journal
https://read.qxmd.com/read/38659619/changes-in-testing-and-treatment-methods-in-osteoporosis-care
#1
JOURNAL ARTICLE
Takashi Nagai, Koji Ishikawa, Koki Tsuchiya, Soji Tani, Yusuke Dodo, Yusuke Oshita, Keizo Sakamoto, Nobuyuki Kawate, Yoshifumi Kudo
Osteoporosis treatment plays a crucial role in preventing fractures, particularly in bedridden patients. We conducted a questionnaire survey presenting hypothetical clinical cases in 2015 and 2020 to investigate trends over a 5-year period. The target population included physicians working in clinics and hospitals within our neighbourhood. The cases were presented, and the questionnaire was administered in a confidential format. The orthopaedic surgeons were matched for age and practice, resulting in 74 cases being included in the analysis...
2024: Journal of Osteoporosis
https://read.qxmd.com/read/38235310/the-effects-of-switch-therapy-in-osteoporosis-treatment-after-romosozumab-after-comparing-with-prior-treatment
#2
JOURNAL ARTICLE
Akira Horikawa, Yuji Kasukawa, Michio Hongo, Akihisa Sano, Naohisa Miyakoshi
Rationale . Although romosozumab is one of the most effective treatments for osteoporosis by increasing bone mineral density in the lumbar spine and femur and recommended for denosumab as switch therapy, these effects regarding its prior treatment have not yet been evaluated clearly. This study focused on the effects of switch therapy from romosozumab to denosumab in regard to prior treatment of osteoporosis including bone mineral density and bone turnover marker and other related factors. Patient Concerns ...
2024: Journal of Osteoporosis
https://read.qxmd.com/read/38179189/quantitative-mr-analysis-of-changes-in-the-radius-bone-marrow-in-osteoporosis
#3
JOURNAL ARTICLE
Tamar K De-Levie, Yael S Schiffenbauer, Ido Druckmann, Vanessa Rouach, Naftali Stern, Itzhak Binderman, Uri Nevo
PURPOSE: This pilot study aimed to explore the feasibility of scanning the human distal radius bone marrow in vivo to detect osteoporosis-related changes using magnetic resonance and evaluate whether the radius may serve as an accessible probing site for osteoporosis. This may lead in the future to the use of affordable means such as low-field MRI scanners for the monitoring of disease progression. METHODS: A clinical trial was performed using a 3T MR scanner, including 26 women assigned into three study groups: healthy-premenopausal ( n  = 7; mean age 48...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/38090017/skeletal-manifestations-bone-pain-and-bmd-changes-in-albanian-type-1-gaucher-patients-treated-with-taliglucerase-alfa
#4
JOURNAL ARTICLE
Virtut Velmishi, Erjon Troja, Marjeta Tanka, Donjeta Bali, Ermira Dervishi, Afërdita Tako, Laurant Kollcaku, Paskal Cullufi
Gaucher disease is a rare, genetic lysosomal disorder leading to lipid accumulation and dysfunctions in multiple organs. Bone involvement is one of the most prevalent aspects of Gaucher disease. Pain, disability, and reduced quality of life remain the most frequent characteristics of bone involvement in Gaucher patients. Patients and Method . In this study, we will take into consideration data from 24 patients diagnosed with type 1 Gaucher disease. We followed them closely for six years in progress. At baseline, all patients started therapy with taliglucerase alfa at a mean dosage of 45 UI/kg; later, during the study, two of them switched their cure toward velaglucerase alfa...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/37588008/additive-effects-of-exercise-and-vitamin-d-supplementation-with-and-without-calcium-on-bone-mineral-density-in-older-adults-a-systematic-review-and-meta-analysis
#5
REVIEW
Cecilie Fischer, Franz Jakob, Matthias Kohl, Stephanie Kast, Simon Von Stengel, Katharina Kerschan-Schindl, Uwe Lange, Friederike Thomasius, Stefan Peters, Michael Uder, Wolfgang Kemmler
Exercise is a recognized component in the prevention and therapy of osteoporosis. The present systematic review and meta-analysis aimed to determine the effect of Vitamin D (Vit-D) added to exercise versus exercise alone on bone mineral density (BMD) at the lumbar spine (LS) or hip in older adults. A systematic review based on six literature databases according to PRISMA included (a) exercise trials, with an exercise (EX) and a combined exercise + Vit-D group (EX + Vit-D), (b) intervention ≥ 6 months, and (c) BMD assessments at LS or hip...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/37138642/osteoporosis-screening-disparities-among-ethnic-and-racial-minorities-a-systematic-review
