journal
https://read.qxmd.com/read/38706919/erratum-circnt5e-promotes-the-proliferation-and-migration-of-bladder-cancer-via-sponging-mir-502-5p-erratum
#1
Jinhui Yang, Xiaoyun Liu, Guangcheng Dai, Lanying Qu, Bo Tan, Bo Zhu, Fuming Qi, Xinyu Gai, Bo Cheng
[This corrects the article DOI: 10.7150/jca.53385.].
2024: Journal of Cancer
https://read.qxmd.com/read/38706918/-kmt2a-mutations-and-high-prevalence-of-dmmr-associated-mutational-signatures-as-prognostic-indicators-in-metastatic-colorectal-cancer
#2
JOURNAL ARTICLE
Zhihang Han, Chuanjun Song, Dongqing Li, Weiyou Zhu, Jiukang Sun, Jialing Yao, Wenyuan Gan, Fufeng Wang, Xiaodong Yang, Lingjun Zhu
The conventional treatment strategies for patients with metastatic colorectal cancer (mCRC) are predominantly guided by the status of RAS and BRAF mutations. Although patients may exhibit analogous pathological characteristics and undergo similar treatment regimens, notable disparities in their prognostic outcomes can be observed. Therefore, tissue and plasma samples from 40 mCRC patients underwent next-generation sequencing targeting 425 cancer-relevant genes. Genomic variations and canonical oncogenic pathways were investigated for their prognostic effects in association with progression-free survival (PFS) of these patients...
2024: Journal of Cancer
https://read.qxmd.com/read/38706917/cs1-expression-pattern-in-nk-cells-and-correlated-factors-in-plasma-cell-dyscrasias-implications-for-elotuzumab-therapy-and-car-t-efficacy
#3
JOURNAL ARTICLE
Chunhui Li, Di Wang, Yanjie Xu, Xia Mao, Yimei Que, Zhe Li, Qiuxia Yu, Menglei Xu, Ning An, Xiaolu Long, Chunrui Li
Treatment with elotuzumab alone has no discernible antitumor effect and progress in chimeric antigen receptor T cells (CAR-T) therapy targeting CS1 is relatively slow. A retrospective analysis was performed on 236 patients with multiple myeloma (MM) and 30 patients with other plasma cell dyscrasias (PCDs). CS1 expression in NK cells, lymphocytes, and monoclonal plasma cells was assessed using multiparameter flow cytometry. Furthermore, new explorations were undertaken regarding the antitumor applications of elotuzumab...
2024: Journal of Cancer
https://read.qxmd.com/read/38706916/correlation-between-messenger-rna-expression-and-clinicopathological-features-of-breast-cancer-a-systematic-review
#4
JOURNAL ARTICLE
Xue Hu, Wanying Xing, Wan Wang
BACKGROUND: Meta analysis was adopted to investigate the correlation between messenger ribonucleic acid (mRNA) expression and clinicopathological features of breast cancer (BC). METHODS: English databases, PubMed, Web of Science, Embase, and The Cochrane Library, etc., were searched using a computer. The time range of retrieval was set to be from the establishment of the database to December 2023. The search terms were set as "mRNA", "Breast cancer", "Pathology", "Clinicopathological characteristics", etc...
2024: Journal of Cancer
https://read.qxmd.com/read/38706915/gpnmb-expression-associates-with-inferior-prognosis-in-patients-with-small-cell-lung-cancer
#5
JOURNAL ARTICLE
Qian Liu, Jun Zhang, Shiqi Mao, Dongdong Zhang, Youhong Dong, Pengchao Hu, Shengxiang Ren
Purpose : Small cell lung cancer (SCLC) is widely recognized for its propensity for early and frequent metastases, which contribute to its status as a refractory malignancy. While the high expression of GPNMB in SCLC is well-documented, the precise correlation between GPNMB expression and the prognosis of SCLC remains undetermined. Methods: HTG Edge-seq was used to screen the differential gene expression between primary SCLC lesions and paired metastatic lymph nodes (LN). The plasma concentration of GPNMB was measured using enzyme-linked immunosorbent assay (ELISA)...
