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Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders

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https://read.qxmd.com/read/30771162/improvement-in-quality-of-care-for-patients-with-type-2-diabetes-in-hungary-between-2008-and-2016-results-from-two-population-based-representative-surveys
#1
Attila Nagy, Nóra Kovács, Anita Pálinkás, Valéria Sipos, Ferenc Vincze, Gergő Szőllősi, Róza Ádány, Árpád Czifra, János Sándor
INTRODUCTION: Due to the increasing trends of recent decades, diabetes prevalence has reached a frequency of 1/11 adults worldwide. However, this disadvantageous trend has not been accompanied by worsened outcome indicators; better short-term (e.g., HbA1c levels) and long-term [e.g., all-cause mortality among type 2 diabetes mellitus (T2DM) patients] outcomes can be observed globally. We aimed to describe changes in the effectiveness of type 2 diabetes mellitus care between 2008 and 2016 based on outcome indicators...
February 15, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30767173/rates-of-hypoglycemia-predicted-in-patients-with-type-2-diabetes-on-insulin-glargine-300-u-ml-versus-first-and-second-generation-basal-insulin-analogs-the-real-world-lightning-study
#2
Jeremy Pettus, Ronan Roussel, Fang Liz Zhou, Zsolt Bosnyak, Jukka Westerbacka, Rachele Berria, Javier Jimenez, Björn Eliasson, Irene Hramiak, Timothy Bailey, Luigi Meneghini
INTRODUCTION: The LIGHTNING study applied conventional and advanced analytic approaches to model, predict, and compare hypoglycemia rates of people with type 2 diabetes (T2DM) on insulin glargine 300 U/ml (Gla-300) with those on first-generation (insulin glargine 100 U/ml [Gla-100]; insulin detemir [IDet]) or second-generation (insulin degludec [IDeg]) basal-insulin (BI) analogs, utilizing a large real-world database. METHODS: Data were collected between 1 January 2007 and 31 March 2017 from the Optum Humedica US electronic health records [EHR] database...
February 14, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30767172/predictive-modeling-of-hypoglycemia-risk-with-basal-insulin-use-in-type-2-diabetes-use-of-machine-learning-in-the-lightning-study
#3
Zsolt Bosnyak, Fang Liz Zhou, Javier Jimenez, Rachele Berria
INTRODUCTION: Hypoglycemia remains a global burden and a limiting factor in the glycemic management of people with diabetes using basal insulins or oral antihyperglycemic drugs. Hypoglycemia data gleaned from randomized controlled trials (RCTs) have limited generalizability, as the strict RCT methodology and inclusion criteria do not fully reflect the real-world clinical picture. Therefore, real-world evidence, gathered from sources including electronic health records (EHR), is increasingly recognized as an important adjunct to RCTs...
February 14, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30758834/the-standard-of-care-in-type-2-diabetes-re-evaluating-the-treatment-paradigm
#4
REVIEW
Viswanathan Mohan, Mark E Cooper, David R Matthews, Kamlesh Khunti
There is currently a worldwide epidemic of type 2 diabetes (T2D) that is predicted to increase substantially in the next few years. With 80% of the global T2D population living in low to middle-income countries, there are issues with cost and of access to appropriate medicines. The objective of this symposium was to provide an overview of the efficacy and safety of glucose-lowering drugs, focussing in particular on sulfonylureas (SUs) in patients with T2D using data taken from both randomised controlled trials (RCTs) and real-world studies, the application of strategies to ensure optimal patient adherence and clinical outcomes, and the optimal use of SUs in terms of dose adjustment and agent choice to ensure the best clinical outcome...
February 13, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30758833/association-of-the-serum-total-cholesterol-to-triglyceride-ratio-with-diabetic-retinopathy-in-chinese-patients-with-type-2-diabetes-a-community-based-study
#5
Yifan Zhong, Song Yue, Jingyang Wu, Peng Guan, Guisen Zhang, Lei Liu, Lei Chen
INTRODUCTION: The relationship of total cholesterol (TC) or triglyceride (TG) to diabetic retinopathy (DR) has proven difficult to determine. In addition, there is no report of any study of the correlation between the TC/TG ratio and DR. This study was therefore undertaken to investigate the relationship between the TC/TG ratio and DR in Chinese adults with type 2 diabetes mellitus. METHODS: A community-based study was conducted from August to October 2014 in Fengyutan, Shenyang, China...
