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Journals Critical Care Research and Pra...

Critical Care Research and Practice

https://read.qxmd.com/read/37795474/rate-of-change-of-rapid-shallow-breathing-index-and-extubation-outcome-in-mechanically-ventilated-patients
#21
JOURNAL ARTICLE
Manjush Karthika, Farhan A Al Enezi, Lalitha V Pillai, Yaseen M Arabi
BACKGROUND: Rapid shallow breathing index (RSBI) has been widely used as a predictor of extubation outcome in mechanically ventilated patients. We hypothesize that the rate of change of RSBI between the beginning and end of a 120-minute spontaneous breathing trial (SBT) could be a better predictor of extubation outcome than a single RSBI measured at the end of SBT in mechanically ventilated patients. Methodology . In this prospective observational study, we enrolled 193 patients who met the inclusion criteria, of whom 33 patients were unable to tolerate a 120-minute SBT and were excluded from the study...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37795473/impact-of-chronic-kidney-disease-on-clinical-outcomes-during-hospitalization-and-five-year-follow-up-after-coronary-artery-bypass-grafting
#22
JOURNAL ARTICLE
Mohamed Laimoud, Mosleh Nazzel Alanazi, Mary Jane Maghirang, Shatha Mohamed Al-Mutlaq, Suha Althibait, Rasha Ghamry, Rehan Qureshi, Boshra Alanazi, Munirah Alomran, Zeina Bakheet, Zohair Al-Halees
BACKGROUND: Chronic kidney disease (CKD) is often associated with multiple comorbidities including diabetes mellitus, and each has its own complications and impact after cardiac surgery including coronary revascularization. The objective of this work was to study the impact of CKD on clinical outcomes after coronary artery bypass grafting (CABG) and to compare outcomes in patients with different grades of renal functions. We retrospectively reviewed all patients who underwent CABG from January 2016 to August 2020 at our tertiary care hospital using electronic medical records...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37766780/value-of-diaphragm-ultrasonography-for-extubation-a-single-blinded-randomized-clinical-trial
#23
JOURNAL ARTICLE
T G Toledo, M R Bacci
INTRODUCTION: Daily evaluation of mechanically ventilated (MV) patients is essential for successful extubation. Proper withdrawal prevents complications and reduces the cost of hospitalization in the intensive care unit (ICU). Diaphragm ultrasonography (DUS) has emerged as a potential instrument for determining whether a patient is ready to be extubated. This study compared the efficacy rate of extubation using a standard withdrawal protocol and DUS in patients with MV. METHODS: A randomized, parallel, single-blind, controlled study was conducted on ICU patients undergoing MV...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37720488/fungal-infections-are-not-associated-with-increased-mortality-in-covid-19-patients-admitted-to-intensive-care-unit-icu
#24
JOURNAL ARTICLE
James Ainsworth, Peter Sewell, Sabine Eggert, Keith Morris, Suresh Pillai
INTRODUCTION: Fungal infection is a cause of increased morbidity and mortality in intensive care patients. Critically unwell patients are at increased risk of developing invasive fungal infections. COVID-19 patients in the intensive care unit (ICU) may be at a particularly high risk. The primary aim of this study was to establish the incidence of secondary fungal infections in patients admitted to the ICU with COVID-19. Secondary aims were to investigate factors that may contribute to an increased risk of fungal infections and to calculate the mortality between fungal and nonfungal groups...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37637470/early-tracheostomy-may-reduce-the-length-of-hospital-stay
#25
JOURNAL ARTICLE
Fernanda Kazmierski Morakami, Ana Luiza Mezzaroba, Alexandre Sanches Larangeira, Lucienne Tibery Queiroz Cardoso, Carlos Augusto Marçal Camillo, Cintia Magalhães Carvalho Grion
INTRODUCTION: There is evidence that prolonged invasive mechanical ventilation has negative consequences for critically ill patients and that performing tracheostomy (TQT) could help to reduce these consequences. The ideal period for performing TQT is still not clear in the literature since few studies have compared clinical aspects between patients undergoing early or late TQT. OBJECTIVE: To compare the mortality rate, length of stay in the intensive care unit, length of hospital stay, and number of days free of mechanical ventilation in patients undergoing TQT before or after ten days of orotracheal intubation...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37608868/change-in-antimicrobial-therapy-based-on-bronchoalveolar-lavage-data-improves-outcomes-in-icu-patients-with-suspected-pneumonia
