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Journal of Thyroid Research

J Karmisholt, S L Andersen, I Bulow-Pedersen, A Carlé, A Krejbjerg, B Nygaard
Purpose. To study predictors of attaining (part 1) and sustaining (part 2) remission in patients with Graves' hyperthyroidism (GH) treated with antithyroid drugs (ATD). Methods. In the prospective first part, the included patients were treated with ATD until a prespecified definition of remission (thyrotropin > 0.4 mU/L and TSH-receptor antibodies (TRAb) ≤ 1. 0 IU/L in a patient receiving a methimazole dose ≤ 5 mg/day, on two occasions two months apart) was met, or for 24 months. In the second part, patients attaining remission in part 1 were randomized to treatment or observation and followed until relapse or for 24 months...
2019: Journal of Thyroid Research
Wei Zhao, Xinyu Li, Xuhan Liu, Lu Lu, Zhengnan Gao
Background: Diabetes mellitus is a common metabolic disease and the prevalence is increasing rapidly. Thyroid disorders including subclinical hypothyroidism (SCH) and low triiodothyronine (T3) syndrome are frequently observed in diabetic patients. We conducted a study to explore thyroid function in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). Methods: We included 103 healthy volunteers, 100 T2DM patients without DN, and 139 with DN...
2018: Journal of Thyroid Research
Guadalupe Vargas-Ortega, Lourdes Balcázar-Hernández, Baldomero González-Virla, Claudia Ramírez-Rentería, Oriana Nieto-Guzmán, Ana Pamela Garrido-Mendoza, Marco Antonio Flores-Maya, Moisés Mercado, Mendoza-Zubieta Victoria
Background: The primary hyperparathyroidism (PHPT) is a common disease for the endocrinologist. The concomitant thyroid disease and differentiated thyroid cancer (DTC) appear to be more frequent in patients with PHPT than in the general population. The aim of this study was to characterize patients with symptomatic PHPT with and without DTC and analyze frequency and risk factors. Methods: We consecutively studied patients with symptomatic PHPT diagnosed and treated at our center between 2013 and 2015...
2018: Journal of Thyroid Research
Luis-Mauricio Hurtado-López, Alejandro Ordoñez-Rueda, Felipe-Rafael Zaldivar-Ramírez, Erich Basurto-Kuba
Background: Optimal neck lymphadenectomy in patients with papillary thyroid cancer (PTC) and microscopic lymph node metastasis needs to be defined in order to aid surgeons in their decision about the best way to proceed in these cases. Methods: Patients who underwent total thyroidectomy and lymphadenectomy at levels IIa to VI were divided into two groups: Group 1 (G1) with macroscopic metastasis detected before surgery and Group 2 (G2) with microscopic metastasis detected in sentinel node during surgery...
2018: Journal of Thyroid Research
Goonj Johri, Gyan Chand, Nitish Gupta, Chaitra Sonthineni, Anjali Mishra, Gaurav Agarwal, Sabaretnam Mayilvaganan, Ashok Kumar Verma, Saroj Kanta Mishra
Scarless (in the neck) endoscopic thyroidectomy (SET) has evolved into a cosmetically preferred alternative to conventional thyroidectomy (ConT). Recently many of our patients are demanding SET; however their goitres are larger than the recommended size of 4-6 cm. Our aim was to compare the outcomes of ET for small (<6 cm) vs large (≥6 cm) goitres and determine its feasibility in such cases. This is a retrospective analysis of prospectively maintained database of patients undergoing ET. Patients were divided into 2 groups: I, small (<6 cm) and II, large goitres (≥6 cm)...
2018: Journal of Thyroid Research
Sudeb Mukherjee, Suhana Datta, S C Mandal
Background: The association between subclinical thyroid dysfunction (defined by no symptoms or clinical features of hypothyroidism but biochemically TSH level in the range of above 5 miu/ml but below 10 miu/ml with normal FT4 level) and Acute Coronary Syndrome (ACS) is not known so far. This study was done to calculate the prevalence of subclinical thyroid dysfunction in patients with ACS. Methods: A retrospective chart review of 1100 consecutive patients was done who presented to Emergency Department with symptoms suggestive of ACS and admitted...
2018: Journal of Thyroid Research
Abilash Nair, C Jayakumari, P K Jabbar, R V Jayakumar, Nishant Raizada, Anjana Gopi, Geena Susan George, T P Seena
Both type 2 diabetes and hypothyroidism are highly prevalent disorders in the community. The existing data regarding prevalence of hypothyroidism in patients with diabetes comes mostly from small studies. There are only two studies with a sample size of more than 1000 diabetic patients, none of which have been done in South Asians. The present study evaluated patients with type 2 diabetes for presence of hypothyroidism and the clinical factors associated with it. The demographic, anthropometric, clinical, and biochemical parameters of consecutively enrolled patients with diabetes were systematically collected and analyzed...
2018: Journal of Thyroid Research
Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
Randomised controlled trials are deemed to be the strongest class of evidence in evidence-based medicine. Failure of trials to prove superiority of T3/T4 combination therapy over standard LT4 monotherapy has greatly influenced guidelines, while not resolving the ongoing debate. Novel studies have recently produced more evidence from the examination of homeostatic equilibria in humans and experimental treatment protocols in animals. This has exacerbated a serious disagreement with evidence from the clinical trials...
