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International Journal of Hypertension

https://read.qxmd.com/read/38445022/epidemiology-and-risk-factors-for-orthostatic-hypotension-and-its-severity-in-residents-aged%C3%A2-%C3%A2-60%C3%A2-years-a-cross-sectional-study
#1
JOURNAL ARTICLE
Mingni Yang, Ruiqiang Peng, Zetuo Wang, Miaoduan Li, Yehua Song, Jianping Niu, Yong Ji
This cross-sectional study investigated the epidemiology and risk factors associated with orthostatic hypotension (OH) and its severity in older adults residing in the Jizhou community of Tianjin and the Jimei community of Xiamen. The study, conducted from March to September 2019, involved adults aged over 60. A comprehensive questionnaire survey was administered, resulting in the enrolment of 4383 older adults. The overall prevalence of OH was found to be 11.7% (516 out of 4383). Notably, a significant gender difference was observed, with a prevalence of 10% among males (194 out of 1926) and 13...
2024: International Journal of Hypertension
https://read.qxmd.com/read/38410720/lipid-horizons-recent-advances-and-future-prospects-in-lbdds-for-oral-administration-of-antihypertensive-agents
#2
REVIEW
Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani
The lipid-based drug delivery system (LBDDS) is a well-established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis. Various LBDDSs verified to be an efficacious mechanism for monitoring hypertension systems are SEDDS (self-nano emulsifying drug delivery), nanoemulsion, microemulsions, vesicular systems (transferosomes and liposomes), and solid lipid nanoparticles. LBDDSs overcome the shortcomings that are associated with antihypertensive agents because around fifty percent of the antihypertensive agents experience a few drawbacks including short half-life because of hepatic first-pass metabolism, poor aqueous solubility, low permeation rate, and undesirable side effects...
2024: International Journal of Hypertension
https://read.qxmd.com/read/38344148/da-chuan-xiong-decoction-ameliorates-sodium-sensitivity-and-plasma-norepinephrine-via-attenuation-of-brain-oxidative-stress-in-the-doca-salt-hypertensive-rats
#3
JOURNAL ARTICLE
Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan
BACKGROUND: Da-Chuan-Xiong Decoction (DCXD) is an aqueous extract from a classic Chinese herbal formula composed of dried rhizomes of Ligusticum chuanxiong Hort and Gastrodia elata Bl. in the mass ratio of 4 : 1. It has been long used to treat chronic cardiovascular disease caused by blood stasis and wind pathogen in the clinic. This experimental study aimed to investigate the blood pressure (BP)-lowering effect of DCXD treatment on hypertension and underlying mechanisms...
2024: International Journal of Hypertension
https://read.qxmd.com/read/38298191/association-of-antihypertensive-drug-related-gene-polymorphisms-with-stroke-in-the-chinese-hypertensive-population
#4
JOURNAL ARTICLE
Huixia Liu, Hua Zhong, Ying Lin, Linzhi Han, Mengshi Chen, Tao Tang, Jing Deng
BACKGROUND: Antihypertensive therapy is crucial for preventing stroke in hypertensive patients. However, the efficacy of antihypertensive therapy varies across individuals, partially due to therapy-related genetic variations among individuals. We investigated the association of antihypertensive drug-related gene polymorphism with stroke in patients with hypertension. METHODS: Demographic information, medication, and outcome data were obtained from a hypertensive patient management system, and a PCR fluorescence probe technique was used to detect 7 gene polymorphic loci ( CYP2D6∗10 , ADRB1 , CYP2C9∗3 , AGTR1 , ACE , CYP3A5∗3 , and NPPA ), and these loci were compared between patients with and without stroke...
