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Hormone Molecular Biology and Clinical Investigation

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https://read.qxmd.com/read/30943171/vitamin-d-status-and-its-relationship-with-systemic-lupus-erythematosus-as-a-determinant-and-outcome-of-disease-activity
#1
Chayanika Dutta, Sanjeeb Kakati, Bhupen Barman, Kaustubh Bora
Background The importance of vitamin D (VD) in systemic lupus erythematosus (SLE) is being increasingly appreciated, with studies suggesting a relationship between VD deficiency and SLE onset/disease activity. We investigated VD status in SLE patients and its associations with disease activity in a geographical region of India receiving low solar ultraviolet-B (UV-B) index. Materials and methods We enrolled 109 SLE patients along with 109 healthy controls belonging to same ethnicity and localities. Demographic and clinico-laboratory information were recorded...
April 3, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30917102/characterizing-the-differential-physiological-effects-of-adipocytokines-visfatin-and-resistin-in-liver-cancer-cells
#2
Candace Miethe, Megan Zamora, Linda Torres, Kelsie G Raign, Curissa J Groll, Ramona S Price
Background Obesity, a major public health concern, increases the risk of developing liver cancer which is the leading cause of cancer-related deaths worldwide. Obesity is associated with increased adiposity and macrophage infiltration both of which promote secretion of adipokines and cytokines in the tumor microenvironment. Specifically, visfatin and resistin have been detected at higher levels in the serum of obese individuals and liver tumors. However, the contribution of these adipocytokines in the progression of liver cancer remains unclear...
March 27, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30913034/endometriosis-and-the-menopause-why-the-question-merits-our-full-attention
#3
Lydia Marie-Scemama, Marc Even, Jean Bouquet De La Joliniere, Jean-Marc Ayoubi
As an estrogen-dependent disease, endometriosis was thought to become less active or regress with the onset of the menopause. However, based on some new data, we are discovering that this pathology can emerge or reappear at this period of life. Clinicians must consider it as a possible cause for cases of pelvic pain, and heavy bleeding. Authors have described a possibility of transformation of the intraperitoneal proliferation into a malignant type with ovarian, bowel and even lung metastasis. The risk of transformation into an ovarian cancer is around 2 or 3%...
March 26, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30904901/combined-study-on-the-single-nucleotide-polymorphisms-in-the-follicle-stimulating-hormone-receptor-ser680asn-and-anti-m%C3%A3-llerian-hormone-receptor-type-ii-482a-g-as-genetic-markers-in-assisted-reproduction
#4
Ioannis G Papanikolaou, Polina Giannelou, Elli Anagnostou, Despoina Mavrogianni, Petros Drakakis, Dimitrios Loutradis
Background Infertile women may have underlying genetic abnormalities. There is, at present, a significant number of studies on the relation between the follicle stimulating hormone receptor (FSHR) or anti-Müllerian hormone type II receptor (AMHRII) polymorphisms and response to in-vitro fertilisation (IVF) treatment. However, it is not yet clear which genotype or combination of genotypes is favourable towards a better ovarian stimulation and pregnancy outcome. Materials and methods In this study we assessed the distribution of the genotypes of FSHR Ser680Asn and of AMHRII -482A>G gene polymorphisms in a group of 126 infertile women and a control group of 100 fertile women by using real-time polymerase chain reaction (RT-PCR)...
March 25, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30878995/adenomyosis-genetics-of-estrogen-metabolism
#5
Natalia Artymuk, Olga Zotova, Lyudmila Gulyaeva
Background To analyze the allelic variants of genes of enzymes involved in estrogen metabolism: CYP1A1, CYP1A2, CYP19 and SULT1A1 using polymerase chain reaction-restriction fragment length polymorphism-restriction fragment length polymorphism (PCR-RFLP) analysis of women with histologically confirmed adenomyosis and women without proliferative diseases of pelvic organs was performed. We studied the following polymorphisms: CYP1A1 M1, T264 → C transition in the 3'-noncoding region; CYP1A2*1F, C734 → A transversion in CYP1A2 gene; C → T transition (Arg264Cys) in exon 7 of CYP19; SULT1A1*2, G638 → A transition (Arg213His) in the SULT1A1 gene...
