journal
Journals World Journal of Gastrointesti...

World Journal of Gastrointestinal Pathophysiology

https://read.qxmd.com/read/38682027/prognostic-significance-of-tumor-budding-desmoplastic-reaction-and-lymphocytic-infiltration-in-patients-with-gastric-adenocarcinoma
#1
JOURNAL ARTICLE
Aysen Yavuz, Kubra Simsek, Anil Alpsoy, Busra Altunay, Elif Ocak Gedik, Betul Unal, Cumhur Ibrahim Bassorgun, Ali Murat Tatli, Gulsum Ozlem Elpek
BACKGROUND: Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid tumors. In this context, Accumulated data suggests that pathological evaluation of tumor budding (TB), desmoplastic reaction (DR), and tumor-infiltrating lymphocytes (TILs) may be crucial in determining tumor behavior in the gastrointestinal tract. Regarding gastric adenocarcinoma (GAC), although some results suggest that TB and TILs may be effective in determining the course of the disease, the data do not agree...
April 22, 2024: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/38682026/prevalence-and-outcome-of-sarcopenia-in-non-alcoholic-fatty-liver-disease
#2
JOURNAL ARTICLE
Suprabhat Giri, Prajna Anirvan, Sumaswi Angadi, Ankita Singh, Anurag Lavekar
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of conditions, progressing from mild steatosis to advanced fibrosis. Sarcopenia, characterized by decreased muscle strength and mass, shares common pathophysiological traits with NAFLD. An association exists between sarcopenia and increased NAFLD prevalence. However, data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain inconsistent. AIM: To analyze the prevalence and outcomes of sarcopenia in patients with NAFLD...
April 22, 2024: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/38682025/sepsis-during-short-bowel-syndrome-hospitalizations-identifying-trends-disparities-and-clinical-outcomes-in-the-united-states
#3
JOURNAL ARTICLE
Dushyant Singh Dahiya, Jennifer Wachala, Shantanu Solanki, Dhanshree Solanki, Asim Kichloo, Samantha Holcomb, Uvesh Mansuri, Khwaja Saad Haq, Hassam Ali, Manesh Kumar Gangwani, Yash R Shah, Teresa Varghese, Hafiz Muzaffar Akbar Khan, Simon Peter Horslen, Thomas D Schiano, Syed-Mohammed Jafri
BACKGROUND: Short bowel syndrome (SBS) hospitalizations are often complicated with sepsis. There is a significant paucity of data on adult SBS hospitalizations in the United States and across the globe. AIM: To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United States. METHODS: The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between 2005-2014. The study cohort was further divided based on the presence or absence of sepsis...
April 22, 2024: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/38682024/des-gamma-carboxy-prothrombin-and-alpha-fetoprotein-levels-as-biomarkers-for-hepatocellular-carcinoma-and-their-correlation-with-radiological-characteristics
#4
JOURNAL ARTICLE
Muhammad Ali Qadeer, Zaigham Abbas, Shaima Amjad, Bushra Shahid, Abeer Altaf, Mehreen Siyal
BACKGROUND: Alpha-fetoprotein (AFP), a commonly used biomarker for hepatocellular carcinoma (HCC), is normal in up to one-third of patients. AIM: To evaluate the diagnostic performance of des-gamma-carboxy-prothrombin (DCP) alone and in combination with AFP. METHODS: In this study, 202 patients with radiologically proven HCC were enrolled, and their DCP and AFP levels were evaluated for their diagnostic performance. RESULTS: The mean age of the enrolled patients was 58...
April 22, 2024: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/38682023/changes-in-the-terminology-and-diagnostic-criteria-of-non-alcoholic-fatty-liver-disease-implications-and-opportunities
#5
REVIEW
Muhammed Mubarak
Fatty liver disease (FLD) is a highly prevalent pathological liver disorder. It has many and varied etiologies and has heterogeneous clinical course and outcome. Its proper nomenclature and classification have been problematic since its initial recognition. Traditionally, it was divided into two main categories: Alcohol-associated liver disease and nonalcoholic FLD (NAFLD). Among these, the latter condition has been plagued with nomenclature and classification issues. The two main objections to its use have been the use of negative (non-alcoholic) and stigmatizing (fatty) terms in its nomenclature...