2024: International Journal of Hypertension
https://read.qxmd.com/read/38023617/the-link-between-overweight-obesity-and-noncommunicable-diseases-in-ethiopia-evidences-from-nationwide-who-steps-survey-2015
#5
JOURNAL ARTICLE
Bedilu Alamirie Ejigu, Fentanesh Nibret Tiruneh
BACKGROUND: Noncommunicable diseases (NCDs) are the leading cause of death worldwide. Each year, 15 million adults die from NCDs; more than 85% of these premature deaths occur in low- and middle-income nations. Evidence indicates that overweight and obesity are the main risk factors for NCDs. Although the literature indicates that the burden of NCDs is increasing in Ethiopia, no research has been conducted to demonstrate a link between overweight/obesity and NCDs. Therefore, the aim of this study is to examine the association between overweight/obesity and the common NCDs while adjusting for other important factors...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37886230/preliminary-consequences-of-blood-pressure-management-and-blood-homocysteine-levels-with-perindopril-in-newly-diagnosed-hypertensive-patients-in-the-vietnamese-population
#6
JOURNAL ARTICLE
Son Kim Tran, An Bao Truong, Phi Hoang Nguyen, Toan Hoang Ngo, Tuyen Long Vu, Khoa Dang Dang Tran, Phuong Minh Vo, Bao The Nguyen, Tuong Le Trong Huynh, Kien Trung Nguyen, Hung Do Tran
BACKGROUND: Perindopril is an ACE inhibitor that aids in both blood pressure regulation and homocysteine reduction. OBJECTIVES: Our study aimed to evaluate the results of controlling blood pressure and blood homocysteine levels by perindopril in patients with primary hypertension. MATERIALS AND METHODS: A cross-sectional descriptive study with a longitudinal follow-up was conducted on 105 primary hypertensive patients treated with perindopril...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37841509/prevalence-of-hypertension-and-associated-factors-among-residents-aged-%C3%A2-18%C3%A2-years-in-ganzhou-china-a-cross-sectional-study
#7
JOURNAL ARTICLE
Junwang Gu, Qi Wang, Wei Qiu, Fen Lin, Chunmei Wu, Ming Hao, Ping Wu
BACKGROUND: Reliable epidemiologic data on the present burden of hypertension are needed in developing region-specific strategies since previous studies have suggested that China is lagging in risk factor management. OBJECTIVE: The study aimed at exploring the prevalence of hypertension and its associated factors among adult residents in Ganzhou, China. Methodology . A multistage, stratified, and cluster random sampling method was used to conduct the cross-sectional survey...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37781274/evaluation-of-mean-platelet-volume-in-children-with-hypertension
#8
JOURNAL ARTICLE
Ismail Yildiz, Ozgur Kizilca
BACKGROUND: Childhood hypertension, a disease with increasing prevalence, can lead to severe health problems. With the increased pressure on the vascular endothelium in hypertension, lesions in the endothelium result in endothelial activation and a process of inflammation, which causes platelet activation and in the bone marrow the release of platelet precursor cells into the peripheral blood stream. During inflammation, changes in the number and size of platelets are observed. With the release of platelet precursors into the peripheral blood stream due to platelet activation, an increase in mean platelet volume (MPV) is also seen...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37645453/covariates-of-knowledge-attitude-practice-and-burdens-among-the-caregivers-of-hypertensive-patients
#9
JOURNAL ARTICLE
Sudipta Deb Nath, Afrin Sultana Chowdhury, Susmita Dey Pinky, Kazi Mahmuda Akter, Nishat Anjum Nourin, Tonmoy Chowdhury, Hossain Ahmed Fahid, K M Shailah Sharmin, Md Mashud Rana, Nazmul Alam, Md Moinul Ahsan, Adnan Mannan
Caregivers of hypertensive patients play a significant role in ensuring adequate patient care and lowering the risk of hypertension-relatedcomplications. Caregivers are ideal study subjects for identifying gaps in hypertension management. Our study aimed to assess the knowledge, attitude, and practice (KAP) of hypertensive patients' caregivers, to identify their extent of involvement in patients' care, and to assess their care-related attributes. A descriptive cross-sectional study was conducted from August 2020 to February 2021 in the eight largest tertiary care medical college hospitals and all eight divisions of Bangladesh, with 949 caregivers enrolled...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37521117/mir-145-alleviates-smooth-muscle-cell-phenotype-transition-via-adam17-mediated-ace2-shedding
#10
JOURNAL ARTICLE
Juan Wen, Baiyi Tang, Lan Guo, Wei Chen, Xiaohong Tang
It has been shown that miR-145 is involved in the differentiation of vascular smooth muscle cells (VSMCs) and may regulate vascular remodeling. However, the molecular mechanisms behind these pathological processes in hypertension are not fully elucidated. The present study was to examine whether miR-145 modulates phenotypic transformation of VSMCs under normal state and synthetic state and to explore the possible role of ADAM17-mediated ACE2 shedding and ACE2-Ang-(1-7)-Mas receptor axis. Wistar rats were fed with high-sucrose/high-fat diet for 30 weeks to establish a metabolic hypertension animal model...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37273529/comorbidity-of-anxiety-and-hypertension-common-risk-factors-and-potential-mechanisms
#11
REVIEW
Tingting Qiu, Zhiming Jiang, Xuancai Chen, Yehua Dai, Hong Zhao
Anxiety is more common in patients with hypertension, and these two conditions frequently coexist. Recently, more emphasis has been placed on determining etiology in patients with comorbid hypertension and anxiety. This review focuses on the common risk factors and potential mechanisms of comorbid hypertension and anxiety. Firstly, we analyze the common risk factors of comorbid hypertension and anxiety including age, smoking, alcohol abuse, obesity, lead, and traffic noise. The specific mechanisms underlying hypertension and anxiety were subsequently discussed, including interleukin (IL)-6 (IL-6), IL-17, reactive oxygen species (ROS), and gut dysbiosis...