February 13, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30737675/use-of-continuous-glucose-monitoring-in-people-with-type-1-diabetes-perspectives-of-two-people-with-diabetes-and-physician-perspective
#6
Isra Ahmed Mohamed, Anthony Fisher, Philippa Cooper, Sufyan Hussain
This article details perspectives from two individuals with type 1 diabetes (T1DM) who use continuous glucose monitoring (CGM) devices to improve their quality of life and self-management of diabetes. It provides a unique perspective of how CGM can make living with T1DM safer and easier, while improving the time spent in the target glucose range (time in range). The perspectives of these two individuals highlight both the immediate need for improved access and support for CGM as well as the need for an understanding of the benefits of using non-medically approved technologies...
February 8, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30737674/insights-for-care-the-healthcare-utilisation-and-cost-impact-of-managing-type-2-diabetes-associated-microvascular-complications
#7
David Chapman, Roland Foxcroft, Laura Dale-Harris, Hanno Ronte, Farid Bidgoli, Srikanth Bellary
INTRODUCTION: The increasing prevalence of type 2 diabetes (T2DM) in the UK imposes a significant burden on the National Health Service (NHS). Despite the availability of effective treatments, the loss of glycaemic control over time results in significant comorbidities, including nephropathy, neuropathy and retinopathy. The cost of treating these microvascular complications has not been well documented, and this study aimed to provide an accurate assessment of the healthcare resource utilisation (HCRU) associated with managing T2DM and its complications...
February 8, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30734901/diagnostic-accuracy-of-glycated-haemoglobin-and-average-glucose-values-in-type-2-diabetes-mellitus-treated-with-premixed-insulin
#8
Magdalena Walicka, Jacek Jozwiak, Jacek Rzeszotarski, Anna Zonenberg, Malgorzata Masierek, Pawel Bijos, Edward Franek
INTRODUCTION: Studies assessing the relationship between glycated haemoglobin (HbA1c) and average blood glucose (ABG) were conducted in small groups of patients on different treatments and may be biased for these reasons. The aim of the study was to assess the relationship between HbA1c and ABG in a large group of type 2 diabetes patients treated with premix insulin. METHODS: In 4257 patients treated with premixed insulin, the parallel point-of-care assessment of HbA1c and ABG from the preceding 90 days (ABG90), calculated automatically from all values measured by the glucometer, was performed twice...
February 8, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30730037/characteristics-of-patients-with-diabetes-initiating-sodium-glucose-co-transporter-2-inhibitors-sglt2i-real-world-results-from-three-administrative-databases-in-japan
#9
Yuichiro Ito, James Van Schyndle, Takuya Nishimura, Toshifumi Sugitani, Tomomi Kimura
INTRODUCTION: The aim of this study was to evaluate the characteristics of new users of sodium glucose co-transporter-2 inhibitors (SGLT2i) in comparison with those of new users of other oral antidiabetic drugs (OADs) using data retrieved from three administrative databases in Japan. METHODS: This study included adult patients from each database who started an OAD between 2014 and 2017. Outpatients who started SGLT2i therapy were included in the SGLT2i cohort. The remaining outpatients were grouped according to the OAD class of their earliest initial prescription after no use of the index OAD during the 6-month pre-index period...
February 7, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30730036/cost-effectiveness-of-continuous-subcutaneous-insulin-infusion-versus-multiple-daily-injections-in-patients-with-poorly-controlled-type-2-diabetes-in-finland
#10
Stephané Roze, Jayne Smith-Palmer, Alexis Delbaere, Karita Bjornstrom, Simona de Portu, William Valentine, Mikko Honkasalo
INTRODUCTION: Although primarily utilized in type 1 diabetes, continuous subcutaneous insulin infusion (CSII) represents a useful treatment alternative for patients with type 2 diabetes who are unable to achieve good glycemic control despite optimization of multiple daily injections (MDI). The aim of the analysis reported here was to investigate the long-term cost-effectiveness of CSII versus MDI in type 2 diabetes patients with poor glycemic control in Finland. METHODS: The IQVIA CORE Diabetes Model was used to make long-term projections of the clinical and economic outcomes associated with CSII use in type 2 diabetes, based on clinical input data from the OpT2mise trial, which showed that CSII was associated with a 1...
