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Drug, Healthcare and Patient Safety

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https://read.qxmd.com/read/30962725/adherence-to-risk-management-guidelines-for-drugs-which-cause-vitamin-d-deficiency-big-data-from-the-swedish-health-system
#1
Ola Nordqvist, Ulrika Lönnbom Svensson, Lars Brudin, Pär Wanby, Martin Carlsson
Purpose: Several medications are known to cause vitamin D deficiency. The aim of this study is to describe vitamin D testing and supplementation in patients using these "risk medications", thereby assessing adherence to medical guidelines. Patients and methods: A database with electronic health records for the population in a Swedish County (≈240,000 inhabitants) was screened for patients prescribed the pre-defined "risk medications" during a 2-year period (2014-2015)...
2019: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30936751/evaluation-to-improve-the-quality-of-medication-preparation-and-administration-in-pediatric-and-adult-intensive-care-units
#2
Theresa Hermanspann, Eva van der Linden, Mark Schoberer, Christina Fitzner, Thorsten Orlikowsky, Gernot Marx, Albrecht Eisert
Purpose: To determine the type, frequency, and factors associated with medication preparation and administration errors in adult intensive care units (ICUs) and neonatal ICUs (NICUs)/pediatric ICUs (PICUs). Patients and methods: We conducted a prospective direct observation study in an adult ICU and NICU/PICU in a tertiary university hospital. Between June 2012 and June 2013, a clinical pharmacist and medical student observed the nursing care staff on weekdays during the preparation and administration of intravenous drugs...
2019: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30881142/pulmonary-hypertension-occurring-with-diazoxide-use-in-a-preterm-infant-with-hypoglycemia
#3
Ranjit I Kylat
Pharmacologic modulation to open the KATP channels with diazoxide is useful in treating hyperinsulinemia. Diazoxide is being used more often in neonates with hyperinsulinemic hypoglycemia. This report highlights a case of severe pulmonary hypertension (PH) with re-opening of ductus arteriosus in an extremely premature infant after the use of diazoxide. The rapid onset of PH with respiratory failure was completely reversible. This case emphasizes the need for extreme caution with use of diazoxide in the premature infant population, especially those with chronic lung disease of prematurity...
2019: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30799958/pattern-of-medication-use-in-geriatric-patients-at-primary-health-care-facilities-in-karawang-indonesia
#4
Rizky Abdulah, Widya N Insani, Novia E Putri, Helda P Purba, Dika P Destiani, Melisa I Barliana
Background: Rational drug use is a critical component in patient care, particularly among the elderly who often have multiple medical problems. The aim of this study was to assess the pattern of medication use among the elderly visiting primary health care facilities. Methods: A retrospective cross-sectional study was conducted at 25 primary health care facilities in Karawang District, Indonesia, and patients aged ≥60 years visiting the facilities from January to December 2014 were included...
2019: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30588126/ceftriaxone-associated-nephrolithiasis-and-gallstone-in-adults
#5
Ghodsiyeh Azarkar, Motahare Mahi Birjand, Alireza Ehsanbakhsh, Bita Bijari, Mohammad Reza Abedini, Masood Ziaee
Background: Ceftriaxone (CTX) is widely used for the treatment of bacterial infections; however, side effects such as gallstone and nephrolithiasis have been reported in children. There is limited information about urinary tract calculi as CTX side effects in adults. Therefore, the present study was aimed to evaluate the incidence of gallstone and nephrolithiasis following CTX administration. Methods: The present study was conducted in the Vali-e-Asr Hospital. Eighty-four patients with various infectious diseases with different daily treatment (mean ± SD: 4...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30538582/clinical-factors-predicting-drug-induced-liver-injury-due-to-flucloxacillin
#6
Mikaela Lindh, Pär Hallberg, Qun-Ying Yue, Mia Wadelius
Objectives: Drug-induced liver injury (DILI) is a serious adverse reaction due to flucloxacillin. The pathogenesis is not fully understood. Female sex, age over 60 years, and a longer treatment duration have been suggested to be predisposing factors. Carriers of HLA-B*57:01 have an 80-fold increased risk, but due to the rarity of the reaction, testing of all patients is not cost-effective. We aimed to validate and detect clinical risk factors for flucloxacillin DILI. Methods: Clinical characteristics of flucloxacillin-treated patients with (n=50) and without DILI (n=2,330) were compared in a retrospective case control study...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30410406/a-pilot-study-on-secondhand-tobacco-exposure-parental-knowledge-about-health-impact-and-feasibility-of-cessation
#7
Hina Walia, Rebecca Miller, Dmitry Tumin, Joseph D Tobias, Roby Sebastian
