Journals World Journal of Gastrointesti...

World Journal of Gastrointestinal Pharmacology and Therapeutics
Marcelo A Ribeiro, Gabriela K Tebar, Helena B Niero, Leticia S Pacheco
Biliary complications like cholelithiasis and choledocholithiasis are more common in bariatric surgery patients due to obesity and rapid weight loss. Patients with a body mass index > 40 face an eightfold risk of developing cholelithiasis. Post-bariatric surgery, especially after laparoscopic Roux-en-Y gastric bypass (LRYGB), 30% of patients develop biliary disease due to rapid weight loss. The aim of this review is to analyze the main biliary complications that occur after bariatric surgery and its management...
July 5, 2024: World Journal of Gastrointestinal Pharmacology and Therapeutics
Nazish Butt, Muhammad Tayyab Usmani, Nimrah Mehak, Saba Mughal, Fakhar Ali Qazi-Arisar, Ghulam Mohiuddin, Gulzar Khan
BACKGROUND: Peptic ulcer disease (PUD) remains a significant healthcare burden, contributing to morbidity and mortality worldwide. Despite advancements in therapies, its prevalence persists, particularly in regions with widespread nonsteroidal anti-inflammatory drugs (NSAIDs) use and Helicobacter pylori infection. AIM: To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal (GI) bleeding in Pakistani population. METHODS: This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December 2022...
May 28, 2024: World Journal of Gastrointestinal Pharmacology and Therapeutics
Nathalie Talbodec, Pauline Le Roy, Peggy Fournier, Benoit Lesage, Elodie Lepoutre, François Castex, Jean Michel Godchaux, Lionel Vandeville, Benjamin Bismuth, Xavier Lesage, Pauline Bayart, Michael Genin, Christel Rousseaux, Veronique Maquet, Salvatore Modica, Pierre Desreumaux, Caroline Valibouze
BACKGROUND: Irritable bowel syndrome (IBS), defined according to the Rome IV diagnostic criteria, is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel habits. First-line recommended treatments are limited to combining drugs targeting predominant symptoms, particularly pain (antispasmodics), constipation (laxatives), and diarrhea (loperamide), yielding only a limited therapeutic gain. GASTRAP® DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of action...
May 28, 2024: World Journal of Gastrointestinal Pharmacology and Therapeutics
Nikola Mitrev, Viraj Kariyawasam
A treat-to-target strategy in inflammatory bowel disease (IBD) involves treatment intensification in order to achieve a pre-determined endpoint. Such uniform and tight disease control has been demonstrated to improve clinical outcomes compared to treatment driven by a clinician's subjective assessment of symptoms. However, choice of treatment endpoints remains a challenge in management of IBD via a treat-to-target strategy. The treatment endpoints for ulcerative colitis (UC), recommended by the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) consensus have changed somewhat over time...
May 5, 2024: World Journal of Gastrointestinal Pharmacology and Therapeutics
Marco Chiarelli, Matilde De Simone, Gerardo Cioffi, Ugo Cioffi
Irritable bowel syndrome with diarrhea is a very frequent clinical condition characterized by disabling intestinal symptoms. This disease presents with daily abdominal pain for at least 3 months related to defecation and associated with a change in the frequency of bowel movements and the shape of the stool. International surveys about this disease report a global prevalence of about 1.5%. A new amino acid based electrolyte solution has recently been commercialized for oral rehydration in diarrhea. It is composed of water, electrolytes, and five selected amino acids that function as sodium co-transporters without containing glucose...
March 20, 2024: World Journal of Gastrointestinal Pharmacology and Therapeutics
Samantha E Niles, Phil Blazy, Samuel N Cheuvront, Robert W Kenefick, Sadasivan Vidyasagar, Adam B Smith, Neil Fawkes, William Denman
BACKGROUND: Amino-acid based medical foods have shown promise in alleviating symptoms of drug induced gastrointestinal side effects; particularly, diarrhea-predominant symptoms. Irritable bowel syndrome (IBS) is a gastrointestinal disorder that affects up to 9% of people globally, with diarrhea predominant IBS (IBS-D) being the most prevalent subtype. Further trials are needed to explore potential added benefits when integrated into standard care for IBS-D. AIM: To assess the effectiveness of an amino acid-based medical food as an adjunct to standard of care for adults with IBS-D...
