journal
Journals Drug, Healthcare and Patient S...

Drug, Healthcare and Patient Safety

https://read.qxmd.com/read/36727107/validation-of-the-safety-attitudes-questionnaire-for-assessing-patient-safety-culture-in-critical-care-settings-of-three-selected-ugandan-hospitals
#21
JOURNAL ARTICLE
Joseph Atukwatse, Vallence Niyonzima, Cliff Asher Aliga, Jalia Nakandi Serwadda, Rosemary Nankunda, Catherine Nakiganda, Peninah Komugabe, Hanifah Nantongo
BACKGROUND: The safety attitudes questionnaire (SAQ) short form (2006) is important for assessing patient safety culture in clinical environments. However, little is known about its validity and applicability in Uganda. This study validated the SAQ short form (2006) for use in assessing patient safety culture in critical care settings of hospitals in the Ugandan context. METHODS: Using a sequential exploratory mixed-methods research design, the face, content and construct validity for the SAQ short form (2006) was assessed in a multi-phased approach...
2023: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36699285/prevalence-and-determinants-of-household-medication-storage-during-the-covid-19-outbreak-in-southwest-ethiopia
#22
JOURNAL ARTICLE
Semere Welday Kahssay, Workineh Woldeselassie Hammeso, Dawit Getachew, Behailu Dessalegn Woldeselassie
BACKGROUND: Most households worldwide keep medicines on hand for various reasons, including emergency use, treatment of acute and chronic diseases, and anticipated future use. Being infected or fear of getting COVID-19 in the current pandemic could increase the storage of drugs at home. Thus, this study aimed to assess the prevalence of household storage of medicines and associated factors in southwest Ethiopia during the COVID-19 outbreak. METHODS: A cross-sectional household survey was conducted from February 1 to May 30, 2022...
2023: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36578774/safety-aspects-and-rational-use-of-lanadelumab-injections-in-the-treatment-of-hereditary-angioedema-hae-clinical-insights
#23
REVIEW
Elena Petkova, Vanya Yordanova, Maria Staevska, Anna Valerieva
Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of skin/mucosal swelling, and/or attacks of severe abdominal pain when it affects the gastrointestinal tract. The disease might be unexpectedly fatal when the upper airways are compromised. HAE clinical presentation, disease course and prognosis are associated with significant disease burden and severely impaired quality of life. Lanadelumab is a breakthrough therapy for the prevention of attacks in HAE type 1 and 2 patients...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36274904/reduction-of-in-hospital-preoperative-waiting-time-of-elective-surgeries-in-the-amidst-of-covid-19-pandemic-experience-from-ethiopia
#24
JOURNAL ARTICLE
Berhanetsehay Teklewold, Engida Abebe, Dagmawi Anteneh, Etsehiwot Haileselassie
Background: The higher demand for surgical services during the advancement of the COVID-19 pandemic has resulted from the need for a pre-admission negative result, the need for extra resources, and a shortage of skilled expertise. This quality improvement project aimed to reduce the in-hospital preoperative waiting time of elective cases to less than 24 hours. Methods: The study was conducted in a tertiary care center. Following the collection of baseline data, we formed a multidisciplinary team to analyze the root causes and intervention ideas of delay using fishbone and driver diagrams, respectively...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36199542/epidemiology-of-snake-bites-linked-with-the-antivenoms-production-in-colombia-2008-2020-produced-vials-do-not-meet-the-needs
#25
JOURNAL ARTICLE
Sebastián Estrada-Gómez, Leidy Johana Vargas-Muñoz, Luis Felipe Higuita-Gutiérrez
Introduction: Snakebite envenomation is a public health event of mandatory reporting in Colombia. It is considered a medical emergency in which the government must guarantee antivenom availability. We describe snakebite epidemiological figures in Colombia between 2008 and 2020 and correlate them with antivenom manufacturing figures to determine rate coverage and the need for antivenom. Methods: We performed an ecological study based on secondary official figures from the National Health Institute, the National Institute for Surveillance of Medicines and Foods, the National Administrative Department of Statistics and the Ministry of Health and Social Protection...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36118374/opioid-utilization-and-management-in-the-setting-of-stewardship-during-inpatient-rehab-care