Introduction: As the primary source of smoke exposure is in the home, the smoking behaviors of parents and other caregivers are key determinants of a child's exposure to secondhand smoke. The perioperative period offers an opportunity to discuss smoking cessation strategies. Methods: This prospective study included 97 parents or caregivers of patients undergoing dental surgery. Caregivers were surveyed in the dental waiting room during the preoperative phase. The primary aim was to determine the feasibility of using the preoperative encounter to offer smoking cessation resources to parents of pediatric patients...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30174460/predictors-of-non-adherence-to-antiretroviral-therapy-at-an-urban-hiv-care-and-treatment-center-in-tanzania
#8
Raphael Z Sangeda, Fausta Mosha, Said Aboud, Appolinary Kamuhabwa, Guerino Chalamilla, Jurgen Vercauteren, Eric Van Wijngaerden, Eligius F Lyamuya, Anne-Mieke Vandamme
Background: Measurement of adherence to antiretroviral therapy (ART) can serve as a proxy for virologic failure in resource-limited settings. The aim of this study was to determine the factors underlying nonadherence measured by three methods. Patients and methods: This is a prospective longitudinal cohort of 220 patients on ART at Amana Hospital in Dar es Salaam, Tanzania. We measured adherence using a structured questionnaire combining a visual analog scale (VAS) and Swiss HIV Cohort Study Adherence Questionnaire (SHCS-AQ), pharmacy refill, and appointment keeping during four periods over 1 year...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30050329/development-and-validation-of-a-questionnaire-to-self-assess-patient-knowledge-of-direct-oral-anticoagulants-kodoa-test
#9
Corina Metaxas, Valerie Albert, Matthias Stahl, Kurt E Hersberger, Isabelle Arnet
Objective: Few studies have examined associations between patient knowledge of direct oral anticoagulants (DOAC) and clinical outcomes, mostly because of the lack of validated questionnaires for assessing knowledge. The aim of this study was to develop and validate a questionnaire to self-assess knowledge of DOAC. Methods: Twelve anticoagulation experts participated in the questionnaire development process to ensure content validity. The Knowledge Of Direct Oral Anticoagulants (KODOA)-test was submitted to patients on DOAC and to pharmacists to assess construct validity...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/30038524/erratum-long-term-safety-profile-of-tolvaptan-in-autosomal-dominant-polycystic-kidney-disease-patients-tempo-extension-japan-trial-corrigendum
#10
(no author information available yet)
[This corrects the article on p. 93 in vol. 9, PMID: 29123425.].
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29928146/therapeutic-potential-of-medicinal-marijuana-an-educational-primer-for-health-care-professionals
#11
REVIEW
Yara Mouhamed, Andrey Vishnyakov, Bessi Qorri, Manpreet Sambi, Sm Signy Frank, Catherine Nowierski, Anmol Lamba, Umrao Bhatti, Myron R Szewczuk
With the proposed Canadian July 2018 legalization of marijuana through the Cannabis Act, a thorough critical analysis of the current trials on the efficacy of medicinal marijuana (MM) as a treatment option is necessary. This review is particularly important for primary care physicians whose patients may be interested in using MM as an alternative therapy. In response to increased interest in MM, Health Canada released a document in 2013 for general practitioners (GPs) as an educational tool on the efficacy of MM in treating some chronic and acute conditions...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29760569/concomitant-use-of-opioid-medications-with-triptans-or-serotonergic-antidepressants-in-us-office-based-physician-visits
#12
Kyle C Molina, Kathleen A Fairman, David A Sclar
Background: Opioids are not recommended for routine treatment of migraine because their benefits are outweighed by risks of medication overuse headache and abuse/dependence. A March 2016 US Food and Drug Administration (FDA) safety communication warned of the risk of serotonin syndrome from using opioids concomitantly with 5-hydroxytryptamine receptor agonists (triptans) or serotonergic antidepressants: selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29713203/evaluating-cardiac-risk-exposure-response-analysis-in-early-clinical-drug-development
#13
REVIEW
Julie Grenier, Sabina Paglialunga, Bruce H Morimoto, Robert M Lester
The assessment of a drug's cardiac liability has undergone considerable metamorphosis by regulators since International Council for Harmonization of Technical Requirement for Pharmaceuticals for Human Use E14 guideline was introduced in 2005. Drug developers now have a choice in how proarrhythmia risk can be evaluated; the options include a dedicated thorough QT (TQT) study or exposure response (ER) modeling of intensive electrocardiogram (ECG) captured in early clinical development. The alternative approach of ER modeling was incorporated into a guidance document in 2015 as a primary analysis tool which could be utilized in early phase dose escalation studies as an option to perform a dedicated TQT trial...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29670404/evaluation-of-vancomycin-therapy-in-the-adult-icus-of-a-teaching-hospital-in-southern-iran
#14
Afsaneh Vazin, Motahare Mahi Birjand, Masoud Darake
