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JOURNAL ARTICLE
Yuxuan Yong, Qinfen Wu, Xinling Meng, Ranran Lu, Huan Xia, Feifei Pei, Xinling Yang
OBJECTIVE: To investigate the role of aberrant Dyrk1a expression in phosphorylation modification at the α -synuclein serine 129 (Ser129) site to analyze its molecular mechanism in mediating apoptosis of PD. METHODS: The protein level of P- α -synuclein (Ser129), α -synuclein, Bcl-2, Bax, active caspase 3, GSK3 β , PI3K, AKT, and cyclinD1 were detected. The mRNA transcript levels of Dyrk1a and DAT and protein levels of IL-1 β , IL-6, COX-2, and TNF- α were detected...
2023: Parkinson's Disease
#22
JOURNAL ARTICLE
Quantitative Analysis of Postural Balance in Faller and Nonfaller Patients with Parkinson's Disease.
Do Young Kwon, Yuri Kwon, Ji-An Choi, Junghyuk Ko, Ji-Won Kim
BACKGROUND: Postural instability has been identified as a fall risk factor with a significant impact on the quality of life of patients with Parkinson's disease (PD). The aim of this study was to compare the center of pressure (COP) between faller and nonfaller patients with PD during static standing. METHODS: Thirty-two faller patients and 32 nonfaller patients with PD participated in this study. All patients performed the static balance test on a force plate. COP data were recorded during quiet standing...
2023: Parkinson's Disease
#23
JOURNAL ARTICLE
Chiu-Ying Chen, Wei-Ning Wang, Ming-Kuei Lu, Yu-Wan Yang, Tsung Yu, Trong-Neng Wu, Chon-Haw Tsai
BACKGROUND: Archery exercise exerts a rehabilitative effect on patients with paraplegia and might potentially serve as complementary physiotherapy for patients with Parkinson's disease. OBJECTIVE: This study aimed to examine the rehabilitative effects of an archery intervention. METHODS: A randomized controlled trial of a 12-week intervention was performed in patients with idiopathic Parkinson's disease. Thirty-one of the 39 eligible patients recruited from a medical center in Taiwan participated in the trial, of whom 16 were in the experimental group practicing archery exercises and 15 were in the control group at the beginning; twenty-nine completed the whole process...
2023: Parkinson's Disease
#24
JOURNAL ARTICLE
Zahra Eghlidos, Aida Abolhassanbeigi, Zahra Rahimian, Samaneh Khazraei, Vahid Reza Ostovan
OBJECTIVE: We aimed to assess the validity and reliability of the Persian version of the NonMotor Symptoms Scale (NMSS) in Iranian patients with PD. METHODS: This cross-sectional study was conducted in patients with PD. After the cross-cultural adaptation of the NMSS, the acceptability, reliability, precision, and validity of the Persian NMSS were evaluated. For this purpose, in addition to NMSS, we used the following measures: Scales for Outcomes in Parkinson's Disease (SCOPA)-Autonomic (SCOPA-AUT), SCOPA-Sleep, Beck's Depression Inventory (BDI) questionnaire, Parkinson's Disease Questionnaire-8 questions (PDQ-8), SCOPA-Motor, SCOPA-Psychiatric Complications (SCOPA-PC), SCOPA-Cognition (SCOPA-COG), Mini-Mental State Examination (MMSE), Hoehn and Yahr Staging (H and Y), and Unified Parkinson Disease Rating Scale (UPDRS)...
2023: Parkinson's Disease
#25
JOURNAL ARTICLE
Rurui Wei, Yan Zhang, Peishan Li, Zeheng Xu, La Zhang, Yan He, Qinfen Wu, Youcai Shi, Yang Yuan, Abudula Aisha
BACKGROUND: Transcranial sonography (TCS) is a noninvasive test that can reveal structural changes in the substantia nigra (SN) in Parkinson's disease (PD). The purpose of this study was to investigate the relationship between SN signatures and clinical features in PD patients in a multiethnic region of China. METHODS: A total of 147 patients with PD were included in the study, and all of whom had underwent a TCS examination. Clinical information was collected from PD patients, and motor and nonmotor symptoms were assessed using assessment scales...
2023: Parkinson's Disease
#26
JOURNAL ARTICLE
Lisa Hoffman, Nicholas D Burt, Nicholas R Piniella, Madison Baker, Nicole Volino, Saeed Yasin, Min-Kyung Jung, Adena Leder, Amber Sousa
BACKGROUND: Non-motor symptoms of Parkinson's disease (PD) such as cognitive impairment are common and decrease patient quality of life and daily functioning. While no pharmacological treatments have effectively alleviated these symptoms to date, non-pharmacological approaches such as cognitive remediation therapy (CRT) and physical exercise have both been shown to improve cognitive function and quality of life in people with PD. OBJECTIVE: This study aims to determine the feasibility and impact of remote CRT on cognitive function and quality of life in patients with PD participating in an organized group exercise program...