2018: Journal of Thyroid Research
Naval Bansal, Sanjay Kumar Yadav, Saroj Kanta Mishra, Kamal Kishore, Anjali Mishra, Gyan Chand, Gaurav Agarwal, Amit Agarwal, Ashok Kumar Verma
Introduction: The concept of short stay thyroidectomy has been tested and in practice in the developed world; the same has not been replicated in countries with limited resources due to lack of organized healthcare system. So, in this study, we tried to analyze if short stay thyroid surgery can be performed in a cost-effective way in developing countries and also if the endocrine surgical trainee can deliver these services safely. Methods: The study was conducted prospectively from January 2013 to July 2014, at Department of Endocrine Surgery, SGPGIMS, Lucknow, India...
2018: Journal of Thyroid Research
Valmore Bermúdez, Juan Salazar, Roberto Añez, Milagros Rojas, Viviana Estrella, María Ordoñez, Maricarmen Chacín, Juan Diego Hernández, Víctor Arias, Mayela Cabrera, Clímaco Cano-Ponce, Joselyn Rojas
Introduction: Subclinical hypothyroidism (ScH) is an endocrine alteration that is related to cardiovascular risk factors, including those categorized as components of the Metabolic Syndrome (MS). However, findings in prior reports regarding an association between these alterations are inconsistent. The purpose of this study was to determine the relationship between both entities in adult subjects from Maracaibo City, Venezuela. Materials and Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multistage sampling...
2018: Journal of Thyroid Research
Mayumi Endo, Jessica B Liu, Marcelle Dougan, Jennifer S Lee
Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. In this cohort, 3,200 patients developed SPM, a substantially higher number than in the reference population of 2,749 with observed to expected ratio (O/E) of 1.16 (95% CI; 1.12-1.21). Bone and joint cancer had the highest O/E ratio of 4...
2018: Journal of Thyroid Research
Toshihiko Kasahara, Akira Miyauchi, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Yasuhiro Ito, Minoru Kihara, Akihiro Miya
Background: Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease. The tumor growth of young patients' PTCs might show spontaneous slowing postoperatively. We compared young PTC patients' postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT). Methods: Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998-2016 had biochemically persistent disease postoperatively...
2018: Journal of Thyroid Research
Riju Menon, C Gopalakrishnan Nair, Misha Babu, Pradeep Jacob, G Praveen Krishna
Introduction: Thyroidectomy is now a less popular therapeutic option for Graves' disease. The frequency of thyroid nodule and the cancer risk of these nodules accompanying Graves' disease are controversial. The outcome of thyroid cancers coexisting with Graves' disease is debated. Study Design: Designed as retrospective case control study of papillary thyroid cancers associated with Graves' disease and those with euthyroid background. Pathological characteristics and outcome of papillary thyroid cancers in the two groups were compared...
2018: Journal of Thyroid Research
Hamid Nawaz Tipu, Dawood Ahmed, Muhammad Mukarram Bashir, Naveed Asif
Background: We hypothesized that anti-thyroid antibodies are more often positive in individuals with deranged thyroid profile. Methods: This prospective cohort was done in Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from Jan 2017 to Oct 2017. All the samples that were referred to us for testing anti-thyroid antibodies (anti-TPO or anti-TG antibodies) and thyroid profile were included in the study. There were no exclusion criteria...
2018: Journal of Thyroid Research
Dimitrios K Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P Korkolis, George H Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
Objective: To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres. Methods: 397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (94 males, 303 females, mean age 53 ± 14.5 years). NLR and PLR were calculated as the absolute neutrophil and absolute platelet counts divided by the absolute lymphocyte count, respectively, based on the preoperative complete blood cell count...
2018: Journal of Thyroid Research
Shirish S Chandanwale, Rahul Nair, Anushree Gambhir, Supreet Kaur, Aditi Pandey, Abhinav Shetty, Piyusha Naragude
Introduction: Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim: Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods: The study included consecutive 110 cases of thyroiditis...
2018: Journal of Thyroid Research
Edmund Muonir Der
Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Materials and Methods: This was a retrospective study from January 1994 to December 2013...
2018: Journal of Thyroid Research
Emin Gurleyik, Fuat Cetin, Sami Dogan, Erman Yekenkurul, Ufuk Onsal, Fatih Gursoy, Alper Ipor
Thyroid reoperations are surgically challenging because of scarring and disturbances in the anatomy of the recurrent laryngeal nerve (RLN). This study was conducted on 49 patients who underwent redo surgery. 61 RLNs were identified and completely exposed. Their functional integrity was evaluated using intraoperative nerve monitoring (IONM). Indications for secondary surgery, anatomical changes secondary to recurrent goiter mass and prior surgery, and results of IONM were studied. Frequent indications for redo surgery were multinodular goiter (MNG) in 19 (38...
2018: Journal of Thyroid Research
Clebson Pantoja Pimentel, Erik Artur Cortinhas-Alves, Edivaldo Herculano Correa de Oliveira, Luiz Carlos Santana-da-Silva
Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing...
2017: Journal of Thyroid Research
Cheuk-Lik Wong, Ho-Kee Vicki Tam, Chun-Kit Vincent Fok, Pong-Kai Ellen Lam, Lai-Ming Fung
Background: Atrial fibrillation (AF) is one of the commonest cardiovascular manifestations of thyrotoxicosis. A significant proportion of patients have persistent AF which may have long term consequences, for example, ischemic stroke. Methods: We performed a retrospective cohort study in a regional hospital from January 2004 to June 2016 to examine the clinical characteristics and outcomes of thyrotoxic patients who presented with atrial fibrillation and to investigate possible factors associated with persistent atrial fibrillation and ischemic stoke...
2017: Journal of Thyroid Research
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