March 15, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30870141/cryptozoospermia-after-treatment-with-clomiphene-citrate-following-long-term-use-of-intramuscular-testosterone-undecanoate-depot-injection-nebido%C3%A2
#6
Tanja Grubić Kezele
Objective To illustrate the importance of treatment duration with intramuscular testosterone undecanoate (Nebido®) for the final spermatogenesis recovery after treatment cessation. Also, to show a subsequent poor efficacy of the selective estrogen receptor modulator (SERM) clomiphene citrate (CC) in treating steroid-induced azoospermia following Nebido® cessation and describe that initial oligozoospermia, existing before starting Nebido®, largely contributes to that treatment outcome. Methodology Setting: Department of Human Reproduction and Department of Endocrinology, Clinical Hospital Center Rijeka, Rijeka, and Department of Endocrinology, Clinical Hospital Center Sestre milosrdnice, Zagreb, Croatia...
March 14, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30851158/early-menarche-is-independently-associated-with-subclinical-hypothyroidism-a-cross-sectional-study
#7
Marianna Kotopouli, Theodora Stratigou, Georgios Antonakos, Gerasimos Socrates Christodoulatos, Irene Karampela, Maria Dalamaga
Background Subclinical hypothyroidism (SH) is more frequent in females than males, with a female to male ratio ranging from 1.5 to 5 in the general population. The aim of this study was to evaluate for the first time the association of reproductive factors, particularly age at menarche, with SH risk. Materials and methods In a cross-sectional study, reproductive factors such as age at menarche, at menopause and at first birth, lactation, parity, full-term pregnancies, reproductive years, use of oral contraceptives and hormonal replacement therapy, somatometric data and insulin resistance parameters were recorded in 72 consecutive female patients with SH and 72 healthy female controls matched on age (±5 years) and date of diagnosis (±1 month)...
March 9, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30840586/increased-irisin-versus-reduced-fibroblast-growth-factor1-fgf1-in-relation-to-adiposity-atherogenicity-and-hematological-indices-in-metabolic-syndrome-patients-with-and-without-prediabetes
#8
Govand Yaseen Saber, Violet Kasabri, Mohammad Issa Saleh, Maysa Suyagh, Lana Halaseh, Ruba Jaber, Hana Abu-Hassan, Sundos Alalawi
Background Irisin and fibroblast growth factor 1 (FGF1) are intricately involved in metabolic syndrome (MetS) and prediabetes (preDM) pathophysiology. This study aimed to compare and correlate irisin and FGF1 plasma levels, adiposity, atherogenicity and hematological indices in 29 normoglycemic MetS and 30 newly diagnosed drug naive prediabetic (PreDM) MetS patients vs. 29 lean and normoglycemic controls. Materials and methods Irisin and FGF1 plasma levels were measured using colorimetric assays. Intergroup comparisons were conducted by analysis of variance (ANOVA)...
March 6, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30739099/brain-intracrinology-of-allopregnanolone-during-pregnancy-and-hormonal-contraception
#9
REVIEW
Nicola Pluchino, Yveline Ansaldi, Andrea R Genazzani
Allopregnanolone (ALLO) has a crucial role in brain development and remodeling. Reproductive transitions associated with endocrine changes affect synthesis and activity of ALLO with behavioral/affective consequences. Pregnancy is characterized by an increased synthesis of progesterone/ALLO by the placenta, maternal and fetal brains. This suggests the critical role of these steroids in maternal brain adaptation during pregnancy and the development of the fetal brain. ALLO is brain protective during complications of pregnancy, such as preterm delivery or intrauterine growth restriction (IUGR), reducing the impact of hypoxia, and excitotoxic brain damage...
