journal
https://read.qxmd.com/read/37261370/the-increasing-level-of-dkk-1-as-a-new-bone-formation-factor-in-patients-with-early-spondyloarthritis
#1
JOURNAL ARTICLE
Yuliasih Yuliasih, Aghnia Permatasari, Lita Diah Rahmawati, Mohammad Imam Wahyudi, Nabilatun Nisa'
The role of dickkopf-related protein 1 (DKK-1) in radiographic development may become a robust marker for early spondyloarthritis (SpA) diagnosis. This study aimed at determining the serum DKK-1 profile in patients with SpA and investigating its relationship with SpA progression. Supported by analyzing the BMD data which aims to affirm the potential of DKK-1 as a biomarker for early diagnosis of SpA, this research may become the early study to produce a robust tool to diminish the fatal impacts in SpA. This cross-sectional study included patients with SpA using ASAS 2010 criteria from Dr...
2023: Autoimmune Diseases
https://read.qxmd.com/read/36338545/interference-of-antinuclear-antibody-ana-in-indirect-immunofluorescence-assay-iifa-based-perinuclear-antineutrophil-cytoplasmic-antibody-panca-interpretation
#2
JOURNAL ARTICLE
Sangeeta Deka, Deepjyoti Kalita, Udaykumar Sasi Rekha, Putul Mahanta, Diksha Rani, Ravi Shankar, Anusha Krishna Raj, Mithilesh Kumar Jha, Gaurav Badoni, Manisha Paul, Shailesh Kumar Gupta, Shailender Negi, Anshu Singh, Kuhu Chatterjee
BACKGROUND: Indirect immunofluorescence assay (IIFA) based on antineutrophil cytoplasmic antibody (ANCA) testing is a commonly employed test for diagnosing autoimmune vasculitis. Antinuclear antibody (ANA) can give rise to a false interpretation of perinuclear-ANCA (pANCA) in ethanol-fixed granulocyte substrates. Analytical interference could frequently occur in setups where ethanol-fixed substrates are used alone. Here, we intend to investigate this ANA interference in pANCA interpretation...
2022: Autoimmune Diseases
https://read.qxmd.com/read/36311276/the-effects-of-hydroalcoholic-extract-of-silk-cocoon-on-hypothalamic-pituitary-gonadal-axis-in-streptozotocin-induced-diabetic-male-rats
#3
JOURNAL ARTICLE
Salma Ahi, Fatemeh Ebrahimi, Hassan Ali Abedi, Hossein Kargar Jahromi, Safar Zarei
BACKGROUND: Diabetes mellitus impairs the reproductive system by damaging the glands and changing their function and hormone secretions. Given the previous studies on medical properties of silk cocoon, the aim of this study was to investigate the effect of the hydroalcoholic extract of silk cocoon on pituitary-gonadal axis hormones and the testis changes in diabetic male rats. METHODS: In this experimental study, 35 male rats were divided into 5 equal groups. Control (C), nontreated diabetic rats (DNT1), and experimental diabetic rats treated (DT1) with a silk cocoon extract at concentrations of 200, 400, and 800 mg/kg for 56 days...
2022: Autoimmune Diseases
https://read.qxmd.com/read/36111059/autoimmune-diseases-induced-or-exacerbated-by-covid-19-a-single-center-experience
#4
JOURNAL ARTICLE
Yuval Ishay, Ariel Kenig, Limor Rubin, Oded Shamriz, Fadi Kharouf
The association between infectious diseases and autoimmunity has long been reported. Specifically, during the coronavirus disease 2019 (COVID-19) pandemic, this relation was further emphasized. The interplay between the two disease processes remains interesting, yet incompletely defined. Herein, we report a case series of six patients presenting with autoimmune phenomena first developed or exacerbated following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe the disease course and discuss the possible mechanisms underlying the association between autoimmunity and COVID-19...
