journal
https://read.qxmd.com/read/38846136/hypoperfusion-in-supramarginal-and-orbital-gyrus-position-discrimination-test-and-microsaccades-as-a-predictor-of-pisa-syndrome-in-parkinson-s-disease
#1
JOURNAL ARTICLE
Asako Yoritaka, Tetsuo Hayashi, Keiko Fusegi, Sachiko Nakayama, Jun Haneda, Nobutaka Hattori
Patients with Parkinson's disease (PD) experience significantly reduced quality of life when PD is complicated with Pisa syndrome (PS). PS is a postural abnormality associated with a lateral bending of the trunk, causing the patient to lean to one side. Microsaccades during fixation are transmitted to the visual cortex, and this gaze movement may be impaired in PD. We aimed to detect presymptomatic signs of PS. We enrolled 50 patients with PD without dementia and investigated the visual systems in patients with concurrent PD and PS based on a Romberg ratio of<1...
2024: Parkinson's Disease
https://read.qxmd.com/read/38828214/a-mixed-methods-approach-to-explore-the-experience-of-pain-and-its-management-in-people-with-parkinson-s-disease
#2
JOURNAL ARTICLE
Vanessa Nguy, Bernadette Brady, Leanne M Hassett, Colleen G Canning, James M Elliott, Natalie E Allen
INTRODUCTION: Pain in Parkinson's disease (PD) is common but poorly understood, with most research to date taking a mechanistic approach. This mixed methods study takes a broader biopsychosocial approach to assess and describe contributors of pain and explore pain management and the relationship between pain and physical activity in people with PD (PwPD) and chronic pain. METHODS: A structured survey evaluated respondents' contributors of pain using standardized, self-report assessments of the following: pain, peripheral neuropathy, central nociplastic change, emotional dysregulation or pathology, and maladaptive cognitions...
2024: Parkinson's Disease
https://read.qxmd.com/read/38803413/continuous-and-unconstrained-tremor-monitoring-in-parkinson-s-disease-using-supervised-machine-learning-and-wearable-sensors
#3
JOURNAL ARTICLE
Fernando Rodriguez, Philipp Krauss, Jonas Kluckert, Franziska Ryser, Lennart Stieglitz, Christian Baumann, Roger Gassert, Lukas Imbach, Oliver Bichsel
BACKGROUND: Accurately assessing the severity and frequency of fluctuating motor symptoms is important at all stages of Parkinson's disease management. Contrarily to time-consuming clinical testing or patient self-reporting with uncertain reliability, recordings with wearable sensors show promise as a tool for continuously and objectively assessing PD symptoms. While wearables-based clinical assessments during standardised and scripted tasks have been successfully implemented, assessments during unconstrained activity remain a challenge...
2024: Parkinson's Disease
https://read.qxmd.com/read/38766569/trait-impulsivity-as-a-feature-of-parkinson-s-disease-treatment-and-progression
#4
REVIEW
Holly Spencer, Ryan S Anderton
Heightened trait impulsivity in both subclinical and pathological senses is becoming increasingly recognised in Parkinson's disease (PD). Impulsive behaviours and impulse control disorders (ICDs) are a consequence of perturbation to the rewards pathway leading individuals to conduct activities in a repetitive, excessive, and maladaptive fashion. Commonly linked to PD, heightened trait impulsivity has been found to primarily manifest in the forms of hypersexuality, pathological gambling, compulsive shopping, and binge eating, all of which may significantly impact social and financial standing...
2024: Parkinson's Disease
https://read.qxmd.com/read/38716035/the-priority-goals-and-underlying-impairments-contributing-to-goal-related-problems-of-people-with-parkinson-s-disease-receiving-a-community-based-rehabilitation-program
#5
JOURNAL ARTICLE
Sarah J Davies, Hannah L Gullo, Emmah Doig
BACKGROUND: Goal setting is a core rehabilitation practice in Parkinson's disease (PD). Targeting therapy towards specific goals leads to greater improvements in performance and psychosocial outcomes. Goal setting in PD is feasible, and although the nature of goals has been described in previous studies, the underlying impairments related to goals have not been described. Understanding the nature of goals ensures that interventions for people with PD are aligned with their needs and priorities...
