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World Journal of Gastrointestinal Pharmacology and Therapeutics

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https://read.qxmd.com/read/30697447/ipilimumab-and-nivolumab-induced-steroid-refractory-colitis-treated-with-infliximab-a-case-report
#1
Ammar B Nassri, Valery Muenyi, Ahmad AlKhasawneh, Bruno De Souza Ribeiro, James S Scolapio, Miguel Malespin, Silvio W de Melo
BACKGROUND: A variety of immune-modulating drugs are becoming increasingly used for various cancers. Despite increasing indications and improved efficacy, they are often associated with a wide variety of immune mediated adverse events including colitis that may be refractory to conventional therapy. Although these drugs are being more commonly used by Hematologists and Oncologists, there are still many gastroenterologists who are not familiar with the incidence and natural history of gastrointestinal immune-mediated side effects, as well as the role of infliximab in the management of this condition...
January 21, 2019: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30697446/opioid-use-and-misuse-in-ulcerative-colitis
#2
Maithili V Chitnavis, Merwise Baray, Patrick G Northup, Anne G Tuskey, Brian W Behm
BACKGROUND: Patients with ulcerative colitis (UC) may be exposed to opioids over their disease duration. The use of such medications carries significant risk, including intestinal dysmotility and potential for addiction. However, the rates of narcotic use and misuse in patients with UC have not been studied extensively. Functional gastrointestinal disorders (FGID) are prevalent in patients with UC, and have been shown to increase the risk of narcotic use and misuse in patients with Crohn's disease...
January 21, 2019: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30697445/update-on-the-management-of-gastrointestinal-varices
#3
REVIEW
Umesha Boregowda, Chandraprakash Umapathy, Nasir Halim, Madhav Desai, Arpitha Nanjappa, Subramanyeswara Arekapudi, Thimmaiah Theethira, Helen Wong, Marina Roytman, Shreyas Saligram
Cirrhosis of liver is a major problem in the western world. Portal hypertension is a complication of cirrhosis and can lead to a myriad of pathology of which include the development of porto-systemic collaterals. Gastrointestinal varices are dilated submucosal veins, which often develop at sites near the formation of gastroesophageal collateral circulation. The incidence of varices is on the rise due to alcohol and obesity. The most significant complication of portal hypertension is life-threatening bleeding from gastrointestinal varices, which is associated with substantial morbidity and mortality...
January 21, 2019: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30595950/potassium-competitive-acid-blockers-are-they-the-next-generation-of-proton-pump-inhibitors
#4
REVIEW
Prashanth Rawla, Tagore Sunkara, Andrew Ofosu, Vinaya Gaduputi
The modern lifestyle caters to an increase in the incidence of peptic ulcer disease, gastroesophageal reflux disease and several other acid-related conditions of the gut. The drugs to prevent these conditions work either through H2 receptor blockade or inhibition of the H+ , K+ ATPase enzyme. Although proton pump inhibitors have been proven to be efficacious, they have a slow onset of action with limited resolution of symptoms in most patients. Potassium-competitive acid blockers (P-CABs) are novel drugs that bind reversibly to K+ ions and block the H+ , K+ ATPase enzyme, thus preventing acid production...
December 13, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30568843/coeliac-disease-in-the-modern-era-severity-of-small-bowel-mucosal-injury-at-diagnosis-with-analysis-of-clinical-correlates-and-rate-of-improvement-on-a-gluten-free-diet
#5
Oliver Cronin, Emma Flanagan, Damian Dowling
AIM: To analyze the relationships between pre-diagnosis coeliac serology, duodenal histopathology, primary presenting symptoms, coeliac-related comorbidity and response to treatment in a modern cohort with new diagnosis of coeliac disease (CD). METHODS: A retrospective cohort study including 99 participants diagnosed with CD between 1999 and 2013. All patients had the following data recorded: baseline characteristics, coeliac serology, small bowel histopathology...
December 5, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30568842/endoscopic-ultrasound-guided-gallbladder-drainage-is-it-ready-for-prime-time
#6
EDITORIAL
Umesha Boregowda, Chandraprakash Umapathy, Arpitha Nanjappa, Helen Wong, Madhav Desai, Marina Roytman, Thimmaiah Theethira, Shreyas Saligram
Management of acute cholecystitis includes initial stabilization and antibiotics. However, the most definitive treatment is cholecystectomy. A small percentage of patients who are not suitable for surgery due to the severity of cholecystitis or comorbidities will require a temporary measure as a bridge to surgery or permanent nonoperative management to decrease the mortality and morbidity. Most of these patients who require conservative management were managed with percutaneous transhepatic cholecystostomy or trans-papillary drainage of gallbladder drainage with cystic duct stenting through endoscopic retrograde cholangiopancreaticography (ERCP)...
