journal
https://read.qxmd.com/read/34336290/association-of-antibiotics-and-other-drugs-with-clinical-outcomes-in-metastatic-melanoma-patients-treated-with-immunotherapy
#21
JOURNAL ARTICLE
Manish D Angrish, Arun Agha, Rossanna C Pezo
Immune checkpoint inhibitors (ICIs) targeting the programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) have improved survival in many advanced cancers including advanced melanoma, renal cell, urothelial, and non-small-cell lung cancers. However, not all patients respond, and immune-related adverse events (irAEs) are common. Commensal gut bacteria may serve as an immunoregulatory link-mediating ICI response and toxicity. Recent studies have shown that a lack of bacterial diversity, known as gut dysbiosis, can have an adverse impact on patients' response to ICIs and predispose to the development of irAEs...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/34327024/determinants-of-sailors-protective-behaviors-in-fishing-spots-against-the-risks-of-sunlight-and-skin-cancer-a-qualitative-study-in-iran
#22
JOURNAL ARTICLE
Ali Asadian, Mojtaba Fattahi Ardakani, Ahmad Sotoudeh, Moradali Zareipour, Ehsan Movahed
Introduction: The growing rate of nonmelanoma skin cancer (NMSC) and melanoma has been a great challenge for global health system. The present research aims to determine sailors' protective behaviors against the risks of sunlight and skin cancer in Iran. Materials and Methods: The present research was qualitative in type, and its data were collected from August to December 2019. To this aim, 23 participants were recruited with whom semistructured interviews were held...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/34306760/vitamin-d-and-vitamin-d-analogs-as-adjuncts-to-field-therapy-treatments-for-actinic-keratoses-current-research-and-future-approaches
#23
REVIEW
Zafer Sattouf, Steven J Repas, Jeffrey B Travers, Craig A Rohan
Actinic keratoses (AK), also known as solar keratoses, are precancerous hyperkeratotic papules caused by long-term exposure to ultraviolet radiation. Management of AK prior to progression to cutaneous malignancy represents an important window of intervention. This is important on a population level, given the high incidence, morbidity, financial costs, and the low but measurable risk of mortality from cutaneous neoplasia. Treatments for AK have been refined for many years with significant progress over the past decade...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/34285817/retrospective-analysis-of-rechallenge-with-ipilimumab-in-patients-with-metastatic-melanoma
#24
JOURNAL ARTICLE
A A Formozo, J R Gomes, R A Schmerling, A C Buzaid
Background: Checkpoint inhibitors are effective in the treatment of several types of cancer, either being used separately or in combination. Ipilimumab pioneered the treatment of metastatic melanoma, and nowadays, it has been used more frequently in combination with anti-PD-1. Since the development of anti-PD1 for melanoma, rechallenge with ipilimumab has not been considered, although its use was considered in early trials. Cases: In this study, we analyzed 22 patients with metastatic melanoma who had benefited from the first treatment with ipilimumab, but eventually had progressive disease...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/34221511/comparison-of-the-effect-of-alpha-and-hydrocortisone-ointments-on-prevention-of-acute-skin-complications-due-to-radiotherapy-in-breast-cancer-patients
#25
JOURNAL ARTICLE
Mansour Rezaei, Ahmad Khoshay, Nasrin Amirifard, Ali Goli, Alireza Abdi
Background: Radiotherapy in breast cancer patients is associated with acute and delayed side effects. This study aimed to compare the effect of alpha and hydrocortisone 1% (H1%) ointments on prevention of acute skin complications due to radiotherapy in breast cancer patients. Methods: This clinical trial was conducted on 86 patients with breast cancer in the radiotherapy center of Imam Reza Hospital of Kermanshah, Iran. Using the records, the patients were selected and randomly divided into alpha and H1% groups after obtaining informed consent...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/33953986/keratinocyte-skin-cancers-in-general-surgery-the-impact-of-anaesthesia-trainee-supervision-and-choice-of-reconstruction