February 11, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30753160/diffuse-massive-adenomyosis-and-infertility-is-it-possible-to-treat-this-condition
#10
Vitaly B Tskhay, Adolf E Schindler, Gyulnar T Mikailly
Background Severe forms of adenomyosis are a serious gynecological problem. In most cases, conservative treatment of this pathology is unsuccessful. Adenomyomectomy by Osada's approach seems to be the most promising solution. The present study evaluated the follow-up results of this type of surgery in patients with adenomyosis and infertility. Materials and methods The prospective study included 26 patients with severe forms of adenomyosis who underwent an adenomyomectomy using Osada's approach. In 18 patients (69%), infertility was the main indication for surgical treatment...
February 6, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30712024/effects-of-different-loading-exercises-on-apelin-levels-and-physical-and-hematologic-parameters-of-swimmers
#11
Aykut Dundar, Sayad Kocahan, Cengiz Arslan
Background The purpose of this study was to investigate the effects of different exercise loads (short, medium and long swimming distances) on apelin levels and some physical and hematologic parameters of male professional swimmers. Materials and methods Apelin levels, hematologic parameters, whole blood values and physical measurements, including body mass index (BMI), aerobic power values and anaerobic power values, were also obtained. Results It was determined that the thrombocyte, erythrocyte and leukocyte values from the hematologic parameters increased after exercise (p < 0...
February 4, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30712023/clinical-implications-of-blood-pressure-variability-bpv-in-pregnancies-a-review
#12
REVIEW
Hanis Hidayu Kasim, Maizatul Azma Masri, Nor Azila Noh, Azlina Mokhtar, Rafidah Hanim Mokhtar
Background Hypertension disorder in pregnancy (HDP) is the second most common contributor to maternal morbidity and mortality worldwide. Blood pressure variability (BPV), with the assistance of ambulatory blood pressure monitoring (ABPM), measures blood pressure readings in pregnant women and has the potential to predict the occurrence of pregnancy-induced hypertension (PIH) or preeclampsia (PE) before any symptoms develop. Methodology Studies involving ABPM among pregnant women were identified using electronic databases such as PubMed, Scopus, Google Scholar, ScienceDirect, Medscape, Ovid and ProQuest...
February 4, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30667366/correlates-of-resistin-and-retinol-binding-protein-4-in-metabolic-syndrome-patients-with-and-without-prediabetes
#13
Abeer Abu Horan, Abla Albsoul-Younes, Violet Kasabri, Maysa Suyagh, Lana Halaseh, Sundus AlAlawi
Background Resistin and retinol-binding protein 4 (RBP4) can work in an intricate in metabolic syndrome (MetS) and prediabetes (PreDM) molecular crosstalk. Materials and methods Resistin and RBP4 were evaluated using colorimetric enzyme-linked immunosorbent assays (ELISAs) in 29 normoglycemic MetS, 30 newly diagnosed drug naïve MetS-preDM patients and 29 lean and normoglycemic controls. Results In this cross-sectional design; the gradual increase in resistin levels (ng/mL), though not ascribed any statistically marked variation, was appreciable in both normoglycemic and preDM MetS groups vs...
January 23, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30964748/preface-to-special-issue-role-of-progestogens-in-women-s-health-an-update
#14
EDITORIAL
Adolf E Schindler, René A Druckmann
No abstract text is available yet for this article.
April 9, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30667367/correlates-of-zinc-finger-bed-domain-containing-protein-3-and-ghrelin-in-metabolic-syndrome-patients-with-and-without-prediabetes
#15
Rawan AbuZayed, Nailya Bulatova, Violet Kasabri, Maysa Suyagh, Lana Halaseh, Sundus AlAlawi
Background Ghrelin and zinc finger BED domain-containing protein 3 (ZBED3) are distinctively cross linked with prediabetes (preDM) and metabolic syndrome (MetS). Materials and methods In a cross-sectional design with 29 normoglycemic MetS and 30 newly diagnosed drug naïve preDM/MetS patients vs. 29 lean and normoglycemic controls; ghrelin and ZBED3 were evaluated using colorimetric enzymatic assays. Results While ZBED3 mean circulating levels (ng/mL) in both MetS groups (normoglycemic and preDM) invariably lacked discrepancy vs...