2022: Autoimmune Diseases
https://read.qxmd.com/read/35911475/a-rare-manifestation-of-bullous-systemic-lupus-erythematosus-in-children-a-10-year-retrospective-study-in-a-tertiary-care-hospital
#5
JOURNAL ARTICLE
Sunee Panombualert, Leelawadee Techasatian, Rattapon Uppala, Piti Ungareewittaya, Charoen Choonhakarn
Bullous systemic lupus erythematosus (BSLE) is an uncommon cutaneous presentation that occurs even less frequent in the pediatric population. A retrospective review was performed from January 2012 to December 2021 in all pediatric patients (aged <18 years) who fulfilled the diagnostic criteria for BSLE to evaluate the clinical characteristics, extracutaneous involvement, histopathologic features, immunofluorescence patterns, serological abnormalities, internal organ involvement, treatments, and outcomes...
2022: Autoimmune Diseases
https://read.qxmd.com/read/35795725/thrombosis-and-anticoagulation-therapy-in-systemic-lupus-erythematosus
#6
REVIEW
Wenjun Yuan, Fengjun Guan
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease in which pathogenic autoantibodies and immune complexes are formed and mediate multiple organ and tissue damage. Thrombosis is one of the most common causes of death in patients with SLE. Anticoagulant therapy blocks the vicious cycle between inflammation and thrombosis, which may greatly improve the long-term prognosis of patients with SLE. However, the etiology and pathogenesis of this disease are very complicated and have not yet been fully clarified...
2022: Autoimmune Diseases
https://read.qxmd.com/read/35769404/t-cell-roles-and-activity-in-chronic-sclerosing-sialadenitis-as-igg4-related-disease-current-concepts-in-immunopathogenesis
#7
REVIEW
Hazim Mahmoud Ibrahem
IgG4-related disease is a multiorgan immunological fibroinflammatory disorder characterized by lymphoplasmacytic infiltration and fibrosis in multiple organs accompanied by high serum IgG4 levels. The salivary glands are the most common organs involved in this disease. Recently, chronic sclerosing sialadenitis affecting salivary glands, formerly known as Küttner's tumor, and Mikulicz's disease have been classified as a class of IgG4-related diseases. The etiopathobiology of IgG4-related disease is not fully understood...
2022: Autoimmune Diseases
https://read.qxmd.com/read/35186331/management-and-outcomes-of-anca-associated-vasculitis-at-a-tertiary-healthcare-facility
#8
JOURNAL ARTICLE
Nabeehah Moollan, Adeel Rafi Ahmed, Mark Denton
RESULTS: Thirty-six patients were included in the final study. Cyclophosphamide was used in 24 patients (66.7%) and, comparatively, rituximab in 7 patients (19.4%) for induction. Seven patients (19.4%) had a documented relapse, and six patients (85.7%) had rituximab as induction therapy for relapse. The majority of patients were on azathioprine (61.1%, 57.1% relapse population) as maintenance therapy. Progression to ESRD occurred in 11 (30.6%), death in 4 (11.1%), established CKD in 15 (41...
2022: Autoimmune Diseases
https://read.qxmd.com/read/35028161/will-14-3-3-%C3%AE-be-a-new-diagnostic-and-prognostic-biomarker-in-rheumatoid-arthritis-a-prospective-study-of-its-utility-in-early-diagnosis-and-response-to-treatment
#9
JOURNAL ARTICLE
Doaa Shawky Alashkar, Radwa Mostafa Elkhouly, Amira Yousef Abd Elnaby, Doaa Waseem Nada
RESULTS: Serum14-3-3 η levels were significantly higher in all RA patients than in controls ( P < 0.001), its sensitivity was 86.7% and 88.3% in early and established RA patients with a significant difference with RF and ACCP at early disease, and the specificity was 96.7%. There was a significant reduction of 14-3-3 η levels 6 months after treatment in the first group ( p =0.004), and there was a significant positive correlation between serum 14-3-3 η levels and parameters of disease activity and severity...
