journal
https://read.qxmd.com/read/33299540/radial-basis-function-artificial-neural-network-for-the-investigation-of-thyroid-cytological-lesions
#21
JOURNAL ARTICLE
Christos Fragopoulos, Abraham Pouliakis, Christos Meristoudis, Emmanouil Mastorakis, Niki Margari, Nicolaos Chroniaris, Nektarios Koufopoulos, Alexander G Delides, Nicolaos Machairas, Vasileia Ntomi, Konstantinos Nastos, Ioannis G Panayiotides, Emmanouil Pikoulis, Evangelos P Misiakos
Objective: This study investigates the potential of an artificial intelligence (AI) methodology, the radial basis function (RBF) artificial neural network (ANN), in the evaluation of thyroid lesions. Study Design . The study was performed on 447 patients who had both cytological and histological evaluation in agreement. Cytological specimens were prepared using liquid-based cytology, and the histological result was based on subsequent surgical samples. Each specimen was digitized; on these images, nuclear morphology features were measured by the use of an image analysis system...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32963752/lack-of-association-between-poor-glycemic-control-in-t2dm-and-subclinical-hypothyroidism
#22
JOURNAL ARTICLE
Pragya Sharma, Rashmi Sinha, Anupa Prasad, J K Mitra
Background: Hypothyroidism is a highly prevalent and multifactorial disorder and has been implicated in the causation of dyslipidemia, dermatological diseases, atherosclerosis, and myocardial dysfunction, as well as endothelial dysfunction. The relationship between subclinical hypothyroidism and type 2 diabetes mellitus is not well established. In the present study, we attempt to find out the prevalence of subclinical hypothyroidism in type 2 diabetes mellitus and its association with glycemic control...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32733666/tumor-volume-kinetic-analyses-might-explain-excellent-prognoses-in-young-patients-with-papillary-thyroid-carcinoma
#23
JOURNAL ARTICLE
Toshihiko Kasahara, Akira Miyauchi, Yasuhiro Ito, Takumi Kudo, Hiroo Masuoka, Takuya Higashiyama, Mitsuru Ito, Minoru Kihara, Akihiro Miya
Introduction: Young patients with papillary thyroid carcinoma (PTC) generally have excellent prognoses despite their often-advanced disease status. The reasons for this excellent prognosis are poorly understood. Objective: To investigate the natural history of PTC in young patients, we compared the observed tumor volume-doubling rate (TV-DR) with the hypothetical tumor volume-doubling rate (hTV-DR) before presentation in young PTC patients. DR is an inverse of the doubling time and indicates the number of doublings that occur in a unit of time...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32454966/possible-effects-of-perchlorate-contamination-of-drinking-water-on-thyroid-health
#24
JOURNAL ARTICLE
Sunny P Orathel, Ronnie Thomas, N Chandramohanakumar, Joy Job Kulavelil, Krishnapillai Girish Kumar, Vadayath Usha Menon, P Jayaprakash, Sajitha Krishnan, P S Manju, Shaiju Param, M G Rajamanickam, U G Unnikrishnan, Joe Thomas, Ponnu Jose
Background: Perchlorate is an anion that occurs as a contaminant in groundwater. It originates from the improper disposal of ammonium perchlorate, a component of rocket fuel. The objective of this study was to explore whether the exposure to perchlorate in drinking water had an impact on the thyroid function of the population residing near an ammonium perchlorate plant in Kerala. Methodology . Using an ecological study design, we compared the serum levels of thyroid-stimulating hormone, thyroxine, and thyroid peroxidase antibodies among a representative sample of 289 study subjects from the area surrounding the ammonium perchlorate enrichment plant to 281 study subjects in a control area...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32454522/diagnosis-and-management-of-graves-disease-in-thailand-a-survey-of-current-practice
#25
JOURNAL ARTICLE
Chutintorn Sriphrapradang
Background: The data on clinical practice patterns in the evaluation and management of Graves' disease (GD) are limited in Asia. The aims of this survey were to report the current practices in the management of GD in Thailand and to examine any international differences in the management of GD. Methods: Members of the Endocrine Society of Thailand who were board certified in endocrinology ( N  = 392) were invited to participate in an electronic survey on the management of GD using the same index case and questionnaire as in previous North American and European surveys...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32426104/distribution-and-prognostic-significance-of-estrogen-receptor-%C3%AE-er-%C3%AE-estrogen-receptor-%C3%AE-er-%C3%AE-and-human-epidermal-growth-factor-receptor-2-her-2-in-thyroid-carcinoma
