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Journal of Clinical Medicine Research

Hisayuki Kastuyama, Hidekatsu Yanai
No abstract text is available yet for this article.
February 2019: Journal of Clinical Medicine Research
Hiroaki Tanaka, Mizuki Yano, Chihiro Kuwabara, Ayaka Kume, Yuri Tamura, Miki Murakami, Ryo Shimizu, Haruhisa Saito, Yoshio Suzuki
Hemoptysis is occasionally experienced in patients with hematological malignancies who have respiratory tract infection and severe thrombocytopenia. Thrombocytopenia due to hematological disease is one cause of hemoptysis. Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy characterized by both a myeloproliferative neoplasm and a myelodysplastic syndrome. This malignancy often infiltrates various extramedullary organs and has a poor prognosis. An 84-year-old Japanese man with CMML was suffered from hemoptysis and dyspnea...
February 2019: Journal of Clinical Medicine Research
Safa Gursoy, Mustafa Akkaya, Mehmet Emin Simsek, Merve Gursoy, Metin Dogan, Murat Bozkurt
Background: This study aimed to investigate the outcomes of matrix-associated autologous chondrocyte implantation (MACI) on the treatment of osteochondral lesions in the knee joint and to determine the factors affecting the functional results. Methods: The study included 34 patients with a cartilage defect in the knee joint who were applied MACI® (GenzymeBiosurgery, Cambridge, Massachusetts, USA) technique between the years 2010 - 2015. The defect localizations and sizes, past surgeries were recorded...
February 2019: Journal of Clinical Medicine Research
Ozlem Korkmaz, Gulsenem Sari, Ilkin Mecidov, Samim Ozen, Damla Goksen, Sukran Darcan
Background: The effect on final height of gonadotropin-releasing hormone analogues (GnRHa) used in the treatment of precocious puberty is controversial. The aim of this study was to determine whether or not GnRHa therapy would make any contribution to final height in precocious puberty of girls with onset of pubertal characteristic development aged 6 - 8 years. Methods: Age at start of puberty, target height standard deviation score (SDS) presentation, follow-up height SDS, body mass index (BMI) SDS, bone age and predicted adult height of 34 female subjects who had reached their final height and with pubertal findings beginning at the ages of 6 - 8 were evaluated...
February 2019: Journal of Clinical Medicine Research
Mohammed Abdalla, Sumit Sohal, Baha'a Al-Azzam, Wiam Mohamed
Background: Sepsis is a leading cause of mortality and morbidity. Recent studies suggest that troponin elevation is associated with increased mortality in sepsis patients. The purpose of this study is to determine the effect of troponin elevation on mechanical ventilation duration and intensive care unit (ICU) length of stay in patients with sepsis. Additionally, we investigated the association between troponin elevation and septic shock. Methods: The study is a retrospective observational cohort study, conducted in a community teaching hospital between October 2015 and April 2018...
February 2019: Journal of Clinical Medicine Research
Paschalis Gavriilidis, Nicola de'Angelis, Aurelio Tobias
Background: Despite the existing evidence, many physicians are reluctant to use opioid analgesia for acute abdominal pain. Methods: We performed updated conventional and network meta-analyses. For the first time to our knowledge, direct and indirect evidence of any type of opioid analgesia was estimated and compared using network meta-analysis. Results: There was no significant difference in the intensity of pain between the two cohorts (mean difference (MD) = 0...
February 2019: Journal of Clinical Medicine Research
Ryota Sone, Kai Matsuba, Rei Tahara, Nobuhiko Eda, Keisei Kosaki, Subrina Jesmin, Shumpei Miyakawa, Koichi Watanabe
Background: High-intensity exercise affects the level of salivary nitric oxide (NO) with an impact on oxidative stress such as a reactive nitrogen-oxide species. However, in athletes with high-intensity training, the relationship between salivary NO levels and oxidative stress is yet to be clear. Additionally, the association of salivary NO levels and the common health disorders of athletes is unknown. Thus, the aim of this cross-sectional study was to clarify the relationship between salivary NO levels and oxidative stress, and the health/medical disorders existing in elite class university athletes...