#26
JOURNAL ARTICLE
William McSweeney, Matthew Leaning, Darius Dastouri
BACKGROUND: Keratinocyte skin cancers are common in Australia, incurring disproportionately high health expenditure in comparison with mortality. General surgeons often excise these lesions as day-surgery. Balancing individual complexities of these cancers with trainee supervision and health expenditure is key to deliver efficacious care and maintain day-surgery volume for patients during a pandemic. METHODS: A retrospective, cross-sectional study was performed, examining 414 procedures from January 2019 to December 2020...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/33747567/effectiveness-of-sun-protection-interventions-delivered-to-adolescents-in-a-secondary-school-setting-a-systematic-review
#27
REVIEW
Bronwen M McNoe, Kate C Morgaine, Anthony I Reeder
Aim: The aim of this systematic review is to summarise the evidence of the effectiveness of interventions targeted to adolescents (13 to 18 years inclusive) and delivered in a secondary school setting with the purpose of improving sun protection behaviour, reducing ultraviolet radiation (UVR) exposure, and/or improving physiological outcomes related to UVR exposure (such as erythema or naevi development). Methods: Peer-reviewed journal articles were identified from seven database searches (Cochrane, Embase, CINAHL, Scopus, Medline, PsycInfo, and Web of Science) to January 2020, forward citation searches of relevant articles, and monitoring of WHO INTERSUN UVR list server for recent publications...
2021: Journal of Skin Cancer
https://read.qxmd.com/read/33381319/inguinal-lymph-node-dissection-for-advanced-stages-of-plantar-melanoma-in-a-low-income-country
#28
JOURNAL ARTICLE
Ollo Roland Somé, Malick Diallo, Damien Konkobo, Nassirou Yabré, Valentin Konségré, Issouf Konaté, Sidy Ka
Background: Advanced stages of plantar acral lentiginous melanoma are common in Africa. Inguinal lymph node dissection (ILND) in these cases plays a critical role in disease-free and overall survival. Our study aims to share our experience in ILND for advanced plantar melanomas. Methods and Study Design . Four-year prospective study. Patients . We included all documented cases of advanced stage plantar melanoma with clinically detectable inguinal lymph node metastasis. Twenty-two of 27 patients identified-with mean age 56 years-underwent ILND...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/33282420/outcomes-of-treatment-for-melanoma-brain-metastases
#29
JOURNAL ARTICLE
Mantas Janavicius, Nadezda Lachej, Giedre Anglickiene, Ieva Vincerzevskiene, Birute Brasiuniene
Background: Historically, melanoma with brain metastases has a poor prognosis. In this retrospective medical record review, we report basic clinicopathological parameters and the outcomes of patients with melanoma and brain metastases treated with different treatment modalities before the era of immunotherapy and modern radiotherapy technique. Methods: Patients with metastatic melanoma were treated with surgery, radiotherapy, and/or systemic therapy from 1998 to 2017...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/33178463/histological-peripheral-margins-and-recurrence-of-melanoma-in-situ-treated-with-wide-local-excision
#30
JOURNAL ARTICLE
Francisco S Moura, Lucy E Homer, Stuart W McKirdy
BACKGROUND: The incidence of melanoma in situ (MIS) is increasing faster compared to invasive melanoma. Despite varying international practice, a minimum of 5 mm surgical excision margin is currently recommended in the UK. There is no clear guidance on the minimum histological peripheral clearance margins. AIM: This study compares the histological peripheral clearance margins of MIS using wide local excision (WLE) to the rate of recurrence and progression to invasive disease...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/33083061/comparative-analysis-of-acral-melanoma-in-chinese-and-caucasian-patients
#31
JOURNAL ARTICLE
Kai Huang, Yu Xu, Emmanuel M Gabriel, Subhasis Misra, Yong Chen, Sanjay P Bagaria