#26
JOURNAL ARTICLE
Anjali Mishra, Niraj Kumari, Chandan Kumar Jha, Raouef Ahamed Bichoo, Shravan Kumar Mishra, Narendra Krishnani, Saroj Kanta Mishra
Purpose: The primary aim of this study was to determine the incidence of estrogen receptor α (ER α ), estrogen receptor β (ER β ), and human epidermal growth factor receptor 2 (HER-2) expression in various subtypes of thyroid carcinoma (TC) of follicular origin and the secondary aim was to correlate the expression with various clinicopathologic prognostic factors. Methods: Immunohistochemistry analysis was performed on archival paraffin-embedded tissue sections (1991-2016)...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32395225/microscopic-positive-tumor-margin-increases-risk-for-disease-persistence-but-not-recurrence-in-patients-with-stage-t1-t2-differentiated-thyroid-cancer
#27
JOURNAL ARTICLE
Olfat Kamel Hasan, Sarah De Brabandere, Irina Rachinsky, David Laidley, Danielle MacNeil, Stan Van Uum
Introduction: Differentiated thyroid cancer (DTC) has an overall excellent prognosis. Patients who develop recurrent disease have a more unfavorable disease course than those with no recurrence. Higher recurrence rates are seen with incomplete surgical resection and gross positive margins. It is unclear whether microscopic positive margin affects disease recurrence rates as much as grossly positive margin. Aim of the Study . To assess whether microscopic positive margin is an independent predictor of disease recurrence in patients with overall low-risk DTC...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32351680/prognostic-significance-of-thyroglobulin-antibodies-in-differentiated-thyroid-cancer
#28
JOURNAL ARTICLE
Jordi L Reverter, Irene Rosas-Allende, Carlos Puig-Jove, Carles Zafon, Ana Megia, Ignasi Castells, Eduarda Pizarro, Manel Puig-Domingo, M Luisa Granada
OBJECTIVE: To investigate whether variations in thyroglobulin autoantibodies (TgAb) are related to the recurrence or persistence of differentiated thyroid carcinoma (DTC) and may therefore be useful as surrogate tumor markers. Design and Methods . We retrospectively studied 98 subjects (83 women, 47 ± 15 years old) from an initial cohort of 1017 patients treated for DTC in five hospitals, with positive TgAb at any time during the follow-up. Patients presented five different patterns of evolution of serum TgAb concentrations: (1) stable positive TgAb, (2) de novo appearance, (3) an increase of more than 50%, (4) TgAb levels from positive to negative, and (5) a decrease of more than 50%...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32351679/the-bethesda-system-for-reporting-thyroid-cytopathology-a-cytohistological-study
#29
JOURNAL ARTICLE
Bakiarathana Anand, Anita Ramdas, Marie Moses Ambroise, Nirmal P Kumar
Introduction: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a significant step to standardize the reporting of thyroid fine needle aspiration (FNA). It has high predictive value, reproducibility, and improved clinical significance. Aim: The study was aimed to evaluate the diagnostic utility and reproducibility of "TBSRTC" at our institute. Methods and Material . The study included 646 thyroid FNAs which were reviewed by three pathologists and classified according to TBSRTC...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/32351678/lymph-node-metastasis-and-extrathyroidal-extension-in-papillary-thyroid-microcarcinoma-in-cyprus-suspicious-subcentimeter-nodules-should-undergo-fna-when-multifocality-is-suspected
#30
JOURNAL ARTICLE
Christos Papaioannou, Demetris Lamnisos, Katerina Kyriacou, Theodoros Lyssiotis, Vasilis Constantinides, Savvas Frangos, Aliki Economides, Panayiotis A Economides
Objective: To determine the prevalence of lymph node (LN) metastasis and extrathyroidal extension (ETE) in patients with papillary thyroid microcarcinoma (PTMC) in Cyprus and to evaluate the role of preoperative ultrasound (U/S) examination. Methods: A retrospective study of 102 patients who underwent thyroidectomy for PTMC in a 2-year period. Preoperatively, all patients had a thyroid and neck U/S examination with LN mapping. Tumor size according to the largest diameter, number of foci, LN metastasis, and ETE data was collected from the histopathological report and was compared to the preoperative U/S reports...
