Nicola d'Avanzo, Donatella Paolino, Antonella Barone, Luigi Ciriolo, Antonia Mancuso, Maria Chiara Christiano, Anna Maria Tolomeo, Christian Celia, Xiaoyong Deng, Massimo Fresta
Cerebrovascular impairment represents one of the main causes of death worldwide with a mortality rate of 5.5 million per year. The disability of 50% of surviving patients has high social impacts and costs in long period treatment for national healthcare systems. For these reasons, the efficacious clinical treatment of patients, with brain ischemic stroke, remains a medical need. To this aim, a liposome nanomedicine, with monosialic ganglioside type 1 (GM1), OX26 (an anti-transferrin receptor antibody), and CDP-choline (a neurotrophic drug) (CDP-choline/OX26Lip) was prepared...
March 13, 2024: Drug Delivery and Translational Research