#6
REVIEW
Anoush Calikyan, Jillian Silverberg, Katherine M McLeod
BACKGROUND: Osteoporosis is a preventable disease that is simple and cost-effective to screen based on clinical practice guidelines, yet many patients go undiagnosed and untreated leading to increased burden of the disease. Specifically, racial and ethnic minorities have lower rates of dual energy absorptiometry (DXA) screening. Inadequate screening may lead to an increased risk of fracture, higher health care costs, and increased morbidity and mortality disproportionately experienced by racial-ethnic minority populations...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/36875869/the-senolytic-drug-fisetin-attenuates-bone-degeneration-in-the-zmpste24-progeria-mouse-model
#7
JOURNAL ARTICLE
William S Hambright, Xiaodong Mu, Xueqin Gao, Ping Guo, Yohei Kawakami, John Mitchell, Michael Mullen, Anna-Laura Nelson, Chelsea Bahney, Haruki Nishimura, Justin Hellwinkel, Andrew Eck, Johnny Huard
Aging leads to several geriatric conditions including osteoporosis (OP) and associated frailty syndrome. Treatments for these conditions are limited and none target fundamental drivers of pathology, and thus identifying strategies to delay progressive loss of tissue homeostasis and functional reserve will significantly improve quality of life in elderly individuals. A fundamental property of aging is the accumulation of senescent cells. Senescence is a cell state defined by loss of proliferative capacity, resistance to apoptosis, and the release of a proinflammatory and anti-regenerative senescence-associated secretory phenotype (SASP)...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/36700240/vertebral-augmentation-for-painful-type-4-osteoporotic-compression-fractures-a-comparative-study
#8
JOURNAL ARTICLE
Mohamed Abdelrahman Abdalla, Ricardo Rodrigues, Christian Ulbricht
BACKGROUND: Type 4 osteoporotic fracture (OF4), according to the classification system of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU), is unstable and requires fixation as per the guidelines of the same group. We evaluated the use of stand-alone vertebral body augmentation (VBA) in pain control of OF4. METHODS: This is a single-centre, in two hospitals, comparative study to evaluate the effectiveness of percutaneous vertebroplasty (PVP) and kyphoplasty (KP) in pain control of OF4...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/36660551/osteoblast-specific-overexpression-of-nucleolar-protein-no66-riox1-in-mouse-embryos-leads-to-osteoporosis-in-adult-mice
#9
JOURNAL ARTICLE
Qin Chen, Krishna M Sinha, Benoit de Crombrugghe, Ralf Krahe
In previous study, we showed that nucleolar protein 66 (NO66) is a chromatin modifier and negatively regulates Osterix activity as well as mesenchymal progenitor differentiation. Genetic ablation of the NO 66 ( RIOX1 ) gene in cells of the Prx 1-expressing mesenchymal lineage leads to acceleration of osteochondrogenic differentiation and a larger skeleton in adult mice, whereas mesenchyme-specific overexpression of NO 66 inhibits osteochondrogenesis resulting in dwarfism and osteopenia. However, the impact of NO66 overexpression in cells of the osteoblast lineage in vivo remains largely undefined...
2023: Journal of Osteoporosis
https://read.qxmd.com/read/36578470/diabetes-mellitus-is-associated-with-poor-bone-microarchitecture-in-older-adults-residing-in-long-term-care-facilities
#10
JOURNAL ARTICLE
Nami Safai Haeri, Mary P Kotlarczyk, Subashan Perera, Susan L Greenspan
OBJECTIVES: Both diabetes mellitus (DM) and osteoporosis are very common in older adults who reside in long-term care (LTC) facilities. Nevertheless, few studies have examined the relationship between diabetes and bone quality in this population. The purpose of this study is to determine if bone mineral density (BMD) or trabecular bone score (TBS) is a better measure of bone quality and skeletal health, in LTC residents with and without a history of DM. Methodology . In this longitudinal cohort study, we examined baseline BMD (lumbar spine, total hip, and femoral neck), TBS, DM, and functional status in 511 LTC residents who were enrolled in two ongoing randomized placebo-controlled osteoporosis clinical trials...
