Journal of Pharmacy & Bioallied Sciences

BACKGROUND: Two HDR brachytherapy regimes were compared, 9.5 Gray per fraction for two fractions and 7.5 Gray per fraction for three fractions. MATERIALS AND METHODS: A total of 80 patients with histologically evident squamous cell carcinoma cervix were taken in the current research after randomization. Radiotherapy dose delivered was 50 Gray/25#/5 weeks with concomitant chemotherapy with weekly cisplatin 35 mg/m2 . Following external chemoradiation, patients were randomized into two arms...

Cancer is a disease triggered by an uncontrolled growth of a group of cells usually from a single cell. Chemotherapy is a common and systematic therapy that involves the use of anticancer drugs also known as chemotherapeutical agents to treat cancer. Tyrosine kinases are a subset of protein kinases that are a family of over 90 enzymes that selectively phosphorylate tyrosine residues in various substrates. Receptors with internal tyrosine kinase activity mediate the actions of several growth factors, differentiation factors, and hormones, resulting in the reproduction and differentiation of the affected cells...

INTRODUCTION: Vitamin D deficiency increases gingivitis risk. Studies show that higher vitamin D levels reduce inflammation. MATERIALS AND METHODS: College conducted a double-blind, randomized, controlled trial on 451 people's vitamin D and gingival health at baseline. For three months, participants were given a placebo (group A), 1000 international units (IU) of vitamin D3 per day (group B), 500 IU per day (group C), or 2000 IU per day (group A). Gingival scores were recorded for three months to assess the anti-inflammatory effect (the first, second, and third)...

BACKGROUND: Human skull consists of various bones. One of them is mandible which is quite resistant, tough and shows systemic differences in form between individuals of different sex. It resists putrefaction also. There are characteristic features in the mandible that help us to differentiate sex in case of unknown victims like in mass disasters or in case fragmentary remains of the skeleton are found. Analysis of mandible with regard to its features is of great assistance in the determination of sex...

AIM: Chewable toothbrushes were compared to traditional manual toothbrushes in terms of their ability to remove plaque and their impact on salivary pH in a sample of school-aged children. MATERIALS AND METHODS: The sample size for this research was 200 youngsters aged 10-12. Saliva was collected by spitting into a clean container, and the pH levels were measured using color-coded pH strips to determine where the person was starting from. The plaque score was measured using the OHI-S index after the application of the disclosing agent...

OBJECTIVES: The study was done to assess the implant-abutment interface static compressive. strength of three design types and implant-abutment connection failure style. MATERIALS AND METHODS: The implants at 306 with respect to the y-axis were aligned using a stainless steel holding device. Twenty specimens from each system totaled 60 total. A unidirectional vertical piston in a computer-controlled universal testing machine (MTS 810) generated static compression loading until failure...

The aim of this in vitro study was to evaluate and compare the dentinal tubule occlusion using nano-hydroxyapatite (n-HAP) containing toothpaste and mouthwash under a scanning electron microscope. The specimens were randomly divided into two groups with five specimens each: group 1-toothpaste group and group 2-mouthwash group. The percentage of the occluded dentinal tubules was assessed at the baseline, 7th , 14th , 21st , and 28th days under a scanning electron microscope. The toothpaste group showed a higher percentage of occluded dentinal tubules as compared to the mouthwash group at the 7th , 14th , 21st , and 28th days, respectively...

INTRODUCTION: Chronic periodontitis is an infectious disease which is multifactorial in etiology. The red complex bacteria have an enzyme capable of hydrolyzing the synthetic trypsin substrate, N-benzoyl-DL-arginine-2-napthylamide (BANA). Tetracycline as a bacteriostatic agent is used in the treatment of periodontitis. OBJECTIVE: The aim of this study was to evaluate clinically and microbiologically the efficacy of tetracycline fibers in conjunction with scaling and root planning in chronic periodontitis patients...

AIM: Incisal guidance (IG) varies with maxillary and mandibular teeth wear. It in turn governs the forces on adhesive restorations. The present study evaluates the variation in forces because of changes in IG. MATERIALS AND METHODS: IG was recorded on 46 subjects along with the distance from centric contact to incisal edge. Biteforce was recorded in the maximum possible intercuspal position (MIP) and in protrusion in the anterior region. Data analysis was performed using SPSS Version 21 at a confidence level ≤0...