2024: Journal of Cancer
https://read.qxmd.com/read/38706914/clinical-implications-of-a-six-protein-signature-in-bone-metastasis-of-renal-cell-carcinoma
#6
JOURNAL ARTICLE
Zheng Liu, Hanwen Mao, Dinggai Chu, Liang Qin, Jiang Wang
Bone metastases is prevalent from renal cell carcinoma (RCC) with poor quality of life and prognosis. Our previous proteomics analysis identified dysregulated proteins in the bone-tropism RCC cells. In this study, we further examined the clinical implications of these proteins using multiple clinical cohorts. We identified 6 proteins with significant upregulation in RCC tumor tissue in comparing to tumor adjacent normal tissue (p<0.05). High expression of these 6 protein-encoding genes significantly correlates with a poor survival in the TCGA-KIRC (Kidney renal clear cell carcinoma) cohort (log-rank test p=2...
2024: Journal of Cancer
https://read.qxmd.com/read/38706913/global-progress-and-future-prospects-of-early-gastric-cancer-screening
#7
REVIEW
Yixiao Huang, Yongfu Shao, Xuan Yu, Chujia Chen, Junming Guo, Guoliang Ye
Gastric cancer is a prevalent malignancy that poses a serious threat to global health. Despite advances in medical technologies, screening methods, and public awareness, gastric cancer remains a significant cause of morbidity and mortality worldwide. Early gastric cancer frequently does not present with characteristic symptoms, while advanced stage disease is characterized by a dismal prognosis. As such, early screening in gastric cancer is of great importance. In recent years, advances have been made globally in both clinical and basic research for the screening of early gastric cancer...
2024: Journal of Cancer
https://read.qxmd.com/read/38706912/lncrna-snhg1-acts-as-a-cerna-for-mir-216a-3p-to-regulate-tmbim6-expression-in-esophageal-squamous-cell-carcinoma
#8
JOURNAL ARTICLE
Ni Kong, Yuheng Chi, Hong Ma, Dongbo Luo
Background: The long noncoding RNA small nucleolar RNA host gene 1 (SNHG1) has been demonstrated to play a crucial role in the progression of esophageal squamous cell carcinoma (ESCC). The current study aims to explore the deeper molecular mechanisms of SNHG1 in ESCC. Methods: Fifty patients with ESCC were enrolled to assess overall survival. Quantitative real-time PCR was performed to measure the levels of SNHG1, miR-216a-3p, and TMBIM6 in ESCC cells. Functional assessments of SNHG1 on ESCC cells were conducted using CCK-8 assay, flow cytometry, and Transwell assays...
2024: Journal of Cancer
https://read.qxmd.com/read/38706911/decreased-expression-of-pld2-promotes-emt-in-colorectal-cancer-invasion-and-metastasis
#9
JOURNAL ARTICLE
Xuan Liu, Lei Shen, Haiyu Wang
Background and Objectives: PLD2 has been identified as playing a critical role in cancer cell motility and migration and other pathophysiological processes. We investigated the expression of PLD2 and its biological functions and clinical implications in human colorectal cancer. Materials and Methods: In this study, the expressions of PLD2 were analyzed in CRC cell lines and CRC samples by RT-PCR, western blot and immunohistochemistry. The PLD enzyme activity was studied using an PLD detection kit. We also performed matrigel invasion assay to evaluate the invasive capabilities in CRC cells...
2024: Journal of Cancer
https://read.qxmd.com/read/38706910/ultrasound-targeted-microbubble-destruction-improves-the-suppression-and-magnetic-resonance-imaging-of-pancreatic-cancer-with-polyethyleneimine-nanogels
#10
JOURNAL ARTICLE
Yang Liu, Yuanqiong Deng, Paul E Constanthin, Fan Li
The chemoresistance of pancreatic cancer tumors urgently needs to be addressed. Pancreatic cancer is characterized by an abundant stroma, with significant fibrous connective tissue formation that encapsulates the tumor parenchyma and forms an interstitial microenvironment. Pancreatic stellate cells (PSCs) play a crucial role in this microenvironment and specially secrete periosteal protein (periostin), which can promote tumor growth, metastasis, and chemoresistance. Therefore, periostin has become a specific target of chemotherapy resistance intervention methods...
