Hormone Molecular Biology and Clinical Investigation

Ajay Patel, Austin Thompson, Lillian Abdelmalek, Beverley Adams-Huet, Ishwarlal Jialal
Background Metabolic syndrome (MetS) is an important contributor to both type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). Although MetS affects one third of American adults, its pathogenesis remains to be elucidated. Tyramine, a derivative of tyrosine, has been shown to act as a catecholamine releasing agent in the human body. The aim of this study is to investigate the role of tyramine as an early biomarker for nascent MetS without the confounding of T2DM, ASCVD or smoking...
November 6, 2019: Hormone Molecular Biology and Clinical Investigation
Jérôme Mathis, Mohammed Amine Jellouli, Laura Sabiani, Joy Fest, Guillaume Blache, Patrice Mathevet
Background Ovarian carcinoma is a poor prognosis cancer mainly due to its late diagnosis. Its incidence is relatively low but mortality is high. The symptomatology is only slightly specific, which complicates diagnostic management. It would therefore be interesting to be able to establish a diagnosis as early as possible in order to improve the prognosis of patients suffering from ovarian cancer. Materials and methods Currently, the combination of an ultrasound examination with a cancer antigen (CA)-125 assay is the most effective diagnostic technique, but not already admitted as a screening method...
November 6, 2019: Hormone Molecular Biology and Clinical Investigation
Jia Xin Mok, Jack Hau Ooi, Khuen Yen Ng, Rhun Yian Koh, Soi Moi Chye
Melatonin is a hormone secreted by the pineal gland under the control of the circadian rhythm, and is released in the dark and suppressed during the day. In the past decades, melatonin has been considered to be used in the treatment for diabetes mellitus (DM). This is due to a functional inter-relationship between melatonin and insulin. Elevated oxidative stress is a feature found in DM associated with diabetic neuropathy (DN), retinopathy (DR), nephropathy and cardiovascular disease. Reactive oxygen species (ROS) and nitrogen oxidative species (NOS) are usually produced in massive amounts via glucose and lipid peroxidation, and this leads to diabetic complications...
November 6, 2019: Hormone Molecular Biology and Clinical Investigation
Mohammad Ali Morowati Sharifabad, Mohammad Rafati Fard, Mojtaba Fattahi Ardakani, Ali Dehghani Ahmadabad, Ahmad Sotudeh
Background Nurse-patient communication is one of the most important care relationships that affects the treatment process. The health action process approach (HAPA) has been used to explain a number of behaviors. However, this approach has not been used to explain nurse-patient communication. Therefore, this study was conducted to investigate effective nurse-patient communication using this approach. Materials and methods In this cross-sectional study, 300 nurses from public hospitals in the center of Iran were enrolled in the study...
October 25, 2019: Hormone Molecular Biology and Clinical Investigation
Rafighe Ghiasi, Roya Naderi, Roghayeh Sheervalilou, Mohammad Reza Alipour
Background Sirtuin1 is a regulator of oxidative stress involved in the management of diabetes complications. Due to the beneficial effects of swimming training in diabetes, this study aimed to investigate the effects of swimming training on pancreatic Sirtuin1, oxidative stress and metabolic parameters in type 2 diabetic male rats. Materials and methods Twenty-eight male Wistar rats (200-250 g) were randomly divided into four groups: control, diabetic, swim trained and swim trained diabetic rats (n = 7). Diabetes was induced by a high-fat diet and streptozotocin injection [35/kg intraperitoneally]...
October 25, 2019: Hormone Molecular Biology and Clinical Investigation
Azadeh Akmali, Marziyeh Saghebjoo
Background There is little data regarding the ability of high-intensity interval training (HIIT) to increase of glycolytic capacity and intramuscular metabolic adaptations. The goal of this study was to evaluate the effects of HIIT (8 weeks, 5 times/week) with short (HIIT1 min: 16 × 1 min work and active recovery at 80-95% and 50-60% VO2max, respectively) and long (HIIT4 min: 4 × 4 min work and active recovery at 80-95% and 50-60% VO2max, respectively) duration intervals and 4 weeks detraining on the levels of phosphofructokinase (PFK), glycogen synthase 1 (GYS1), monocarboxylate transporter 4 (MCT4) and lactate dehydrogenase (LDH) activity in the rats' gastrocnemius muscle...