#26
JOURNAL ARTICLE
Laura Murphy, Kori Leblanc, Souzi Badr, Emily Ching, Lynda Mao, Naomi Steenhof, Bassem Hamandi, Bonita Rubin, Ada Seto, Andrea D Furlan
BACKGROUND: Opioid utilization and management in an inpatient rehabilitation setting have not been widely described, despite the unique opportunities that exist in this setting to support opioid stewardship across transitions in care. We aimed to characterize opioid utilization and management by interprofessional teams across a large, inpatient rehabilitation setting after incorporation of opioid stewardship principles by pharmacists as part of their daily practice. PATIENTS AND METHODS: This was a retrospective chart review at Toronto Rehab, University Health Network, Toronto, Canada...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36105663/clinical-utility-and-tolerability-of-tolvaptan-in-the-treatment-of-autosomal-dominant-polycystic-kidney-disease-adpkd
#27
REVIEW
Rupesh Raina, Ahmad Houry, Pratik Rath, Guneive Mangat, Davinder Pandher, Muhammad Islam, Ala'a Grace Khattab, Joseph K Kalout, Sumedha Bagga
Autosomal dominant polycystic kidney disease, also known as ADPKD, is the most common hereditary kidney disease, affecting different age groups. ADPKD can eventually lead to end-stage renal disease. The etiology of ADPKD is genetic, resulting in the formation of cysts containing fluids on the kidneys. Patients with ADPKD present a range of symptoms following a decline in kidney function. Pain, stones, proteinuria and osteoporosis are few of the many symptoms, resulting from decreased kidney function. Tolvaptan, a selective V2 receptor antagonist, is the etiological treatment used for ADPKD...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/36039072/describing-and-quantifying-wrong-patient-medication-errors-through-a-study-of-incident-reports
#28
JOURNAL ARTICLE
Megumi Takahashi, Hiroshi Okudera, Masahiro Wakasugi, Mie Sakamoto, Hiromi Shimizu, Tokie Wakabayashi, Tsuneaki Yamanouchi, Hisashi Nagashima
Purpose: Our aim was to inform a new definition of wrong-patient errors, obtained through an analysis of incident reports related to medication errors. Methods: We investigated wrong-patient medication errors in incident reports voluntarily reported by medical staff using a web-based incident reporting system from 2015 to 2016 at a university hospital in Japan. Incident report content was separately evaluated by four evaluators using investigational methods for clinical incidents from the Clinical Risk Unit and the Association of Litigation and Risk Management...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35915655/knowledge-and-perceptions-of-nurse-practitioners-on-adverse-events-following-immunization-and-barriers-to-reporting-in-the-central-region-eritrea-a-cross-sectional-study
#29
JOURNAL ARTICLE
Nuru Abdu, Asmerom Mosazghi, Tedros Yehdego, Eyasu H Tesfamariam, Mulugeta Russom
Background: Though vaccines are generally considered extremely safe and effective, they have been associated with some serious adverse events following immunization (AEFIs). AEFIs might be related to either the vaccine, immunization error, anxiety related to immunization, and/or coincidental events. If they are not reported and investigated in timely fashion, they can create rumors and confidence gaps. In the last few years, reporting AEFIs in the Central Region of Eritrea, compared to other regions, has been found to be very low, with the root cause for this variation unknown, making intervention strategies challenging...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35903308/clinical-manifestations-and-genetic-influences-in-sulfonamide-induced-hypersensitivity
#30
REVIEW
Pungki Afifah Asyraf, Ivanna Fauziyah Kusnadi, Jonathan Stefanus, Miski Aghnia Khairinisa, Rizky Abdulah