2024: Journal of Cancer
https://read.qxmd.com/read/38706909/acox2-serves-as-a-favorable-indicator-related-to-lipid-metabolism-and-oxidative-stress-for-biochemical-recurrence-in-prostate-cancer
#11
JOURNAL ARTICLE
Zeheng Tan, Yulin Deng, Zhiduan Cai, Huichan He, Zhenfeng Tang, Yuanfa Feng, Jianheng Ye, Ren Liu, Shanghua Cai, Huiting Huang, Zhaodong Han, Weide Zhong, Kai Guo
Given the heterogeneity of tumors, there is an urgent need for accurate prognostic parameters in prostate cancer (PCa) patients. Lipid metabolism (LM) reprogramming and oxidative stress (OS) play a vital role in the progression of PCa. In this work, we identified five LM-OS-related genes (including ACOX2, PPRAGC1A, PTGS1, PTGS2, and HAO1) associated with the biochemical recurrence (BCR) of PCa. Subsequently, a prognostic signature was established based on these five genes. Kaplan-Meier survival estimates, receiver operating characteristic curves, and relationship analysis between risk score and clinical characters were applied to measure the robustness of the signature in an external cohort...
2024: Journal of Cancer
https://read.qxmd.com/read/38706908/cross-talk-of-three-molecular-subtypes-of-telomere-maintenance-defines-clinical-characteristics-and-tumor-microenvironment-in-gastric-cancer
#12
JOURNAL ARTICLE
Mengpei Yan, Zhijun Zhang, Luyao Wang, Hongxin Huang, Jihuan Wang, Chengjun Zhu, Zheng Li, Zekuan Xu
Background: Telomere maintenance takes part in the regulation of gastric cancer (GC) pathogenesis and is essential for patients' clinical features. Though the correlation between a single telomere maintenance-related gene and GC has previously been published, comprehensive exploration and systematic analysis remain to be studied. Our study is aimed at determining telomere maintenance-related molecular subtypes and examining their role in GC. Methods: By analyzing the transcriptome data, we identified three telomere maintenance-associated clusters (TMCs) with heterogeneity in clinical features and tumor microenvironment (TME)...
2024: Journal of Cancer
https://read.qxmd.com/read/38706907/knockdown-of-lrp5-promotes-proliferation-and-invasion-of-tongue-squamous-cell-carcinoma-through-compensatory-activation-of-akt-signaling
#13
JOURNAL ARTICLE
Chengze Wang, Yongzheng Li, Xiaoyan Miao, Ying Wang, Guoli Yang
The role of LRP5, a critical receptor in the Wnt signaling pathway, remains unexplored in tongue squamous cell carcinoma (TSCC). This study investigates the impact of LRP5 knockdown on the biological behaviors of TSCC cell lines both in vitro and in vivo . Our findings indicate that LRP5 knockdown significantly enhances cell proliferation, migration, and invasion in CAL27 and SCC25 cell lines. RNA-seq analysis reveals compensatory activation of the Akt pathway, with 119 genes significantly upregulated post-LRP5 knockdown...
2024: Journal of Cancer
https://read.qxmd.com/read/38706906/retraction-capsaicin-and-cold-exposure-promote-emt-mediated-premetastatic-niche-formation-to-facilitate-colorectal-cancer-metastasis
#14
Feifei Nong, Shangping Xing
[This retracts the article DOI: 10.7150/jca.83985.].
2024: Journal of Cancer
https://read.qxmd.com/read/38706905/mir-760-exerts-a-critical-regulatory-role-in-glioma-proliferation-migration-and-invasion-by-modulating-mmp2-expression
#15
JOURNAL ARTICLE
Zhengting Qian, Heng Xin, Zhen Jia, Jiageng Xia, Yong Tang, Xiang Li, Heming Wu, Youwu Fan
Background: Glioma represents the predominant subtype of brain tumor, characterized by an unfavorable prognosis. Current evidence indicates the involvement of microRNAs (miRNAs) in the initiation and progression of glioma malignancies. While miR-760 has been recognized in the context of tumorigenesis, its precise role in gliomas remains insufficiently explored. Methods: In this investigation, we harnessed the GSE25631 database to scrutinize the aberrant expression profiles of microRNAs, whereby the diminished expression of miR-760 in glioblastoma was validated...
2024: Journal of Cancer
https://read.qxmd.com/read/38706904/trpv3-regulates-breast-cancer-cell-proliferation-and-apoptosis-by-egfr-akt-pathway
#16
JOURNAL ARTICLE
Yan Xie, Hyo In Kim, Qianzhi Yang, Jinghao Wang, Wei Huang
Breast cancer (BC) is one of the most common cancer types worldwide and the first cause of cancer-related deaths in women. Transient receptor potential vanillin 3 (TRPV3) has been preliminarily discovered to play an important role in various cancers, including BC. Here, we explored the effect of TRPV3 on breast cancer cells and its potential mechanism. TRPV3 level was measured in BC tissue and adjacent noncancerous breast tissue using real-time RT-PCR and Western blot. Wound healing was used to detect cell migration...