Background: Acral melanoma (AM) is a rare subtype of melanoma, which is one of the least common in Caucasian patients but is a common subtype of melanoma in Chinese patients. It is unclear if prognosis differs between Chinese and Caucasian patients diagnosed with AM. The aim of our study is to investigate patient characteristics and survival differences between Chinese and Caucasian AM patients. Methods: Two large institutional melanoma databases from Fudan University Shanghai Cancer Center (FUSCC) and Mayo Clinic enterprise were retrospectively reviewed from 2009 to 2015...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/32802514/a-histopathological-study-of-skin-lesions-in-individuals-with-oculocutaneous-albinism-in-togo-in-2019
#32
JOURNAL ARTICLE
Bayaki Saka, Julienne Noude Teclessou, Sefako Abla Akakpo, Piham Gnossike, Kwamé Doh, Saliou Adam, Abas Mouhari-Toure, Garba Mahamadou, Panawé Kassang, Yvette Elegbede Moise, Tchin Darre, Koussake Kombate, Palokinam Pitché
Objective: The aim of this study was to study the histopathological patterns of skin lesions in persons with albinism (PWA) in Togo in 2019. Method: During two mobile skin care clinics in 2019, biopsies/excisional biopsies were performed in PWA in case of clinical doubt or in front of lesions suspected to be cancerous for histological examination. Anatomopathological reports were thus analysed. Results: During the two mobile skin care clinics, 115 biopsies/excisional biopsies were carried out in 79 PWA, with a mean age of 24 ± 16...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/32665864/sunsmart-accreditation-and-use-of-a-professional-policy-drafting-service-both-positively-and-independently-associated-with-high-sun-protective-hat-scores-derived-from-primary-school-policies
#33
JOURNAL ARTICLE
A I Reeder, E E Iosua, B McNoe, A-C L Petersen
Background: The head and neck are exposed to the highest solar ultraviolet radiation levels and experience a disproportionate skin cancer burden. Sun protective hats can provide an effective barrier. Since early life exposure contributes to skin cancer risk, the World Health Organisation recommends prevention programmes in schools. The New Zealand SunSmart Schools programme is one example. Two criteria concern wearing hat outdoors: students are required to wear a hat providing protection for the face, neck, and ears; if a suitable hat is not worn, students must play in shaded areas...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/32411476/an-analysis-of-biopsies-for-suspected-skin-cancer-at-a-tertiary-care-dermatology-clinic-in-the-western-cape-province-of-south-africa
#34
JOURNAL ARTICLE
Johann de Wet, Minette Steyn, Henry F Jordaan, Rhodine Smith, Saskya Claasens, Willem I Visser
Background: Skin cancer is a growing health concern worldwide. It is the most common malignancy in South Africa and places a large burden on the public healthcare sector. There is a paucity of published scientific data on skin cancer in South Africa. Objectives: To report the findings of biopsies performed in patients with suspected skin cancer attending the Tygerberg Academic Hospital (TAH) Dermatology outpatient department (OPD) in the Western Cape Province of South Africa...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/32231797/skin-cancer-prevalence-in-outdoor-workers-of-ski-resorts
#35
JOURNAL ARTICLE
Yolanda Gilaberte, Josep Manel Casanova, Ana Julia García-Malinis, Salvador Arias-Santiago, Maria Reyes García de la Fuente, Marta Pamiés-Gracia, Javier Ramirez-Palomino, Isabel Ruiz-Campos, Tamara Gracia-Cazaña, Agustín Buendia-Eisman
Background: Snow reflectivity and altitude increase the exposure of ski resort workers to solar ultraviolet radiation. The aim was to assess the presence of skin cancer in ski resorts workers and compare it with other groups of outdoor workers reviewing published studies. Methods: An observational cross-sectional prospective study was conducted in the three largest ski resorts in Spain: Baqueira Beret, Lleida; Formigal, Huesca and Sierra Nevada, Granada. All outdoor workers including ski instructors were invited to participate in the study...