Drug hypersensitivity is an inflammatory or immune reaction induced by drugs. It can be fatal if not appropriately treated and cause the risk of long-term complications. Sulfonamides are classified as antimicrobial drugs with a broad spectrum effective for gram-positive and gram-negative bacteria. This antibacterial agent works by competitively inhibiting folic acid synthesis, which prevents the growth and proliferation of microorganisms. In its use as antibiotics, sulfonamides can also cause adverse reactions in specific individuals...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35880007/psychiatric-disorders-and-genotoxicity-following-primary-metal-on-polyethylene-total-hip-arthroplasty-and-their-correlation-to-cobalt-chromium-levels
#31
JOURNAL ARTICLE
Omaima I Abdel Hamid, Mohamed E Attia, Jon M Hirshon, Mohamed El-Shinawi, Moustafa El-Hussaini, Maged El-Setouhy
Introduction: Hip arthroplasty (HA) using implantable metal components is among the commonest orthopedic interventions. However, it can be followed by several complications following corrosion and the release of metal ions. Several studies proved that damaged genomic DNA may contribute to the pathophysiology of mental disorders. Aim: The current work aims to evaluate the psychiatric disorders in metal on polyethylene hip arthroplasty (MOP-HA) patients and its correlation to cobalt/chromium (Co/Cr) levels and genotoxicity...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35860695/clinical-efficacy-safety-tolerability-and-real-world-data-of-patiromer-for-the-treatment-of-hyperkalemia
#32
REVIEW
Gates Colbert, Shilpa Sannapaneni, Edgar V Lerma
Hyperkalemia remains one of the most difficult consequences of disease state and treatment for patients with chronic kidney disease, heart failure, and diabetes. Controlling hyperkalemia can be difficult, but has become easier with the introduction of novel oral potassium binders. Patiromer was approved in 2015 for the treatment of hyperkalemia by the FDA in the United States. Several pivotal trials proved its efficacy, safety, and improved tolerability compared with previous hyperkalemia treatments. Additionally, many real-world publications and trials have given deeper insights into the capabilities of patiromer...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35634137/influence-of-medical-education-on-medicine-use-and-self-medication-among-medical-students-a-cross-sectional-study-from-kabul
#33
JOURNAL ARTICLE
Ahmad Farid Daanish, Ershad Ahmad Mushkani
Objective: To compare the prevalence of self-medication among first- and fifth-year medical students at Kabul University of Medical Sciences. Methods: A cross-sectional study was conducted with the participation of all first- and fifth-year medical students by using a short, self-administered questionnaire. The prevalence of self-medication was estimated in the entire study population and also in those who had used medicines in the preceding one week. Results: Of the total 302 students, the prevalence of medicine use was 38%...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35607639/pancytopenia-due-to-possible-drug-drug-interactions-between-low-dose-methotrexate-and-proton-pump-inhibitors
#34
Dan Tao, Hui Wang, Fangfang Xia, Wenlu Ma
Methotrexate (MTX) has been widely used with a wide range of doses in the treatment of certain neoplastic diseases, severe psoriasis, and rheumatoid arthritis. At higher dose, monitoring of serum MTX elimination is performed because delayed elimination can result in serious and potentially life-threatening toxicities. A number of medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), salicylates, phenylbutazone, phenytoin, sulfonamides, and some oral antibiotics, are known to interact with MTX therapy through various mechanisms...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35607638/obstacles-and-opportunities-in-information-transfer-regarding-medications-at-discharge-a-focus-group-study-with-hospital-physicians
#35
JOURNAL ARTICLE
Maria Glans, Patrik Midlöv, Annika Kragh Ekstam, Åsa Bondesson, Annika Brorsson
Purpose: This qualitative study aimed to investigate experiences and perceptions of hospital physicians regarding the discharging process, focusing on information transfer regarding medications. Methods: By purposive sampling three focus groups were formed. To facilitate discussions and maintain consistency, a semi-structured interview guide was used. Discussions were audio recorded and transcribed verbatim. Qualitative content analysis was used to analyze the anonymized data...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35502287/challenges-of-medical-error-reporting-in-mizan-tepi-university-teaching-hospital-a-qualitative-exploratory-study
