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International Journal of Nephrology

Javier Enrique Cely, Oscar G Rocha, María J Vargas, Rafael M Sanabria, Leyder Corzo, Roberto E D'Achiardi, Eduardo A Zúñiga
Background: Acid-base disorders have been previously described in patients with chronic hemodialysis, with metabolic acidosis being the most important of them; however, little is known about the potential changes in acid-base status of patients on dialysis living at high altitudes. Methods: Cross-sectional study including 93 patients receiving chronic hemodialysis on alternate days and living in Bogotá, Colombia, at an elevation of 2,640 meters (8,661 feet) over sea level (m...
2018: International Journal of Nephrology
Miguel Ángel Gómez-Sámano, Paloma Almeda-Valdes, Daniel Cuevas-Ramos, María Fernanda Navarro-Flores, Héctor Donaldo Espinosa-Salazar, Mayela Martínez-Saavedra, Jefsi Argelia León-Domínguez, Víctor Manuel Enríquez-Estrada, Ana Laura López-González, Ana Laura Sarmiento-Moreno, Lucero Alejandra Rivera-González, Óscar Alfredo Juárez-León, Bernardo Pérez-González, Yessica Ávila-Palacios, Lineth Sigala-Pedroza, Eira Huerta-Ávila, María Angelina Vargas-Álvarez, Carlos Sánchez-Jaimes, Mariana Cárdenas-Vera, Roopa Mehta, Manuel Alejandro López-Flores A La Torre, Iliana Manjarrez-Martínez, Griselda Xochitl Brito-Córdova, Julia M Zuarth-Vázquez, Arturo Vega-Beyhart, Guadalupe López-Carrasco, Richard J Johnson, Francisco Javier Gómez-Pérez
The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. The median daily fructose intake was estimated with a prospective food registry during 3 days (2 week-days and one weekend day) and they were divided into low fructose intake (<25 g/day) and high fructose intake (≥ 25 g/day)...
2018: International Journal of Nephrology
Anna Salmela, Tom Törnroth, Tuija Poussa, Agneta Ekstrand
Aim: We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse. Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14.9-17.7)] follow-up were retrospectively collected. Results: Overall, 55% of the patients had microscopic polyangiitis (MPA) and 45% had granulomatosis with polyangiitis (GPA)...
2018: International Journal of Nephrology
Randa I Farah
Aim: To determine the prevalence and frequency of different pathological patterns of glomerulonephritis (GN) in adolescent (age ≥ 11 years) and adult Jordanian patients. Materials and Methods: A retrospective analysis of all clinical and pathological reports of Jordanian patients who had native renal biopsies at the University of Jordan hospital between January 2007 and March 2018 to assess the prevalence and pathological pattern of GN. The data were analyzed statistically using descriptive statistics, the chi-squared test, and Fisher's exact tests...
2018: International Journal of Nephrology
B L Goh, A Soraya, A Goh, K L Ang
Background: Hyperphosphatemia in chronic kidney disease (CKD) patients is often treated with calcium carbonate (CaCO3) despite the fact that CaCO3 is associated with increased calcium load and potentially increased cardiovascular risk. Alternative treatments with noncalcium-based phosphate binders do not increase the calcium load but are more costly. This study analyzes the cost-effectiveness of sevelamer versus CaCO3 for the treatment of hyperphosphatemia in stage III-V predialysis CKD patients in Malaysia...
2018: International Journal of Nephrology
Benjamin A Derman, Jochen Reiser, Sanjib Basu, Agne Paner
Introduction: Renal insufficiency (RI) in Multiple Myeloma (MM) portends a higher tumor burden and worse prognosis. Reversal of RI in newly diagnosed MM (NDMM) improves patient outcomes, but it is unknown if there is a disparity in renal recovery in NDMM between African Americans (AA) and non-African Americans. Methods: A retrospective chart review was conducted of 690 patients with NDMM at Rush University Medical Center from 2005 to 2016. 118 patients (59 AA and 59 non-AA) with NDMM and an estimated glomerular filtration rate (eGFR) < 90 mL/min/1...
2018: International Journal of Nephrology
Andreas Pasch, Willi Jahnen-Dechent, Edward R Smith
Phosphate is an important cardiovascular risk factor and lowering elevated blood phosphate concentrations is a main therapeutic target in kidney patients. Phosphate is subject to the blood mineral buffering system which controls the precipitation of calcium and phosphate. Calciprotein particles (CPP), self-assembling complexes of calcium phosphate and serum proteins, are the nanomorphological correlates of this system. CPP1 are spherical, 50-100 nm in diameter, and contain amorphous mineral. CPP2 are oblongated, 100-200nm in the long axis, and they contain a crystalline mineral core...
2018: International Journal of Nephrology
Hodaka Yamada, Makoto Kuro-O, Shunsuke Funazaki, San-E Ishikawa, Masafumi Kakei, Kazuo Hara
Renal function decline is associated with progressive type 2 diabetes mellitus, which causes mineral and bone disorders. In the present study, we defined the ratio of urinary phosphate excretion (mg/day) to serum fibroblast growth factor 23 as the nephron index. We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up...
2018: International Journal of Nephrology
Kerstin Benz, Karl-Friedrich Hilgers, Christoph Daniel, Kerstin Amann
Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population. Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population. Among other structural and functional factors advanced calcification of atherosclerotic plaques as well as of the arterial and venous media has been described as potentially relevant for this high cardiovascular morbidity and mortality...