2024: Parkinson's Disease
https://read.qxmd.com/read/38623494/home-based-titration-with-duodenal-infusion-of-levodopa-carbidopa-intestinal-gel-in-people-with-parkinson-s-disease-an-observational-feasibility-study
#6
JOURNAL ARTICLE
Trine Hørmann Thomsen, Nick Schou Nielsen, Asher Lou Isenberg, Michael Hougaard Møller, Jesper Bøje Clausen, Inge Mona Schack Frederiksen, Louise Olsen, Mahsa Javidi, Jeanet Vilhelmsen, Marc Klee Olsen, Bo Biering-Sørensen
BACKGROUND: Testing and titration of the right levodopa equivalent dose are usually performed during a hospital admission. However, optimal dose titration in people with Parkinson's disease (PwPs) may depend on home environment, emotional stress, and physical activity of everyday life. OBJECTIVE: Firstly, to evaluate the feasibility and safety of a home-based LCIG titration program and patients'/caregivers' satisfaction. Secondly, to identify barriers and facilitators for home-based titration...
2024: Parkinson's Disease
https://read.qxmd.com/read/38476865/focused-ultrasound-thalamotomy-for-tremor-relief-in-atypical-parkisnsonism
#7
JOURNAL ARTICLE
Alon Sinai, Maria Nassar, Lev Shornikov, Marius Constantinescu, Menashe Zaaroor, Ilana Schlesinger
BACKGROUND: Magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) VIM-thalamotomy has established efficacy and safety in tremor relief in patients with essential tremor and Parkinson's disease. The efficacy and safety in patients with atypical parkinsonism have not been reported. OBJECTIVE: To report on the efficacy and safety of FUS VIM-thalamotomy in 8 patients with parkinsonism, multiple system atrophy-Parkinsonian type (MSA-P) ( n  = 5), and dementia with Lewy bodies (DLB) ( n  = 3)...
2024: Parkinson's Disease
https://read.qxmd.com/read/38419645/improvement-by-medication-less-than-expected-in-parkinson-s-disease-blinded-evaluation-of-levodopa-response
#8
JOURNAL ARTICLE
Mette Niemann Johansen, Anna Handberg, Mohamed El Haddouchi, Josefine Grundtvig, Steen Rusborg Jensen, Lisette Salvesen, Annemette Løkkegaard
BACKGROUND: The latest Movement Disorder Society (MDS) diagnostic criteria require a good and sustained response to medication to get a diagnosis of Parkinson's disease, PD. OBJECTIVE: The aim of this study was to evaluate levodopa response in a group of patients with probable PD, diagnosed by movement disorder specialists. METHODS: An acute levodopa challenge test (LDCT) was performed after pausing the dopaminergic medication for 6 half-times...
2024: Parkinson's Disease
https://read.qxmd.com/read/38419644/transfection-of-the-bdnf-gene-in-the-surviving-dopamine-neurons-in-conjunction-with-continuous-administration-of-pramipexole-restores-normal-motor-behavior-in-a-bilateral-rat-model-of-parkinson-s-disease
#9
JOURNAL ARTICLE
Alina Benítez-Castañeda, Verónica Anaya-Martínez, Armando de Jesús Espadas-Alvarez, Ana Luisa Gutierrez-Váldez, Luis Fernando Razgado-Hernández, Patricia Emmanuelle Reyna-Velazquez, Liz Quintero-Macias, Daniel Martínez-Fong, Benjamín Florán-Garduño, Jorge Aceves
In Parkinson's disease (PD), progressive degeneration of nigrostriatal innervation leads to atrophy and loss of dendritic spines of striatal medium spiny neurons (MSNs). The loss disrupts corticostriatal transmission, impairs motor behavior, and produces nonmotor symptoms. Nigral neurons express brain-derived neurotropic factor (BDNF) and dopamine D3 receptors, both protecting the dopamine neurons and the spines of MSNs. To restore motor and nonmotor symptoms to normality, we assessed a combined therapy in a bilateral rat Parkinson's model, with only 30% of surviving neurons...
2024: Parkinson's Disease
https://read.qxmd.com/read/38356939/preoperative-attention-memory-problem-affects-the-quality-of-life-of-parkinson-s-disease-patients-after-deep-brain-stimulation-a-cohort-study
#10
JOURNAL ARTICLE
Ying Gao, Jue Wang, Linbin Wang, Dianyou Li, Bomin Sun, Xian Qiu
OBJECTIVES: The aim of this study was to investigate the impact of nonmotor symptoms (NMS) on the quality of life (QoL) outcome after subthalamic nucleus deep brain stimulation (STN-DBS) at the 1-year follow-up. METHODS: Ninety-three patients diagnosed with Parkinson's disease (PD), who underwent subthalamic nucleus deep brain stimulation (STN-DBS) between April 2020 and August 2021, were included in this study. Demographic information was gathered through a self-designed questionnaire...