April 22, 2024: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/37727283/novel-non-colonizing-single-strain-live-biotherapeutic-product-ads024-protects-against-clostridioides-difficile-infection-challenge-in-vivo
#6
JOURNAL ARTICLE
Christopher K Murphy, Michelle M O'Donnell, James W Hegarty, Sarah Schulz, Colin Hill, R Paul Ross, Mary C Rea, Ronald Farquhar, Laurent Chesnel
BACKGROUND: The Centers for Disease Control and Prevention estimate that Clostridioides difficile ( C. difficile ) causes half a million infections (CDI) annually and is a major cause of total infectious disease death in the United States, causing inflammation of the colon and potentially deadly diarrhea. We recently reported the isolation of ADS024, a Bacillus velezensis ( B. velezensis ) strain, which demonstrated direct in vitro bactericidal activity against C. difficile , with minimal collateral impact on other members of the gut microbiota...
August 24, 2023: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/37304923/role-of-p53-suppression-in-the-pathogenesis-of-hepatocellular-carcinoma
#7
REVIEW
Heena B Choudhary, Satish K Mandlik, Deepa S Mandlik
In the world, hepatocellular carcinoma (HCC) is among the top 10 most prevalent malignancies. HCC formation has indeed been linked to numerous etiological factors, including alcohol usage, hepatitis viruses and liver cirrhosis. Among the most prevalent defects in a wide range of tumours, notably HCC, is the silencing of the p53 tumour suppressor gene. The control of the cell cycle and the preservation of gene function are both critically important functions of p53. In order to pinpoint the core mechanisms of HCC and find more efficient treatments, molecular research employing HCC tissues has been the main focus...
June 1, 2023: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/37035275/role-of-t-box-transcription-factor-3-in-gastric-cancers
#8
REVIEW
Naoki Asano, Akira Imatani, Akio Takeuchi, Masashi Saito, Xiao-Yi Jin, Waku Hatta, Kaname Uno, Tomoyuki Koike, Atsushi Masamune
The expression of T-box transcription factor 3 (TBX3) has been identified in various cancers, including gastric cancers. Its role in breast cancers and melanomas has been intensively studied, and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported. Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis. Considering its pivotal role in the initiation and progression of cancers, TBX3 could be a promising therapeutic target for gastric cancers...
March 22, 2023: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/37035274/novel-cabin-score-outperforms-other-prognostic-models-in-predicting-in-hospital-mortality-after-salvage-transjugular-intrahepatic-portosystemic-shunting
#9
JOURNAL ARTICLE
Jake Krige, Eduard Jonas, Chanel Robinson, Steve Beningfield, Urda Kotze, Marc Bernon, Sean Burmeister, Christo Kloppers
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) is now established as the salvage procedure of choice in patients who have uncontrolled or severe recurrent variceal bleeding despite optimal medical and endoscopic treatment. AIM: To analysis compared the performance of eight risk scores to predict in-hospital mortality after salvage TIPS (sTIPS) placement in patients with uncontrolled variceal bleeding after failed medical treatment and endoscopic intervention...
March 22, 2023: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/37035273/polymorphism-of-genes-encoding-drug-metabolizing-and-inflammation-related-enzymes-for-susceptibility-to-cholangiocarcinoma-in-thailand
#10
JOURNAL ARTICLE
Gyokukou You, Lu Zeng, Hideaki Tanaka, Emi Ohta, Takahiro Fujii, Kazuhiko Ohshima, Masakazu Tanaka, Nobuyuki Hamajima, Chutiwan Viwatthanasittiphong, Mantana Muangphot, Dhiraphol Chenvidhya, Adisorn Jedpiyawongse, Banchob Sripa, Masanao Miwa, Satoshi Honjo
BACKGROUND: Cholangiocarcinoma (CCA) is an intractable cancer, and its incidence in northeastern Thailand is the highest worldwide. Infection with the liver fluke Opisthorchis viverrini (OV) has been associated with CCA risk. However, animal experiments have suggested that OV alone does not induce CCA, but its combination with a chemical carcinogen like nitrosamine can cause experimentally induced CCA in hamsters. Therefore, in humans, other environmental and genetic factors may also be involved...