2022: Journal of Osteoporosis
https://read.qxmd.com/read/35959212/expression-of-concern-on-a-radiographic-study-on-the-associations-of-age-and-prevalence-of-vertebral-fractures-with-abdominal-aortic-calcification-in-japanese-postmenopausal-women-and-men
#11
https://read.qxmd.com/read/35656005/evaluation-of-knowledge-attitudes-and-practices-related-to-osteoporosis-and-correlates-of-perceived-high-risk-among-people-living-in-two-main-districts-of-lebanon
#12
JOURNAL ARTICLE
Joanna Nohra, Yonna Sacre, Afif Abdel-Nour, Haider Mannan
Background: The prevalence of osteoporosis is increasing in Lebanon. Aim: We evaluated the knowledge, attitudes, and practices related to osteoporosis and correlates of its perceived high risk among people living in Beirut and Mount Lebanon districts of Lebanon. Methods: This study is a cross-sectional study which consisted of 376 participants that were selected from the two districts within two or three households after two geographical areas were randomly selected from each stratum classified by education and altitude...
2022: Journal of Osteoporosis
https://read.qxmd.com/read/35573185/a-radiological-assessment-of-the-prevalence-of-osteoporosis-in-male-patients-seen-in-a-south-african-hospital-a-retrospective-analysis
#13
JOURNAL ARTICLE
Lebohang Siwela, Nausheen Khan, Adziambei Mudau
Developing countries are predicted to bear the burden of osteoporosis in the coming decades. The prevalence of osteoporosis in South African men is unknown, but is thought to be rare. Opportunistic screening for osteoporosis can be performed using quantitative computed tomography (CT) obtained for various clinical indications. We assessed the frequency of osteoporosis in male patients using quantitative computed tomography (CT) obtained for various clinical indications. Data were collected from abdominal and spinal CT scans performed at the radiology department of a provincial tertiary hospital between January 2019 and January 2021...
2022: Journal of Osteoporosis
https://read.qxmd.com/read/35392590/bone-mineral-density-and-trabecular-bone-score-in-predicting-vertebral-fractures-in-male-employees-of-the-electricity-generating-authority-of-thailand
#14
JOURNAL ARTICLE
Chaninart Sakulpisuti, Chanika Sritara, Arpakorn Kositwattanarerk, Praman Fuangfa, Chaiyawat Suppasilp, Prin Vathesatogkit, Dujrudee Matchariyakul, Boonsong Ongphiphadhanakul, Piyamitr Sritara
Purpose: Osteoporotic VF is frequently asymptomatic and affects not only women but also men. Identifying patients at risk is essential for early management and prevention. BMD and the TBS are measurements of bone strength and trabecular microarchitecture, respectively. Their role in VF prediction in men is less well-studied. We determined the BMD and TBS predictive ability for osteoporotic VF in men. Methods: A total of 115 male participants of the Electricity Generating Authority of Thailand (EGAT) cohorts without a history of VF who completed the baseline BMD and TBS measurements in 2012 and a thoracolumbar spine radiograph in 2017 were recruited...
2022: Journal of Osteoporosis
https://read.qxmd.com/read/35198139/evaluation-of-bone-mineral-density-serum-osteocalcin-and-osteopontin-levels-in-postmenopausal-women-with-type-2-diabetes-mellitus-with-without-osteoporosis
#15
JOURNAL ARTICLE
Ali B Roomi, Abdul-Hassan Mahdi Salih, Sarmad D Noori, Wassan Nori, Saba Tariq
Objective: Osteoporosis (OP) is a worldwide ailment; we aim to establish new biomarkers in diagnosis by determining the levels of serum osteocalcin and osteopontin along with bone mineral density (BMD) and lumbar T-score, in postmenopausal women with type 2 diabetes mellitus (T2DM) with or without OP. Methods: This observational study included 160 postmenopausal women who were an attendee at outpatient clinics in Al-Hussein Hospital, Thi-Qar province; subdivided into 3 groups based on their T-score testing: Group I ( n  = 40) comprised postmenopausal women without T2DM as controls, Group II ( n  = 60) comprised postmenopausal women with T2DM but without OP, and Group III ( n  = 60) comprised postmenopausal women with T2DM with OP...