2024: Parkinson's Disease
https://read.qxmd.com/read/38264500/a-systematic-review-and-meta-analysis-of-the-efficacy-and-safety-of-rasagiline-or-pramipexole-in-the-treatment-of-early-parkinson-s-disease
#11
REVIEW
Pauli Seppänen, Markus M Forsberg, Miia Tiihonen, Heikki Laitinen, Selena Beal, David C Dorman
BACKGROUND: Rasagiline or pramipexole monotherapy has been suggested for the management of early Parkinson's disease (PD). The aim of this research was to systematically review the clinical efficacy and safety of rasagiline or pramipexole in early PD (defined as disease duration ≤5 years and Hoehn and Yahr stage of ≤3). METHODS: Randomized controlled trials (RCTs) of rasagiline or pramipexole for early PD published up to September 2021 were retrieved...
2024: Parkinson's Disease
https://read.qxmd.com/read/38235044/alprazolam-reduces-freezing-of-gait-fog-and-improves-fog-related-gait-deficiencies
#12
JOURNAL ARTICLE
Abdullah Al Jaja, Téa Sue, Margaret Prenger, Ken N Seergobin, Jessica A Grahn, Penny A MacDonald
BACKGROUND: Freezing of gait (FOG) is an intractable motor symptom in Parkinson's disease (PD) that increases fall risk and impairs the quality of life. FOG has been associated with anxiety, with experimental support for the notion that anxiety itself provokes FOG. We investigated the effect of acute anxiety reduction via alprazolam on FOG in PD. METHODS: In ten patients with PD, FOG, and normal cognition, we administered 0.25 mg alprazolam in one session and placebo in another, in counterbalanced order...
2024: Parkinson's Disease
https://read.qxmd.com/read/38149092/single-cell-analyses-reveal-necroptosis-s-potential-role-in-neuron-degeneration-and-show-enhanced-neuron-immune-cell-interaction-in-parkinson-s-disease-progression
#13
JOURNAL ARTICLE
Xiaomei Zeng, Zhifen Han, Kehan Chen, Peng Zeng, Yidan Tang, Lijuan Li
Parkinson's disease (PD) is a common neuron degenerative disease among the old, characterized by uncontrollable movements and an impaired posture. Although widely investigated on its pathology and treatment, the disease remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) has been applied to the area of PD, providing valuable data for related research. However, few works have taken deeper insights into the causes of neuron death and cell-cell interaction between the cell types in the brain...
2023: Parkinson's Disease
https://read.qxmd.com/read/38106542/sex-differences-in-the-allele-distribution-of-pglyrp2-variant-rs892145-in-parkinson-s-disease
#14
JOURNAL ARTICLE
Caroline Ran, Karin Wirdefeldt, Olof Sydow, Per Svenningsson, Rochellys Diaz Heijtz
INTRODUCTION: Parkinson's disease (PD) is a complex multifactorial disease, involving genetic susceptibility, environmental risk factors, and gene-environmental interactions. The microbiota-gut-brain axis is hypothesized to play a role in the pathophysiology of PD, and peptidoglycan recognition proteins (PGLYRPs), which modulate the gut microbiota, are, therefore, relevant candidate genes for PD. METHODS: Using quantitative real-time PCR, we genotyped three PGLYRP variants (rs892145, rs959117, and rs10888557) and performed an association analysis in 508 PD patients and 585 control individuals...
2023: Parkinson's Disease
https://read.qxmd.com/read/37908843/the-role-of-muscle-strength-in-the-sit-to-stand-task-in-parkinson-s-disease
#15
JOURNAL ARTICLE
José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez, Robert Fekete
BACKGROUND: Rising from a chair or the sit-to-stand (STS) task is frequently impaired in individuals with Parkinson's disease (PD). These patients commonly attribute such difficulties to weakness in the lower extremities. However, the role of muscle strength in the STS transfer task has not been fully elucidated. OBJECTIVE: We aim at determining the role of muscle strength in the STS task. METHODS: We studied 90 consecutive patients with PD and 52 sex- and age-matched controls...
