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Therapeutic Delivery

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https://read.qxmd.com/read/30678550/nanomedicines-for-cancer-therapy-current-status-challenges-and-future-prospects
#1
Gizem Bor, Intan Diana Mat Azmi, Anan Yaghmur
The emergence of nanomedicine as an innovative and promising alternative technology shows many advantages over conventional cancer therapies and provides new opportunities for early detection, improved treatment, and diagnosis of cancer. Despite the cancer nanomedicines' capability of delivering chemotherapeutic agents while providing lower systemic toxicity, it is paramount to consider the cancer complexity and dynamics for bridging the translational bench-to-bedside gap. It is important to conduct appropriate investigations for exploiting the tumor microenvironment, and achieving a more comprehensive understanding of the fundamental biological processes in cancer and their roles in modulating nanoparticle-protein interactions, blood circulation, and tumor penetration...
January 25, 2019: Therapeutic Delivery
https://read.qxmd.com/read/30678543/how-can-the-challenges-faced-by-nanoparticle-based-pulmonary-drug-formulations-be-overcome
#2
Shing Fung Chow, Jingwen Weng, Bianfei Xuan, Ka Yee Wan
No abstract text is available yet for this article.
January 25, 2019: Therapeutic Delivery
https://read.qxmd.com/read/30729888/therapeutic-delivery-industry-update-covering-october-2018
#3
Iain Simpson
This industry update covers the period from 1 to 31 October 2018 and is based on information sourced from company press releases, scientific literature, patents and various news websites. With the expiry in Europe of AbbVie's (IL, USA) principal patent on Humira this month, the first biosimilar versions of the drug have been launched. AstraZeneca (Cambridge, UK) announced that is has out-licensed two none core drugs to Grunenthal (Aachen, German), while Pfizer (NY, USA) announced the creation of a new company, set up in collaboration with Bain Capital (MA, USA) to exploit Pfizer's clinical and preclinical assets in the neuroscience field...
February 2019: Therapeutic Delivery
https://read.qxmd.com/read/30729887/stability-and-biological-testing-of-taurine-conjugated-bile-acid-antioxidant-microcapsules-for-diabetes-treatment
#4
Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Hani Al-Salami
AIM: Taurine-conjugated bile acids possess positive formulation-stabilization effects, which are desirable in diabetes treatments. The taurine-conjugated bile acid, taurocholic acid (TCA), has shown promising formulation-stabilizing effects on the delivery of the antioxidant drug, probucol (PB), but success is limited due to its poor release profile. This study aimed to design new PB-TCA formulations using new polymers, and examine antioxidant and antidiabetic effects using β-cells for PB with or without TCA...
February 2019: Therapeutic Delivery
https://read.qxmd.com/read/30729886/improving-the-bioavailability-of-curcumin-is-micro-nanoencapsulation-the-key
#5
Sabrina Barbosa de Souza Ferreira, Marcos Luciano Bruschi
No abstract text is available yet for this article.
February 2019: Therapeutic Delivery
https://read.qxmd.com/read/30729885/erratum
#6
(no author information available yet)
No abstract text is available yet for this article.
February 2019: Therapeutic Delivery
https://read.qxmd.com/read/30729884/a-review-of-ccr5-antibodies-against-hiv-current-and-future-aspects
#7
Pavan Kumar Prathipati, Subhra Mandal, Christopher J Destache
HIV is one of the most devastating viral infections the world has ever encountered. Ever since HIV was first identified in the 1980s, it has claimed millions of lives worldwide. There has been tremendous research and development in the diagnosis, prevention and treatment of HIV. Small molecules have been shown to reduce the virus to nondetectable level in human plasma, however, there are reservoirs of latent virus that reemerge if antiretroviral therapy is stopped. There is no vaccine to prevent or cure HIV...
February 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730825/understanding-the-basis-of-transcutaneous-vaccine-delivery
#8
Carlos Gamazo, Yadira Pastor, Eneko Larrañeta, Melibea Berzosa, Juan M Irache, Ryan F Donnelly
Under many circumstances, prophylactic immunizations are considered as the only possible strategy to control infectious diseases. Considerable efforts are typically invested in immunogen selection but, erroneously, the route of administration is not usually a major concern despite the fact that it can strongly influence efficacy. The skin is now considered a key component of the lymphatic system with tremendous potential as a target for vaccination. The purpose of this review is to present the immunological basis of the skin-associated lymphoid tissue, so as to provide understanding of the skin vaccination strategies...
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730824/mefenamic-acid-loaded-solid-smedds-an-innovative-aspect-for-dose-reduction-and-improved-pharmacodynamic-profile
#9
Mukesh Kumar, Dilpreet Singh, Neena Bedi
AIM: The current investigation is focused on solid self-microemulsifying drug-delivery systems (S-SMEDDS) of mefenamic acid (MFA) for improving pharmacodynamic activity. Methodology & results: Solubility assessment in various lipid excipients and optimization of pseudoternary plots were carried out for development of liquid SMEDDS. The optimized liquid SMEDD formulation was spray dried to solid dosage form and observed with enhanced amorphization or molecular dispersion of MFA in S-SMEDDS, as evident from x-ray diffractometry and differential scanning calorimetry studies...