2023: Parkinson's Disease
#27
REVIEW
Sorayya Rezayi, Meysam Rahmani Katigari, Leila Shahmoradi, Mehrbakhsh Nilashi
INTRODUCTION: Parkinson's disease (PD) is the second most common neurological disorder. Patients with PD were affected by the COVID-19 pandemic in many different ways. This study's principal purpose is to assess PD patients' vulnerability to COVID-19 and its consequences. METHOD: This systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines. A thorough search was conducted in the Medline (through PubMed) and Scopus databases from inception to January 30, 2022...
2023: Parkinson's Disease
#28
JOURNAL ARTICLE
Yunan Zhou, Zhihui Li, Chunling Chi, Chunmei Li, Meimei Yang, Bin Liu
Parkinson's disease (PD) is the second most common neurodegenerative disease, with significant socioeconomic burdens. One of the crucial pathological features of PD is the loss of dopaminergic neurons in the substantia nigra (SN). However, the exact pathogenesis remains unknown. Moreover, therapies to prevent neurodegenerative progress are still being explored. We performed bioinformatics analysis to identify candidate genes and molecular pathogenesis in the SN of patients with PD. We analyzed the expression profiles, GSE49036 and GSE7621, which included 31 SN tissues in PD samples and 17 SN tissues in healthy control samples, and identified 86 common differentially expressed genes (DEGs)...
2023: Parkinson's Disease
#29
JOURNAL ARTICLE
Diego Santos-García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Silvia Jesús, Maria Teresa Buongiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernández Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C Martínez Castrillo, Pilar Sánchez Alonso, Maria G Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Marta Blázquez Estrada, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Oriol de Fábregues, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M L López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, Study Group Coppadis
INTRODUCTION: Drooling in Parkinson's disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods . PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study...
2023: Parkinson's Disease
#30
JOURNAL ARTICLE
Suzette Shahmoon, Patricia Limousin, Marjan Jahanshahi
This pilot study aimed to explore how caregiver spouses make sense of themselves one and five years after their partner's deep brain stimulation (DBS) surgery for Parkinson's disease. 16 spouse (8 husbands and 8 wives) caregivers were recruited for the interview. Eight struggled to reflect on their own lived experience and primarily focused on the impact of PD on their partners, such that their transcripts were no longer viable for interpretative phenomenological analysis (IPA). A content analysis showed (1) how these 8 caregivers shared less than half as many self-reflections than the other caregivers, (2) that there was a bias to reflect on their partner's experience answering the opening question, (3) the bias continued when answering subsequent questions, and (4) there was a lack of awareness of this bias...
2023: Parkinson's Disease
#31
JOURNAL ARTICLE
Atsuhiko Sugiyama, Hajime Yokota, Shigeki Hirano, Jiaqi Wang, Shoichi Ito, Satoshi Kuwabara
This study aimed to explore morphological changes of hippocampal subfields in patients with multiple system atrophy (MSA) with and without cognitive impairment using FreeSurfer-automated segmentation of hippocampal subfield techniques and their relationship with cognitive function. We enrolled 75 patients with MSA classified as cognitively impaired MSA (MSA-CI, n = 40) and cognitively preserved MSA (MSA-CP, n = 35), as well as 68 healthy controls. All participants underwent three-dimensional volume T1-weighted magnetic resonance imaging...
2023: Parkinson's Disease
#32
JOURNAL ARTICLE
Zeynep Tuncer, Gamze Dereli Can, Hava Dönmez Keklikoğlu, Fatma Ayşen Eren, Fatma Yülek, Orhan Deniz
BACKGROUND: In Parkinson's disease (PD), dopamine deficiency is present not only in the nigrostriatal pathway but also in the retinal and visual pathways. Optic coherence tomography (OCT) can be used as morphological evidence of visual influence from early nonmotor symptoms. The aim of this study was to investigate the relationship of OCT and visual evoked potentials (VEPs) of eyes with the severity of clinical findings and ocular findings in PD. METHODS: A group of 42 patients diagnosed with idiopathic PD and a control group of 29 people between the ages of 45-85 were included in our study...
2023: Parkinson's Disease
#33
JOURNAL ARTICLE
Jong Hyeon Ahn, Jin Whan Cho, Jinyoung Youn
INTRODUCTION: Fatigue and orthostatic hypotension (OH) are common and disabling nonmotor symptoms (NMSs) of Parkinson's disease (PD), but none of the studies have reported on the longitudinal association between fatigue and OH. METHODS: Drug-naïve PD patients were recruited from a hospital-based cohort and evaluated with the Parkinson Fatigue Scale (PFS), head-up tilt test, Unified PD Rating Scale, Hoehn and Yahr stage, Montreal Cognitive Assessment, Scale for Outcomes in PD-Autonomic (SCOPA-AUT), Beck Depression Inventory (BDI), Beck Anxiety Inventory, PD Sleep Scale, and medications at the baseline and follow-up visits...