2023: Parkinson's Disease
https://read.qxmd.com/read/37868355/protective-role-of-ampk-against-pink1-b9-flies-neurodegeneration-with-improved-mitochondrial-function
#16
JOURNAL ARTICLE
Guoliang Xiang, Xueyi Wen, Wenjing Wang, Tianchan Peng, Jiazhen Wang, Qinghua Li, Junfang Teng, Ying Cui
Adenosine 5'-monophosphate-activated protein kinase ( AMPK )'s effect in PTEN -induced kinase 1 ( PINK1 ) mutant Parkinson's disease (PD) transgenic flies and the related mechanism is seldom studied. The classic MHC-Gal4/UAS PD transgenic flies was utilized to generate the disease characteristics specifically expressed in flies' muscles, and Western blot (WB) was used to measure the expression of the activated form of AMPK to investigate whether activated AMPK alters in PINK1 B9 PD flies. MHC-Gal4 was used to drive AMPK overexpression in PINK1 B9 flies to demonstrate the crucial role of AMPK in PD pathogenesis...
2023: Parkinson's Disease
https://read.qxmd.com/read/37854895/compliance-with-national-and-international-guidelines-in-the-treatment-of-nonmotor-symptoms-in-late-stage-parkinson-s-disease
#17
JOURNAL ARTICLE
Kristina Rosqvist, Per Odin
BACKGROUND: National as well as international Parkinson's disease (PD) treatment guidelines are available to guide clinicians. Previous research has shown that nonmotor symptoms (NMS) are pronounced in late-stage PD and has suggested that current treatment is insufficient and could be improved. OBJECTIVES: The aim of this study was to investigate to which degree the national and international treatment guidelines are followed in the treatment of NMS in late-stage PD...
2023: Parkinson's Disease
https://read.qxmd.com/read/37854894/the-neuroprotective-effect-of-isotetrandrine-on-parkinson-s-disease-via-anti-inflammation-and-antiapoptosis-in-vitro-and-in-vivo
#18
JOURNAL ARTICLE
Ching-Hu Wu, Kun-Ling Lin, Cheng-Yu Long, Chien-Wei Feng
Parkinson's disease (PD) is one of the most influential diseases in the world, and the current medication only can relieve the clinical symptoms but not slow the progression of PD. Therefore, we intend to examine the neuroprotective activity of plant-derived compound isotetrandrine (ITD) in vitro and in vivo. In vitro , cells were cotreated with ITD and LPS to detect the inflammatory-related protein and mRNA. In vivo , zebrafish were pretreated with ITD and inhibitors prior to 6-OHDA treatment. Then, the behavior was monitored at 5 dpf...
2023: Parkinson's Disease
https://read.qxmd.com/read/37799489/levodopa-prescription-patterns-in-patients-with-advanced-parkinson-s-disease-a-japanese-database-analysis
#19
JOURNAL ARTICLE
Atsushi Takeda, Toru Baba, Jun Watanabe, Masahiko Nakayama, Hiroyuki Hozawa, Miwako Ishido
Prescription doses of levodopa in patients with advanced Parkinson's disease (PD) are generally lower in Japan than in the United States or Europe, although Japanese guidelines for the management of PD recommend increasing the dosage as the disease progresses. However, data regarding levodopa prescription practices in patients with advanced PD in the clinical setting are limited. This retrospective observational study analyzed patterns of drug use for patients with advanced PD in Japan using claims data from hospitalized patients in the Medical Data Vision Co...
2023: Parkinson's Disease
https://read.qxmd.com/read/37791037/a-dual-glp-1-gip-receptor-agonist-is-more-effective-than-liraglutide-in-the-a53t-mouse-model-of-parkinson-s-disease
#20
JOURNAL ARTICLE
Zijuan Zhang, Ming Shi, Zhengmin Li, Yuan Ling, Luke Zhai, Ye Yuan, He Ma, Li Hao, Zhonghua Li, Zhenqiang Zhang, Christian Hölscher
Parkinson's disease (PD) is a complex syndrome with many elements, such as chronic inflammation, oxidative stress, mitochondrial dysfunction, loss of dopaminergic neurons, build-up of alpha-synuclein ( α -syn) in cells, and energy depletion in neurons, that drive the disease. We and others have shown that treatment with mimetics of the growth factor glucagon-like peptide 1 (GLP-1) can normalize energy utilization, neuronal survival, and dopamine levels and reduce inflammation. Liraglutide is a GLP-1 analogue that recently showed protective effects in phase 2 clinical trials in PD patients and in Alzheimer disease patients...
2023: Parkinson's Disease
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