2022: Journal of Osteoporosis
https://read.qxmd.com/read/35003621/characteristics-associated-with-acute-phase-response-following-first-zoledronic-acid-infusion-in-brazilian-population-with-osteoporosis
#16
JOURNAL ARTICLE
Bruno S A Ferreira, Bernardo M da Cunha, Luciana P Valadares, Larissa A Moreira, Frederico G A Batista, Cristiane da F Hottz, Marina M P Lins, Gabriel G R Magalhães, Luanna M de Arruda, Sergio H R Ramalho
We aimed to evaluate characteristics associated with acute-phase response (APR) following first zoledronic acid infusion in a Brazilian cohort. This retrospective cohort study enrolled all adults with osteoporosis who underwent a first zoledronic acid infusion at our centre between June 2015 and June 2019. Clinical demographics (age, sex, diabetes, smoking, body mass index, and previous oral bisphosphonate use) and laboratory data (calcium, parathyroid hormone, renal function, and serum 25-hydroxyvitamin D and carboxy-terminal crosslinked telopeptide of type 1 collagen [CTX], both before and after infusion) were compared between patients with and without APR...
2021: Journal of Osteoporosis
https://read.qxmd.com/read/34733465/treatment-of-glucocorticoid-induced-osteoporosis-and-risk-factors-for-new-vertebral-fractures-in-female-patients-with-autoimmune-diseases
#17
JOURNAL ARTICLE
Koichiro Shinoda, Hirofumi Taki
We aimed to evaluate the compliance of physicians with the 2014 guidelines of the Japanese Society for Bone and Mineral Research, for the prevention and treatment of glucocorticoid (GC) induced osteoporosis (GIO) and to investigate the risk of fracture and other associated risk factors in bisphosphonate-treated patients. We evaluated 90 female patients with nonrheumatoid arthritis autoimmune diseases who received long-term GC treatment (≥12 months). Clinical characteristics, including age, GC dose, history of fragility fractures, osteoporosis treatments, as well as lumbar (L2-L4) and femoral neck bone mineral density, were collected from the patients' medical charts...
2021: Journal of Osteoporosis
https://read.qxmd.com/read/34631005/site-specific-volumetric-skeletal-changes-in-women-with-a-distal-forearm-fracture
#18
JOURNAL ARTICLE
Axel Wihlborg, Karin Bergström, Ingrid Bergström, Paul Gerdhem
Purpose: To assess site-specific volumetric bone and muscle changes, as well as demographic and biochemical changes, in postmenopausal women with a low-energy distal forearm fracture. Methods: In a cross-sectional case-control study, postmenopausal women with a distal forearm fracture were compared with age- and gender-matched controls. In total, 203 postmenopausal women (104 cases and 99 controls), with a mean age of 65 years, were included. Measurements included peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) as well as blood sampling and questionnaires...
2021: Journal of Osteoporosis
https://read.qxmd.com/read/34567509/association-of-postoperative-neutrophil-lymphocyte-ratio-nlr-and-monocyte-lymphocyte-ratio-mlr-with-the-presence-of-osteoporosis-in-japanese-patients-after-hip-fracture-surgery-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
Hirofumi Bekki, Takeshi Arizono, Daiki Hama, Akihiko Inokuchi, Takahiro Hamada, Ryuta Imamura
Background: The diagnosis of osteoporosis is based on bone mineral density measurements expressed as a percentage of the young adult mean (YAM) in Japan. Osteoporosis is defined as YAM <70%, and intervention is recommended at this cutoff. Because osteoporosis has a strong association with systemic metabolic disorders, we postulated that patients with YAM <70% had higher inflammatory biomarker concentrations owing to the higher systemic stress compared with YAM >70%. Method: We retrospectively reviewed 94 patients with low-trauma hip fractures...
2021: Journal of Osteoporosis
https://read.qxmd.com/read/34194720/a-phase-iv-study-of-the-safety-and-efficacy-of-cinnopar-%C3%A2-in-iranian-patients-with-osteoporosis
#20
JOURNAL ARTICLE
Ahmadreza Jamshidi, Farhad Gharibdoost, Sima Sedighi, Asghar Hajiabbasi, Amir-Hossein Salari, Alireza Khabbazi, Peyman Mottaghi, Ahmad Tahammoli Roudsari, Mehrdad Aghaei, Irandokht Shenavar Masooleh, Araz Sabzvari, Nassim Anjidani
The safety of teriparatide has been studied in various phase III and phase IV trials. However, a postmarketing study of the biosimilar of teriparatide, CinnoPar® , has not been conducted on Iranian patients. This was a phase IV study conducted on osteoporotic patients who received an Iranian teriparatide biosimilar with a dose of 20  μ g daily. The primary outcome of this study was to monitor for adverse events (AEs). Effectiveness as the secondary outcome was measured using the EQ-5D quality-of-life questionnaire and back pain Visual Analogue Scale (VAS) score...
2021: Journal of Osteoporosis
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