December 12, 2023: World Journal of Gastrointestinal Pharmacology and Therapeutics
Michael Braude, Dilip T Ratnam, Louise Marsh, Joshua H Abasszade, Anouk T Dev
BACKGROUND: Highly effective and well-tolerated direct-acting antiviral (DAA) therapies have revolutionised the management of hepatitis C virus (HCV); however, niche populations face treatment barriers. DAAs co-prescribed with several first-generation anti-epileptic drugs (AEDs) are contraindicated due to drug-drug interactions. A common example is carbamazepine whereby steady-state carbamazepine reduces the maximum concentration and area under the curve of velpatasvir, glecaprevir and pibrentasvir due to potent cytochrome P450 (CYP) 3A4 induction...
July 5, 2023: World Journal of Gastrointestinal Pharmacology and Therapeutics
Thanapon Yaowmaneerat, Apichet Sirinawasatien
Fluid therapy/resuscitation is mandatory in acute pancreatitis due to the pathophysiology of fluid loss as a consequence of the inflammatory process. For many years, without clear evidence, early and aggressive fluid resuscitation with crystalloid solutions (normal saline solution or Ringer lactate solution) was recommended. Recently, many randomized control trials and meta-analyses on fluid therapy have revealed that high fluid rate infusion is associated with increased mortality and severe adverse events compared to those resulting from moderate fluid rates, and this has triggered a paradigm shift in fluid management strategies...
May 5, 2023: World Journal of Gastrointestinal Pharmacology and Therapeutics
Jin-Guang Jiang, Qian Luo, Shuang-Shuang Li, Tian-Ying Tan, Kai Xiong, Tao Yang, Tian-Bao Xiao
BACKGROUND: Slow transit constipation (STC) is a disorder with delayed colonic transit. Cinnamic acid (CA) is an organic acid in natural plants, such as Radix Scrophulariae (Xuan Shen), with low toxicity and biological activities to modulate the intestinal microbiome. AIM: To explore the potential effects of CA on the intestinal microbiome and the primary endogenous metabolites-short-chain fatty acids (SCFAs) and evaluate the therapeutic effects of CA in STC. METHODS: Loperamide was applied to induce STC in mice...
March 5, 2023: World Journal of Gastrointestinal Pharmacology and Therapeutics
Jonathan Willman, Brandon Lucke-Wold
In this commentary, we summarize some of the key points of the original paper "Timing of percutaneous endoscopic gastrostomy tube placement in post-stroke patients does not impact mortality, complications, or outcomes" and offer support for the proposed results. Specifically, we address how early percutaneous endoscopic gastrostomy (PEG) tube placement may reduce hospital length of stay and costs. We also discuss topics related to the article including PEG weaning and post-stroke nutritional formulation. However, we note that concerns purported by previous studies that early PEG placement may worsen outcomes are not fully addressed, and further research is needed...
January 20, 2023: World Journal of Gastrointestinal Pharmacology and Therapeutics
Nandakumar Mohan, Simone Jarrett, Alexander Pop, Daniel Rodriguez, Robert Dudnick
BACKGROUND: Obscure small bowel bleeding is defined as gastrointestinal bleeding (GIB) that is unidentifiable with esophagogastroduodenoscopy and a colonoscopy with video capsule endoscopy (VCE) being the next gold standard step for evaluation. Small bowel transit time (SBTT) is a metric of a VCE study that is defined as the time the capsule takes to travel through the small intestine. AIM: To determine if SBTT within the VCE study, correlates to overall detection of obscure small bowel bleeds...
November 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Saad Saffo, Anil Nagar
BACKGROUND: In monotherapy studies for bleeding peptic ulcers, large volumes of epinephrine were associated with a reduction in rebleeding. However, the impact of epinephrine volume in patients treated with combination endoscopic therapy remains unclear. AIM: To assess whether epinephrine volume was associated with bleeding outcomes in individuals who also received endoscopic thermal therapy and/or clipping. METHODS: Data from 132 patients with Forrest class Ia, Ib, and IIa peptic ulcers were reviewed...
September 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Kavya M Reddy, Preston Lee, Parul J Gor, Antonio Cheesman, Noor Al-Hammadi, David John Westrich, Jason Taylor
BACKGROUND: Percutaneous Endoscopic Gastrostomy (PEG) tubes are often placed for dysphagia following a stroke in order to maintain sufficient caloric intake. The 2011 ASGE guidelines recommend delaying PEG tube placement for two weeks, as half of patients with dysphagia improve within 2 wk. There are few studies comparing outcomes based on timing of PEG tube placement, and there is increasing demand for early PEG tube placement to meet requirements for timely discharge to rehab and skilled nursing facilities...