2023: International Journal of Hypertension
https://read.qxmd.com/read/37201134/summary-of-known-genetic-and-epigenetic-modification-contributed-to-hypertension
#12
REVIEW
Tiar Masykuroh Pratamawati, Idrus Alwi, Asmarinah
Hypertension is a multifactorial disease due to a complex interaction among genetic, epigenetic, and environmental factors. Characterized by raised blood pressure (BP), it is responsible for more than 7 million deaths per annum by acting as a leading preventable risk factor for cardiovascular disease. Reports suggest that genetic factors are estimated to be involved in approximately 30 to 50% of BP variation, and epigenetic marks are known to contribute to the initiation of the disease by influencing gene expression...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36968629/intensive-blood-pressure-control-and-diabetes-mellitus-incidence-for-patients-with-impaired-fasting-glucose-a-secondary-analysis-of-sprint
#13
JOURNAL ARTICLE
Beiru Lin, Xiaochuan Liu, Sichen Yao, Zhigang Pan
BACKGROUND: Previous studies indicated that intensive blood pressure (BP) control (systolic BP < 120 mm·Hg) compared with standard BP control (<140 mm·Hg) was associated with an increased risk of type 2 diabetes (T2D) and impaired fasting glucose (IFG) among hypertensive patients with normoglycemia. However, the impact of intensive BP control on the incidence of T2D for those with IFG is still unknown. METHODS: This was a secondary analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) of the study...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36959846/ethnicity-disparities-in-the-prevalence-awareness-treatment-and-control-rates-of-hypertension-in-china
#14
JOURNAL ARTICLE
Yanan Yang, Kunlin He, Yuewen Zhang, Xiuming Wu, Weizhong Chen, Dongqing Gu, Ziqian Zeng
OBJECTIVES: Previous studies reported that there were disparities in hypertension management among different ethnic groups, and this study aimed to systematically determine the prevalence, awareness, treatment, and control rates of hypertension in multiple Chinese ethnic groups. METHODS: We searched Embase, PubMed, and Web of Science for articles up to 25 October, 2022. The pooled prevalence, awareness, treatment, and control rates of hypertension were estimated with 95% confidence intervals (CI)...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36938116/efficacy-and-safety-of-eplerenone-for-treating-chronic-kidney-disease-a-meta-analysis
#15
JOURNAL ARTICLE
Honglei Hu, Mengdie Cao, Yao Sun, Xingqian Jin, Xiaodong Zhao, Xiangguo Cong
BACKGROUND: In recent years, a large amount of clinical evidence and animal experiments have demonstrated the unique advantages of mineralocorticoid receptor antagonists (MRA) for treating chronic kidney disease (CKD). AIMS: Accordingly, the present study aimed to systematically assess the second-generation selective MRAs eplerenone's safety and effectiveness for treating CKD. METHODS: Four databases (PubMed, The Cochrane Library, Embase, and Web of Science) were searched for randomized controlled trials (RCT) correlated with eplerenone for treating CKD up to September 21, 2022...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36777237/positive-association-between-hemoglobin-concentration-and-blood-pressure-in-adults-a-cross-sectional-study-based-on-rafsanjan-cohort-study
#16
JOURNAL ARTICLE
Gholamreza Bazmandegan, Mitra Abbasifard, Hamid Ostadebrahimi, Mohammadreza Gholamrezapour, Zahra Kamiab