BACKGROUND: Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the monosaccharides. Numerous illness conditions and cancers have been linked to increased levels of protein-bound fucose. MATERIALS AND METHODS: In the current study, the serum fucose levels of patients with oral squamous cell carcinoma (OSCC) and healthy individuals were assessed and compared...

INTRODUCTION: Breast cancer is the most widely recognized malignant growth in ladies in India and accounts for 14% of all tumors in women. Modified radical mastectomy (MRM) is a surgery done for breast cancer. It leads to about 30% chances of postoperative nausea and vomiting (PONV) and 40% pain in the immediate postoperative period. OBJECTIVES: Changes in blood pressure after intubation, waiting time for postoperative pain medication, and possibility of adverse effects...

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BACKGROUND: To assess the prevalence of psychiatric morbidity and stress burden among the patients with limb fractures and compare them with age and gender matched control group. MATERIALS AND METHODS: The cross-sectional study was conducted on 25 patients each of lower and upper limb fractures, presenting 2 weeks or more after the fracture to orthopedics OPD of Dayanand Medical College and Hospital. Psychiatric manifestations and stress burden were assessed using Mini International Neuropsychiatric Interview (M...

AIM AND OBJECTIVES: The purpose of this study was to use cone bar CT to investigate the root trench morphology of two-hundred mesiobuccal permanent first molars in the maxilla. MATERIALS AND METHODS: The distobuccal and palatal roots were removed at the furcation in 250 maxillary first molars. The mesiobuccal roots were then imaged using cone beam computed tomography on all specimens. The specimens were analyzed and compared to one another." This study looked into the following factors...

AIM: Serratia marcescens genes fumC, icd, and mdh were molecularly typed in various groups of 200 clinical samples. RESULTS: According to the findings, 38 (19%) of the isolates are Serratia marcescens. All these bacterial isolates had their DNA extracted. Then, using particular primers, the genes fumC, icd, and mdh are detected and amplified. These genes were sequenced, and the results were aligned with NCBI sequences. Using the Geneious version 9 software, gene sequences were analyzed...

OBJECTIVES: This research was done to assess the periodontal ligament cells viability using propolis, coconut water, aloe vera, and soy milk storage media. MATERIALS AND METHODS: Periodontal ligament cells were taken from freshly extracted teeth and stored into four groups of storage media: Group A-propolis, Group B-coconut water, Group C-aloe vera, and Group D-soy milk. Later, the cell viability was assessed at 1, 12, and 24 hours. RESULTS: The periodontal ligament cell viability was significantly greater in propolis, followed by coconut water, aloe vera, and soy milk...

In several regions throughout the globe, caesarean sections constitute the most common nonobstetric surgery, followed by hysterectomy, which is the surgical excision of the uterus. While it is not the only solution for reproductive organ issues, it is the most effective technique to treat many illnesses over the long term. The uterus is a very critical reproductive organ for all age groups as this is not only essential for giving birth but also for hormonal-related physiology in women's life. The quality of life is impacted by a number of hysterectomy-related effects on females...

BACKGROUND: Our goal in conducting this study was to see how well-informed patients are about dental implants as a method of prosthodontic rehabilitation. MATERIALS AND METHODS: "In this cross-sectional study, 500 new dental students were asked questions using a pre-made, self-administered questionnaire. A pilot study was carried out to verify the reliability of the survey instrument. Analysis of the data was performed in SPSS 16 (SPSS). We used the P 0.05 thresholds for the Student's T-test and the ANOVA to determine statistical significance...

UNLABELLED: To evaluate the characteristics of a thermomechanically loaded composite resin enhanced with graphene nanoparticles. A total of 60 specimens were manufactured with Test group TG1 (20), TG2 (20), and control group CG (20). All samples were subjected to surface roughness using a three-dimensional (3D) Optical profilometer and flexural strength. All specimens were subjected to thermomechanical cyclic loading. Microhardness measurement was performed with a microhardness tester...

Developmental disturbances in the permanent dentition are commonly seen due to traumatic injuries to the primary teeth, especially intrusive and avulsion injuries of the overlaying primary incisors. These disturbances may range from enamel discoloration or hypoplasia, crown/root dilaceration, odontoma-like malformation and eruption disturbances. Concrescence is extremely rare in anterior teeth. This case report describes a rare case that showed a concrescence of the unerupted maxillary right lateral incisor and maxillary central incisor with crown dilaceration...