Grant Hogg, Eric A Severson, Li Cai, Heidi M Hoffmann, Kimberly A Holden, Kerry Fitzgerald, Angela Kenyon, Qiandong Zeng, Michael Mooney, Sabrina Gardner, Wenjie Chen, Narasimhan Nagan, Deborah Boles, Scott Parker, Tamara J Richman, Stanley Letovsky, Henry Dong, Steven M Anderson, Shakti Ramkissoon, Prasanth Reddy, Marcia Eisenberg, Anjen Chenn, Taylor J Jensen
Myeloid neoplasms represent a broad spectrum of hematological disorders for which somatic mutation status in key driver genes is important for diagnosis, prognosis and treatment. Here we summarize the findings of a targeted, next generation sequencing laboratory developed test in 24,639 clinical myeloid samples. Data were analyzed comprehensively and as part of individual cohorts specific to acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN). Overall, 48,015 variants were detected, and variants were found in all 50 genes in the panel...
November 2023: Cancer Genetics