October 19, 2019: Hormone Molecular Biology and Clinical Investigation
Sahar Mohammadi Sefat, Ramin Shabani, Marzieh Nazari
Background The present study aimed to explore the effect of 8 weeks of concurrent aerobic-resistance training on thyroid stimulating hormone (TSH), thyroxine (T4), blood lipid profile, and blood glucose hemostasis in adolescent girls with hypothyroidism. Materials and methods In this clinical trial, 20 adolescent girls with hypothyroidism [age: 12.10 ± 1.94 years; body mass index (BMI): 25.25 ± 2.91 kg/m2] were selected and randomly assigned to experimental and control groups. The experimental group was treated with 8 weeks of concurrent aerobic [60-80% heart rate reserve (HHR)] and resistance (40-65% of 1RM) training...
October 16, 2019: Hormone Molecular Biology and Clinical Investigation
Evelyn Lee Pian Ting, Soon Leong Yong, Ganapaty Suhashini, Marcus Kang
Chorioangioma or chorangioma is a benign placental tumour which occurs in 1% of the pregnancies. Large lesions of more than 4-5 cm in size, also known as giant chorangiomas, are rare with the incidence of 1:3500 and 1:9000 birth. Unlike small tumours, the giant chorangiomas are highly associated with pregnancy complications. We report a case of multiple large chorangiomas resulting in an extremely preterm delivery. A 24-year-old primigravida presented at 25 weeks of gestation for threatened preterm labour. Transabdominal ultrasound revealed an echogenic mass on the placenta measuring 8...
October 11, 2019: Hormone Molecular Biology and Clinical Investigation
Laura Knabben, Sara Imboden, Michel D Mueller
Background Clinical practices and testing strategies in patients with ovarian cancer differ worldwide. We therefor wanted to give an overview over the current data to advise best clinical practice. Materials and methods A systematic review of the literature was performed with the aim to define which ovarian cancer patients to refer for genetic counseling and how to perform genetic testing. We also discuss the timing of genetic testing and clinical relevance of the BRCA mutation status. Results The germline mutation rate in patients with ovarian cancer is high, independent of family history, age at diagnosis and histology...
October 2, 2019: Hormone Molecular Biology and Clinical Investigation
Aida Kalok, Rizna Abdul Cader, Ima Indirayani, Abdul Kadir Abdul Karim, Shamsul Azhar Shah, Nor Azlin Mohamed Ismail, Mohd Hashim Omar, Mohamad Nasir Shafiee
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory condition with multi-organ involvement predominantly affecting young women. There are very limited studies in pregnancy in Asian SLE patients and therefore we embarked on this study to identify pregnancy outcomes of Malaysian women with SLE. Materials and methods We performed a retrospective study of pregnancy outcomes in SLE patients in our institution from January 2007 to December 2014. A total of 71 pregnancies from 44 women were analysed...
September 25, 2019: Hormone Molecular Biology and Clinical Investigation
Anastasia Drakou, Despoina Mavrogianni, Konstantinos Ntzeros, Athanasios Protopapas, Petros Drakakis, Dimitrios Loutradis
Background Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine which plays an important role in the pathogenesis of many diseases. Endometriosis is one of the most common gynecological diseases. The purpose of this study was to investigate the association of TNF-α-1031T/C polymorphism with the genetic susceptibility of endometriosis in a European population. Materials and methods In this case-control study, 51 endometriosis patients and 67 healthy control women participated. We used endometrial tissue from the patients and peripheral blood from the healthy women to extract DNA...
September 20, 2019: Hormone Molecular Biology and Clinical Investigation
Nikolaos Machairiotis, Georgia Ntali, Paraskevi Kouroutou, Lina Michala
Bisphosphonates (BPs) are potent inhibitors of osteoclast mediated bone resorption. These drugs are widely used in the management of osteoporosis and other diseases, characterized by high bone turnover. The effect of BPs on gestation and lactation, when they are used as therapeutic agents in premenopausal women, is yet unknown. We conducted a detailed literature review and identified the cases of BPs use in young women, as well as, the effects of this therapy on the gestation and the embryo. The published data, regarding the use of BPs in premenopausal women and their effects on the pregnancy outcome, are limited...
September 20, 2019: Hormone Molecular Biology and Clinical Investigation
Fauziah Jummaat, Shuhaila Ahmad, Nor Azlin Mohamed Ismail
Background Amniocentesis is a well-known invasive procedure which is commonly carried out in the second trimester. The indication for amniocentesis varies throughout countries and centers. Despite providing significant prenatal diagnosis; many maternal and fetal complications have been reported from previous studies. Materials and methods This retrospective study aimed to determine the maternal and fetal complications following amniocentesis. This study involved all patients who underwent amniocentesis from January 2012 until June 2017 in a tertiary centre...
