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World Journal of Stem Cells

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https://read.qxmd.com/read/30705714/regenerative-potential-of-mouse-embryonic-stem-cell-derived-pdgfr%C3%AE-cardiac-lineage-committed-cells-in-infarcted-myocardium
#1
Seon Pyo Hong, Sukhyun Song, Seungjoo Lee, Hyeonju Jo, Hyoung Kyu Kim, Jin Han, Jae-Hyeong Park, Sung Woo Cho
BACKGROUND: Pluripotent stem cell-derived cardiomyocytes (CMs) have become one of the most attractive cellular resources for cell-based therapy to rescue damaged cardiac tissue. AIM: We investigated the regenerative potential of mouse embryonic stem cell (ESC)-derived platelet-derived growth factor receptor-α (DGFRα)+ cardiac lineage-committed cells (CLCs), which have a proliferative capacity but are in a morphologically and functionally immature state compared with differentiated CMs...
January 26, 2019: World Journal of Stem Cells
https://read.qxmd.com/read/30705713/current-methods-for-the-maturation-of-induced-pluripotent-stem-cell-derived-cardiomyocytes
#2
REVIEW
Pranav Machiraju, Steven C Greenway
Induced pluripotent stem cells (iPSCs) were first generated by Yamanaka and colleagues over a decade ago. Since then, iPSCs have been successfully differentiated into many distinct cell types, enabling tissue-, disease-, and patient-specific in vitro modelling. Cardiovascular disease is the greatest cause of mortality worldwide but encompasses rarer disorders of conduction and myocardial function for which a cellular model of study is ideal. Although methods to differentiate iPSCs into beating cardiomyocytes (iPSC-CMs) have recently been adequately optimized and commercialized, the resulting cells remain largely immature with regards to their structure and function, demonstrating fetal gene expression, disorganized morphology, reliance on predominantly glycolytic metabolism and contractile characteristics that differ from those of adult cardiomyocytes...
January 26, 2019: World Journal of Stem Cells
https://read.qxmd.com/read/30705712/applications-of-stem-cells-and-bioprinting-for-potential-treatment-of-diabetes
#3
REVIEW
Shweta Anil Kumar, Monica Delgado, Victor E Mendez, Binata Joddar
Currently, there does not exist a strategy that can reduce diabetes and scientists are working towards a cure and innovative approaches by employing stem cell-based therapies. On the other hand, bioprinting technology is a novel therapeutic approach that aims to replace the diseased or lost β-cells, insulin-secreting cells in the pancreas, which can potentially regenerate damaged organs such as the pancreas. Stem cells have the ability to differentiate into various cell lines including insulin-producing cells...
January 26, 2019: World Journal of Stem Cells
https://read.qxmd.com/read/30705711/human-adult-pluripotency-facts-and-questions
#4
EDITORIAL
Luminita Labusca, Kaveh Mashayekhi
Cellular reprogramming and induced pluripotent stem cell (IPSC) technology demonstrated the plasticity of adult cell fate, opening a new era of cellular modelling and introducing a versatile therapeutic tool for regenerative medicine. While IPSCs are already involved in clinical trials for various regenerative purposes, critical questions concerning their medium- and long-term genetic and epigenetic stability still need to be answered. Pluripotent stem cells have been described in the last decades in various mammalian and human tissues (such as bone marrow, blood and adipose tissue)...
January 26, 2019: World Journal of Stem Cells
https://read.qxmd.com/read/30613314/platelet-rich-plasma-enhances-adipose-derived-stem-cell-mediated-angiogenesis-in-a-mouse-ischemic-hindlimb-model
#5
Chia-Fang Chen, Han-Tsung Liao
AIM: To evaluate the angiogenic effect of platelet-rich plasma (PRP)-preconditioned adipose-derived stem cells (ADSCs) both in vitro and in a mouse ischemic hindlimb model. METHODS: ADSCs were divided based on culture medium: 2.5% PRP, 5% PRP, 7.5% PRP, and 10% PRP. Cell proliferation rate was analyzed using the MTS assay. The gene expression of CD31, vascular endothelial growth factor, hypoxia-inducible factors, and endothelial cell nitric oxide synthase was analyzed using reverse transcription polymerase chain reaction...
December 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30613313/functional-and-molecular-mechanism-of-intracellular-ph-regulation-in-human-inducible-pluripotent-stem-cells
#6
Shih-Chi Chao, Gwo-Jang Wu, Shu-Fu Huang, Niann-Tzyy Dai, Hsu-Kai Huang, Mei-Fang Chou, Yi-Ting Tsai, Shiao-Pieng Lee, Shih-Hurng Loh
AIM: To establish a functional and molecular model of the intracellular pH (pHi ) regulatory mechanism in human induced pluripotent stem cells (hiPSCs). METHODS: hiPSCs (HPS0077) were kindly provided by Dr. Dai from the Tri-Service General Hospital (IRB No. B-106-09). Changes in the pHi were detected either by microspectrofluorimetry or by a multimode reader with a pH-sensitive fluorescent probe, BCECF, and the fluorescent ratio was calibrated by the high K+ /nigericin method...