2022: Autoimmune Diseases
https://read.qxmd.com/read/34790416/protective-effect-of-hyperbaric-oxygen-treatment-on-axon-degeneration-after-acute-motor-axonal-neuropathy
#10
JOURNAL ARTICLE
Ni Komang Sri Dewi Untari, Kurnia Kusumastuti, Guritno Suryokusumo, I Ketut Sudiana
Objectives: Acute motor axonal neuropathy (AMAN) is a disease that leads to acute flaccid paralysis and may result from the binding of antibody and antigen to the spinal cord. The objective of this study is to evaluate the protective effect of hyperbaric oxygen treatment (HBOT) on axon degeneration of the spinal cord and sciatic nerve of the AMAN model rabbit. Axonal degeneration was assessed by evaluating glutathione (GSH) activity, interleukin-1 β (IL-1 β ) expression, and clinical and histopathological features...
2021: Autoimmune Diseases
https://read.qxmd.com/read/34567800/fungal-infections-among-psoriatic-patients-etiologic-agents-comorbidities-and-vulnerable-population
#11
JOURNAL ARTICLE
Mostafa Chadeganipour, Shahla Shadzi, Rasoul Mohammadi
Background: Psoriasis is a chronic inflammatory disorder of the skin and joint, affecting nearly 2-3% of the general population. It is assumed that imbalance between the types of natural microflora can accelerate the onset of the disease. Some fungi can play the role of superantigens and prolong chronic inflammation in the skin of psoriatic patients. The aim of the present investigation was to identify fungal species isolated from patients with psoriasis. Methods: From March 2016 to May 2019, 289 patients with prior diagnosis of psoriasis were included in this survey...
2021: Autoimmune Diseases
https://read.qxmd.com/read/34194823/corrigendum-to-gender-and-ethnicity-based-differences-in-clinical-and-laboratory-features-of-myasthenia-gravis
#12
Fawzi Abukhalil, Ayyaz Alam Sultan, Bijal Mehta, Erin Saito, Sejal Mehta, Aaron McMurtray
[This corrects the article DOI: 10.1155/2015/197893.].
2021: Autoimmune Diseases
https://read.qxmd.com/read/34055402/interleukin-18-in-brazilian-rheumatoid-arthritis-patients-can-leflunomide-reduce-it
#13
JOURNAL ARTICLE
Pablo Ramon Gualberto Cardoso, Claudia Diniz Lopes Marques, Kamila de Melo Vilar, Andrea Tavares Dantas, Angela Luzia Branco Pinto Duarte, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo
OBJECTIVES: Rheumatoid arthritis affects about 1% of the world's population. This is a chronic autoimmune disease. It is predominant in females with progressive joint damage. Immune cells are involved, especially Th1/Th17 lymphocytes and their inflammatory cytokines. These proteins have different functions in the immune system, such as IL-16 is a chemotactic factor; IL-18 can activate NF κ B transcription producing inflammatory proteins; IL-31 can activate the JAK/STAT pathway which leads to the production of inflammatory factors in chronic diseases; IL-33 promotes IL-16 secretion which causes lymphocyte recruitment, and IL-32 and IL-34 appear to increase TNF secretion by macrophages activation in AR...
2021: Autoimmune Diseases
https://read.qxmd.com/read/33833871/new-studies-of-pathogenesis-of-rheumatoid-arthritis-with-collagen-induced-and-collagen-antibody-induced-arthritis-models-new-insight-involving-bacteria-flora
#14
REVIEW
Ryoichi Hashida, Yasunori Shimozuru, Jessica Chang, Ibis Agosto-Marlin, Takaki Waritani, Kuniaki Terato
Much public research suggests that autoimmune diseases such as rheumatoid arthritis (RA) are induced by aberrant "self" immune responses attacking autologous tissues and organ components. However, recent studies have reported that autoimmune diseases may be triggered by dysbiotic composition changes of the intestinal bacteria and an imbalance between these bacteria and intestinal immune systems. However, there are a few solid concepts or methods to study the putative involvement and relationship of these inner environmental factors in RA pathogenesis...
2021: Autoimmune Diseases
https://read.qxmd.com/read/33505716/familial-risks-between-pernicious-anemia-and-other-autoimmune-diseases-in-the-population-of-sweden
#15
JOURNAL ARTICLE
Xinjun Li, Hauke Thomsen, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
Background: Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients...