September 20, 2019: Hormone Molecular Biology and Clinical Investigation
Sandra M Gonzalez, Wbeimar Aguilar-Jimenez, Natalia Alvarez, Maria T Rugeles
Background Dendritic cells (DCs) play a crucial role during HIV-1 transmission due to their ability to transfer virions to susceptible CD4+ T cells, particularly in the lymph nodes during antigen presentation which favors the establishment of systemic infection. As mature dendritic cells (mDCs) exhibit a greater ability to transfer virions, compared to immature DCs (iDCs), maintenance of an iDC phenotype could decrease viral transmission. The immunomodulatory vitamin D (VitD) has been shown to reduce activation and maturation of DCs; hence, we hypothesized that it would reduce viral transference by DCs...
September 20, 2019: Hormone Molecular Biology and Clinical Investigation
Marcel Bäumler, Delphine Gallant, René Druckmann, Walther Kuhn
Ovarian cancer has a high mortality rate. The most common serous type spreads rapidly throughout the peritoneal cavity when 5-year survival is 10%. If diagnosed in earlier stages where the cancer is still confined to the ovary, this survival rate is about 90%. This is the reason to be interested in screening at earlier stages in the average-risk general population. Thus, annual transvaginal ultrasound (TVS) alone or as a multimodal screening test following serum carbohydrate antigen 125 (CA125) has been investigated...
September 17, 2019: Hormone Molecular Biology and Clinical Investigation
Narges Marefati, Amin Mokhtari-Zaer, Farimah Beheshti, Sareh Karimi, Zahra Mahdian, Mehdi Khodamoradi, Mahmoud Hosseini
Background Modulatory effects of soy extract and estradiol on the central nervous system (CNS) have been reported. The effect of soy on scopolamine-induced spatial learning and memory in comparison to the effect of estradiol was investigated. Materials and methods Ovariectomized rats were divided into the following groups: (1) control, (2) scopolamine (Sco), (3) scopolamine-soy 20 (Sco-S 20), (4) scopolamine-soy 60 (Sco-S 60), (5) scopolamine-estradiol 20 (Sco-E 20) and (6) scopolamine-estradiol 60 (Sco-E 60)...
September 4, 2019: Hormone Molecular Biology and Clinical Investigation
Mohamad Nasir Shafiee, Chew Kah Teik, Reena Rahayu Md Zain, Nirmala Kampan
Uterine leiomyosarcoma (LMS) is rare but primary ovarian LMS is even rarer constituting less than 0.1% of all gynecologic disorders. Neither histologic features nor immunohistochemistry could be utilized to distinguish between uterine or ovarian origin. We illustrate a clinical case of metastatic LMS to the ovary in a woman with underlying uterine fibroid presenting with anemia with heavy menses.
August 9, 2019: Hormone Molecular Biology and Clinical Investigation
Philippe Kadhel, Aurélie Revaux, Marie Carbonnel, Iptissem Naoura, Jennifer Asmar, Jean Marc Ayoubi
The best prognosis for advanced ovarian cancer is provided by no residual disease after primary cytoreductive surgery. It is thus important to be able to predict resectability that will result in complete cytoreduction, while avoiding unnecessary surgery that may leave residual disease. No single procedure appears to be sufficiently accurate and reliable to predict resectability. The process should include a preoperative workup based on clinical examination, biomarkers, especially tumor markers, and imaging, for which computed tomography, as well as sonography, magnetic resonance imaging and positron-emission tomography, can be used...
August 9, 2019: Hormone Molecular Biology and Clinical Investigation
Sara Tato-Varela, Walther Kuhn
Ovarian cancer is the second most common malignant neoplasm of the genital tract. Staging procedures for ovarian cancer include longitudinal laparotomy, hysterectomy, bilateral salpingo-oophorectomy and infragastric omentectomy as well as systematic pelvic and para-aortic lymphadenectomy. In general, the goal of this primary procedure is to achieve the maximum cytoreduction of all abdominal diseases; a residual disease <1 cm defines optimal cytoreduction, however, a maximal effort should be made to remove all gross disease as this offers superior survival outcomes...
August 9, 2019: Hormone Molecular Biology and Clinical Investigation
Shereen M Aleidi, Eman Shayeb, Jameel Bzour, Eman Y Abu-Rish, Mohammad Hudaib, Sundus Al Alawi, Yasser Bustanji
Background Insulin-like growth factor-I (IGF-I) is homologous to proinsulin and possesses glucose reducing activity. The association between the level of IGF-I and diabetes has been highlighted. However, this association is controversial due to the influence of different factors including obesity. The aim of the study was to evaluate serum level of IGF-I in type 2 diabetic patients compared to control subjects. Materials and methods A cross-sectional study involving 100 participants was conducted. Serum levels of IGF-I were measured using enzyme-linked immunosorbent assay (ELISA) and the fasting plasma glucose (FPG) levels were measured using the glucose oxidase method...
August 9, 2019: Hormone Molecular Biology and Clinical Investigation
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