#26
JOURNAL ARTICLE
Bharti Chogtu, Vrinda Mariya Elenjickal, Dharma U Shetty, Mahsheeba Asbin, Vasudeva Guddattu, Rahul Magazine
Flexible bronchoscopy (FB) is often performed in critically ill patients with suspected pneumonia. It is assumed that there will be an association with improved outcomes when bronchoalveolar lavage (BAL) data lead to a change in antimicrobial therapy. Methods. This study included a retrospective cohort of intensive care unit (ICU) patients who underwent FB for a diagnosis of suspected pneumonia. The study compared the outcome of patients in whom antimicrobial modification was carried out based on BAL reports versus those in whom it was not carried out...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37583653/investigating-the-utility-of-the-sofa-score-and-creating-a-modified-sofa-score-for-predicting-mortality-in-the-intensive-care-units-in-a-tertiary-hospital-in-jordan
#27
JOURNAL ARTICLE
Anas H A Abu-Humaidan, Fatima M Ahmad, Laith S Theeb, Abdelrahman J Sulieman, Abdelkader Battah, Amjad Bani Hani, Mahmoud Abu Abeeleh
BACKGROUND: The utility of the Sequential Organ Failure Assessment (SOFA) score in predicting mortality in the intensive care unit (ICU) has been demonstrated before, but serial testing in various settings is required to validate and improve the score. This study examined the utility of the SOFA score in predicting mortality in Jordanian ICU patients and aimed to find a modified score that required fewer laboratory tests. METHODS: A prospective observational study was conducted at Jordan University Hospital (JUH)...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37547450/early-neuromuscular-electrical-stimulation-preserves-muscle-size-and-quality-and-maintains-systemic-levels-of-signaling-mediators-of-muscle-growth-and-inflammation-in-patients-with-traumatic-brain-injury-a-randomized-clinical-trial
#28
JOURNAL ARTICLE
Luciana Vieira, Paulo Eugênio Silva, Priscilla Flavia de Melo, Vinicius Maldaner, Joao Q Durigan, Rita de Cassia Marqueti, Otavio Nobrega, Sunita Mathur, Chris Burtin, Fabrício Barin, Wilcelly Machado-Silva, Sergio Ramalho, Gaspar R Chiappa, Nadia Oliveira Gomes, Celso R F Carvalho, Graziella F B Cipriano, Gerson Cipriano
OBJECTIVE: To investigate the effects of an early neuromuscular electrical stimulation (NMES) protocol on muscle quality and size as well as signaling mediators of muscle growth and systemic inflammation in patients with traumatic brain injury (TBI). DESIGN: Two-arm, single-blinded, parallel-group, randomized, controlled trial with a blinded assessment. Setting . Trauma intensive care unit at a university hospital. Participants . Forty consecutive patients on mechanical ventilation (MV) secondary to TBI were prospectively recruited within the first 24 hours following admission...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37497269/developing-a-preliminary-clinical-prediction-model-for-prognosis-of-pneumonia-complicated-with-heart-failure-based-on-metagenomic-sequencing
#29
JOURNAL ARTICLE
Rongyuan Yang, Yong Duan, Dawei Wang, Qing Liu
BACKGROUND: The predictive factors of prognosis in patients with pneumonia complicated with heart failure (HF) have not been fully investigated yet, especially with the use of next-generation sequencing (NGS) of metagenome. METHODS: Patients diagnosed with pneumonia complicated with HF were collected and divided into control group and NGS group. Univariate and multivariate logistic regression and LASSO regression analysis were conducted to screen the predictive factors for the prognosis, followed by nomogram construction, ROC curve plot, and internal validation...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37457639/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-on-supine-vs-nonsupine-endotracheal-intubation
#30
JOURNAL ARTICLE
Chriselyn F Palma, Radwan Mashina, Claire Chen, Tareq Arar, Marwan Mashina, Yussef Al Ghoul, Banreet Dhindsa, Rajany Dy
BACKGROUND: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to compare the safety and efficacy of supine vs. nonsupine positions during intubation. METHODS: Based on the literature from inception to October 2020, 13 studies with nonemergent intubation in supine and nonsupine positions were chosen using PRISMA and MOOSE protocols. Pooled estimates were calculated using random-effects models with 95% confidence interval (CI)...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37342313/extracorporeal-membrane-oxygenation-to-support-covid-19-patients-a-propensity-matched-cohort-study