December 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30613312/cancer-stem-cell-impact-on-clinical-oncology
#7
REVIEW
Mariel E Toledo-Guzmán, Gabriele D Bigoni-Ordóñez, Miguel Ibáñez Hernández, Elizabeth Ortiz-Sánchez
Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo- and radio-resistance. Several mechanisms have been studied to explain chemo- and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes...
December 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30631392/pancreatic-cancer-stem-cells-perspectives-on-potential-therapeutic-approaches-of-pancreatic-ductal-adenocarcinoma
#8
REVIEW
Claudia Di Carlo, Jessica Brandi, Daniela Cecconi
Pancreatic ductal adenocarcinoma is one of the most aggressive solid tumours of the pancreas, characterised by a five-year survival rate less than 8%. Recent reports that pancreatic cancer stem cells (PCSCs) contribute to the tumorigenesis, progression, and chemoresistance of pancreatic cancer have prompted the investigation of new therapeutic approaches able to directly target PCSCs. In the present paper the non-cancer related drugs that have been proposed to target CSCs that could potentially combat pancreatic cancer are reviewed and evaluated...
November 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30631391/single-cell-analysis-of-tumors-creating-new-value-for-molecular-biomarker-discovery-of-cancer-stem-cells-and-tumor-infiltrating-immune-cells
#9
REVIEW
Ramin Radpour, Farzad Forouharkhou
Biomarker-driven individualized treatment in oncology has made tremendous progress through technological developments, new therapeutic modalities and a deeper understanding of the molecular biology for tumors, cancer stem cells and tumor-infiltrating immune cells. Recent technical developments have led to the establishment of a variety of cancer-related diagnostic, prognostic and predictive biomarkers. In this regard, different modern OMICs approaches were assessed in order to categorize and classify prognostically different forms of neoplasia...
November 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30631390/cytokines-in-adipose-derived-mesenchymal-stem-cells-promote-the-healing-of-liver-disease
#10
REVIEW
Saifun Nahar, Yoshiki Nakashima, Chika Miyagi-Shiohira, Takao Kinjo, Zensei Toyoda, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi, Jiro Fujita
Adipose-derived mesenchymal stem cells (ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield ( i.e ., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, anti-apoptotic effects, and control of immune cells via cell-cell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure...
November 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30397424/efficacy-and-safety-of-autologous-stem-cell-transplantation-for-decompensated-liver-cirrhosis-a-retrospective-cohort-study
#11
Ming-Fang Wang, You-Bing Li, Xiao-Juan Gao, Hao-Yang Zhang, Su Lin, Yue-Yong Zhu
AIM: To evaluate the long-term efficacy and safety of autologous stem cell transplantation (SCT) for decompensated liver cirrhosis. METHODS: Consecutive patients with decompensated liver cirrhosis were included and assigned into the SCT group and non-transplantation (non-SCT) group according to whether they received SCT treatment. Patients were followed up for ten years. The long-term survival rate and incidence of hepatocellular carcinoma (HCC) were compared between groups...
October 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30397423/hematopoietic-stem-cell-transplantation-for-crohn-s-disease-gaps-doubts-and-perspectives
#12
EDITORIAL
Milton Artur Ruiz, Roberto Luiz Kaiser Junior, Lilian Piron-Ruiz, Tatiana Peña-Arciniegas, Priscila Samara Saran, Luiz Gustavo De Quadros
Crohn's disease (CD) is an inflammatory bowel disease that can affect any site of the digestive system. It occurs due to an immunological imbalance and is responsible for intestinal mucosal lesions and complications such as fistulas and stenoses. Treatment aims to stabilize the disease, reducing the symptoms and healing intestinal lesions. Surgical procedures are common in patients. Cell therapy was initially used to treat this disease in patients who also suffered from lymphoma and leukemia and were considered to be good candidates for autologous and allogeneic transplantation...
October 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30310531/regulatory-role-of-sphingosine-kinase-and-sphingosine-1-phosphate-receptor-signaling-in-progenitor-stem-cells
#13
REVIEW
Mei Li Ng, Nagendra S Yarla, Mario Menschikowski, Olga A Sukocheva
Balanced sphingolipid signaling is important for the maintenance of homeostasis. Sphingolipids were demonstrated to function as structural components, second messengers, and regulators of cell growth and survival in normal and disease-affected tissues. Particularly, sphingosine kinase 1 (SphK1) and its product sphingosine-1-phosphate (S1P) operate as mediators and facilitators of proliferation-linked signaling. Unlimited proliferation (self-renewal) within the regulated environment is a hallmark of progenitor/stem cells that was recently associated with the S1P signaling network in vasculature, nervous, muscular, and immune systems...
