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Journal of Adolescent and Young Adult Oncology

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https://read.qxmd.com/read/30869557/health-literacy-in-adolescent-and-young-adult-cancer-patients-and-its-association-with-health-outcomes
#1
Diana Richter, Anja Mehnert, Dirk Forstmeyer, Jochen Ernst, Kristina Geue
This cross-sectional German study examined the frequency of health literacy (HL) in adolescents and young adult (AYA) cancer patients and the factors associated with HL. A sample of 206 AYA-aged patients (80.1% female; age 15-39 years) completed measures of HL, health-related quality of life (HRQoL), depression, and sociodemographic characteristics; 28% had a sufficient HL score. Males and patients with higher education levels reported higher HL scores. Regression revealed positive associations between HL and HRQoL and depressive symptoms...
March 14, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30869555/schwannoma-formation-in-childhood-cancer-survivors-exposed-to-total-body-irradiation-case-series
#2
Emily Anderson, Nadine Linendoll, Carl B Heilman, Ron I Riesenburger, Miriam A O'Leary, Knarik Arkun, Tara J Nail, Martin Goodman, Susan K Parsons
Childhood cancer survivors are at risk for ongoing health risks related to their initial treatment. One potential long-term complication following radiation is the development of secondary tumors, including peripheral nerve tumors, such as schwannomas. We present three adolescent and young adult (AYA)-aged survivors of pediatric cancer (22-40 years), followed in our AYA survivorship clinic. Each was found to have a schwannoma many years following total body irradiation for a childhood primary malignancy. We highlight a late effect of low-dose total body irradiation as well as the importance of long-term monitoring in this population...
March 14, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30835153/ambulatory-hematopoietic-stem-cell-transplantation-in-young-adults-with-acute-myeloid-leukemia-treated-with-venetoclax-and-low-doses-of-cytarabine-report-of-two-cases
#3
Juan Antonio Flores-Jiménez, Michael Ariel Pimentel-Morales, Oscar González-Ramella, Dante Vega-Cortés, Miguel Ángel Zambrano-Velarde
Acute myelogenous leukemia (AML) represents ∼33% of those in adolescents and young adults. Hematopoietic cell transplantation in its various practices has been used as a treatment for acute myeloid leukemia, especially in refractory or relapsing patients. In this study, we describe two young adults with AML who were treated at our hospital. One was refractory to conventional treatment and the other case was relapsed after a first complete remission. They achieved complete remission with new combined treatment (venetoclax + cytarabine) consolidating them with hematopoietic stem cell transplantation...
March 5, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30822262/management-of-sarcoma-in-adolescents-and-young-adults-an-australian-population-based-study
#4
Victoria M White, Lisa M Orme, Gemma Skaczkowski, Ross Pinkerton, Michael Coory, Michael Osborn, Helen Bibby, Wayne Nicholls, Rachel Conyers, Marianne B Phillips, Rosemary Harrup, Rick Walker, Kate Thompson, Antoinette Anazodo
BACKGROUND: While overall survival (OS) for cancer in adolescents and young adults (AYA) has improved, there has been little change in AYA survival for several types of sarcomas. Using national data for Australia we describe (1) the treatment centers caring for AYA sarcoma, (2) treatments provided, and (3) survival outcomes. PROCEDURE: National population-based study assessing treatment of 15-24 year-olds diagnosed with soft tissue sarcoma (STS), bone sarcoma (BS), and Ewing family tumors (ET) between 2007 and 2012...
March 1, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30817225/congruence-of-reproductive-goals-and-fertility-related-attitudes-of-adolescent-and-young-adult-males-and-their-parents-after-cancer-treatment
#5
Leena Nahata, Taylor L Morgan, Amanda C Ferrante, Nicole M Caltabellotta, Nicholas D Yeager, Joseph R Rausch, Sarah H O'Brien, Gwendolyn P Quinn, Cynthia A Gerhardt
PURPOSE: Approximately half of all males experience fertility impairment after cancer treatment, which can diminish quality of life. Parents are often responsible for sharing health-related information, and parental recommendation strongly impacts fertility-related decisions; yet it remains unclear whether adolescents and young adults' (AYAs) and their parents' fertility-related goals/attitudes align. This study examined parent-AYAs congruence on fertility-related attitudes and (grand) parenthood goals during survivorship, and if parents were aware of their sons' parenthood goals and reproductive concerns...