2020: Journal of Skin Cancer
https://read.qxmd.com/read/31772775/male-sex-is-an-inherent-risk-factor-for-basal-cell-carcinoma
#36
JOURNAL ARTICLE
Ioannis D Bassukas, Athina Tatsioni
Basal cell carcinoma (BCC) is more frequent among females <40 years old; however, it affects preferentially older males (>60 years old). In order to contribute to the study of the still largely unknown mechanisms that underlie this peculiar sex-dependent shift, we compared the kinetics of the increase of the age-specific BCC incidence rates ( R ) as a function of age in males and females. Studies reporting sex-stratified R were found using a PubMed search and male to female age-specific incidence rate ratios (RR) were calculated for each age-class as reported in each study and assigned to the mean of the corresponding age periods...
2019: Journal of Skin Cancer
https://read.qxmd.com/read/31380120/erratum-to-basal-cell-carcinoma-pathology-requests-and-reports-are-lacking-important-information
#37
Firas Al-Qarqaz, Khaldon Bodoor, Awad Al-Tarawneh, Haytham Eloqayli, Wisam Al Gargaz, Diala Alshiyab, Jihan Muhaidat, Mohammad Alqudah, Rowida Almomani, Maha Marji
[This corrects the article DOI: 10.1155/2019/4876309.].
2019: Journal of Skin Cancer
https://read.qxmd.com/read/31346477/nonmelanoma-skin-cancer-at-critical-facial-sites-results-and-strategies-of-the-surgical-treatment-of-102-patients
#38
JOURNAL ARTICLE
Carlos Alberto Ferreira de Freitas, Andreza Negreli Santos, Guilherme Canho Bittner, Baltazar Dias Sanabria, Maria Margarida Morena Domingos Levenhagen, Günther Hans-Filho
Background: To evaluate the surgical treatment results of a consecutive series of patients with nonmelanoma skin cancer in critical facial regions such as the nose, lip, eyelid, ear, forehead, cheek, and chin. Methods: This was a prospective observational cohort study evaluating the surgical treatment results of 102 patients with nonmelanoma skin cancer who underwent surgical excision and required some type of reconstruction. The reconstruction strategy used, histological type and margins, aesthetic result, and complications were evaluated...
2019: Journal of Skin Cancer
https://read.qxmd.com/read/31275656/sternectomy-for-treating-advanced-non-melanoma-skin-cancer
#39
JOURNAL ARTICLE
Victor Emmanuel Gadelha Pinheiro, Bianca Rohsner Bezerra, Luís Arthur Brasil Gadelha Farias, Irapuan Teles de Araujo Filho, Marcio Ribeiro Studart da Fonseca
Introduction: Skin cancer is a rare indication of sternectomy. Our goal is to report the clinical course of seven patients who underwent sternectomy for skin cancer. Methods: The survey data were collected from medical records of patients treated between 2008 and 2018 at Ceará Cancer Institute. Results: All patients had prolonged sunlight exposure and average disease time of two years and age of 60 years. Most patients recovered favorably after treatment with prolonged survival...
2019: Journal of Skin Cancer
https://read.qxmd.com/read/31139472/immunohistochemical-analysis-of-braf-v600e-mutation-and-p16-expression-in-malignant-melanoma-in-lagos-nigeria-a-10-year-retrospective-study
#40
JOURNAL ARTICLE
O Obadofin, K Badmos, N Orsi, M Bipin, O Rotimi, A Banjo
Background: In Blacks, malignant melanoma (MM) is associated with greater morbidity and mortality compared to Caucasians. MMs with BRAF V600E mutation as well as those with loss of p16 protein expression are associated with aggressive behavior and worse prognosis. Objectives: We determined BRAF (V600E) mutation status and loss of p16 expression in MM cases in Lagos, Nigeria, and correlated these with histopathologic parameters and patients' age. Methods: Forty-five cases of MM received between January 2005 and December 2014 in the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital were subjected to immunohistochemical studies to determine BRAF V600E mutation and p16 protein expression...
2019: Journal of Skin Cancer
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