#36
JOURNAL ARTICLE
Msganaw Derese, Wubetu Agegnehu
Background: Medical error is defined as "an act of omission or commission in planning or execution that contributes or could contribute to an unintended result". It is a serious public health problem that can pose a threat to patient safety and if managed it can be an opportunity to an organizational learning. This study aimed to assess the challenges of error reporting. Methods: Explorative qualitative cross-sectional study was conducted. The study was conducted among healthcare providers in Mizan-Tepi University Teaching Hospital...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35369039/knowledge-and-attitude-of-women-towards-herbal-medicine-usage-during-pregnancy-and-associated-factors-among-mothers-who-gave-birth-in-the-last-twelve-months-in-dega-damot-district-northwest-ethiopia
#37
JOURNAL ARTICLE
Tazeb Alemu Anteneh, Abayneh Aklilu Solomon, Animut Tagele Tamiru, Nebiyu Solomon Tibebu, Haymanot Nigatu Alemu, Selam Yibeltal Desalegn, Hiwotie Getaneh Ayalew, Marta Yimam Abegaz, Azmeraw Ambachew Kebede
Background: The use of herbal medicine is increasing globally, particularly in developing countries including Ethiopia, yet little is known regarding its effect and safety during pregnancy. Pregnant women prefer herbal medicine due to easy accessibility, traditional and cultural beliefs, and comparatively low cost. This study aimed to assess women's knowledge and attitude towards the effects of herbal medicine usage during pregnancy and associated factors among women who gave birth in the last twelve months in Dega Damot district...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35369038/the-predictors-influencing-the-rational-use-of-antibiotics-among-public-sector-a-community-based-survey-in-thailand
#38
JOURNAL ARTICLE
Thaw Zin Lin, Isareethika Jayasvasti, Sariyamon Tiraphat, Supa Pengpid, Manisthawadee Jayasvasti, Phetlada Borriharn
Background: The spread and emergence of antimicrobial resistance is the significant public health concerns over past decades. The major leading cause comes from irrational use of antibiotics. Aim: To explore the characteristics of rational use of antibiotics and identify its predictive factors among public sector living in Nakhon Nayok Province, Thailand. Methods: This project was conducted by using the data-source from Rational Use of Antibiotics (RUA) Survey Project at Nakhon Nayok Province...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35299593/an-atypical-case-of-extreme-polypharmacy
#39
Michael A Veronin
A commonly reported definition of polypharmacy is the numerical definition of 5 or more medications daily, and definitions have ranged from 2 or more to 11 or more medications. In this case report, an extreme case of polypharmacy is presented, highlighted by the inordinate number of drugs used over time throughout the patient's care. A 48-year-old African American female with multiple comorbidities experienced a serious adverse drug event (ADE) prompting reporting to MedWatch, the US Food and Drug Administration's adverse drug event reporting system...
2022: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/35115843/self-medication-practice-with-antibiotics-and-its-associated-factors-among-community-of-bule-hora-town-south-west-ethiopia
#40
JOURNAL ARTICLE
Fitsum Demissie, Kelil Ereso, Getahun Paulos
Background: Self-medication with antibiotics is being practiced worldwide with high prevalence, mostly in developing countries. Several factors induce the practice of self-medication, such as irrational and uncontrolled dispensing of medicinal substances, difficulty accessing health-care systems, and cost of diagnosis. Thus, this study assessed the prevalence of self-medication with antibiotics, and its associated factors among the community of Bule-Hora town, South West Ethiopia. Methods: A community-based cross-sectional study design was used...
2022: Drug, Healthcare and Patient Safety
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