2018: International Journal of Nephrology
Bianca Ballarin Albino, Mariele Gobo-Oliveira, André Luís Balbi, Daniela Ponce
Purpose: This trial aimed to compare mortality and recovery of renal function in acute kidney injury (AKI) patients treated with different durations of prolonged hemodialysis (PHD) sessions (6 h versus 10 h). Methodology: We included patients with sepsis-associated AKI, >18 years, who are in use of a norepinephrine (lower than 0.7 ucg/kg/min). Results: One hundred and ninety-four patients were treated with 531 sessions of PHD (G1=104 and G2=90 patients)...
2018: International Journal of Nephrology
Helen J Sims-Williams, Hugh P Sims-Williams, Edith Mbabazi Kabachelor, Benjamin C Warf
Background: To describe the extent of renal disease in Ugandan children surviving at least ten years after spina bifida repair and to investigate risk factors for renal deterioration in this cohort. Patients and Methods: Children who had undergone spina bifida repair at CURE Children's Hospital of Uganda between 2000 and 2004 were invited to attend interview, physical examination, renal tract ultrasound, and a blood test (creatinine). Medical records were retrospectively reviewed...
2018: International Journal of Nephrology
Cristin D W Kaspar, Keia Sanderson, Seza Ozen, Priya S Verghese, Megan Lo, Timothy E Bunchman, Scott E Wenderfer, Jason Kidd
Objective: To assess practice pattern similarities and differences amongst pediatric rheumatologists and nephrologists in the management of pediatric Granulomatosis with Polyangiitis (GPA). Methods: A voluntary survey was distributed to the Midwest Pediatric Nephrology Consortium Group (MWPNC) and an international pediatric rheumatology email listserv in 2016-2017. Data were collected on general practice characteristics and preferences for induction management under three clinical scenarios (A-C): newly diagnosed GPA with glomerulonephritis, GPA with rapidly progressive glomerulonephritis, and GPA with pulmonary hemorrhage...
2018: International Journal of Nephrology
Murat Tuğcu, Umut Kasapoğlu, Gülizar Şahin, Süheyla Apaydın
Introduction: The number of geriatric patients is increasing in hemodialysis population over the years and mortality is higher in this group of patients. This study evaluated the factors affecting geriatric hemodialysis patient survival. Materials and Methods: This retrospective cohort study enrolled patients discharged from our nephrology clinic from 2009 to 2014. Data collected included demographics, Eastern Cooperative Oncology Group-Performance Status, vascular access type, and metabolic parameters...
2018: International Journal of Nephrology
L Y Wong, A S T Liew, W T Weng, C K Lim, A Vathsala, M P H S Toh
Background: Chronic Kidney Disease (CKD) is a major public health problem worldwide. There is limited literature on a model to project the number of people with CKD. This study projects the number of residents with CKD in Singapore by 2035 using a Markov model. Methods: A Markov model with nine mutually exclusive health states was developed according to the clinical course of CKD, based on a discrete time interval of 1 year. The model simulated the transition of cohorts across different health states from 2007 to 2035 using prevalence, incidence, mortality, disease transition, and disease detection rates...
2018: International Journal of Nephrology
Artur Q B da Silva, Taina V de Sandes-Freitas, Juliana B Mansur, Jose Osmar Medicina-Pestana, Gianna Mastroianni-Kirsztajn
There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=41). Only patients with histological diagnosis of MN in kidney grafts were included. Clinical and laboratory presentation, histological findings, treatment, and outcomes were detailed. Patients were predominantly male (58...
2018: International Journal of Nephrology
Mayerly Prada Rico, Carmen Inés Rodríguez Cuellar, Monica Fernandez Hernandez, Luz Stella González Chaparro, Olga Lucía Prado Agredo, Ricardo Gastelbondo Amaya
Introduction: Renal biopsy is the principal instrument to evaluate the diagnosis and prognosis of children with kidney disease. There are relatively few studies establishing epidemiology of its findings in the pediatric population. Methods: A descriptive study was conducted to describe characteristics of pediatric patients who had undergone a renal biopsy over the last 10 years in a national reference center, trying to accomplish an etiopathogenic approach of biopsy findings...
2018: International Journal of Nephrology
Muzamil Olamide Hassan, Raquel Duarte, Therese Dix-Peek, Caroline Dickens, Sagren Naidoo, Ahmed Vachiat, Sacha Grinter, Pravin Manga, Saraladevi Naicker
Background: Transforming growth factor- β (TGF- β ) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF- β isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atherosclerosis in South African CKD patients. Methods: We studied 120 CKD patients and 40 healthy controls. Serum TGF- β 1, TGF- β 2, TGF- β 3, endotoxin, and inflammatory markers were measured...
2018: International Journal of Nephrology
Peter Kangwagye, Joselyn Rwebembera, Tony Wilson, Francis Bajunirwe
Background: Routine testing of microalbuminuria and retinopathy is not done among patients with high blood pressure in resource-limited settings. We determined the prevalence of microalbuminuria and retinopathy and their risk factors among hypertensive patients at a large hospital in western Uganda. Methods: We consecutively recruited nondiabetic patients with hypertension at the outpatients' clinic over a period of 3 months. Spot urine samples were tested for urine albumin...
2018: International Journal of Nephrology
Makoto Kuro-O
The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society...
2018: International Journal of Nephrology
Ramya Hettiarachchi, Chrishantha Abeysena
Background: Chronic kidney disease (CKD) is associated with high morbidity and mortality. Hence, CKD patients are often in chronic psychological distress. The objective of the study was to describe factors associated with psychological distress of CKD patients attending National Nephrology Unit. Methods: A descriptive cross-sectional study was conducted among 382 CKD patients above 18 years of age applying systematic sampling. The data was collected using self-administered questionnaires to assess the psychological distress (GHQ-12), social support (SSQ6), coping strategies (BRIEFCOPE), pain (0 to 10 numeric pain rating scale), and physical role limitation due to ill health (SF36QOL)...
2018: International Journal of Nephrology
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