#31
JOURNAL ARTICLE
Björn Stessel, Maayeen Bin Saad, Lotte Ullrick, Laurien Geebelen, Jeroen Lehaen, Philippe Jr Timmermans, Michiel Van Tornout, Ina Callebaut, Jeroen Vandenbrande, Jasperina Dubois
BACKGROUND: In patients with severe respiratory failure from COVID-19, extracorporeal membrane oxygenation (ECMO) treatment can facilitate lung-protective ventilation and may improve outcome and survival if conventional therapy fails to assure adequate oxygenation and ventilation. We aimed to perform a confirmatory propensity-matched cohort study comparing the impact of ECMO and maximum invasive mechanical ventilation alone (MVA) on mortality and complications in severe COVID-19 pneumonia...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37325272/mri-and-the-critical-care-patient-clinical-operational-and-financial-challenges
#32
REVIEW
Barbara McLean, Douglas Thompson
Neuroimaging in conjunction with a neurologic examination has become a valuable resource for today's intensive care unit (ICU) physicians. Imaging provides critical information during the assessment and ongoing neuromonitoring of patients for toxic-metabolic or structural injury of the brain. A patient's condition can change rapidly, and interventions may require imaging. When making this determination, the benefit must be weighed against possible risks associated with intrahospital transport. The patient's condition is assessed to decide if they are stable enough to leave the ICU for an extended period...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37197156/critical-care-nurses-adherence-to-ethical-codes-and-its-association-with-spiritual-well-being-and-moral-sensitivity
#33
JOURNAL ARTICLE
Marzieh Momennasab, Zohreh Homayoon, Camellia Torabizadeh
BACKGROUND: Adherence to ethical codes is a major pillar of nursing care that is affected by various factors. Identifying these factors can lead to better ethical performance. The present study was conducted to determine critical care nurses' adherence to ethical codes and its association with spiritual well-being (SWB) and moral sensitivity (MS). METHODS: In this descriptive-correlational study, data were collected using the moral sensitivity questionnaire (MSQ) by Lützén et al...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37197155/in-icu-outcomes-of-critically-ill-patients-in-a-reference-cameroonian-intensive-care-unit-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Edgar Mandeng Ma Linwa, Charles Binam Bikoi, Joel Tochie Noutakdie, Emmanuel Ndoye Ndo, Jean Moise Bikoy, Charlotte Eposse Ekoube, Raissa Fogue Mogoung, Igor Simo Ghomsi, Michael Ngenge Budzi, Esther Eleonore Ngo Linwa, Martin Geh Meh, David Mekolo
INTRODUCTION: Mortality rate amongst critically ill patients admitted to the intensive care unit (ICU) is disproportionately high in sub-Saharan African countries such as Cameroon. Identifying factors associated with higher in-ICU mortality guides more aggressive resuscitative measures to curb mortality, but the dearth of data on predictors of in-ICU mortality precludes this action. We aimed to determine predictors of in-ICU mortality in a major referral ICU in Cameroon. Methodology ...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/36937742/impact-of-quality-improvement-bundle-on-compliance-with-resuscitation-guidelines-during-in-hospital-cardiac-arrest-in-children
#35
JOURNAL ARTICLE
Pranali Awadhare, Karma Barot, Ingrid Frydson, Niveditha Balakumar, Donna Doerr, Utpal Bhalala
INTRODUCTION: Various quality improvement (QI) interventions have been individually assessed for the quality of cardiopulmonary resuscitation (CPR). We aimed to assess the QI bundle (hands-on training and debriefing) for the quality of CPR in our children's hospital. We hypothesized that the QI bundle improves the quality of CPR in hospitalized children. METHODS: We initiated a QI bundle (hands-on training and debriefing) in August 2017. We conducted a before-after analysis comparing the CPR quality during July 2013-May 2017 (before) and January 2018-December 2020 (after)...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/36911499/mechanical-power-in-prone-position-intubated-patients-with-covid-19-related-ards-a-cohort-study
#36
JOURNAL ARTICLE