February 28, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30817217/the-impact-of-financial-toxicity-on-psychological-well-being-coping-self-efficacy-and-cost-coping-behaviors-in-young-adults-with-cancer
#6
Bridgette Thom, Catherine Benedict
PURPOSE: The increase in cost-sharing between patients and payers has resulted in financial toxicity in cancer patients, particularly among young adult (YA) patients and survivors (<40 years of age). This study explored financial toxicity and its impact on psychological well-being, self-efficacy for coping with cancer, and cost-coping behaviors among a sample of YA cancer patients and survivors. METHODS: One hundred forty YAs completed an anonymous online survey...
February 28, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30811262/pregnancy-screening-and-contraceptive-counseling-in-young-women-with-hodgkin-lymphoma-a-single-center-retrospective-review
#7
Laura Wheaton, Sarah Alexander
PURPOSE: Chemotherapeutic agents used to treat Hodgkin lymphoma are teratogenic. Pregnancy screening before the start of chemotherapy is supported by clinical guidelines. There are limited data on pregnancy screening before the start of Hodgkin therapy but previous studies suggest that it is not consistently completed. The objective of this study is to evaluate the completion of pregnancy screening before the start of chemotherapy in females with Hodgkin lymphoma. METHODS: A retrospective chart review was performed for all female patients, regardless of age, with newly diagnosed Hodgkin lymphoma from 2000 to 2015 at the Hospital for Sick Children...
February 27, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30794081/short-term-changes-in-cardiac-function-in-osteosarcoma-patients-receiving-anthracyclines
#8
Susan C Gilchrist, Michael Roth, J Andrew Livingston, Michelle A T Hildebrandt, Eugenie S Kleinerman, Jose Banchs
Studies of cardiac function in adolescent and young adult survivors have been performed at least a decade after anthracycline exposure, with little knowledge of short-term changes in cardiac function in this age group. To this end, we evaluated cardiac function within a 2-year period among 18 patients who received high-dose anthracyclines for osteosarcoma treatment. At 2 years, there was a significant decline in left ventricular ejection fraction (p = 0.005), with 8 of 18 patients having a >10% reduction...
February 22, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30794068/uncertainty-in-young-adult-survivors-of-childhood-and-adolescent-cancer-with-lower-extremity-bone-tumors-in-japan
#9
Shoko Katsumoto, Mitsue Maru, Tsukasa Yonemoto, Rumi Maeda, Keisuke Ae, Seiichi Matsumoto
PURPOSE: Childhood and adolescent survivors of cancerous lower-extremity bone tumors may be at unique risk of uncertainty about their future because of their specific cancer and/or physical disabilities secondary to treatment. This study aimed at clarifying survivors' uncertainty and related factors, including physical functioning, limb pain, and management of affected limbs. METHODS: Self-administered questionnaires were distributed at two cancer hospitals in Japan...
February 22, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30789284/cancer-related-fatigue-and-associated-factors-in-young-adult-cancer-patients
#10
Erik Nowe, Michael Friedrich, Katja Leuteritz, Annekathrin Sender, Yve Stöbel-Richter, Thomas Schulte, Andreas Hinz, Kristina Geue
PURPOSE: Cancer-related fatigue (CRF) is a highly burdensome and long-lasting symptom of cancer and its therapy. This study aims to examine the severity of CRF in its different dimensions and to assess medical and sociodemographic factors associated with CRF in young adults with cancer (adolescents and young adults [AYAs]). METHODS: Patients with malignant cancer (diagnosed within the last 4 years) aged 18-39 years at diagnosis were assessed. CRF was measured using the European Organisation for Research and Treatment of Cancer Quality of Life Fatigue Module (EORTC QLQ-FA12) Questionnaire...