February 7, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30725400/incretin-based-antihyperglycemic-agents-for-the-management-of-acute-ischemic-stroke-in-patients-with-diabetes-mellitus-a-review
#11
REVIEW
Dimitrios Milonas, Triantafyllos Didangelos, Apostolos I Hatzitolios, Konstantinos Tziomalos
Diabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest that incretin-based antihyperglycemic agents might exert beneficial effects in patients with DM who suffer ischemic stroke. It appears that these agents exert neuroprotective actions that might both reduce infarct size and promote recovery...
February 6, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30725399/efficacy-of-autologous-bone-marrow-mononuclear-cell-transplantation-therapy-for-type-2-diabetes-mellitus-an-updated-meta-analysis
#12
Xue-Jun Guo, Feng-Ju Li, Yu-Zhuo He, Shu-Fang Hou, Hong-Bin Zhu, Ying Cheng, Zhen Nan, Xiao-Yan Lin
INTRODUCTION: Studies of the effects of stem cell therapy on type 2 diabetes mellitus (T2DM) have not reached consistent results. Our meta-analysis aimed to systematically evaluate the efficacy of autologous bone marrow-derived stem cells (ABM-MNCs) on T2DM. METHODS: We systematically searched PubMed, EMBASE, Web of Science, and the Cochrane Library for studies published between 1980 and May 2018. Two researchers screened the literature independently following the inclusion and exclusion criteria...
February 6, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30721451/effect-of-remote-glucose-monitoring-utilizing-computerized-insulin-dose-adjustment-algorithms-a-pilot-project
#13
Mayer B Davidson, S Joshua Davidson
INTRODUCTION: Primary care physicians are often challenged to adjust insulin doses. To facilitate this process, we evaluated in a safety net clinic the work flow and glycemic effects of remote glucose monitoring utilizing Federal Drug Administration (FDA) cleared, Conformité Européenne (CE) registered software that contained computerized algorithms for insulin dose adjustments to help clinicians make dosing decisions for insulin-requiring patients. METHODS: Patients taking insulin for at least 6 months with HbA1c levels of at least 8...
February 5, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30706366/evidence-based-consensus-on-positioning-of-sglt2i-in-type-2-diabetes-mellitus-in-indians
#14
REVIEW
Awadhesh Kumar Singh, Ambika G Unnikrishnan, Abdul H Zargar, Ajay Kumar, Ashok K Das, Banshi Saboo, Binayak Sinha, Kalyan Kumar Gangopadhyay, Pradeep G Talwalkar, Samit Ghosal, Sanjay Kalra, Shashank Joshi, Surendra Kumar Sharma, Usha Sriram, Viswanathan Mohan
The current diabetes management strategies not only aim at controlling glycaemic parameters but also necessitate continuous medical care along with multifactorial risk reduction through a comprehensive management concept. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a group of evolving antidiabetic agents that have the potential to play a pivotal role in the comprehensive management of patients with diabetes due to their diverse beneficial effects. SGLT2i provide moderate glycaemic control, considerable body weight and blood pressure reduction, and thus have the ability to lower the risk of macrovascular and microvascular complications...
January 31, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30706365/efficacy-of-real-time-continuous-glucose-monitoring-to-improve-effects-of-a-prescriptive-lifestyle-intervention-in-type-2-diabetes-a-pilot-study
#15
Penelope J Taylor, Campbell H Thompson, Natalie D Luscombe-Marsh, Thomas P Wycherley, Gary Wittert, Grant D Brinkworth
INTRODUCTION: Optimising patient adherence to prescribed lifestyle interventions to achieve improved blood glucose control remains a challenge. Combined use of real-time continuous glucose monitoring systems (RT-CGM) may promote improved glycaemic control. This pilot study examines the effects of a prescriptive lifestyle modification programme when combined with RT-CGM on blood glucose control and cardiovascular disease risk markers. METHODS: Twenty adults (10 men, 10 women) with obesity and type-2 diabetes (T2D) (age 60...