December 5, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30397535/challenges-in-the-management-of-pancreatic-exocrine-insufficiency
#7
EDITORIAL
Benjamin Myles Shandro, Rani Nagarajah, Andrew Poullis
Pancreatic exocrine insufficiency (PEI) occurs when the insufficient secretion or function of pancreatic enzymes leads to maldigestion, most commonly as a result of chronic pancreatitis and pancreatic cancer. The condition is associated with significant morbidity and reductions in quality of life, even in milder forms. The challenges in approaching this condition include the non-specific presentation of mild to moderate PEI, and the lack of a convenient, accurate diagnostic test in this cohort. Classical symptoms appear late in the disease, and the diagnosis should be considered before steatorrhoea develops...
October 25, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30191078/colorectal-cancer-screening-use-among-insured-adults-is-out-of-pocket-cost-a-barrier-to-routine-screening
#8
Abhilash Perisetti, Hafiz Khan, Nayana E George, Rachana Yendala, Aamrin Rafiq, Summre Blakely, Drew Rasmussen, Nathan Villalpando, Hemant Goyal
AIM: To describe the characteristics of adults who needed to see a doctor in the past year but could not due to the extra cost and assess the impact of limited financial resources on the receipt of routine fecal occult blood test, sigmoidoscopy, or colonoscopy for colon cancer screening among insured patients. METHODS: Data obtained from the 2012 Behavioral Risk Factor Surveillance System included 215436 insured adults age 50-75 years. We computed frequencies, adjusted odds ratios (aORs), and 95%CIs using SAS v9...
September 5, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/30090645/blood-glucose-response-after-oral-intake-of-lactulose-in-healthy-volunteers-a-randomized-controlled-cross-over-study
#9
Jasmin Steudle, Christiane Schön, Manfred Wargenau, Lioba Pauly, Susann Schwejda-Güttes, Barbara Gaigg, Angelika Kuchinka-Koch, John F Stover
AIM: To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects. METHODS: The study was performed as prospective, randomized, two-part study with 4-way cross-over design with n = 12 in each study arm. Capillary blood glucose levels were determined over a time period of 180 min after intake of a single dose of 10 g or 20 g lactulose provided as crystal or liquid formulation. During the manufacturing process of lactulose, impurities with sugars ( e...
August 7, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29736303/hypothyroidism-in-patients-with-autoimmune-pancreatitis
#10
Ryoko Shimizuguchi, Terumi Kamisawa, Yuka Endo, Masataka Kikuyama, Sawako Kuruma, Kazuro Chiba, Taku Tabata, Satomi Koizumi
AIM: To examine thyroid function and clinical features of hypothyroidism in autoimmune pancreatitis (AIP) patients. METHODS: We examined thyroid function in 77 patients with type 1 AIP (50 males, 27 females; median age 68 years, range 33-85) diagnosed according to the Japanese diagnostic criteria for AIP 2011. We compared clinical and serological findings between patients with and without various categories of hypothyroidism. The change in hypothyroidism after steroid therapy was also examined...
May 6, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29430324/erratum-for-factors-associated-with-visceral-fat-accumulation-in-the-general-population-in-okinawa-japan-world-j-gastrointest-pharmacol-ther-2016-7-261-267
#11
Shingo Arakaki, Tatsuji Maeshiro, Akira Hokama, Jiro Fujita
[This corrects the article on p. 261 in vol. 7, PMID: 27158542.].
February 6, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29430323/declining-use-of-combination-infliximab-and-immunomodulator-for-inflammatory-bowel-disease-in-the-community-setting
#12
Joshua C Berkowitz, Joanna Stein-Fishbein, Sundas Khan, Richard Furie, Keith S Sultan
AIM: To describe trends of combination therapy (CT) of infliximab (IFX) and immunomodulator (IMM) for inflammatory bowel disease (IBD) in the community setting. METHODS: A retrospective study was conducted of all IBD patients referred for IFX infusion to our community infusion center between 04/01/01 and 12/31/14. CT was defined as use of IFX with either azathioprine, 6-mercaptopurine, or methotrexate. We analyzed trends of CT usage overall, for Crohn's disease (CD) and ulcerative colitis (UC), and for the subgroups of induction patients...
February 6, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29430322/monitoring-inflammatory-bowel-disease-during-pregnancy-current-literature-and-future-challenges
#13
REVIEW
Tenzin Choden, Rohan Mandaliya, Aline Charabaty, Mark C Mattar
Inflammatory bowel disease has a high prevalence in women of childbearing age and can have a significant impact on pregnancy, from conceiving to carrying the pregnancy. Active disease during pregnancy is known to have negative effects on pregnancy outcomes; therefore, careful monitoring during this period is an important but challenging aspect of care and is crucial as it affects important management decisions. Recent data seems to suggest that endoscopy is a relatively safe procedure during all trimesters of pregnancy...