2020: Journal of Thyroid Research
https://read.qxmd.com/read/31949891/superior-approach-of-recurrent-laryngeal-nerve-review-of-the-literature
#31
REVIEW
Koné Fatogoma Issa, Dao Sidiki, Cissé Naouma, Diarra Kassim, Konaté N'Faly, Samaké Djibril, Tafo Neuilly, Haidara Abdoul Wahab, Guindo Boubacary, Soumaoro Siaka, Singaré Kadidiatou, Timbo Samba Karim, Kéita Mohamed Amadou
The identification and dissection of the recurrent laryngeal nerve is essential to guarantee its anatomical and functional integrity. The superior approach of the recurrent nerve is a reliable surgical alternative. Various indications are recognized with a reliable landmark. This is the entry point into the larynx under the inferior horn of the thyroid cartilage. The limits of this technique, namely, the extralaryngeal divisions and the hemorrhages encountered at the point of entry of the larynx are a source of morbidity of the recurrent laryngeal nerve...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31871616/thyroidectomy-in-a-surgical-volunteerism-mission-analysis-of-464-consecutive-cases
#32
JOURNAL ARTICLE
Rifat Latifi, Mahir Gachabayov, Shekhar Gogna, Renato Rivera
Although surgical volunteer missions (SVMs) have become a popular approach for reducing the burden of surgical disease worldwide, the outcomes of specific procedures in the context of a mission are underreported. The aim of this study was to evaluate outcomes and efficiency of thyroid surgery within a surgical mission. This was a retrospective analysis of medical records of all patients who underwent thyroid surgery within a SVM from 2006 to 2019. Postoperative complication rate was the safety endpoint, whereas length of hospital stay (LOS) was the efficiency endpoint...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31687124/a-hospital-based-study-of-iodine-nutrition-status-of-breastfeeding-mothers-in-bangladesh
#33
JOURNAL ARTICLE
Jobaida Naznin, Mohammad Fariduddin, Mashfiqul Hasan, Mohammad Atiqur-Rahman, Nusrat Sultana, Mohammad Anowar-Hossain, Sharmin Chowdhury, Muhammad Abul Hasanat
Adequacy of iodine nutrition status in breastfeeding mothers is vital in preventing iodine deficiency disorder (IDD) in neonates and children. The aim of the study was to assess urinary iodine status in breastfeeding mothers attending Bangabandhu Sheikh Mujib Medical University (BSMMU) hospital in Bangladesh. In this cross-sectional study carried out from January 2014 to January 2015, urinary iodine (UI; μ gm/L) level of 266 mothers (age 26.6 ± 4.7 years (mean ± SD), exclusively breastfeeding: 132 and nonexclusively breastfeeding: 134), recruited on consecutive basis from BSMMU outdoor and indoor, were measured in spot urine following the wet digestion method...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31662841/challenges-in-interpreting-thyroid-stimulating-hormone-results-in-the-diagnosis-of-thyroid-dysfunction
#34
REVIEW
Salman Razvi, Sindeep Bhana, Sanaa Mrabeti
The pituitary hormone, thyrotropin (TSH), is regarded as the primary biomarker for evaluating thyroid function and is useful in guiding treatment with levothyroxine for patients with hypothyroidism. The amplified response of TSH to slight changes in thyroid hormone levels provides a large and easily measured signal in the routine care setting. Laboratories provide reference ranges with upper and lower cutoffs for TSH to define normal thyroid function. The upper limit of the range, used to diagnose subclinical (mild) hypothyroidism, is itself a matter for debate, with authoritative guidelines recommending treatment to within the lower half of the range...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31534663/study-of-vitamin-d-level-and-vitamin-d-receptor-polymorphism-in-hypothyroid-egyptian-patients
#35
JOURNAL ARTICLE
Hoda A ElRawi, Nashwa S Ghanem, Naglaa M ElSayed, Hala M Ali, Laila A Rashed, Mai M Mansour