2021: Autoimmune Diseases
https://read.qxmd.com/read/33312727/retracted-galectin-1-4-and-7-were-associated-with-high-activity-of-disease-in-patients-with-rheumatoid-arthritis
#16
Autoimmune Diseases
[This retracts the article DOI: 10.1155/2019/3081621.].
2020: Autoimmune Diseases
https://read.qxmd.com/read/32802495/therapeutic-plasma-exchange-as-a-treatment-for-autoimmune-neurological-disease
#17
JOURNAL ARTICLE
Ivana Nieto-Aristizábal, Álvaro J Vivas, Pablo Ruiz-Montaño, Cristian C Aragón, Iván Posso-Osorio, Jairo Quiñones, Julián Alejandro Rivillas, Gabriel J Tobón
INTRODUCTION: Therapeutic plasma exchange (TPE) is commonly used as treatment of certain autoimmune neurological diseases (ANDs), and its main objective is the removal of pathogenic autoantibodies. Our aim was to describe the clinical profile and the experience with the usage of TPE in patients with ANDs at our institution. METHODS: This is an observational retrospective study, including medical records of patients with diagnosis of ANDs who received TPE, between 2011 and 2018...
2020: Autoimmune Diseases
https://read.qxmd.com/read/32789026/the-influence-of-reactive-oxygen-species-in-the-immune-system-and-pathogenesis-of-multiple-sclerosis
#18
REVIEW
Mohammad Javad Tavassolifar, Mohammad Vodjgani, Zahra Salehi, Maryam Izad
Multiple roles have been indicated for reactive oxygen species (ROS) in the immune system in recent years. ROS have been extensively studied due to their ability to damage DNA and other subcellular structures. Noticeably, they have been identified as a pivotal second messenger for T-cell receptor signaling and T-cell activation and participate in antigen cross-presentation and chemotaxis. As an agent with direct toxic effects on cells, ROS lead to the initiation of the autoimmune response. Moreover, ROS levels are regulated by antioxidant systems, which include enzymatic and nonenzymatic antioxidants...
2020: Autoimmune Diseases
https://read.qxmd.com/read/32566271/autoimmune-mechanisms-of-interferon-hypersensitivity-and-neurodegenerative-diseases-down-syndrome
#19
JOURNAL ARTICLE
Ashraya Jagadeesh, Leonard E Maroun, Lisa M Van Es, Richard M Millis
Down syndrome (DS), also known as trisomy 21 (T21), is associated with interferon (IFN) hypersensitivity, as well as predilections for Alzheimer's dementia (AD) and various autoimmune diseases. IFN- α and IFN- γ receptors are encoded on chromosome 21 (Ch21). It remains unclear how other Ch21 genes contribute to the neuropathological features of DS/T21. This study tests the hypothesis that identifying IFN-stimulated response element (ISRE) control sites on Ch21 will mark novel candidate genes for DS/T21-related IFN hypersensitivity and neuropathology not previously reported to be associated with IFN functions...
2020: Autoimmune Diseases
https://read.qxmd.com/read/32509344/the-effects-of-alternate-day-corticosteroids-in-autoimmune-disease-patients
#20
JOURNAL ARTICLE
Genny Margarita Chaia-Semerena, María Eugenia Vargas-Camaño, Cesar Daniel Alonso-Bello, Jorge Javier Guillén-Toledo, Ricardo Leopoldo Guido-Bayardo, Fernando Lozano-Patiño, Mariano Daniel Temix-Delfín, María Isabel Castrejón-Vázquez
INTRODUCTION: Several studiesdemonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects in patients. For this reason, the current recommendation for the use of these medications is in a short cycle to avoid adverse effects when used frequently and for prolonged periods of time. OBJECTIVES: To learn variations in serum levels of autoantibodies in autoimmune diseases treated with steroids on alternate days, as well as whether there are differences in the response to them depending on the type of disease...
2020: Autoimmune Diseases
journal
journal
43322
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.