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Journal of Asthma and Allergy

Anne V McLaughlin, Anita Bhandari, Craig M Schramm
Background: Reversible obstruction on spirometry may be used to diagnose asthma. As per 2005 American Thoracic Society (ATS) guidelines, our pulmonary center began using 360 µg (four puffs) of albuterol rather than 180 µg (two puffs) to determine reversibility on spirometry starting in 2009. Hypothesis: We hypothesized that fewer patients would respond to two puffs of albuterol than four puffs during spirometric testing. Methods: We retrospectively reviewed records from new asthmatics seen in Pediatric Pulmonary Clinic from March 2002 to April 2014 who performed reproducible spirometry...
2019: Journal of Asthma and Allergy
Jean-Pierre Llanos, Christopher F Bell, Elizabeth Packnett, Ellen Thiel, Debra E Irwin, Beth Hahn, Hector Ortega
Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy. Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan™ Commercial Database...
2019: Journal of Asthma and Allergy
Basima A Almomani, Laith N Al-Eitan, Nour A Al-Sawalha, Shaher M Samrah, Mohammed N Al-Quasmi
Background: Rates of asthma in Jordan have been doubled in the past decade, but this increased prevalence was not met with improved asthma control protocols. The aim of the present study was to assess whether there was any significant association between the level of asthma control and certain single-nucleotide polymorphisms (SNPs) in five genes: ( ADRB2 ; rs1042713 and rs1042714), ( CRHR1 ; rs1876828, rs242939, and rs242941), ( STIP1 ; rs2236647), ( ADH5 , rs1154400), and ( ARG1 ; rs2781659)...
2019: Journal of Asthma and Allergy
Sean O'Quinn, Xiao Xu, Ian Hirsch
Background: Patients with severe, uncontrolled asthma experience debilitating symptoms that result in meaningful reductions to health-related quality of life. Benralizumab is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody that reduces exacerbations and improves asthma symptoms for patients with severe, uncontrolled eosinophilic asthma. Objective: The objective of this study was to evaluate improvements in daily asthma-related health status outcomes following treatment with benralizumab...
2019: Journal of Asthma and Allergy
Francis Nissen, Ian J Douglas, Hana Müllerová, Neil Pearce, Chloe I Bloom, Liam Smeeth, Jennifer K Quint
Background: Distinct asthma phenotypes have previously been suggested, including benign asthma, atopic asthma and obese non-eosinophilic asthma. This study aims to establish if these phenotypes can be identified using data recorded in primary care clinical records and reports on patient characteristics and exacerbation frequency. Methods: A population-based cohort study identified 193,999 asthma patients in UK primary care from 2007 to 2017. We used linked primary and secondary care data from the Clinical Practice Research Datalink, Hospital Episode Statistics and Office for National Statistics...
2019: Journal of Asthma and Allergy
Christina C Kao, Amit D Parulekar
Asthma is a heterogeneous disease, which may be classified into phenotypes and endotypes based on clinical characteristics and molecular mechanisms. The best described endotype of severe asthma is type 2 (T2)-high asthma, characterized by release of inflammatory cytokines by T helper 2 (TH 2) cells and type 2 innate lymphoid cells cells. Prostaglandin D2 contributes to T2 inflammation through binding of the G-protein-coupled receptor chemoattractant receptor-homologous molecule expressed on TH 2 cells (CRTH2)...
2019: Journal of Asthma and Allergy
Jonathan Grigg, Anjan Nibber, James Y Paton, Alison Chisholm, Theresa W Guilbert, Alan Kaplan, Steve Turner, Nicolas Roche, Elizabeth V Hillyer, David B Price
Background: An inhaled corticosteroid (ICS) or leukotriene receptor antagonist (LTRA) may prevent wheezing/asthma attacks in preschoolers with recurrent wheeze when added to short-acting β-agonist (SABA). Objective: The aim of this historical matched cohort study was to assess the effectiveness of these treatments for preventing wheezing/asthma attacks. Methods: Electronic medical records from the Optimum Patient Care Research Database were used to characterize a UK preschool population (1-5 years old) with two or more episodes of wheezing during 1 baseline year before first prescription (index date) of ICS or LTRA, or repeat prescription of SABA...