2023: Parkinson's Disease
#34
JOURNAL ARTICLE
Joy Read, Sarah Cable, Gergely Bartl, Charlotte Löfqvist, Susanne Iwarsson, Anette Schrag
BACKGROUND: The complex nature of late-stage Parkinson's requires multiagency support and leads to an increased burden on family members who assume a multiplicity of responsibilities. The aim of this study is to further understand the lived experiences of family-caregivers and their perception of, and satisfaction with, service provision. METHODS: This qualitative substudy was a part of the European multicentre Care of Late-Stage Parkinsonism (CLaSP) project. Purposive sampling resulted in a sample of eleven family-caregivers of people with late-stage Parkinson's, who were interviewed using semistructured open-ended questions...
2023: Parkinson's Disease
#35
JOURNAL ARTICLE
Agnes Wilhelm, Tanja Riedl, Christian Paumann, Jessie Janssen
BACKGROUND: Freezing of Gait (FoG) is a disabling symptom of Parkinson's Disease (PD) and is defined as a "brief episodic absence or marked reduction of forward progression of the feet despite the intention to walk." Compensatory strategies such as cueing and high frequency vibrotactile stimulation can reduce FoG severity and improve gait parameters. A new Sternal high frequency Vibrotactile Stimulation Device (SVSD) with cueing function has been developed, however the clinical effects of this device are yet to be fully investigated...
2022: Parkinson's Disease
#36
JOURNAL ARTICLE
Philippe Damier, Emily J Henderson, Jesús Romero-Imbroda, Laura Galimam, Nick Kronfeld, Tobias Warnecke
INTRODUCTION: In Parkinson's disease (PD), the quality of life of both patients and caregivers is affected. While key issues relating to quality of life may not emerge in conversations with healthcare professionals (HCPs), unguarded social media conversations can provide insight into how people with Parkinson's disease (PwPD) and their caregivers are affected. We conducted a qualitative and quantitative netnographic study of PD conversations posted on social media sites over a 12-month period...
2022: Parkinson's Disease
#37
JOURNAL ARTICLE
Denise Becker, Angelina Maric, Simon J Schreiner, Fabian Büchele, Christian R Baumann, Daniel Waldvogel
BACKGROUND: Postural instability and falls are considered a major factor of impaired quality of life in patients with advanced Parkinson's disease (PD). The knowledge of the time at which postural instability occurs will help to provide the evidence required to introduce fall-prevention strategies at the right time in PD. OBJECTIVE: To investigate whether postural instability of patients with different age at disease onset is associated with age or with disease duration of PD...
2022: Parkinson's Disease
#38
JOURNAL ARTICLE
Yu-Ting Ling, Qian-Qian Guo, Si-Min Wang, Li-Nan Zhang, Jin-Hua Chen, Yi Liu, Ruo-Heng Xuan, Bo Qu, Li-Ge Liu, Zhi-Shuang Wen, Jia-Kun Xu, Lu-Lu Jiang, Wen-Biao Xian, Bin Wu, Chang-Ming Zhang, Ling Chen, Jin-Long Liu, Nan Jiang
INTRODUCTION: Postoperative delirium can increase cognitive impairment and mortality in patients with Parkinson's disease. The purpose of this study was to develop and internally validate a clinical prediction model of delirium after deep brain stimulation of the subthalamic nucleus in Parkinson's disease under general anesthesia. METHODS: We conducted a retrospective observational cohort study on the data of 240 patients with Parkinson's disease who underwent deep brain stimulation of the subthalamic nucleus under general anesthesia...
2022: Parkinson's Disease
#39
JOURNAL ARTICLE
Jade E Kenna, Megan C Bakeberg, Maddison Y Abonnel, Frank L Mastaglia, Ryan S Anderton
BACKGROUND: Gastrointestinal symptoms (GIS) in people with Parkinson's disease (PwP) are often underreported and may remain untreated. Constipation is a common nonmotor symptom that can adversely affect health-related quality of life (QoL); however, the impact of other GIS has not been adequately investigated. OBJECTIVES: To investigate the relationship between QoL and constipation using the Bristol Stool Chart, bowel movement frequency, and a perceived constipation measure; and to explore the relationship between QoL and other GIS in an Australian PD cohort...
2022: Parkinson's Disease
#40
JOURNAL ARTICLE
Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher
Insulin desensitization has been observed in the brains of patients with Parkinson's disease (PD), which is a progressive neurodegenerative disorder for which there is no cure. Semaglutide is a novel long-actingglucagon-likepeptide-1 (GLP-1) receptor agonist that is on the market as a treatment for type 2 diabetes. It is in a phase II clinical trial in patients with PD. Two previous phase II trials in PD patients showed good effects with the older GLP-1 receptor agonists, exendin-4 and liraglutide. We have developed a dual GLP-1/GIP receptor agonist (DA5-CH) that can cross the blood-brain barrier (BBB) at a higher rate than semaglutide...
2022: Parkinson's Disease
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