INTRODUCTION: Identification of factors associated with blood pressure (BP), including hemoglobin, can be used in diagnosing, controlling, and predicting the prognosis of patients. This study aims to investigate the cross-sectional association between hemoglobin concentration and BP in people aged 35-70 years in a cohort study of Rafsanjan, Iran. METHOD: This cross-sectional study was conducted on 9398 urban and rural population of Rafsanjan adult cohort study as a part of the prospective epidemiological research studies in Iran (PERSIAN)...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36726690/evaluation-of-arterial-stiffness-and-its-relation-to-innovative-anthropometric-indices-in-persian-adults
#17
JOURNAL ARTICLE
Zahra Ataee, Atena Aghaee, Seyyed Reza Sobhani, Elaheh Ebrahimi Miandehi, Parisa Pirzadeh, Maryam Alinezhad-Namaghi, Saeid Eslami, Sahar Sobhani
BACKGROUND: BMI has been evaluated as an old criterion to evaluate obesity in individuals, but it does not assess abdominal obesity and lean mass. We aimed to evaluate the possible relationship of new anthropometric indices (namely, a body shape index (ABSI), the body roundness index (BRI), the visceral adiposity index (VAI), the visceral fat area (VFA), and waist-hip ratio (WHR)), with one of the known critical factors of atherosclerosis, arterial stiffness. METHODS: Overall 5921 individuals were enrolled and were divided into four groups according to BMI...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36704237/antihypertensive-effects-of-esaxerenone-in-older-patients-with-primary-aldosteronism
#18
JOURNAL ARTICLE
Masanori Fujimoto, Suzuka Watanabe, Katsushi Igarashi, Yutaro Ruike, Kazuki Ishiwata, Kumiko Naito, Akiko Ishida, Masaya Koshizaka, Sawako Suzuki, Yuki Shiko, Hisashi Koide, Koutaro Yokote
DESIGN: Retrospective cohort study. Patients . The data was obtained from a total of 87 PA patients treated with esaxerenone. The treatment group comprised 33 patients who received esaxerenone as first-line therapy and 54 patients that switched from another MRA to esaxerenone. Measurements . Blood pressure (BP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), serum potassium level, estimated glomerular filtration rate (eGFR), urinary albumin-creatinine ratio (UACR), and brain natriuretic peptide (BNP) were assessed before and after treatment with esaxerenone...
2023: International Journal of Hypertension
https://read.qxmd.com/read/36618449/the-association-between-hypertension-and-insomnia-a-bidirectional-meta-analysis-of-prospective-cohort-studies
#19
REVIEW
Dingwei Liu, Chao Yu, Ke Huang, Shawn Thomas, Wei Yang, Song Liu, Jie Kuang
BACKGROUND: Studies on bidirectional associations between hypertension and insomnia are inconclusive. The purpose of this meta-analysis was to systematically review and summarize the current evidence from epidemiological studies that evaluated this relationship. MATERIALS AND METHODS: PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wan Fang, and VIP databases were searched for studies published up to May 2021. Prospective cohort studies that reported the relationship between hypertension and insomnia in adults were included...
2022: International Journal of Hypertension
https://read.qxmd.com/read/36532605/continuous-positive-linear-association-between-the-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-hypertension-a-cross-sectional-study
#20
JOURNAL ARTICLE
Yaqing Zhou, Haijun Dan, Long Bai, Limei Jia, Baojin Lu, Guoqiang Gu, Wei Cui
BACKGROUND: Hypertension poses a major threat to human health, and inflammation is associated with hypertension. The monocyte to high-density lipoprotein cholesterol ratio (MHR) represents a new inflammatory indicator. However, the relationship between the MHR and hypertension remains unclear. The present study investigated the association of MHR with hypertension. METHOD: For this cross-sectional study, we continuously collected data from the Physical Examination Centre of the Second Hospital of Hebei Medical University ( N  = 6632)...
2022: International Journal of Hypertension
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