Marcelo Augusto Duarte Silveira, Hayna Malta-Santos, Jéssica Rebouças-Silva, Flávio Teles, Erica Batista Dos Santos Galvão, Sergio Pinto de Souza, Fábio Ricardo Dantas Dutra, Marcel Miranda Dantas Gomes, Maurício Brito Teixeira, Luis Filipe Miranda Rebelo da Conceição, Carolina Sa Nascimento, Carolina Kymie Vasques Nonaka, Rodrigo Silva Cezar, Paulo Benigno Pena Batista, Andresa Aparecida Berretta, Valeria M Borges, Rogerio da Hora Passos
BACKGROUND: Patients on haemodialysis (HD) present a significant inflammatory status, which has a pronounced negative impact on their outcomes. Propolis is a natural resin with anti-inflammatory and immunomodulatory properties. We assessed the safety and impact of a standardized Brazilian green propolis extract (EPP-AF®) on the inflammatory status in patients under conventional HD. METHODS: Patients were assigned to receive 200 mg/day of EPP-AF® for 4 weeks followed by 4 weeks without the drug, and changes in plasma levels of interleukins (ILs), interferon gamma (IFN- γ ), tumour necrosis factor-alpha (TNF- α ), and high-sensitivityc-reactive protein (HsCRP) were measured...
2022: International Journal of Nephrology