Roberto Stalla Alves da Fonseca, Viviane Martins Correa Boniatti, Michelle Carneiro Teixeira, Alessandra Preisig Werlang, Francielle Martins, Pedro Henrique Rigotti Soares, Leonardo da Silva Marques, Wagner Luis Nedel
BACKGROUND: Respiratory monitoring of mechanical ventilation (MV) is relevant and challenging in COVID-19. Mechanical power (MP) is a novel and promising monitoring tool in acute distress respiratory syndrome (ARDS), representing the amount of energy transferred from the ventilator to the patient. It encompasses several setting parameters and patient-dependent variables that could cause lung injury. MP can therefore be an additional tool in the assessment of these patients. OBJECTIVE: This study aims to evaluate respiratory monitoring through MP and its relationship with mortality in patients with COVID-19-related ARDS (CARDS) under mechanical ventilation (MV) and prone position (PP) strategies...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/36875553/occurrence-risk-factors-and-outcomes-of-pulmonary-barotrauma-in-critically-ill-covid-19-patients-a-retrospective-cohort-study
#37
JOURNAL ARTICLE
Hasan M Al-Dorzi, Haifa Al Mejedea, Reema Nazer, Yara Alhusaini, Aminah Alhamdan, Ajyad Al Jawad
OBJECTIVE: Pulmonary barotrauma has been frequently observed in patients with COVID-19 who present with acute hypoxemic respiratory failure. This study evaluated the prevalence, risk factors, and outcomes of barotrauma in patients with COVID-19 requiring ICU admission. METHODS: This retrospective cohort study included patients with confirmed COVID-19 who were admitted to an adult ICU between March and December 2020. We compared patients who had barotrauma with those who did not...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/36814471/knowledge-regarding-mechanical-ventilation-and-practice-of-ventilatory-care-among-nurses-working-in-intensive-care-units-in-selected-governmental-hospitals-in-addis-ababa-ethiopia-a-descriptive-cross-sectional-study
#38
JOURNAL ARTICLE
Kedir Abdureman Hassen, Micheal Alemayehu Nemera, Andualem Wubetie Aniley, Ararso Baru Olani, Sofoniyas Getaneh Bedane
INTRODUCTION: Mechanical ventilation (MV) is a backbone and major supportive modality in intensive care units (ICUs) even though it has side effects and complications. Knowledge of nurses about mechanical ventilators and good practice of nursing care for the ventilated patient plays a crucial role in improving the effectiveness of mechanical ventilation, preventing harm, and optimizing the patient outcome. This study intended to assess the knowledge regarding MV and the practice of ventilator care among nurses working in the ICU...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/36761157/association-of-lower-antispike-antibody-levels-with-mortality-in-icu-patients-with-covid-19-disease
#39
JOURNAL ARTICLE
Sangeeta Yelle, Rahul Amte, Vishwanath Gella, Sasikala Mitnala, Deepika Gujjarlapudi, Mohammed Ismail, Ledo Thankachan, Sandhyarani Adla, Fatima Unnisa, Sivakumar Reddy, Duvvur Nageshwar Reddy
BACKGROUND: Though vaccines have been reported as highly efficacious in preventing severe COVID-19 disease, there is emerging data of severe infections, albeit a small number, in vaccinated individuals. We have conducted a retrospective observational study to assess the clinical characteristics, immunological response, and disease outcomes among the vaccinated and unvaccinated patients admitted to the ICU with severe COVID-19 disease. METHODS: Study Design and Participants ...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/36785544/meeting-the-unmet-need-in-the-management-of-mdr-gram-positive-infections-with-oral-bactericidal-agent-levonadifloxacin
#40
REVIEW
Yatin Mehta, K C Mishra, Yashesh Paliwal, Pradeep Rangappa, Sharmili Sinha, Sandeep Bhapkar
Levonadifloxacin (intravenous) and its oral prodrug alalevonadifloxacin are broad-spectrum antibacterial agents developed for the treatment of difficult-to-treat infections caused by multidrug-resistant Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus , atypical bacteria, anaerobic bacteria, and biodefence pathogens as well as Gram-negative bacteria. Levonadifloxacin has a well-defined mechanism of action involving a strong affinity for DNA gyrase as well as topoisomerase IV. Alalevonadifloxacin with widely differing solubility and oral bioavailability has pharmacokinetic profile identical to levonadifloxacin...
2022: Critical Care Research and Practice
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