September 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30310530/gingival-derived-mesenchymal-stem-cells-an-endless-resource-for-regenerative-dentistry
#14
EDITORIAL
Mohammed E Grawish
The gingiva, the masticatory portion of the oral mucosa, is excised and discarded frequently during routine dental treatments and following tooth extraction, dental crown lengthening, gingivectomy and periodontal surgeries. Subsequent to excision, healing eventually happens in a short time period after gingival surgery. Clinically, the gingival tissue can be collected very easily and, in the laboratory, it is also very easy to isolate gingival-derived mesenchymal stem cells (GMSCs) from this discarded gingival tissue...
September 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30190780/stem-cell-derived-exosomes-an-emerging-tool-for-myocardial-regeneration
#15
REVIEW
Erzsebet Lazar, Theodora Benedek, Szilamer Korodi, Nora Rat, Jocelyn Lo, Imre Benedek
Cardiovascular diseases (CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction (AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, loss of functional cardiomyocytes as a result of ischaemic injury leads to ventricular failure, resulting in significant alteration to quality of life and increased mortality. Therefore, many attempts have been made in recent years to identify new tools for the regeneration of functional cardiomyocytes...
August 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30079130/stem-cell-therapy-for-faecal-incontinence-current-state-and-future-perspectives
#16
REVIEW
Jacobo Trébol, Ana Carabias-Orgaz, Mariano García-Arranz, Damián García-Olmo
Faecal continence is a complex function involving different organs and systems. Faecal incontinence is a common disorder with different pathogeneses, disabling consequences and high repercussions for quality of life. Current management modalities are not ideal, and the development of new treatments is needed. Since 2008, stem cell therapies have been validated, 36 publications have appeared (29 in preclinical models and seven in clinical settings), and six registered clinical trials are currently ongoing. Some publications have combined stem cells with bioengineering technologies...
July 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/30079129/ectopic-expression-of-the-osteogenic-master-gene-runx2-in-melanoma
#17
EDITORIAL
Maria Teresa Valenti, Luca Dalle Carbonare, Monica Mottes
The transcription factor RUNX2 is the osteogenic master gene expressed in mesenchymal stem cells during osteogenic commitment as well as in pre-osteoblasts and early osteoblasts. However, RUNX2 is also ectopically expressed in melanoma and other cancers. Malignant melanoma (MM) is a highly metastatic skin cancer. The incidence of MM has increased considerably in the past half-century. The expression levels and mutation rates of genes such as BRAF , KIT , NRAS , PTEN , P53 , TERT and MITF are higher in melanoma than in other solid malignancies...
July 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/29988882/murine-models-based-on-acute-myeloid-leukemia-initiating-stem-cells-xenografting
#18
REVIEW
Cristina Mambet, Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu, Carmen Cristina Diaconu
Acute myeloid leukemia (AML) is an aggressive malignant disease defined by abnormal expansion of myeloid blasts. Despite recent advances in understanding AML pathogenesis and identifying their molecular subtypes based on somatic mutations, AML is still characterized by poor outcomes, with a 5-year survival rate of only 30%-40%, the majority of the patients dying due to AML relapse. Leukemia stem cells (LSC) are considered to be at the root of chemotherapeutic resistance and AML relapse. Although numerous studies have tried to better characterize LSCs in terms of surface and molecular markers, a specific marker of LSC has not been found, and still the most universally accepted phenotypic signature remains the surface antigens CD34+CD38- that is shared with normal hematopoietic stem cells...
June 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/29988866/applications-of-stem-cells-in-orthodontics-and-dentofacial-orthopedics-current-trends-and-future-perspectives
#19
REVIEW
Shiva Safari, Arezoo Mahdian, Saeed Reza Motamedian
A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes. Also, orthodontics is in close relation with dentofacial orthopedics which involves bone regeneration. In this review current and future applications of stem cells (SCs) in orthodontics and dentofacial orthopedics have been discussed. For craniofacial anomalies, SCs have been applied to regenerate hard tissue (such as treatment of alveolar cleft) and soft tissue (such as treatment of hemifacial macrosomia)...
June 26, 2018: World Journal of Stem Cells
https://read.qxmd.com/read/29849930/stem-cells-as-delivery-vehicles-for-regenerative-medicine-challenges-and-perspectives
#20
REVIEW
Luminita Labusca, Dumitru Daniel Herea, Kaveh Mashayekhi
The use of stem cells as carriers for therapeutic agents is an appealing modality for targeting tissues or organs of interest. Combined delivery of cells together with various information molecules as therapeutic agents has the potential to enhance, modulate or even initiate local or systemic repair processes, increasing stem cell efficiency for regenerative medicine applications. Stem-cell-mediated delivery of genes, proteins or small molecules takes advantage of the innate capability of stem cells to migrate and home to injury sites...
May 26, 2018: World Journal of Stem Cells
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