2018: Journal of Asthma and Allergy
Bhumika Aggarwal, Sumitra Shantakumar, David Hinds, Aruni Mulgirigama
Background: Asthma and allergic rhinitis (AR) frequently coexist, and having both asthma and AR is associated with uncontrolled asthma and a heavier disease burden. The Asia-Pacific Survey of Physicians on Asthma and Allergic Rhinitis (ASPAIR) aimed to assess physicians' perceptions and their management practices for patients with coexistent disease. Materials and methods: A total of 1,204 general physicians and pediatricians from six countries in Asia, who routinely treat asthma patients, were interviewed in-person...
2018: Journal of Asthma and Allergy
Ana Maria Baptista Menezes, Paula Duarte de Oliveira, Cauane Blumenberg, Efrain Sanchez-Angarita, Gloria Isabel Niño-Cruz, Ignacio Zabert, Janaina Calu Costa, Luiza Isnardi Cardoso Ricardo, Rafaela Costa Martins, Fernando César Wehrmeister
Purpose: Asthma is a highly prevalent noncommunicable lung disease. The aim of this study was to evaluate the longitudinal association of obesity/adiposity with wheezing and atopy. Methods: The population of the study was composed of participants from the 1993 Pelotas (Brazil) Birth Cohort. The following outcome variables were measured at 22 years: wheezing in the last 12 months, wheezing with atopy, wheezing without atopy, only atopy, and persistent wheezing at 18 and 22 years...
2018: Journal of Asthma and Allergy
Pamela L Zeitlin, Mila Leong, Jeremy Cole, Raburn M Mallory, Vivian H Shih, Richard F Olsson, Mitchell Goldman
Background and objectives: Benralizumab is a humanized, afucosylated monoclonal antibody against the IL-5Rα. Initial monthly followed by every-other-month injections result in rapid and nearly complete eosinophil depletion. We evaluated whether three doses of benralizumab modifies antibody response to seasonal influenza vaccination for adolescent/young adult patients with moderate to severe asthma. Methods: ALIZE (NCT02814643) was a Phase IIIb randomized controlled trial of patients aged 12-21 years receiving medium- to high-dosage inhaled corticosteroids/long-acting β2 -agonists...
2018: Journal of Asthma and Allergy
Ignacio Esteban-Gorgojo, Darío Antolín-Amérigo, Javier Domínguez-Ortega, Santiago Quirce
Although non-eosinophilic asthma (NEA) is not the best known and most prevalent asthma phenotype, its importance cannot be underestimated. NEA is characterized by airway inflammation with the absence of eosinophils, subsequent to activation of non-predominant type 2 immunologic pathways. This phenotype, which possibly includes several not well-defined subphenotypes, is defined by an eosinophil count <2% in sputum. NEA has been associated with environmental and/or host factors, such as smoking cigarettes, pollution, work-related agents, infections, and obesity...
2018: Journal of Asthma and Allergy
David Langton, Nicole Gaffney, Wei Chin Wang, Frank Thien, Virginia Plummer
Background: A significant correlation has been previously demonstrated between the quantum of radiofrequency treatment delivered at bronchial thermoplasty and the degree of improvement in an asthmatic patient's symptoms. The standard bronchoscope used for bronchial thermoplasty has an outer diameter of 4.8 mm at the distal tip. Thinner bronchoscopes are now available with the same internal channel size (2.0 mm). This study assesses whether using a thinner bronchoscope facilitates bronchial thermoplasty by increasing the radiofrequency activations delivered...
2018: Journal of Asthma and Allergy
Wai Sze Tong, Agatha Wt Yuen, Christine Yy Wai, Nicki Yh Leung, Ka Hou Chu, Patrick Sc Leung
Seafood allergy is a hypersensitive disorder with increasing prevalence worldwide. Effective and accurate diagnostic workup for seafood allergy is essential for clinicians and patients. Parvalbumin and tropomyosin are the most common fish and shellfish allergens, respectively. The diagnosis of seafood allergies is complicated by cross-reactivity among fish allergens and between shellfish allergens and other arthropods. Current clinical diagnosis of seafood allergy is a complex algorithm that includes clinical assessment, skin prick test, specific IgE measurement, and oral food challenges...