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730823/exosomes-fighting-cancer-with-cancer
#10
Hanin Alyamani, Mohammad A Obeid, Rothwelle J Tate, Valerie A Ferro
Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composition of exosomes is described. This review then focuses on the use of exosomes in cancer diagnostics and therapeutics.
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730822/a-novel-method-for-conjugating-the-terminal-amine-of-peptide-ligands-to-cholesterol-synthesis-irgd-cholesterol
#11
Matthew G Fete, Jamie L Betker, Richard K Shoemaker, Thomas J Anchordoquy
AIM: Conventional conjugation reactions often involve the use of activated PEG as a linker, but concerns about PEG-mediated reduction in intracellular delivery and enhanced immunogenicity have generated interest in developing methods that eliminate the need for a PEG linker. MATERIALS & METHODS: Reaction conditions were identified that specifically couples the terminal amine of a cyclic iRGD peptide (CRGDRGPDC) to the hydroxyl moiety of cholesterol through a short carbamate linker...
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730821/%C3%AE-fetoprotein-binding-toxins-and-teratogens-against-cancer
#12
Vladimir N Pak
No abstract text is available yet for this article.
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730820/an-industry-update-the-latest-developments-in-therapeutic-delivery-covering-september-2018
#13
Oliver C Steinbach
The present industry update covers the period 1-30 September 2018, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. Various technologies using reformulations of know drugs with nanoparticles, hydrogels, aerosols, etc. emerged in new financing rounds (BioTime; CA, USA, SiSaf; Guildford, UK, Cassion Biotech; TX, USA), intellectual property protection (TFF Pharmaceuticals; TX, USA), repackaging (Leiters; CA, USA) and reformulation (Virpax Pharmaceuticals; PA, USA) demonstrating it does not have to be new active ingredients utilizing novel drug delivery formats...
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30730819/corrigendum
#14
(no author information available yet)
No abstract text is available yet for this article.
January 2019: Therapeutic Delivery
https://read.qxmd.com/read/30444462/spray-congealing-a-versatile-technology-for-advanced-drug-delivery-systems
#15
Serena Bertoni, Luisa S Dolci, Beatrice Albertini, Nadia Passerini
Spray congealing is a low cost, simple and versatile method to produce microparticles without the use of organic or aqueous solvent. This review provides a detailed picture of the pharmaceutical applications of this technology, with an overview of the spray-congealed-based drug-delivery systems. First, the basic principles and equipment of spray congealing technology are presented. Then, representative examples of the drug-delivery systems are examined and critically discussed. Emphasis is given on the role of formulation variables, together with practical considerations for formulation design...
November 2018: Therapeutic Delivery
https://read.qxmd.com/read/30444461/eudragit-%C3%A2-based-microcapsules-of-probucol-with-a-gut-bacterial-processed-secondary-bile-acid
#16
Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Hani Al-Salami
AIM: Deoxycholic acid (DCA) has improved gliclazide oral absorption, while Eudragit® (ED) polymers have improved formulation stability of antidiabetic drugs. The aim of the study is to test if DCA and ED encapsulation will optimize the release and stability of the potential antidiabetic drug probucol (PB). MATERIALS & METHODS:  The PB formulations were prepared using ED polymers and DCA, and formulations were analyzed for their rheological and biological properties...
November 2018: Therapeutic Delivery
https://read.qxmd.com/read/30444460/industry-update-the-latest-developments-in-the-field-of-therapeutic-delivery-july-2018
#17
Peter Timmins
No abstract text is available yet for this article.
November 2018: Therapeutic Delivery
https://read.qxmd.com/read/30444459/photodynamic-therapy-of-cancer-with-liposomal-photosensitizers
#18
Nejat Düzgüneş, Jaroslaw Piskorz, Paulina Skupin-Mrugalska, Tomasz Goslinski, Jadwiga Mielcarek, Krystyna Konopka
The photodynamic reaction involves the light-induced generation of an excited state in a photosensitizer molecule (PS), which then results in the formation of reactive oxygen species in the presence of oxygen, or a direct modification of a cellular molecule. Most PSs are porphyrinoids, which are highly lipophilic, and are administered usually in liposomes to facilitate their effective delivery to target cells. The currently available liposomal formulations are Visudyne® and Fospeg® . Novel PSs were developed and tested for their photodynamic activity against cancer cells...
November 2018: Therapeutic Delivery
https://read.qxmd.com/read/30444456/industry-update-covering-august-2018
#19
Louise Rosenmayr-Templeton
No abstract text is available yet for this article.
November 2018: Therapeutic Delivery
https://read.qxmd.com/read/30444455/long-circulating-liposomes-challenges-and-opportunities
#20
Suyash Deodhar, Alekha K Dash
The poor pharmacokinetic parameters and low solubility of many anticancer therapeutics have warranted the use of drug-delivery systems such as liposomes. Overcoming some drawbacks of the conventional liposomes, targeted liposomal delivery by longer circulation time by addition of poly(ethylene glycol) to the liposomal surface and further adding specific ligands to achieve ligand selective retention and uptake has been introduced. PEGylated liposomes are the only second-generation liposomal formulations in clinical use and are now being challenged with the allergenic response they pose even in the treatment of naive patients...
November 2018: Therapeutic Delivery
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