Amir M Alhajjat, Beverly S Strong, Emily T Durkin, Lucas E Turner, Ram K Wadhwani, Emily F Midura, Sundeep G Keswani, Aimen F Shaaban
In utero hematopoietic cellular transplantation (IUHCT) holds great promise for the treatment of congenital diseases of cellular dysfunction such as sickle cell disease, immunodeficiency disorders and inherited metabolic disorders. However, repeated failures in clinical cases of IUHCT that do not involve an immunodeficiency disease force a closer examination of the fetal immune system. While the mechanisms regulating T cell tolerance have been previously studied, the educational mechanisms leading to NK cell tolerance in prenatal chimeras remain unknown...
October 2013: Chimerism