January 22, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30653467/a-miracle-pregnancy-outcome-of-severe-placental-abruption
#16
Joyce Chin Sing Ting, Xiu Sing Wong, Soon Leong Yong, Marcus Kang
Severe placental abruption is associated with high maternal and perinatal morbidity and mortality. Prompt delivery is usually mandatory in this situation. We report a case of a 33-year-old woman, gravida 5, para 3 + 1, at 26 weeks + 3 days' gestation who had severe placental abruption involving 40% of the placental surface complicated with maternal moderate anaemia and thrombocytopenia. In view of the extreme foetal prematurity and stable condition of both mother and foetus, expectant management was undertaken...
January 17, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30653466/novel-strategies-for-clinical-investigation-and-biomarker-discovery-a-guide-to-applied-metabolomics
#17
REVIEW
Gabriel Carneiro, Andres Lopez Radcenco, Joseph Evaristo, Gustavo Monnerat
Metabolomics is an emerging technology that is increasing both in basic science and in human applications, providing a physiological snapshot. It has been highlighted as one of the most wide ranging and reliable tools for the investigation of physiological status, the discovery of new biomarkers and the analysis of metabolic pathways. Metabolomics uses innovative mass spectrometry (MS) allied to chromatography or nuclear magnetic resonance (NMR). The recent advances in bioinformatics, databases and statistics, have provided a unique perception of metabolites interaction and the dynamics of metabolic pathways at a system level...
January 17, 2019: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30667194/retraction-of-reciprocal-role-of-hbd2-and-hbd3-on-the-adaptive-immune-response-by-measuring-t-lymphocyte-proliferation-in-terms-of-cd4-and-ccr6-expression
#18
(no author information available yet)
Retraction of: Nima Taefehshokr, Alireza Isazadeh, Amin Oveisi, Yashar Azari Key and Sina Taefehshokr. Reciprocal role of hBD2 and hBD3 on the adaptive immune response by measuring T lymphocyte proliferation in terms of CD4 and CCR6 expression. Hormone Molecular Biology and Clinical Investigation. Volume 35, Issue 1-3, Article ID: 20180023. (DOI: 10.1515/hmbci-2018-0023). This article has been retracted by the editors/the publisher due to suspected academic misconduct which has not been refuted by the authors...
December 19, 2018: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30517076/ovarian-reserve-in-adolescent-girls-born-prematurely
#19
Svetlana Elgina, Natalia Artymuk, Elena Nikulina
Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. The levels of estradiol (p = 0.027), anti-Müllerian hormone (p = 0...
December 5, 2018: Hormone Molecular Biology and Clinical Investigation
https://read.qxmd.com/read/30496135/proportional-correlates-of-cystatin-c-with-pentraxin-3-visceral-adiposity-index-and-atherogenicity-index-of-plasma-but-not-blood-indices-in-metabolic-syndrome-patients-with-and-without-prediabetes
#20
Musa Moh'd Waleed Al-Batsh, Abla Albsoul-Younes, Violet Kasabri, Maysa Suyagh, Sundos Alalawi, Nada Yasin
Background Pentraxin-3 (PXT-3) and cystatin-C (Cys-C) are robustly related with central obesity and insulin resistance in prediabetes/metabolic syndrome (preDM-MetS). Materials and methods This cross-sectional study aimed to compare and correlate PXT-3 and Cys-C plasma levels in 29 normoglycemic MetS patients, 30 newly diagnosed drug naive preDM-MetS cases vs. 29 normoglycemic lean controls. Results Unlike PXT-3; Cys-C level was significantly higher in normoglycemic MetS (but not preDM-MetS) vs. healthy controls...
November 29, 2018: Hormone Molecular Biology and Clinical Investigation
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