February 2019: Journal of Clinical Medicine Research
Mustafa Ozturk, Afsin Ipekci, Sevil Kusku Kiyak, Yonca Sinem Akdeniz, Yavuz Aydin, Ibrahim Ikizceli, Ozgur Sogut
Background: Increased use of warfarin for the treatment and prophylaxis of many diseases has increased the frequency of adverse events. Emergency departments (EDs) are the first places where early interventions for bleeding and other complaints related to warfarin use are performed. This study assessed the characteristics of patients receiving warfarin and the risk factors for bleeding complication among those admitted to the ED. Methods: Patients admitted to the ED for any reason other than trauma during a 1-year period were retrospectively reviewed...
February 2019: Journal of Clinical Medicine Research
Elena A Usacheva, Lance R Peterson, Katherine Mendoza, Donna M Schora, M Moazzem Hossain, Jian-Ping Jin
Background: Current diagnostics of Clostridium difficile infection (CDI) heavily relies on detection of the disease-causing organism. The objective of this study was to investigate a cytoskeletal protein, tropomyosin (Tpm), as a CDI biomarker. Methods: Fecal Tpm was tested by monoclonal antibodies (mAbs) in a 12-month prospective study. Remnant diarrheal clinical specimens and relevant clinical data were collected. The CDI positive (CDI+ , n = 230) and CDI negative (CDI- , n = 228) groups were composed of samples testing positive or negative by polymerase chain reaction (PCR) (Xpert® C...
February 2019: Journal of Clinical Medicine Research
Keisuke Okamura, Kazuyuki Shirai, Motoyasu Miyazaki, Tetsu Okuda, Yosuke Takamiya, Miwa Goto, Hidenori Urata
Background: One of the treatment options for type 2 diabetes mellitus (DM) is a combination drug (CD) that contains the dipeptidyl peptidase-4 inhibitor (DPP4I) alogliptin (AG) together with pioglitazone (PG). This CD can improve impaired insulin secretion and insulin resistance, which are the two major pathologic factors for type 2 DM, and is also expected to increase adherence to treatment. We conducted a multicenter open-label prospective study to examine the usefulness of this CD for routine management of type 2 DM...
February 2019: Journal of Clinical Medicine Research
Fotios S Fousekis, Vasileios I Theopistos, Ioannis V Mitselos, Alexandros Skamnelos, Athanasios Kavvadias, Konstantinos H Katsanos, Dimitrios K Christodoulou
Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tract. PSC is strongly associated with inflammatory bowel disease (IBD), mainly with ulcerative colitis, and most PSC patients have underlying IBD. The pathophysiological interactions between IBD and PSC are unclear, although it seems that the patients with IBD and PSC have a distinct phenotype. IBD with coexisting PSC is more extensive and is characterized by milder activity compared to IBD alone. The coexistence of PSC increases the risk for colorectal cancer in IBD patients and lifelong annual surveillance colonoscopy is recommended...
February 2019: Journal of Clinical Medicine Research
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
No abstract text is available yet for this article.
January 2019: Journal of Clinical Medicine Research
Rikako Yabuki, Ei-Ichi Baba, Kazutaka Shirokane, Atsushi Tsuchiya, Motohiro Nomura
Persistent primitive hypoglossal artery is a rare anastomosis between the carotid and basilar arteries, and sometimes associated with cerebral aneurysms. However, association of persistent primitive hypoglossal artery with aneurysms located on arteries other than persistent primitive hypoglossal artery itself or posterior circulation is very rare. An 80-year-old woman suffered from subarachnoid hemorrhage, whose angiography demonstrated aneurysms on the left middle cerebral artery and anterior communicating artery, and the left persistent primitive hypoglossal artery...
January 2019: Journal of Clinical Medicine Research
Anastasios Katsourakis, Ioannis Vrabas, Vassilios Papanikolaou, Stylianos Apostolidis, Iosif Chatzis, George Noussios
Background: Pancreatic resection is still a challenging operation characterised by high morbidity. The quality of life in patients after pancreatectomy is a critical outcome. The aim of our trial is to prove whether or not exercise has any benefit to the life of these patients. Methods: The study was an open-label, randomized clinical trial. The patients were selected according to the Consolidated Standard of Reporting Trials criteria. The study was registered at the International Standard Randomized Controlled Trial registry (ISRCTN) with the study ID ISRCTN1087174...