January 31, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30706364/treating-patients-with-type-2-diabetes-mellitus-uncontrolled-on-basal-insulin-in-the-czech-republic-cost-effectiveness-of-ideglira-versus-iglarlixi
#16
Johannes Pöhlmann, Monika Russel-Szymczyk, Pavel Holík, Karel Rychna, Barnaby Hunt
INTRODUCTION: Few patients with type 2 diabetes mellitus (T2DM) achieve recommended glycemic control targets in the Czech Republic. Novel therapies, such as fixed-ratio combinations of basal insulin plus glucagon-like peptide-1 receptor agonists, may contribute to better glycemic control. In the analysis presented here, the present analysis assessed the long-term cost-effectiveness of two fixed-ratio combinations, IDegLira (insulin degludec/liraglutide) and iGlarLixi (insulin glargine/lixisenatide), for the treatment of patients with T2DM inadequately controlled with basal insulin from a healthcare payer perspective in the Czech Republic...
January 31, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30706363/a-practical-guide-to-delivering-nutritional-advice-to-people-with-diabetes
#17
Pamela A Dyson
Dietary advice is fundamental to the management of diabetes. Although ideally such advice should be delivered by a state-registered dietitian, it is more usually delivered by other health professionals. The primary focus for those with type 1 diabetes is carbohydrate counting and insulin adjustment and for the majority of people with type 2 diabetes, weight management is key. Patient-centred care is emphasised for the delivery of dietary advice. It is widely recognised that knowledge alone is not sufficient to induce behaviour change and practical approaches to a variety of behavioural interventions are discussed...
January 31, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30701468/real-time-sharing-and-following-of-continuous-glucose-monitoring-data-in-youth
#18
John B Welsh, Mark Derdzinski, Andrew Scott Parker, Sarah Puhr, Annika Jimenez, Tomas Walker
BACKGROUND: Those caring for children and adolescents with diabetes often use glucose concentration and trending information in management decisions. Some continuous glucose monitoring (CGM) systems offer real-time sharing and monitoring capabilities through mobile apps carried by the person with diabetes and the caregiver(s), respectively. Few large studies have explored real-world associations between sharing and following, CGM utilization, and glycemic outcomes. METHODS: We performed a retrospective evaluation of device usage and glycemic control in 15,000 youth ranging in age from 2 to 18 years by analyzing anonymized data that had been uploaded with a mobile app that provides optional sharing...
January 30, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30689140/ertugliflozin-compared-to-other-anti-hyperglycemic-agents-as-monotherapy-and-add-on-therapy-in-type-2-diabetes-a-systematic-literature-review-and-network-meta-analysis
#19
Ann M McNeill, Glenn Davies, Eliza Kruger, Stacey Kowal, Tim Reason, Flavia Ejzykowicz, Hakima Hannachi, Nilo Cater, Euan McLeod
INTRODUCTION: Ertugliflozin is a new sodium-glucose co-transporter-2 inhibitor (SGLT2i) for the treatment of type 2 diabetes mellitus. As there are no head-to-head trials comparing the efficacy of SGLT2is, the primary objective of this analysis was to indirectly compare ertugliflozin to other SGLT2i in patient populations with inadequately controlled glycated hemoglobin (HbA1c > 7.0%) and previously treated with either diet/exercise, metformin alone or metformin plus a dipeptidyl peptidase-4 inhibitor (DPP4i)...
January 28, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/30661221/epidemiology-quality-of-life-and-costs-associated-with-hypoglycemia-in-patients-with-diabetes-in-spain-a-systematic-literature-review
#20
REVIEW
Mercedes Núñez, Silvia Díaz, Tatiana Dilla, Jesús Reviriego, Antonio Pérez
OBJECTIVE: To assess the burden of hypoglycemia in patients with diabetes mellitus (DM) in Spain, including epidemiological data and information relating to healthcare resource utilization (HRU) and costs, and patients' quality of life (QoL). METHODS: A systematic literature review (SLR) was conducted to identify studies that included original information on epidemiology, HRU and costs, and/or QoL associated with hypoglycemia in patients with DM in Spain, published in either Spanish or English, between January 2007 and April 2017...
January 19, 2019: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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