to 77 years) were included in this study and analyzed for CLO and NCLO concentrations...
2024: Frontiers in Pharmacology
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