January 2019: Journal of Clinical Medicine Research
Paschalis Gavriilidis, Nicola de'Angelis, Konstantinos Katsanos, Salomone Di Saverio
Background: The existing evidence on the treatment of complicated appendicitis favors conservative treatment rather than acute appendicectomy. Update traditional meta-analysis and consequently cumulative meta-analysis was performed to track the accumulation of evidence over time. Methods: Studies were identified by a systematic literature search of the EMBASE, PubMed, Cochrane Library and Google Scholar databases. The main outcome measures were duration of the first hospitalization, overall duration of hospitalization, duration of intravenous (IV) antibiotic treatment, overall complications, abdominal/pelvic abscesses, wound infections, re-admissions and unplanned re-operations...
January 2019: Journal of Clinical Medicine Research
Tomohiko Yamamoto, Shin-Ichiro Miura, Kazuyuki Shirai, Hidenori Urata
Background: While reduction of accumulated body fluid using loop diuretics is a commonly used therapeutic option for acute heart failure (AHF), some patients, especially those with chronic kidney disease (CKD), show significantly poor treatment response to loop diuretics. Tolvaptan (TLV) has shown effectiveness against AHF in several studies. We have been using TLV for AHF treatment, and it displayed favorable outcome even in patients with CKD. This study aimed to assess the therapeutic effectiveness of TLV in AHF patients...
January 2019: Journal of Clinical Medicine Research
Faraz Siddiqui, Moiz Ahmed, Saqib Abbasi, Akshay Avula, Abdul Hasan Siddiqui, Jobin Philipose, Hafiz M Khan, Tahir M A Khan, Liliane Deeb, Michel Chalhoub
Background: The goal of our study was to determine the impact of gastrointestinal bleeding (GIB) on in-hospital outcomes among acute respiratory distress syndrome (ARDS) patients, and subsequently determine the potential risk factors for the development of GIB. Methods: ARDS patients with and without GIB were identified using the National Inpatient Sample (2002 - 2012). Linear regression analysis was used to assess impact of GIB on in-hospital mortality, length of stay and total charges...
January 2019: Journal of Clinical Medicine Research
Hirokazu Kakuda, Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi
Background: We investigated the potential mechanism underlying body weight reduction by the sodium glucose cotransporter 2 (SGLT2) inhibitor, tofogliflozin, during treatment and after subsequent washout. Methods: Ten Japanese men with type 2 diabetes (average age: 66.3 years) were orally administered tofogliflozin (20 mg/day) for 8 weeks followed by a subsequent 8-week washout period (16 weeks). Results: Significant reductions were observed in blood glucose, hemoglobin A1c (HbA1c), uric acid, body weight and waist circumference with an increase in high-molecular weight (HMW) adiponectin at 8 weeks...
January 2019: Journal of Clinical Medicine Research
Christine Lux-Battistelli, Daniel Battistelli
Background: Little is known about the prevalence of vitamin C deficiency in the population of individuals who are withdrawing from alcohol, and about possible consequences of latent scurvy. The aim of this study was to evaluate the prevalence of vitamin C deficiency in patients who were withdrawing from alcohol, its correlation with latent scurvy (mainly tiredness and weakness) and the change in the latter symptoms at 3 months after oral vitamin C supplementation. Methods: A total of 47 patients (33 males, 14 females) who volunteered to undertake alcohol detoxification were included prospectively between January 2014 and November 2016...
January 2019: Journal of Clinical Medicine Research
Asif Khan, Jay Patel, Dikshya Sharma, Saleha Riaz, Seleshi Demissie, Anita Szerszen
Background: "There is a high prevalence of obstructive sleep apnea (OSA) among patients with atrial fibrillation (AF). There is also strong evidence that proper OSA management can reduce AF recurrence." Polysomnography is the gold standard for OSA diagnosis, but screening tests, such as STOP-BANG, have been successful in identifying patients at risk for OSA. Our study assesses screening rates for OSA in patients with persistent AF, and willingness of patients at increased risk for OSA towards further diagnostic evaluation...
January 2019: Journal of Clinical Medicine Research
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