2024: Journal of Cancer
https://read.qxmd.com/read/38706903/identification-of-the-expression-of-tie1-and-its-mediated-immunosuppression-in-gastric-cancer
#17
JOURNAL ARTICLE
Zhenqi Gong, Qing Zheng, Baizhi Li, Huaiming Wang, Hongwu Chen, Shaoxiong Lin
Background: Recently, various evidence has confirmed that Tyrosine Kinase with Immunoglobulin-like and EGF-like domains 1 (TIE1) promotes tumor growth in many cancers. However, the precise mechanism underlying TIE1's involvement in Gastric Cancer (GC) remains elusive. This research aimed to investigate the biological function of TIE1 in regulating GC progression. Methods: The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), GEPIA2.0, Sangerbox3.0 and TIMER databases were used to analyze the TIE1 expression...
2024: Journal of Cancer
https://read.qxmd.com/read/38706902/prognostic-value-and-therapeutic-potential-of-nek-family-in-stomach-adenocarcinoma
#18
JOURNAL ARTICLE
Xunjian Zhou, Hui Nie, Chunrong Wang, Xiaoqian Yu, Xuejie Yang, Xiaoyun He, Chunlin Ou
Never in mitosis gene A-related kinase (NEK) is an 11-membered family of serine/threonine kinases (NEK1-NEK11), which are known to play important roles in the formation and development of cancer. However, few studies have examined the roles of these kinases in the development of stomach adenocarcinoma (STAD). In this study, we conducted a comprehensive analysis of the relationships between the NEKs family members and STAD. The differential expression of the NEK genes in STAD was validated using The Cancer Genome Atlas (TCGA) and Tumor Immune Estimation Resource (TIMER) databases, and their prognostic and diagnostic values of NEKs in STAD were assessed using the Kaplan-Meier plotter and TCGA data...
2024: Journal of Cancer
https://read.qxmd.com/read/38706901/angiogenesis-related-lncrnas-index-a-predictor-for-cesc-prognosis-immunotherapy-efficacy-and-chemosensitivity
#19
JOURNAL ARTICLE
Xueyuan Huang, Guangming Yi, Jiayu Xu, Siqi Gou, Haiqing Chen, Xiaoyan Chen, Xiaomin Quan, Linjia Xie, Alexander Tobias Teichmann, Guanhu Yang, Hao Chi, Qin Wang
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is a common gynecologic tumor and patients with advanced and recurrent disease usually have a poor clinical outcome. Angiogenesis is involved in the biological processes of tumors and can promote tumor growth and invasion. In this paper, we created a signature for predicting prognosis based on angiogenesis-related lncRNAs (ARLs). This provides a prospective direction for enhancing the efficacy of immunotherapy in CESC patients. We screened seven OS-related ARLs by univariate and multivariate regression analyses and Lasso analysis and developed a prognostic signature at the same time...
2024: Journal of Cancer
https://read.qxmd.com/read/38706900/cell-free-nucleic-acid-as-promising-diagnostic-biomarkers-for-gastric-cancer-a-systematic-review
#20
JOURNAL ARTICLE
Qun Zhang, Zhouyuan Du, Xiaoxiao Wang, Fen Li, Yi Liu, Jingjing Sun, Lin Zhang, Yong Xiao, Xiaoming Lu, Haixin Yu, Tao Liu
Background: Gastric cancer (GC) is a common malignancy with early detection being crucial for survival. Liquid biopsy analysis using cell-free nucleic acid is a preferred method for detection. Hence, we conducted a systematic review to assess the diagnostic efficacy of cell-free nucleic acid markers for GC. Methods: We searched PubMed and ISI Web of Science databases for articles that conformed to our inclusion and exclusion criteria from 2012 to 2022. The following information was abstracted: first author, year of publication, country/region, age, male proportion, tumor stage for cases, specimen type, measurement method, targeted markers and diagnostic related indicators (including sensitivity, specificity, AUC, P-value)...
2024: Journal of Cancer
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