February 21, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30785806/delay-in-treatment-after-cancer-diagnosis-in-adolescents-and-young-adults-does-facility-transfer-matter
#11
Jin Mou, Effie L Bolieu, Bethann M Pflugeisen, Paul J Amoroso, Beth Devine, Laura-Mae Baldwin, Laura L Frank, Rebecca H Johnson
BACKGROUND: Timeliness is one of the fundamental yet understudied quality metrics of cancer care. Little is known about cancer treatment delay among adolescent and young adult (AYA) cancer patients. This study assessed cancer treatment delay, with a specific focus on facility transfer and diagnosis/treatment interval. METHODS: Based on MultiCare Health System's (MHS's) institutional cancer registry data of AYA patients diagnosed during 2006-2015, this study analyzed patient demographics, insurance, clinical characteristics, and time of diagnosis and treatment initiation...
February 20, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30762449/exploring-physical-self-perceptions-among-survivors-of-adolescent-and-young-adult-cancer
#12
Amanda Wurz, Jennifer Brunet
This study explored the factor structure of four subscales from the Physical Self-Description Questionnaire-Short Form (PSDQ-S). Associations between subscales and personal and medical factors were also examined. The analytic sample consisted of 89 survivors of adolescent and young adult cancer (Mage at time of study  = 32.96 ± 4.37 years; Mage at diagnosis  = 31.16 ± 4.84 years; 75.3% female). Confirmatory factor analysis suggested a reasonable fit to the data, indicating that the PSDQ-S subscales examined could be used in future investigations with this population [χ2 (38) = 46...
February 14, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30759036/cancer-mortality-among-adolescents-and-young-adults-15-29-years-old-according-to-the-population-size-of-brazilian-municipalities
#13
Max Moura de Oliveira, Patrícia Ferreira Nomellini, Maria Paula Curado
OBJECTIVE: Analyze cancer mortality and trends among adolescents and young adults (AYAs) according to the population size of Brazilian municipalities. METHODS: Ecological study on cancer mortality time trends between 1996 and 2012. Brazilian municipalities were stratified according to the number of inhabitants: ≤49,999; 50,000-99,999; 100,000-499,999; and ≥500,000. Death data were collected from the Mortality Information System. Time trends were estimated with the Joinpoint Regression Program...
February 13, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30707642/an-argument-for-adolescent-and-young-adult-cancer-registry-one-model
#14
Lila M Pereira, Tara Giblin, Allyson Flower, Jeremy Rosenblum
Over the last several years, there has been increasing awareness around the unique challenges faced by adolescent and young adult (AYA) cancer patients. More cancer centers across the United States are introducing AYA-specific programs to help improve outcomes for these patients. However, given the nature of the United States health care system, there is little ability to track the efficacy of these programs and identify important variables with respect to both interdisciplinary interventions offered and medical and psychosocial outcomes...
February 1, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30702361/changes-in-anti-m%C3%A3-llerian-hormone-and-inhibin-b-in-children-treated-for-cancer
#15
Anne-Lotte L F van der Kooi, Marry M van den Heuvel-Eibrink, Sjoerd A A van den Berg, Wendy van Dorp, Saskia M F Pluijm, Joop S E Laven
PURPOSE: Diminished reproductive function can be a major late effect of childhood cancer treatment. This study evaluates the changes, and occurrence of possible recovery, in gonadal function markers in children treated for cancer. METHODS: Gonadal function markers were measured before (T0), directly after (T1), and 1 year after (T2) end of treatment of childhood cancer. Anti-Müllerian hormone (AMH) was measured in girls and inhibin B in boys and compared to reference populations...