September 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Mirella Brasil Lopes, Andre Castro Lyra, Raquel Rocha, Fernanda Gomes Coqueiro, Carla Andrade Lima, Carolina Cunha de Oliveira, Genoile Oliveira Santana
BACKGROUND: Low bone mineral density (BMD) is common in patients with inflammatory bowel disease. However, nutritional risk factors for low BMD in the ulcerative colitis (UC) population are still poorly understood. AIM: To investigate the association of anthropometric indicators and body composition with BMD in patients with UC. METHODS: This is a cross-sectional study on adult UC patients of both genders who were followed on an outpatient basis...
July 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Ali Islek, Gokhan Tumgor
Biliary atresia (BA) and choledochal cysts are diseases of the intrahepatic and extrahepatic biliary tree. While their exact etiopathogeneses are not known, they should be treated promptly due to the potential for irreversible parenchymal liver disease. A diagnosis of BA may be easy or complicated, but should not be delayed. BA is always treated surgically, and performing the surgery before the age of 2 mo greatly increases its effectiveness and extends the time until the need for liver transplantation arises...
July 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
K G Rashmi, Sadishkumar Kamalanathan, Jayaprakash Sahoo, Dukhabandhu Naik, Pazhanivel Mohan, Biju Pottakkat, Sitanshu Sekhar Kar, Rajan Palui, Ayan Roy
BACKGROUND: Acute pancreatitis (AP) presenting as an initial manifestation of primary hyperparathyroidism (PHPT) is uncommon, and its timely diagnosis is crucial in preventing recurrent attacks of pancreatitis. AIM: To determine the clinical, biochemical, and radiological profile of PHPT patients presenting as AP. METHODS: This is a retrospective observational study, 51 consecutive patients admitted with the diagnosis of PHPT during January 2010 and October 2021 at a tertiary care hospital in Puducherry, India was included...
July 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Zhi-Peng Li, Dong-Hui Xu, Lian-Ping He, Xin-Juan Wang
The effect of Fuzhuan brick tea (FBT) on metabolism in obese mice is mediated by regulation of N-methyltransferase by aryl hydrocarbon receptor. The expression of the phosphatidylethanolamine N-methyltransferase gene is regulated by many transcription factors, and those specific to this effect need further investigation. Experimental animal studies have been designed to observe the effects of a single drug or the sequential effects of drugs. A washout period should be included if different drugs ( e.g. , antibiotics and FBT) are given to avoid or reduce additive effects or synergy...
May 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Silvia Bona, Sabrina Alves Fernandes, Andrea C Janz Moreira, Graziella Rodrigues, Elizângela G Schemitt, Fabio Cangeri Di Naso, Cláudio A Marroni, Norma P Marroni
BACKGROUND: Melatonin (MLT) is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations, due to its action against free radicals. AIM: To evaluate the effect of MLT on carbon tetrachloride (CCl4 ) induced liver injury in rats in terms of oxidative stress, reticular stress, and cell damage. METHODS: Twenty male Wistar rats (230-250 g) were divided into four groups: Control rats, rats treated with MLT alone, rats treated with CCl4 alone, and rats treated with CCl4 plus MLT...
March 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Ankith Bhasi, Itish Patnaik, Prasan Kumar Panda, Ashok Singh
BACKGROUND: Eosinophilia and related organ damage are extensively studied hot topics among rare disorders. Any addition to the cohort of available case reports of the same will be adding knowledge for better management of this less known entity. CASE SUMMARY: In this article, we describe a 27-year-old Indo-Aryan man who presented with abdominal pain, abdominal distension, and loose stools for variable days. He had splinter hemorrhages in the majority of fingernails...
March 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
Ana Luiza Vilar Guedes, Amanda Lopes Lorentz, Larissa Fernandes de Almeida Rios Rios, Beatriz Camara Freitas, Adriano Gutemberg Neves Dias, Ana Luísa Eckhard Uhlein, Felipe Oliveira Vieira Neto, Jobson Felipe Soares Jesus, Túlio de Sá Novaes Torres, Raquel Rocha, Vitor D Andrade, Genoile Oliveira Santana
BACKGROUND: Inflammatory bowel disease (IBD) is associated with complications, frequent hospitalizations, surgery and death. The introduction of biologic drugs into the therapeutic arsenal in the last two decades, combined with an expansion of immunosuppressant therapy, has changed IBD management and may have altered the profile of hospitalizations and in-hospital mortality (IHM) due to IBD. AIM: To describe hospitalizations from 2008 to 2018 and to analyze IHM from 1998 to 2017 for IBD in Brazil...
January 5, 2022: World Journal of Gastrointestinal Pharmacology and Therapeutics
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