March 22, 2023: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36743656/growth-hormone-and-gastrointestinal-malignancy-an-intriguing-link
#11
REVIEW
Rajan Palui, Kalyani Sridharan, Sadishkumar Kamalanathan, Jayaprakash Sahoo, Dukhabandhu Naik
Growth hormone (GH) excess is associated with several systemic complications, one of which is the increased risk of neoplastic processes particularly of the gastrointestinal (GI) tract. Among the GI neoplasms, the most reported association is with benign and malignant neoplasms of the colon. In the majority of published literature, an increased incidence of GI neoplasms, both colonic adenomas as well as colorectal carcinoma is reported. However, the studies on colon cancer-specific mortality rate are conflicting with recent studies reporting similar cancer-specific mortality rates in comparison to controls...
January 22, 2023: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36532302/knowledge-regarding-celiac-disease-among-healthcare-professionals-patients-and-their-caregivers-in-turkey
#12
JOURNAL ARTICLE
Yasin Sahin, Eylem Sevinc, Nevzat Aykut Bayrak, Fatma Ilknur Varol, Ulas Emre Akbulut, Ayşegül Bükülmez
BACKGROUND: Celiac disease (CD) is one of the most prevalent chronic disorders. The clinical manifestations of CD are diverse and may present with gastrointestinal findings, extra-intestinal findings or no symptoms. Although there has been a marked increase in the prevalence of CD in the past 30 years, up to 95% of patients with CD remain undiagnosed. As most cases have atypical signs or no symptoms, the diagnosis of CD is either missed or delayed. In addition, one of the most important reasons for the delay in diagnosis may be the poor knowledge of healthcare professionals (HCPs) regarding CD...
November 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36187603/covid-19-in-patients-with-gastrointestinal-stromal-tumors-recommendations-for-management-and-vaccination
#13
REVIEW
Violeta Snegarova, Dimitrina Miteva, Milena Gulinac, Monika Peshevska-Sekulovska, Hristiana Batselova, Tsvetelina Velikova
The coronavirus disease 2019 (COVID-19) pandemic profoundly affected the management and treatment of patients with malignancies. Based on the progress reported in the literature, we reviewed the recommendations for treatment and vaccination in patients with gastrointestinal stromal tumor (GIST) during COVID-19. We focus on whether there is a risk and what could be the possible effects of vaccinating patients with GIST/cancer. Since the situation is quickly changing, and the health services have been severely disrupted, the diagnosis, treatment and recommendations for vaccination of these patients against COVID-19 are still not updated...
September 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36187602/influence-of-the-covid-19-pandemic-in-the-gastrointestinal-oncology-setting-an-overview
#14
REVIEW
Breno Bittencourt de Brito, Hanna Santos Marques, Filipe Antônio França da Silva, Maria Luísa Cordeiro Santos, Glauber Rocha Lima Araújo, Lara de Araujo Valente, Fabrício Freire de Melo
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been impacting healthcare in various ways worldwide and cancer patients are greatly affected by the coronavirus disease 2019 (COVID-19) pandemic. The reorganization of the health facilities in order to supply the high demand resulting from the aforementioned infection as well as the social isolation measures led to impairments for the diagnosis and follow-up of patients with gastrointestinal cancers, which has had an impact on the prognosis of the oncologic patients...
September 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36187601/epilepsy-and-the-gut-perpetrator-or-victim
#15
REVIEW
Mohammed Al-Beltagi, Nermin Kamal Saeed
The brain and the gut are linked together with a complex, bi-path link known as the gut-brain axis through the central and enteric nervous systems. So, the brain directly affects and controls the gut through various neurocrine and endocrine processes, and the gut impacts the brain via different mechanisms. Epilepsy is a central nervous system (CNS) disorder with abnormal brain activity, causing repeated seizures due to a transient excessive or synchronous alteration in the brain's electrical activity. Due to the strong relationship between the enteric and the CNS, gastrointestinal dysfunction may increase the risk of epilepsy...
September 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36187600/electrical-neuromodulation-therapy-for-inflammatory-bowel-disease
#16
REVIEW
Farah Yasmin, Abdul Moiz Sahito, Syeda Lamiya Mir, Govinda Khatri, Somina Shaikh, Ambresha Gul, Syed Adeel Hassan, Thoyaja Koritala, Salim Surani
Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal (GI) tract. It has financial and quality of life impact on patients. Although there has been a significant advancement in treatments, a considerable number of patients do not respond to it or have severe side effects. Therapeutic approaches such as electrical neuromodulation are being investigated to provide alternate options. Although bioelectric neuromodulation technology has evolved significantly in the last decade, sacral nerve stimulation (SNS) for fecal incontinence remains the only neuromodulation protocol commonly utilized use for GI disease...