Background: Vancomycin resistance in intensive care units (ICUs) accounts for significant morbidity and excess costs. The objective of the present study was to determine the appropriateness of vancomycin use in the various ICUs of Nemazee Hospital, Shiraz, Iran. Methods: This prospective study was performed on 95 critically ill patients (48 males and 47 females) who were treated with vancomycin for at least 3 subsequent doses in 6 ICUs during 12 months. Required demographic, clinical, and paraclinical data were collected by a pharmacist...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29593437/calculating-reading-ease-score-of-patient-package-inserts-in-iran
#15
Vahideh Zarea Gavgani, Sedigheh Mirzadeh-Qasabeh, Jalal Hanaee, Hadi Hamishehkar
Background: The patient package inserts (PPIs), which contain the necessary information about medications intended for patients, need to be expressed in a clear language comprehensible to everyone. Objective: This study aimed to evaluate the readability and understandability of the drug package inserts for the inexpert people. Methods: The readability of the 158 PPIs of the 33 drugs, registered and manufactured in Iran, was calculated. The main criterion for selecting PPIs to include in this study was of those top-selling drugs during the year 2015 according to the Social Security Organization in Iran...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29445304/prevalence-of-medication-errors-in-primary-health-care-at-bahrain-defence-force-hospital-prescription-based-study
#16
Fatema Aljasmi, Fatema Almalood, Ahmed Al Ansari
Background: One of the important activities that physicians - particularly general practitioners - perform is prescribing. It occurs in most health care facilities and especially in primary health care (PHC) settings. Objectives: This study aims to determine what types of prescribing errors are made in PHC at Bahrain Defence Force (BDF) Hospital, and how common they are. Methods: This was a retrospective study of data from PHC at BDF Hospital...
2018: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29184448/older-adults-and-high-risk-medication-administration-in-the-emergency-department
#17
Mitchell Kim, Steven H Mitchell, Medley Gatewood, Katherine A Bennett, Paul R Sutton, Carol A Crawford, Itay Bentov, Mamatha Damodarasamy, Stephen J Kaplan, May J Reed
Background: Older adults are susceptible to adverse effects from opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and benzodiazepines (BZDs). We investigated factors associated with the administration of elevated doses of these medications of interest to older adults (≥65 years old) in the emergency department (ED). Patients and methods: ED records were queried for the administration of medications of interest to older adults at two academic medical center EDs over a 6-month period...
2017: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/29123425/long-term-safety-profile-of-tolvaptan-in-autosomal-dominant-polycystic-kidney-disease-patients-tempo-extension-japan-trial
#18
Satoru Muto, Tadashi Okada, Moriyoshi Yasuda, Hidetsugu Tsubouchi, Koji Nakajima, Shigeo Horie
Aim: The aim of this trial (ClinicalTrials.gov identifier: NCT01280721) was to investigate the long-term safety profile of tolvaptan in Japanese patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: This open-label multicenter trial was conducted to examine adverse drug reactions (ADRs) related to tolvaptan up to an additional 3 years in 135 Japanese patients who participated in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and its Outcomes (TEMPO) 3:4 trial at doses of 60-120 mg/d...
2017: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/28932128/a-suspected-case-of-autoinduction-of-voriconazole-metabolism-in-a-patient-with-cerebral-aspergillosis
#19
Martin J Ferguson, Maria L Randles, Declan G de Freitas
OBJECTIVE: This study aims to report a case of accelerated metabolism of voriconazole in a patient with cerebral aspergillosis. CASE SUMMARY: A 36-year-old woman developed cerebral aspergillosis after immunosuppressive treatment for suspected atypical hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. She was treated with voriconazole using therapeutic drug monitoring to guide dosing. After an initial high level, her dose was reduced, but over the following weeks, she required several dose increases in order to achieve a voriconazole level within the target range...
2017: Drug, Healthcare and Patient Safety
https://read.qxmd.com/read/28860862/early-rehospitalizations-of-frail-elderly-patients-the-role-of-medications-a-clinical-prospective-observational-trial
#20
Niklas Ekerstad, Kristoffer Bylin, Björn W Karlson
BACKGROUND AND OBJECTIVE: Early readmissions of frail elderly patients after an episode of hospital care are common and constitute a crucial patient safety outcome. Our purpose was to study the impact of medications on such early rehospitalizations. PATIENTS AND METHODS: This is a clinical, prospective, observational study on rehospitalizations within 30 days after an acute hospital episode for frail patients over the age of 75 years. To identify adverse drug reactions (ADRs), underuse of evidence-based treatment and avoidability of rehospitalizations, the Naranjo score, the Hallas criteria and clinical judgment were used...
2017: Drug, Healthcare and Patient Safety
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