February 6, 2018: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29152407/fecal-microbiota-transplantation-against-irritable-bowel-syndrome-rigorous-randomized-clinical-trials-are-required
#14
Amin Talebi Bezmin Abadi
Halkjær et al searched systematically nine articles including 48 patients, and concluded that fecal microbiota transplantation (FMT) can be an ideal treatment option for irritable bowel syndrome (IBS) subjects. Regardless of the few successes in current traditional therapies (change in diet, herbal medicine and antibiotics) in IBS, a sharp increase in interests in the FMT option has been reported in the current century. However, there is a long list of unclear issues concerning the application of FMT for the treatment of IBS...
November 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29152406/protozoan-parasites-in-irritable-bowel-syndrome-a-case-control-study
#15
Khaled A Jadallah, Laila F Nimri, Rola A Ghanem
AIM: To investigate the putative role of protozoan parasites in the development of irritable bowel syndrome (IBS). METHODS: The study included 109 IBS consecutive adult patients fulfilling the Rome III criteria and 100 healthy control subjects. All study subjects filled a structured questionnaire, which covered demographic information and clinical data. Fresh stool samples were collected from patients and control subjects and processed within less than 2 h of collection...
November 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/29152405/association-of-mir-146-rs2910164-mir-196a-rs11614913-mir-221-rs113054794-and-mir-224-rs188519172-polymorphisms-with-anti-tnf-treatment-response-in-a-greek-population-with-crohn-s-disease
#16
Ioannis Papaconstantinou, Christina Kapizioni, Evangelia Legaki, Elena Xourgia, George Karamanolis, Antonios Gklavas, Maria Gazouli
AIM: To investigate the correlation between rs2910164, rs11 614913, rs113054794, and rs188519172 polymorphisms and response to anti-TNF treatment in patients with Crohn's disease (CD). METHODS: One hundred seven patients with CD based on standard clinical, endoscopic, radiological, and pathological criteria were included in the study. They all received infliximab or adalimumab intravenously or subcutaneously at standard induction doses as per international guidelines...
November 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/28828197/transition-care-in-inflammatory-bowel-disease-a-needs-assessment-survey-of-quebec-gastroenterologists-and-allied-nurses
#17
Matthew Strohl, Xun Zhang, Dominique Lévesque, Talat Bessissow
AIM: To determine the tools needed and problems encountered during the transition of inflammatory bowel disease (IBD) patients from pediatric to adult gastroenterologists (GIs) in Québec, Canada. METHODS: We conducted a needs assessment survey of Quebec health care professionals (HCPs). The survey was handed out to 136 Québec HCPs at a local conference in 2013. Additionally, it was emailed to any other HCPs in Quebec involved in caring for IBD patients. The completed surveys were compiled to derive descriptive data...
August 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/28828196/use-of-proton-pump-inhibitors-in-general-practice
#18
Cesare Tosetti, Ilaria Nanni
AIM: To evaluate the characteristics of the prescription of the proton pump inhibitor drugs (PPI) and the adherence to the indications of the guidelines regulating the reimbursement limitations set forth by the Italian Drug Agency. METHODS: Thirty general practitioners (GP) participated in the study, providing data on more than 40000 patients in total. The population was divided into non occasional users of PPI drugs (PPI users) and non-users (PPI non-users) based on evidence of a prescription of at least 3 packs of PPIs in the last 90 d before analysis...
August 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/28828195/critically-ill-patients-and-gut-motility-are-we-addressing-it
#19
REVIEW
Alfredo Vazquez-Sandoval, Shekhar Ghamande, Salim Surani
Gastrointestinal (GI) dysmotility is a common problem in the critically ill population. It can be a reflection and an early sign of patient deterioration or it can be an independent cause of morbidity and mortality. GI dysmotility can be divided for clinical purposes on upper GI dysmotility and lower GI dysmotility. Upper GI dysmotility manifests by nausea, feeding intolerance and vomiting; its implications include aspiration into the airway of abdominal contents and underfeeding. Several strategies to prevent and treat this condition can be tried and they include prokinetics and post-pyloric feeds...
August 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://read.qxmd.com/read/28828194/phage-therapy-an-alternative-to-antibiotics-in-the-age-of-multi-drug-resistance
#20
REVIEW
Derek M Lin, Britt Koskella, Henry C Lin
The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice. Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. Biotechnological advances have further expanded the repertoire of potential phage therapeutics to include novel strategies using bioengineered phages and purified phage lytic proteins...
August 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
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