Purpose: The current study aimed at assessing vitamin D level and vitamin D receptor polymorphism in hypothyroid Egyptian patients and its effect on hypothyroidism and thyroid morphology, also to find a causal relation between vitamin D and hypothyroidism. Methods: This case-control study was conducted on 35 hypothyroid patients and 35 matched unrelated healthy controls. Total serum 25-hydroxyvitamin D3 and thyroid antibodies were measured using a human ELISA kit...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31428301/antithyroid-peroxidase-antibodies-in-multinodular-hashimoto-s-thyroiditis-indicate-a-variant-etiology
#36
JOURNAL ARTICLE
Pabithadevi B Mehanathan, R Raskin Erusan, K Shantaraman, S M Kannan
INTRODUCTION: Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder, which predominantly presents as a diffuse goiter, with few studies which report HT presenting as multinodular goiter, with variable frequencies ranging from 59% to 78.6% especially from south Indian populations. This variant clinical presentation may have diagnostic challenges which require further analysis. Anti-TPO antibodies are more common (90-95%) in Hashimoto's thyroiditis than anti-TG antibodies in Hashimoto's thyroiditis...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31360432/medullary-thyroid-carcinoma-an-update-on-imaging
#37
REVIEW
Sergiy V Kushchayev, Yevgeniya S Kushchayeva, Sri Harsha Tella, Tetiana Glushko, Karel Pacak, Oleg M Teytelboym
Medullary thyroid carcinoma (MTC), arising from the parafollicular C cells of the thyroid, accounts for 1-2% of thyroid cancers. MTC is frequently aggressive and metastasizes to cervical and mediastinal lymph nodes, lungs, liver, and bones. Although a number of new imaging modalities for directing the management of oncologic patients evolved over the last two decades, the clinical application of these novel techniques is limited in MTC. In this article, we review the biology and molecular aspects of MTC as an important background for the use of current imaging modalities and approaches for this tumor...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31275541/performance-of-the-american-thyroid-association-risk-classification-in-a-single-center-cohort-of-pediatric-patients-with-differentiated-thyroid-cancer-a-retrospective-study
#38
JOURNAL ARTICLE
Raad Alwithenani, Sarah DeBrabandere, Irina Rachinsky, S Danielle MacNeil, Mahmoud Badreddine, Stan Van Uum
Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy in children. Retrospective studies show conflicting results regarding predictors of persistent and recurrent disease after initial therapy. In 2015, the American Thyroid Association (ATA) proposed a clinical classification system to identify pediatric thyroid cancer patients at risk for persistent/recurrent disease. Material and Methods: We retrospectively included all patients in our registry diagnosed with papillary DTC at ≤ 18 years of age...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31249658/treatment-outcomes-in-anaplastic-thyroid-cancer
#39
JOURNAL ARTICLE
Kelsey L Corrigan, Hannah Williamson, Danielle Elliott Range, Donna Niedzwiecki, David M Brizel, Yvonne M Mowery
Background: Anaplastic thyroid cancer (ATC) is rare, accounting for 1-2% of thyroid malignancies. Median survival is only 3-10 months, and the optimal therapeutic approach has not been established. This study aimed to evaluate outcomes in ATC based on treatment modality. Methods: Retrospective review was performed for patients treated at a single institution between 1990 and 2015. Demographic and clinical covariates were extracted from the medical record. Overall survival (OS) was modeled using Kaplan Meier curves for different treatment modalities...
2019: Journal of Thyroid Research
https://read.qxmd.com/read/31015954/spectrum-of-thyroid-abnormalities-among-children-living-with-hiv-in-lagos-nigeria
#40
JOURNAL ARTICLE
Adeseye Akinsete, Elizabeth Oyenusi, Babatunde Odugbemi, Tinuola Odugbemi, Edamisan Temiye
Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) were analyzed in 83 children living with HIV on HAART and 51 controls...
2019: Journal of Thyroid Research
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