January 31, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30676852/patterns-of-referral-for-fertility-preservation-among-female-adolescents-and-young-adults-with-breast-cancer-a-population-based-study
#16
Ann Korkidakis, Katherine Lajkosz, Michael Green, Donna Strobino, Maria Velez
PURPOSE: To assess the fertility preservation (FP) referral rates and patterns of newly diagnosed breast cancer in female adolescent and young adult (AYA) patients. METHODS: Women aged 15-39 years with newly diagnosed breast cancer in Ontario from 2000 to 2017 were identified using the Ontario Cancer Registry. Exclusion criteria included prior sterilizing procedure, health insurance ineligibility, and prior infertility or cancer diagnosis. Women with a gynecology consult between cancer diagnosis and chemotherapy commencement with the billed infertility diagnostic code (ICD-9 628) were used as a surrogate for FP referral...
January 24, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30676208/a-tri-institutional-approach-to-address-disparities-in-children-s-oncology-group-clinical-trial-accrual-for-adolescents-and-young-adults-and-underrepresented-minorities
#17
Nupur Mittal, Jonathan Davidson, Mario F Martinez, Reynaldo Sanchez, Nitin Sane, Lisa Giordano, Daniel K Choi, Paul Kent, Dipti Dighe, Asneha Iqbal, Cathleen Kiely, Kathleen Breen, John G Quigley, Rosalind Catchatourian, Steven Gitelis, Mary Lou Schmidt
PURPOSE: Enrollment in Children's Oncology Group (COG) clinical trials has led to significant improvements in survival; however, disparities in survival persist, particularly among ethnic minorities, adolescents and young adults (AYAs), and the underinsured, partly due to inadequate access to cooperative group cancer clinical trials. In 2008, two COG sites University of Illinois at Chicago (UIC) and Rush University Medical Center, and a nonmember institution, John H Stroger Hospital, created a unified COG program utilizing one lead Institutional Review Board and research team...
January 24, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30657424/hematopoietic-cell-transplantation-in-young-adult-acute-lymphoblastic-leukemia-a-united-states-population-level-analysis
#18
Lori Muffly, Qian Li, Elysia Alvarez, Justine Kahn, Lena Winestone, Rosemary Cress, Dolly C Penn, Theresa H M Keegan
In this population-based evaluation of adolescents and young adults (AYA) acute lymphoblastic leukemia (ALL), we describe patterns of care (POC) and outcomes regarding hematopoietic cell transplantation (HCT) in first complete remission (CR1). Data were abstracted from the 2013 United States Surveillance, Epidemiology, and End Results POC study; newly diagnosed AYA ALL were included. Multivariable logistic regression evaluated associations with HCT in CR1; Cox proportional hazards regression evaluated survival associations...
January 18, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30653388/individual-experiences-and-utilization-of-supportive-resources-in-adolescents-and-young-adults-with-cancer
#19
Abbey Elsbernd, Christopher Crenner, Tarris Rosell, Jyoti Panicker
BACKGROUND: Adolescents and young adults (AYAs) with cancer are often impacted by distress due to disease and treatment. Despite these concerns, prior research has found that AYAs do not utilize support resources, do not find these resources adequate, and or do not have adequate access to services. OBJECTIVE: The objective of this project was to understand and identify AYA patient concerns and experiences throughout cancer treatment, what resources were utilized, how they were identified, and how supportive care resources for AYA cancer patients can be improved...
January 17, 2019: Journal of Adolescent and Young Adult Oncology
https://read.qxmd.com/read/30653384/-figure-out-what-it-is-you-love-to-do-and-live-the-life-you-love-the-experiences-of-young-adults-returning-to-work-after-primary-cancer-treatment
#20
Emily K Drake, Robin Urquhart
This study explored young adult (YA; 18-39 years of age) cancer survivors' perspectives on and experiences with return to work (RTW) following primary cancer treatment. A prospective qualitative longitudinal method was employed, using in-depth telephone interviews at three time points. Data were analyzed using thematic analysis. Five people (ages 25-40) participated and four themes were identified: YAs face uncertainty about RTW; cancer may be a catalyst for career change; employment benefits are important; and YA-specific resources are needed to support RTW...
January 17, 2019: Journal of Adolescent and Young Adult Oncology
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