2018: Journal of Asthma and Allergy
(no author information available yet)
[This corrects the article on p. 101 in vol. 11, PMID: 29950869.].
2018: Journal of Asthma and Allergy
Ahmed R Alsuwaidi, Alia M Alkalbani, Afaf Alblooshi, Junu George, Ghaya Albadi, Salwa M Kamal, Hassib Narchi, Abdul-Kader Souid
Introduction: Respiratory infections have significant effects on childhood asthma. Viral respiratory infections, such as rhinovirus and respiratory syncytial virus are likely to be important in the development and exacerbation of asthma. In this study, we investigated the nasopharyngeal colonization in children with asthma to determine the prevalence of pathogens and their contribution to respiratory symptoms and airway resistance during winter. Methods: From December 2016 to March 2017, 50 nasopharyngeal specimens were collected from 18 patients (age, 5...
2018: Journal of Asthma and Allergy
Eva Santamaría, Iñaki Izquierdo, Marta Valle, Jan Vermeulen, Paul Potter
Background: There are few clinical trials that assess the efficacy of antihistamines in very young children. Rupatadine is a second-generation antihistamine indicated for the treatment of allergic rhinitis (AR) and urticaria. In this study, AR symptoms were evaluated before and after daily 1 mg/mL rupatadine oral solution administration in 2-5-year-old children. Methods: A multicenter open-label study was carried out in 2-5-year-old children with AR. Safety assessments were collected during the study including spontaneous adverse events, vital signs, and electrocardiogram (QTc interval)...
2018: Journal of Asthma and Allergy
Michel Aubier, Gabriel Thabut, Caroline Fabry-Vendrand
Background and objective: Benralizumab (Fasenra™ ) has recently been approved as add-on maintenance treatment for adult patients with severe eosinophilic asthma inadequately controlled despite high-dosage inhaled corticosteroids plus long-acting β2 -agonists. We aimed to identify and describe the clinical characteristics and disease burden of patients with severe, uncontrolled, eosinophilic asthma in France who may be eligible for treatment with benralizumab. Patients and methods: This was a retrospective analysis of a prospective, noninterventional, observational study of patients in France enrolled in the Asthma and Bronchial Obstruction Cohort (COBRA)...
2018: Journal of Asthma and Allergy
Guadalupe Salazar, Geeta Tarwala, Marina Reznik
Background: Asthma is one of the most common chronic diseases of childhood affecting 6.2 million (8.4%) children (<18 years old) in the USA. Asthma is also a leading cause of school absenteeism. Daily administration of preventive asthma medications improves asthma control. However, poor medication adherence is one of the barriers in achieving improved asthma outcomes. School-based supervised asthma therapy programs have been implemented to address this barrier. Objectives: To conduct a review of the literature on school-based supervised asthma therapy interventions and the effect on outcomes in children with persistent asthma...
2018: Journal of Asthma and Allergy
David B Price, Frank Trudo, Jaco Voorham, Xiao Xu, Marjan Kerkhof, Joanna Ling Zhi Jie, Trung N Tran
Purpose: Prior work suggests a threshold of four courses/year of systemic corticosteroid (SCS) therapy is associated with adverse consequences. The objective of this study was to investigate the onset of adverse outcomes beginning at SCS initiation in a broad asthma population. Patients and methods: This historical matched cohort study utilized anonymized, longitudinal medical record data (1984-2017) of patients (≥18 years) with active asthma. Matched patients with first SCS prescription (SCS arm) and no SCS exposure (non-SCS arm) were followed until first outcome event...
2018: Journal of Asthma and Allergy
Louisa Owens, Ingrid A Laing, Guicheng Zhang, Stephen Turner, Peter N Le Souëf
Purpose: The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort. Participants and methods: This prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and immunological assessments at 1, 6, 11, 18 and 24 years of age. Subjects were recruited from an urban maternity hospital. Retention rates varied from 45% to 72% at follow-up assessments...
2018: Journal of Asthma and Allergy
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