September 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36161231/common-polymorphisms-of-protein-tyrosine-phosphate-non-receptor-type-2-gene-are-not-associated-with-risk-of-crohn-s-disease-in-indian
#17
JOURNAL ARTICLE
Kaushik Chatterjee, Amit Kumar Dutta, Ashish Goel, Rekha Aaron, Vijayalekshmi Balakrishnan, Ajith Thomas, Anoop John, Rajeeb Jaleel, Deepu David, Reuben Thomas Kurien, S D Chowdhury, Ebby George Simon, A J Joseph, Prasanna Premkumar, Anna B Pulimood
BACKGROUND: Multiple genetic risk factors for Crohn's disease (CD) have been identified. However, these observations are not consistent across different populations. The protein tyrosine phosphate non-receptor type 2 ( PTPN2 ) gene plays a role in various aspects of host defense including epithelial barrier function, autophagy, and innate and adaptive immune response. Two common polymorphisms in the PTPN2 gene (rs2542151 and rs7234029) have been associated with risk of CD in Western countries...
July 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/36161230/hepatomusculoskeletal-disorders-coining-a-new-term-might-improve-the-management-of-the-musculoskeletal-manifestations-of-chronic-liver-disease
#18
JOURNAL ARTICLE
Christos Tsagkaris, Stavros P Papadakos, Dimitrios V Moysidis, Andreas S Papazoglou, Alexandra Koutsogianni, Marios Papadakis
Chronic liver disease can affect many body systems including the musculoskeletal system. The pathogenetic crosstalk between the liver and organs such as the brain and the kidneys has already been described with compound terms merging the organs affected by the pathology, such as the hepatorenal syndrome. Nevertheless, the musculoskeletal manifestations of chronic liver disease have not been coined with such a term to date. Because of this shortage, documenting the musculoskeletal implications of chronic liver disease in both research and clinical practice is challenging...
July 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/35720167/utility-of-fibroscan-based-scoring-systems-to-narrow-the-risk-group-of-nonalcoholic-fatty-liver-disease-with-comorbidities
#19
JOURNAL ARTICLE
Kouichi Miura, Hiroshi Maeda, Naoki Morimoto, Shunji Watanabe, Mamiko Tsukui, Yoshinari Takaoka, Hiroaki Nomoto, Rie Goka, Kazuhiko Kotani, Hironori Yamamoto
BACKGROUND: Vibration-controlled transient elastography (VCTE) is proposed as a second step of examination to assess liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) after triaging by the fibrosis-4 (FIB-4) index. Recently, VCTE-based scoring systems, including FibroScan-AST (FAST), Agile 3+, and Agile 4, emerged to determine the status of NAFLD. However, the significance of these scoring systems remains unknown in narrowing the high-risk group of NAFLD patients with comorbidities, including hepatocellular carcinoma (HCC) and esophagogastric varices (EGV)...
May 22, 2022: World Journal of Gastrointestinal Pathophysiology
https://read.qxmd.com/read/35720166/evaluating-the-regulation-of-transporter-proteins-and-p-glycoprotein-in-rats-with-cholestasis-and-its-implication-for-digoxin-clearance
#20
JOURNAL ARTICLE
Parker Giroux, Patrick B Kyle, Chalet Tan, Joseph D Edwards, Michael J Nowicki, Hua Liu
BACKGROUND: Cardiac and hepatic functionality are intertwined in a multifaceted relationship. Pathologic processes involving one may affect the other through a variety of mechanisms, including hemodynamic and membrane transport effects. AIM: To better understand the effect of extrahepatic cholestasis on regulations of membrane transporters involving digoxin and its implication for digoxin clearance. METHODS: Twelve adult rats were included in this study; baseline hepatic and renal laboratory values and digoxin pharmacokinetic (PK) studies were established before evenly dividing them into two groups to undergo bile duct ligation (BDL) or a sham procedure...
May 22, 2022: World Journal of Gastrointestinal Pathophysiology
journal
journal
43335
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.