Katharyn L Flickinger, Alexandra Weissman, Jonathan Elmer, Patrick J Coppler, Francis X Guyette, Melissa J Repine, Cameron Dezfulian, David Hopkins, Adam Frisch, Ankur A Doshi, Jon C Rittenberger, Clifton W Callaway
Hypothermia has multiple physiological effects, including decreasing metabolic rate and oxygen consumption (VO2 ). There are few human data about the magnitude of change in VO2 with decreases in core temperature. We aimed to quantify to magnitude of reduction in resting VO2 as we reduced core temperature in lightly sedated healthy individuals. After informed consent and physical screening, we cooled participants by rapidly infusing 20 mL/kg of cold (4°C) saline intravenously and placing surface cooling pads on the torso...
July 3, 2023: Therapeutic Hypothermia and Temperature Management